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Search Results for " pressure "

Targets Recommended: Adrenergic Receptor

300

抑制剂 & 化合物

36

天然产物

4

化合物库

15

重组蛋白

16

同位素标记化合物

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Cat. No.	Product Name
L7110	抗高血压化合物库		678 compounds
	678 种高血压相关的小分子，用于高通量和高内涵筛选；
L6130	萜类天然产物库		622 compounds
	622 种萜类天然产物的独特集合，可用于高通量筛选和高内涵筛选；
L6120	黄酮类天然产物库		514 compounds
	514 种黄酮类天然产物的独特集合，可用于高通量筛选和高内涵筛选；
L8720	细胞焦亡化合物库		1066 compounds
	1066 种细胞焦亡相关的化合物，可以用于细胞焦亡相关研究。

化合物库

抗高血压化合物库

Cat.No: L7110

Compounds: 678

萜类天然产物库

Cat.No: L6130

Compounds: 622

黄酮类天然产物库

Cat.No: L6120

Compounds: 514

细胞焦亡化合物库

Cat.No: L8720

Compounds: 1066

Cat. No.	Product Name	Target	Signaling Pathways
T5471	GUANABENZ	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	GUANABENZ 是一种中枢 alpha-2 肾上腺素能激动剂。它的作用机制是作为肾上腺素能 α2-激动剂。
T11831	LDN-27219	Others	Others
	LDN-27219 是一种人组织型转谷氨酰胺酶抑制剂(IC50:600 nM)。
T6792	BQ-123 BQ123	Endothelin Receptor	GPCR/G Protein
	BQ-123 是高效的内皮素 A(ETA)受体选择性拮抗剂，其IC50=7.3 nM，Ki=25 nM。它能够降低高血压大鼠血压，抑制内皮素-1 介导的人肺动脉平滑肌细胞增殖。
T3174	Taprenepag CP-544326	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Taprenepag (CP-544326) 是一种有效的选择性前列腺素 E2 受体激动剂，EC50为 2.8 nM，可用于研究开角治疗高眼压和青光眼的试验。
T21957	Guanabenz hydrochloride NE56490	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Guanabenz hydrochloride (NE56490) 是一种具有降血压作用的口服活性 α2-肾上腺素受体激动剂。
T7686	Ramiprilat	RAAS	Endocrinology/Hormones
	Ramiprilat 是 Ramipril 的活性代谢物，是一种口服有活力的血管紧张素转换酶 (ACE) 抑制剂，其 Ki=7 pM。它可用于研究心力衰竭以及高血压。
T12670	(Rac)-MGV354 MGV354,外消旋MGV354	Others	Others
	(Rac)-MGV354 (MGV354) 是 MGV354 的外消旋体，MGV354 是可溶性鸟苷酸环化酶活化剂，在 GTM-3E 和 CHO 细胞中 EC50分别为 5 nM 和小于 0.5 nM。
T8599	Betazole dihydrochloride 盐酸倍他唑,Betazole hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betazole dihydrochloride (Betazole hydrochloride) 是吡唑类组胺，是一种口服活性 H2受体激动剂，能诱导胃酸分泌，导致胆总管压力立即显著升高。它作为一种诊断剂，用于研究胃酸分泌能力。
T6581	Methyclothiazide Duretic,Enduron,甲氯噻嗪,Aquatensen	Others; Carbonic Anhydrase	Metabolism; Others
	Methyclothiazide (Aquatensen) 是一种具有口服活性的利尿剂，也是一种降压剂。它能够拮抗体外的电压依赖性钙通道的 (VDCC) 活性，也可以抑制内源性血管收缩刺激导致的血管反应。
T22368	Metyrosine 甲酪氨酸,α-Methyltyrosine	COX	Immunology/Inflammation; Neuroscience
	Metyrosine (α-Methyltyrosine) 是一种选择性酪氨酸羟化酶抑制剂，可显著抑制高 COX-2 活性和有效控制血压，具有抗炎和抗溃疡作用。
T21454	Nicardipine Cardene,Dagan,尼卡地平,Antagonil,Flusemide	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Nicardipine (Cardene) 是一种二氢吡啶类钙通道阻滞剂，可阻断心脏钙通道，IC50为 1 μM，可用于治疗心绞痛和高血压。
T22398	Phenidone 菲尼酮,1-phenyl-3-pyrazolidinone	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	Phenidone (1-phenyl-3-pyrazolidinone) 是可口服发环氧化酶和脂氧合酶双重抑制剂，可改善实验性自身免疫性脑脊髓炎大鼠的瘫痪，降低自发性高血压大鼠的血压，可用作照片显像剂。
T4277	Osilodrostat LCI699	Glucocorticoid Receptor; Others; Hydroxylase	Endocrinology/Hormones; Metabolism; Others
