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TMPY-02521
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HIST3H2A Protein, Human, Recombinant
histone cluster 3, H2a,MGC3165
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Human
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E. coli
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Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machinery that set them are crucial regulators that can control cellular proliferation, differentiation,... |
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TMPH-00088
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Expansin-B1 Protein, Arabidopsis thaliana, Recombinant (His)
EXPB1,Expansin-B1,Ath-ExpBeta-1.5,Beta-expansin-1
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Arabidopsis thaliana
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E. coli
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May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found. |
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TMPH-00108
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UBC11 Protein, Arabidopsis thaliana, Recombinant (His)
Ubiquitin-conjugating enzyme E2-17 kDa 11,Ubiquitin-conjugat...
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Arabidopsis thaliana
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E. coli
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Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC11 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.6 kDa and the accession number is P35134. |
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TMPH-00107
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UBC10 Protein, Arabidopsis thaliana, Recombinant (His)
Ubiquitin carrier protein 10/12,Ubiquitin-conjugating enzyme...
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Arabidopsis thaliana
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E. coli
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Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC10 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.6 kDa and the accession number is P35133. |
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TMPH-00155
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Barstar Protein, Bacillus amyloliquefaciens, Recombinant (His & Myc)
Barstar,Ribonuclease inhibitor
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Bacillus amyloliquefaciens
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E. coli
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Inhibitor of the ribonuclease barnase. Forms a one-to-one non-covalent complex. Barstar Protein, Bacillus amyloliquefaciens, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.7 kDa and the accession number is P11540. |
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TMPH-03601
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Streptavidin Protein, S. avidinii, Recombinant (His)
Streptavidin
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Streptomyces avidinii
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P. pastoris (Yeast)
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The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin). Streptavidin Protein, S. avidinii, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.5 kDa and the accession number is P22629. |
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TMPH-03613
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NblA Protein, Synechococcus elongatus, Recombinant (His & Myc)
nblA,Phycobilisome degradation protein NblA
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Synechococcus elongatus
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E. coli
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Involved in phycobilisome (PBS) degradation during nutrient deprivation. May mark the PBS for degradation by covalent association with PBS components or may disrupt the PBS via ionic interactions. NblA Protein, Synechococcus elongatus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.5 kDa and the accession number is P35087. |
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TMPJ-01221
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UBE2J2 Protein, Human, Recombinant (GST)
NCUBE-2,UBE2J2,Ubiquitin-Conjugating Enzyme E2 J2,NCUBE2,Non...
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Human
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E. coli
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Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic reticulum, catalyzes the covalent attachment of ubiquitin to other proteins. UBE2J2 may play a important role in the selective degradation of misfolded membrane protein from the endoplasmic reticulum. |
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TMPJ-01278
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SENP8 Protein, Human, Recombinant (His)
DEN1,Protease Cysteine 2,NEDP1,Sentrin-Specific Protease 8,D...
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Human
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E. coli
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Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8 from targeted proteins such as CUL2 , CUL4A in vivo, or p53. but it does not show activity against ubiquitin or SUMO proteins. |
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TMPH-00109
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UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc)
E2 ubiquitin-conjugating enzyme 8,Ubiquitin carrier protein ...
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Arabidopsis thaliana
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E. coli
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Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.0 kDa and the accession number is P35131. |
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TMPH-00087
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Expansin-A1 Protein, Arabidopsis thaliana, Recombinant (His & Myc)
Expansin-A1,Alpha-expansin-1,EXPA1,Ath-ExpAlpha-1.2
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Arabidopsis thaliana
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E. coli
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Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found. Expansin-A1 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.2 kDa and the accession number is Q9C554. |
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TMPJ-01198
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UBE2R2 Protein, Human, Recombinant (His)
UBC3B,Ubiquitin-Conjugating Enzyme E2-CDC34B,CDC34B,Ubiquiti...
