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BR102375
还可以产品编号 T10596Cas号 2366255-59-4
BR102375 is a non-TZD PPAR γ full agonist (EC50: 0.28 μM) for the treatment of type 2 diabetes.
BR102375
还可以产品编号 T10596Cas号 2366255-59-4
BR102375 is a non-TZD PPAR γ full agonist (EC50: 0.28 μM) for the treatment of type 2 diabetes.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 10,600 | 6-8周 | |
| 50 mg | ¥ 13,800 | 6-8周 | |
| 100 mg | ¥ 17,500 | 6-8周 |
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产品介绍
生物活性
化学信息
| 产品描述 | BR102375 is a non-TZD PPAR γ full agonist (EC50: 0.28 μM) for the treatment of type 2 diabetes. |
| 体外活性 | BR102375 (Compound 18) (10 μM) increases gene expression levels relevant to PPARγ activation and enhances glucose uptake under insulin stimulation. BR102375 (10 nM, 100 nM, 1 μM; 6 days, 14 days) shows a concentration-dependent, insulin-sensitive effects on adipogenesis [1]. |
| 体内活性 | BR102375 has decent efficacy on the mouse diabetes model.BR102375 reveals significant suppressive effect on random blood glucose increase(75 mpk, p.o., bid), shows a decent effect on insulin resistance on the Oral glucose tolerance test (OGTT), and discloses similar findings in body weight gain almost identical to Pioglitazone [1]. |
| 分子量 | 554.64 |
| 分子式 | C31H34N6O4 |
| CAS No. | 2366255-59-4 |
| 密度 | 1.28 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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