	Osilodrostat (LCI699) 是一种有效的人11β-羟化酶和醛固酮合成酶抑制剂，IC50分别值为2.5 和0.7nM。
T0142	Brinzolamide 布林佐胺,AL-4862	Carbonic Anhydrase	Metabolism
	Brinzolamide (AL-4862) 是一种碳酸酐酶(carbonic anhydrase)II 抑制剂(IC50:3.19 nM)。
T4488	GSK-25 GSK25	ROCK; S6 Kinase; mTOR	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	GSK-25 是一种选择性的，具有口服活性的 ROCK1抑制剂。它对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性，RSK1的 IC50 为 398 nM，p70S6K 的 IC50 为 1000nM。它可抑制 P450，对 CYP2C9、CYP2D6和 CYP3A4的 IC50分别为2.5、5.2和2.5 μM。
T0145	Felodipine 非洛地平,CGH-869	Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Felodipine (CGH-869) 是一种长效的 1, 4-二氢吡啶钙通道抑制剂，可跨越血脑屏障，可诱导自噬，具有抗高血压活性。它通过选择性作用于血管平滑肌，尤其是阻力血管来降低血压。
T6716	Valsartan Diovan,缬沙坦,Tareg,CGP 48933	RAAS	Endocrinology/Hormones
	Valsartan (CGP 48933) 是一种血管紧张素 II 受体拮抗剂，有用于高血压和心力衰竭的研究潜力。
T26745	BAY 73-1449 BAY-73-1449,BAY73-1449	Others	Others
	BAY 73-1449 是前列环素受体选择性拮抗剂，在人 HEL 细胞和大鼠 DRG 的 cAMP 分析中具有很高的效价，IC50小于 0.1 nM。BAY 73-1449在降血压方面有研究的价值。
T0106	Methazolamide L584601,醋甲唑胺,CL 8490	Carbonic Anhydrase	Metabolism
	Methazolamide (CL 8490) 是一种磺胺衍生物，用作碳酸酐酶 (carbonic anhydrase) 抑制剂，对人 carbonic anhydrase II 的 Ki=为 14 nM。它是降低眼压的药物，能够抑制由青光眼及其他眼病引起的眼压升高的作用。
T8315	1-Cyclohexyl-3-dodecyl urea CDU,N-Cyclohexyl-N-dodecyl urea,NCND	Epoxide Hydrolase	Metabolism
	1-Cyclohexyl-3-dodecyl urea (NCND) 是高选择性的可溶性环氧化物水解酶 (sEH) 抑制剂，能够增强血管紧张素 II (Ang II) 高血压中的环氧二十碳三烯酸 (EETs) 水平，并降低血压。
T28482	Firibastat QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150	Aminopeptidase	Metabolism
	Firibastat (RB150) 是一种具有口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A(APA) 抑制剂 (Ki=200 nM)，选择性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III，降低血压。
T0696	Naftopidil KT-611,萘哌地尔,BM-15275	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil (KT-611) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力Ki 分别为 3.7 nM、20 nM 、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
T0197	Terazosin hydrochloride 盐酸特拉唑嗪,Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Terazosin hydrochloride (Hytrin) 是一种竞争性和口服活性的 α1-肾上腺素受体拮抗剂，是一种喹唑啉衍生物。它通过舒张血管和打开膀胱来起作用。它可用于良性前列腺增生和高血压的研究。
T2547	Droxidopa 屈昔多巴,屈西多巴,SM5688,DOPS,L-DOPS	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Droxidopa (L-DOPS) 是 Droxidopa (w/w80%) 和 Pharmaceutical starch (w/w20%) 的混合物，能透过血脑屏障，可作为神经递质去甲肾上腺素和肾上腺素的原药。
T3518	GSK269962A GSK269962B,GSK 269962,GSK269962A HCl	ROCK; S6 Kinase	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	GSK269962A (GSK269962A HCl) 是一种有效的ROCK 抑制剂，具有抗炎和血管舒张作用。它作用于重组人ROCK1和ROCK2，IC50分别为 1.6 和 4 nM。
T6600	Naftopidil dihydrochloride KT-611,KT-611 2HCl,盐酸萘哌地尔,Naftopidil DiHCl	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil dihydrochloride (KT-611 2HCl) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力Ki 分别为 3.7 nM、20 nM、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