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Human
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E. coli
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Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, UBE2R2 catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. It may be involved in degradation of katenin. |
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TMPJ-00033
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UBE2B Protein, Human, Recombinant (His)
Ubiquitin-Conjugating Enzyme E2 B,hHR6B,Ubiquitin-Conjugatin...
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Human
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HEK293 Cells
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Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2B interacts with RAD18, UBR2, and WAC. UBE2B is required for post-replicative DNA damage repair. Additional, UBE2B plays a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia. |
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TMPJ-01334
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UBE2Z Protein, Human, Recombinant (His)
Uba6-Specific E2 Conjugating Enzyme 1,Ubiquitin Carrier Prot...
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Human
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E. coli
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Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta, pancreas, spleen, and testis. It is ubiquitinates proteins that catalyze the covalent attachment of ubiquitin to other proteins. It has shown that ZUBE2Z participate in signaling pathways, and may be involved in apoptosis regulation. |
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TMPY-02129
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Transglutaminase 3/TGM3 Protein, Human, Recombinant (His)
transglutaminase 3,UHS2,TGE
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Human
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Baculovirus Insect Cells
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Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutaminase 3 (TGM3) is a member of a family of Ca2+-dependent enzymes that catalyze covalent cross-linking reactions between proteins or peptides. TGM3 isoform is widely expressed and is important for epithelial barrier formation. It is a zymogen, requiring proteolysis for activity. Calc... |
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TMPH-01265
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PELI3 Protein, Human, Recombinant (His)
PELI3,E3 ubiquitin-protein ligase pellino homolog 3
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Human
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E. coli
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E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. PELI3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 54.8 kDa and the access... |
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TMPJ-01069
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Serpin A1e Protein, Mouse, Recombinant (His)
Dom5,α-1-antitrypsin 1-5,Serpina1e,Spi1-5,Serine protease in...
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Mouse
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HEK293 Cells
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Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein ... |
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TMPY-02842
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UBE2L6 Protein, Human, Recombinant (His)
UBCH8,ubiquitin-conjugating enzyme E2L 6,RIG-B
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Human
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E. coli
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UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain. These domains accommodate the ATP-activated ubiquitin (Ub) or ubiquitin-like (UBL) protein via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the E1 and E3 enzymes and connect activation to covalent modi... |
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TMPJ-00985
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UBE2A Protein, Human, Recombinant (GST, His)
RAD6A,HR6A,Ubiquitin-Protein Ligase A,UBE2A,hHR6A,Ubiquitin ...
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Human
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E. coli
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Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2A catalyzes the covalent attachment of ubiquitin to other proteins. UBE2A is re... |
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TMPJ-01362
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UBAP1 Protein, Human, Recombinant (His)
Nasopharyngeal Carcinoma-Associated Gene 20 Protein,UBAP1,Ub...
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Human
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E. coli
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Ubiquitin-Associated Protein 1 (UBAP1) belongs to the UBA domain family. Members of this family are related to ubiquitin and the ubiquitination pathway. Because of their cytogenetic location, this UBA domain family member is being studied as a putative target for mutation in nasopharyngeal carcinomas. UBAP1 is highly expressed in the heart, brain, placenta, lung, skeletal muscle, liver, and pancreas. UBAP1 consists of two UBA domains and one UMA domain. The ubiquitin associated domain is through... |
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TMPJ-01403
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UBE2D4 Protein, Human, Recombinant (GST)
Ubiquitin-Conjugating Enzyme E2 D4,Ubiquitin-Protein Ligase ...
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Human
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E. coli
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Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational protein modification, protein K6-linked ubiquitination, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, and protein K63-linked ubiquitination. UBE2D4 regulate of protein metabolic process... |
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TMPY-00323
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Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)
NS3
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HCV
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E. coli
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HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, t... |
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TMPJ-01089
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TFF1 Protein, Mouse, Recombinant (His)
Bcei,Protein pS2,Ps2,Trefoil factor 1,Tff1
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Mouse
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HEK293 Cells
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Trefoil Factor 1 (TFF1) belongs to the three structurally related secreted proteins that contain trefoil domains.TFF1 is an approximately peptide that has an important effect in epithelial regeneration and wound healing.It originates from musculus and highly expressed by goblet cells of the gastric and intestinal mucosa and by conjunctival goblet cells. TFF1 is a copper-binding protein that can form disulfide-linked homodimers, associate into disulfide-linked complexes with Gastrokine 2, and fo... |
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TMPJ-01055
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HBA1 Protein, Human, Recombinant (His)
α-globin,Hemoglobin subunit alpha,HBH,HBA-T3,Alpha-globin,He...
