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EN171是一种能够共价修饰14-3-3的C38与C96位置,增强其与ERα、YAP及TAZ的相互作用的共价配体,从而损害雌激素受体和Hippo通路的转录活性。此外,EN171不只是一种分子胶水,促进天然蛋白质间的相互作用,它还可作为共价14-3-3招募者,在异功能双分子中,将如BRD4与BCL6的核新底物隔离至细胞质。
EN171是一种能够共价修饰14-3-3的C38与C96位置,增强其与ERα、YAP及TAZ的相互作用的共价配体,从而损害雌激素受体和Hippo通路的转录活性。此外,EN171不只是一种分子胶水,促进天然蛋白质间的相互作用,它还可作为共价14-3-3招募者,在异功能双分子中,将如BRD4与BCL6的核新底物隔离至细胞质。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol. |
分子量 | 270.37 |
分子式 | C17H22N2O |
CAS No. | 2191110-79-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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