T1215	Nicardipine hydrochloride 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride	Calcium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂，IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩，从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。
T6991	Nitroprusside disodium dihydrate 硝普钠二水合物,硝普钠,Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate	Guanylate cyclase; Autophagy	Autophagy; GPCR/G Protein
	Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) 是一种血管扩张剂，通过在血液中自发释放 NO 发挥作用。它可在谷胱甘肽耗竭的成骨细胞中诱导自噬，用于急性高血压和心力衰竭的研究。
T22419	S-Methylisothiourea sulfate (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐	NOS; NO Synthase; HSV	Immunology/Inflammation; Microbiology/Virology
	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂，在感染性休克的啮齿动物模型中发挥有益作用。
T20656	Verapamil NSC 135784,维拉帕米,NSC-135784,CP-16533-1,(±)-Verapamil	P450; Calcium Channel; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Verapamil (CP-16533-1) 是一种非二氢吡啶类钙通道阻滞剂，一种 P-gp 抑制剂，也是一种 CYP3A4 抑制剂，具有口服活性。Verapamil 可以用于治疗高血压、心绞痛、心肌梗塞等。
T1010	Verapamil hydrochloride Manidon,盐酸维拉帕米,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride	P450; Calcium Channel; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Verapamil hydrochloride (Verapamil HCl) 是一种钙通道阻滞剂，是一种可口服的 P 糖蛋白 (P-gp) 抑制剂，可抑制CYP3A4，用于高血压、心律不齐和心绞痛的研究。
T1050	Prazosin hydrochloride Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress	Potassium Channel; MRP; Adrenergic Receptor; ABC; Autophagy	Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Prazosin hydrochloride (Vasoflex) 是一种选择性肾上腺素能 α-1 拮抗剂，可降低外周阻力并放松血管平滑肌。它可用于研究高血压和酒精使用障碍。它是一种合成哌嗪衍生物，具有降压抗肾上腺素能特性。它抑制有机阳离子转运蛋白 OCT-1 和 OCT-3，IC50分别为 1.8 和 13 μM 。
T21395	Finerenone BAY948862,BAY-948862,BAY94-8862,非奈利酮,BAY 94-8862,BAY-94-8862,BAY 948862	Glucocorticoid Receptor	Endocrinology/Hormones
	Finerenone (BAY-948862) 是一种选择性、具有口服活性的、非甾体类盐皮质激素受体拮抗剂 (IC50=18 nM)。与糖皮质激素受体、雄激素受体和孕酮受体相比，它表现出良好的选择性 (>500-fold)。它在心肾疾病研究中具有潜在的应用前景，如 2 型糖尿病和慢性肾脏疾病。
T6701	Terazosin hydrochloride dihydrate Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate,盐酸特拉唑嗪(二水合物)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Terazosin hydrochloride dihydrate (Heitrin dihydrate) 是一种竞争性和口服活性的 α1-肾上腺素受体(α1-adrenoceptor) 拮抗剂，是一种喹唑啉衍生物，通过舒张血管和打开膀胱的方式起作用。它可用于研究良性前列腺增生 (BPH) 和高血压。
T9220	Naftopidil hydrochloride 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-,萘哌地尔盐酸盐,KT-611 hydrochloride,BM-15275 hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil hydrochloride (BM-15275 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 分别为 3.7 nM、20 nM、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