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Human
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E. coli
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Hemoglobin subunit alpha 1 (HBA1), also known as α2β2, is a hetero-tetramer consisting of two α and two β subunits held together by non-covalent interactions. Each subunit contains a heme group with an iron atom in the Fe2+ state. Cooperativity of Hemoglobin (Hb) in binding with O2 and allosteric regulatory binding properties with CO2, H+, Cl−, and 2,3-DPG (2,3-bisphosphoglycerate) are based on subunit interactions. HBA1 is the most common type of Hb in adult humans, which mediates the transport... |
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TMPY-03052
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MFAP5 Protein, Human, Recombinant (His)
microfibrillar associated protein 5,MFAP-5,AAT9,MAGP2,MP25,M...
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Human
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HEK293 Cells
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MFAP5 (Microfibril Associated Protein 5, also known as MAGP2) is a Protein Coding gene. MFAP5 is a component of the elastin-associated microfibrils. It belongs to the MFAP family. As a 25-kD microfibril-associated glycoprotein, MFAP5 is rich in serine and threonine residues. It stimulates the assembly of elastic fibers, a complex structure composed of a tropoelastin inner core and microfibril outer mantle comprising proteins such as fibrillins and microfibril-associated glycoproteins that guide ... |
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TMPH-01241
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TOP1 Protein, Human, Recombinant (His & Myc)
DNA topoisomerase 1,TOP1,DNA topoisomerase I
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Human
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Baculovirus Insect Cells
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Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates a... |
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TMPJ-00486
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SUMO2 Protein, Human, Recombinant (His)
HSMT3,Ubiquitin-Like Protein SMT3A,SUMO-3,SMT3A,Sentrin-2,SM...
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Human
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E. coli
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Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and l... |
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TMPY-02642
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UBE2W Protein, Human, Recombinant (His)
UBC16,UBC-16,ubiquitin-conjugating enzyme E2W (putative)
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Human
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E. coli
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Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2W is a member of th... |
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TMPJ-01100
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UBE2V1 Protein, Human, Recombinant (His)
TRAF6-Regulated IKK Activator 1 Beta Uev1A,P/OKcl.19,TRAF6-R...
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Human
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E. coli
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Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inactive on its own. However, in the cytoplasm UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13, which mediates the synthesis Lys63-linked Ubiquitin chains and is required for NF-kappa B activation. UBE2V1 is required for UBE2N (Ubc13)/UBE2V1 Complex-dependent Ly... |
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TMPH-00651
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Lpp Protein, E. coli, Recombinant (His & KSI)
Major outer membrane lipoprotein Lpp,Braun lipoprotein,Murei...
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E. coli
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E. coli
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An outer membrane lipoprotein that controls the distance between the inner and outer membranes; adding residues to Lpp increases the width of the periplasm. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to the maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane. The m... |
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TMPH-01270
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TRAIP Protein, Human, Recombinant (His)
E3 ubiquitin-protein ligase TRAIP,TRAF-interacting protein,T...
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Human
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E. coli
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E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm... |
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TMPH-01263
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PRKN Protein, Human, Recombinant (His & SUMO)
PRKN,Parkin RBR E3 ubiquitin-protein ligase,E3 ubiquitin-pro...
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Human
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E. coli
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Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det... |
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TMPH-02631
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PRKN Protein, Mouse, Recombinant (GST)
E3 ubiquitin-protein ligase parkin,Prkn,Parkin RBR E3 ubiqui...
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Mouse
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E. coli
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Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det... |
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