DS45500853

Name: DS45500853
Brand: TargetMol
SKU: T40349
Rating: 4.5 (1 reviews)

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产品编号 T40349Cas号 2735803-28-6

DS45500853, an estrogen-related receptor α (ERRα) agonist, acts as an inhibitor of the binding interaction between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM), exhibiting an IC50 of 0.80 μM. This compound holds potential for research pertaining to metabolic disorders, particularly type 2 diabetes mellitus (T2DM).

DS45500853

还可以

产品编号 T40349Cas号 2735803-28-6

规格	价格	库存	数量
2 mg	¥ 1,380	5日内发货
1 mL x 10 mM (in DMSO)	¥ 2,280	5日内发货

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产品描述	DS45500853, an estrogen-related receptor α (ERRα) agonist, acts as an inhibitor of the binding interaction between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM), exhibiting an IC50 of 0.80 μM. This compound holds potential for research pertaining to metabolic disorders, particularly type 2 diabetes mellitus (T2DM).
体外活性	DS45500853 (compound 5c; 0.002, 0.006, 0.017, 0.051, 0.015, 0.046, 1.4, 4.2, 12.5 μg/mL; 18 h) inhibits the transcriptional activity of full-length ERRα in MG63 cells with an EC 50 of 5.4 μM[1]. DS45500853 binds in the ligand-binding pocket (LBP) of the ERRα LBD as inverse agonist II[1].