T1203	Nadolol Anabet,Corgard,Solgol,苯甲丁氮酮,纳多洛尔,SQ11725	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物，是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂，可用于高血压，心绞痛和血管性头痛的研究。
TP2058L	Catestatin acetate Catestatin acetate(142211-96-9 free base)	Endogenous Metabolite; AChR	Metabolism; Neuroscience
	Catestatin acetate 是 nAChR 的非竞争性拮抗剂，可抑制儿茶酚胺的释放。 Catestatin acetate 调节心脏功能和血压。
T78216	cis-ent-Tadalafil (6S,12aR)-Tadalafil,Tadalafil, (6S,12aR)-,cis-ent-IC-351	Others	Others
	cis-ent-Tadalafil (cis-ent-IC-351) 是一种具有高效和选择性的 PDE5 抑制剂，可降低血压。
TP1295	Angiotensin I (human, mouse, rat) Angiotensin 1 Human,血管紧张素 1 (人)	Others	Others
	Angiotensin I (human, mouse, rat) 是血管紧张素Ⅱ的前体物质，在血管紧张素转化酶 (ACE) 的参与下裂解成血管紧张素Ⅱ。
T26841	BMS 182874 BMS182874,BMS-182874	Endothelin Receptor	GPCR/G Protein
	BMS 182874 是一种口服有效的高选择性内皮素受体 endothelin receptor ETA 拮抗剂，对 ETA 的 IC50 值为0.150 μM，对 ETA 的 Ki 值为0.055 μM。BMS 182874 能够在大鼠高血压模型中降低 Deoxycorticosterone acetate 诱导的动脉压，可用于研究心血管疾病。
T34146	Propanidid FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Propanidid (Sombrevin) 是一种 γ-氨基丁酸 A 型受体 (GABAA) 激动剂，也是一种可快速发挥作用的静脉注射麻醉剂,可以降低动脉血压。
T9545	Compound 1T-0219 (SC)	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Compound 1T-0219 (SC) 是一种 AKT1-FAK 相互作用的阻断剂，可减少对人 SW620 结肠癌细胞中细胞外压力的 FAK 磷酸化的刺激，而不影响基础 FAK 磷酸化。
T71961	TUN-92046 DM-α-KG,T71961,Dimethyl 2-ketoglutarate,Dimethyl 2-oxoglutarate	Others	Others
	TUN-92046 （Dimethyl 2-oxoglutarate）是一种膜渗透性α酮戊二酸类似物，抑制压力过载诱导的心肌病中适应不良的自噬。
T6422	Brimonidine Tartrate AGN190342 tartrate,304 tartrate,酒石酸溴莫尼定,AGN190342 (tartrate),UK 14304 (tartrate),UK14304 tartrate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Brimonidine Tartrate (AGN190342 tartrate) 是一种 alpha2 Adrenergic Receptor (alpha2-AR) 受体激动剂。
T31640	Enrasentan SB-217242,SB 217242,SB217242	Endothelin Receptor	GPCR/G Protein
	Enrasentan（sb-217242）是一种 ET（A）和 ET（B）受体的混合拮抗剂，可降低血压、防止心肌肥大和保护心肌功能。
T62747	Lorundrostat MLS101,MT 4129,MLS-101,MT4129,MT-4129,MLS 101	Others	Others
	Lorundrostat (MT-4129) 是一种醛固酮合酶抑制剂，具有降高血压活性，可降低收缩压。
TP2446L	Angiotensin amide acetate 血管紧张素胺,Angiotensin amide acetate(53-73-6 Free base)	Others	Others
	Angiotensin amide acetate 是Angiotensin amide 的衍生物。Angiotensin amide 是一种八肽酰胺，可以通过血管收缩来提高血压。
T12478L	Pinacidil 吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134	Potassium Channel	Membrane transporter/Ion channel
	Pinacidil (P 1134) 是钾通道的有效激活剂。Pinacidil 通过打开 K+-通道使血管平滑肌超极化，显示出抗高血压活性。它显著改善再灌注功能和心脏顺应性。它具有直接的心脏保护作用。
T10595	BQ-788 BQ788	Endothelin Receptor	GPCR/G Protein
	BQ-788 是一种具有选择性和有效性的 ETB 受体拮抗剂，具有潜在的高血压活性，抑制 ET-1 与 ETB 受体结合，抑制外源性 ET-1 诱导的冠状动脉灌注压升高。
T6262	Evacetrapib LY2484595	CETP	Metabolism
	Evacetrapib (LY2484595) 是 CETP 的选择性抑制剂，在人血浆中，抑制人重组 CETP 蛋白 (IC50:5.5 nM) 和 CETP (IC50:36 nM) 活性。

