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AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).
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AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 1,540 | 5日内发货 | |
5 mg | ¥ 2,610 | 5日内发货 | |
25 mg | ¥ 8,930 | 8-10周 | |
50 mg | ¥ 11,600 | 8-10周 | |
100 mg | ¥ 17,900 | 8-10周 |
产品描述 | AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM). |
靶点活性 | FFA1/GPR40:0.16 μM |
体内活性 | AM-1638 exhibits moderate cross-species plasma clearance and volume of distribution, resulting in plasma half-lives suitable for evaluation of its antidiabetic properties in mouse, rat, and cynomologus monkey. AM-1638 exhibits antidiabetic activity in BDF/DIO mice[1]. Moreover, oral administration of full agonist AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%). |
分子量 | 514.63 |
分子式 | C33H35FO4 |
CAS No. | 1142214-62-7 |
密度 | 1.193 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 250 mg/mL (485.79 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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