化合物

Cat.No: T5471

Target: Adrenergic Receptor

Cat.No: T11831

Target: Others

Cat.No: T6792

Synonym: BQ123

Target: Endothelin Receptor

Cat.No: T3174

Synonym: CP-544326

Target: Prostaglandin Receptor

Guanabenz hydrochloride

Cat.No: T21957

Synonym: NE56490

Target: Adrenergic Receptor

Cat.No: T7686

Target: RAAS

Cat.No: T12670

Synonym: MGV354,外消旋MGV354

Target: Others

Betazole dihydrochloride

Cat.No: T8599

Synonym: 盐酸倍他唑,Betazole hydrochloride

Target: Histamine Receptor

Methyclothiazide

Cat.No: T6581

Synonym: Duretic,Enduron,甲氯噻嗪,Aquatensen

Target: Others, Carbonic Anhydrase

Cat.No: T22368

Synonym: 甲酪氨酸,α-Methyltyrosine

Target: COX

Cat.No: T21454

Synonym: Cardene,Dagan,尼卡地平,Antagonil,Flusemide

Target: Calcium Channel

Cat.No: T22398

Synonym: 菲尼酮,1-phenyl-3-pyrazolidinone

Target: Lipoxygenase, COX

Cat.No: T4277

Synonym: LCI699

Target: Glucocorticoid Receptor, Others, Hydroxylase

Cat.No: T0142

Synonym: 布林佐胺,AL-4862

Target: Carbonic Anhydrase

Cat.No: T4488

Synonym: GSK25

Target: ROCK, S6 Kinase, mTOR

Cat.No: T0145

Synonym: 非洛地平,CGH-869

Target: Calcium Channel, Autophagy

Cat.No: T6716

Synonym: Diovan,缬沙坦,Tareg,CGP 48933

Target: RAAS

Cat.No: T26745

Synonym: BAY-73-1449,BAY73-1449

Target: Others

Cat.No: T0106

Synonym: L584601,醋甲唑胺,CL 8490

Target: Carbonic Anhydrase

1-Cyclohexyl-3-dodecyl urea

Cat.No: T8315

Synonym: CDU,N-Cyclohexyl-N-dodecyl urea,NCND

Target: Epoxide Hydrolase

Cat.No: T28482

Synonym: QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150

Target: Aminopeptidase

Cat.No: T0696

Synonym: KT-611,萘哌地尔,BM-15275

Target: Adrenergic Receptor

Terazosin hydrochloride

Cat.No: T0197

Synonym: 盐酸特拉唑嗪,Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic

Target: Adrenergic Receptor

Cat.No: T2547

Synonym: 屈昔多巴,屈西多巴,SM5688,DOPS,L-DOPS

Target: Adrenergic Receptor

Cat.No: T3518

Synonym: GSK269962B,GSK 269962,GSK269962A HCl

Target: ROCK, S6 Kinase

Naftopidil dihydrochloride

Cat.No: T6600

Synonym: KT-611,KT-611 2HCl,盐酸萘哌地尔,Naftopidil DiHCl

Target: 5-HT Receptor, Adrenergic Receptor

Nicardipine hydrochloride

Cat.No: T1215

Synonym: 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride

Target: Calcium Channel, Adrenergic Receptor, AChR, Autophagy

Nitroprusside disodium dihydrate

Cat.No: T6991

Synonym: 硝普钠二水合物,硝普钠,Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate

Target: Guanylate cyclase, Autophagy

S-Methylisothiourea sulfate

Cat.No: T22419

Synonym: (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐

Target: NOS, NO Synthase, HSV

Cat.No: T20656

Synonym: NSC 135784,维拉帕米,NSC-135784,CP-16533-1,(±)-Verapamil

Target: P450, Calcium Channel, P-gp

Verapamil hydrochloride

Cat.No: T1010

Synonym: Manidon,盐酸维拉帕米,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride

Target: P450, Calcium Channel, P-gp

Prazosin hydrochloride

Cat.No: T1050

Synonym: Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress

Target: Potassium Channel, MRP, Adrenergic Receptor, ABC, Autophagy

Cat.No: T21395

Synonym: BAY948862,BAY-948862,BAY94-8862,非奈利酮,BAY 94-8862,BAY-94-8862,BAY 948862

Target: Glucocorticoid Receptor

Terazosin hydrochloride dihydrate

Cat.No: T6701

Synonym: Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate,盐酸特拉唑嗪(二水合物)

Target: Adrenergic Receptor

Naftopidil hydrochloride

Cat.No: T9220

Synonym: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-,萘哌地尔盐酸盐,KT-611 hydrochloride,BM-15275 hydrochloride

Target: Adrenergic Receptor

Cat.No: T1203

Synonym: Anabet,Corgard,Solgol,苯甲丁氮酮,纳多洛尔,SQ11725

Target: Adrenergic Receptor

Catestatin acetate

Cat.No: TP2058L

Synonym: Catestatin acetate(142211-96-9 free base)

Target: Endogenous Metabolite, AChR

cis-ent-Tadalafil

Cat.No: T78216

Synonym: (6S,12aR)-Tadalafil,Tadalafil, (6S,12aR)-,cis-ent-IC-351

Target: Others

Angiotensin I (human, mouse, rat)

Cat.No: TP1295

Synonym: Angiotensin 1 Human,血管紧张素 1 (人)

Target: Others

Cat.No: T26841

Synonym: BMS182874,BMS-182874

Target: Endothelin Receptor

Cat.No: T34146

Synonym: FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol

Target: GABA Receptor

Compound 1T-0219 (SC)

Cat.No: T9545

Target: FAK

Cat.No: T71961

Synonym: DM-α-KG,T71961,Dimethyl 2-ketoglutarate,Dimethyl 2-oxoglutarate

Target: Others

Brimonidine Tartrate

Cat.No: T6422

Synonym: AGN190342 tartrate,304 tartrate,酒石酸溴莫尼定,AGN190342 (tartrate),UK 14304 (tartrate),UK14304 tartrate

Target: Adrenergic Receptor

Cat.No: T31640

Synonym: SB-217242,SB 217242,SB217242

Target: Endothelin Receptor

Cat.No: T62747

Synonym: MLS101,MT 4129,MLS-101,MT4129,MT-4129,MLS 101

Target: Others

Angiotensin amide acetate

Cat.No: TP2446L

Synonym: 血管紧张素胺,Angiotensin amide acetate(53-73-6 Free base)

Target: Others

Cat.No: T12478L

Synonym: 吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134

Target: Potassium Channel

Cat.No: T10595

Synonym: BQ788

Target: Endothelin Receptor

Cat.No: T6262

Synonym: LY2484595

Target: CETP

Cat. No.	Product Name	Target	Signaling Pathways
T13482	2'-O-Methyladenosine	Endogenous Metabolite	Metabolism
	2'-O-Methyladenosine 是甲基化腺嘌呤的残基，在正常人群和腺苷脱氨基酶缺乏病人的尿液中均可被检测到。它显示出独特的降血压活性。
T0022	Taurine 牛磺酸,2-Aminoethanesulfonic acid	LDL; Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Taurine (2-Aminoethanesulfonic acid) 是一种含硫氨基酸的有机渗透剂，为胆汁盐的形成提供底物，并在调节细胞内游离钙浓度方面发挥作用，有激活脂肪细胞自噬的能力。
TCS0324	2-Pentylfuran 2-N-Pentylfuran,2-正戊基呋喃,2-Amylfuran	Others	Others
	2-Pentylfuran (2-N-Pentylfuran) 是一种马铃薯蒸汽挥发油于常压状态下分离得到的化合物。
T1071L	DL-Adrenaline Hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	DL-Adrenaline Hydrochloride 是天然存在的拟交感神经胺的盐酸盐，具有收缩血管、降低眼内压的活性。
T5S0229	Isosakuranetin 4'-Methylnaringenin,异野樱素,异樱花亭	Others	Others
	Isosakuranetin (4'-Methylnaringenin) 是一种黄烷酮黄酮类化合物，存在于 Citrus bergamia 果实中。
T6S2238	Eupalinolide B	Others	Others
	Eupalinolide B 是一种胚芽倍半萜，分离自Eupatorium lindleyanum 中。它对BGC-823、A-549 和 HL-60 等肿瘤细胞具有细胞毒性。
T2782L	Catharanthine Tartrate(2468-21-5(free base))	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Catharanthine Tartrate(2468-21-5(free base)) 是从马达加斯加长春花中分离得到的天然产物，Catharanthine Tartrate 抑制电压操作的L 型Ca2+通道，具有抗癌和降血压活性。
T6S0654	Isocorynoxeine 7-Isocorynoxeine,异去氢钩藤碱	5-HT Receptor	GPCR/G Protein; Neuroscience
	Isocorynoxeine (7-Isocorynoxeine) 是钩藤中的一种生物碱，剂量依赖性抑制5-HT2A 受体介导的电流反应，IC50为 72.4 μM。
T7040	Angiotensin II human DRVYIHPF,Angiotensin II,Hypertensin II,血管紧张素Ⅱ,Ang II,血管紧张素II	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Angiotensin II human (Ang II) 是一种生物活性肽，一种血管收缩剂。Angiotensin II 可以与 AT1R 和 AT2R 相互作用，调节人类血压，刺激交感神经，增加醛固酮生物合成和肾脏活动。
T5014	Prostaglandin E2 地诺前列酮,前列腺素 E2,PGE2,Dinoprostone,Prostaglandin E2 (PGE2)	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E2 (PGE2) 是一种天然激素，参与人体内的各种生理过程，包括平滑肌收缩和放松、调节血管扩张和收缩、调节血压和炎症调节。
T5968	DL-Homocysteine thiolactone hydrochloride DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐	Endogenous Metabolite	Metabolism
	DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) 是具有根生长抑制特性的环状氨基酸衍生物。
T4S1518	Pseudoginsenoside RT1 拟人参皂苷 RT1,假人参皂苷RT1	Others	Others
	Pseudoginsenoside RT1 是分离自 Randia siamensis 中，具有鱼毒素作用。它可导致血压下降、心率加快和子宫自发收缩力增加。
T5S1708	Dendrobine	Others; Influenza Virus	Microbiology/Virology; Others
	Dendrobine 是从石斛中分离的一种生物碱，对甲型流感病毒具有抗病毒活性。
T21418	Lisinopril Linopril,赖诺普利,Zestril,Prinivil,Lisipril	RAAS	Endocrinology/Hormones
	Lisinopril (Prinivil) 是一种血管紧张素转化酶抑制剂，能够作用于高血压，充血性心力衰竭和心脏病等。
TN1465	Cannabigerol	NOS; 5-HT Receptor; ROS	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cannabigerol 是一种植物大麻素，是一种高亲和力 α2-肾上腺素能受体激动剂、中度亲和力 5-HT1A 受体拮抗剂和低亲和力 CB1/CB2受体拮抗剂。它可降低眼压，有潜力治疗青光眼。
T3744	Veratric acid Veratrumenoic acid,藜芦酸,3,4-Dimethoxybenzoic acid	Reactive Oxygen Species; COX	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Veratric acid (3,4-Dimethoxybenzoic acid) 是从蔬菜和水果中得到的一种可口服多酚，具有抗氧化、保护心血管和抗炎活性。当细胞受到 UVB 辐射时，它能够减少上调的 COX-2 表达，降低 PGE2 和 IL-6 水平。
T0530	Flavanone 2-Phenyl-4-chromanone,4-Flavanone,2,3-Dihydroflavone,黄烷酮,2-Phenylchroman-4-one	Others; Aromatase	Endocrinology/Hormones; Others
	Flavanone (2-Phenylchroman-4-one) 是天然的黄酮类化合物，对人类雌激素合成酶芳香化酶具有抑制作用。
TN1733	Hesperetin 7-O-glucoside	Anti-infection; Antibacterial; HMG-CoA Reductase	Metabolism; Microbiology/Virology
	Hesperetin 7-O-glucoside 是通过 Hesperidin 的酶促转化产生的一种人 HMG-CoA 还原酶抑制剂，具有降压作用，可抑制幽门螺杆菌的生长。
T3332	Isosteviol 异甜菊醇,(-)-Isosteviol	IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂，属于四环二萜糖苷，是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶，具有抗菌、抗癌和抗结核作用。
T0522	Diammonium Glycyrrhizinate 甘草酸二铵,Glycyrrhizin	Dehydrogenase	Metabolism
	Diammonium Glycyrrhizinate (Glycyrrhizin) 是分离自甘草中的化合物，有抗炎作用。
T78479	Manool	Others	Others
	Manool 是一种来自丹参的二萜，在小鼠黑色素瘤模型中显示出抗肿瘤活性。Manool 可使癌细胞细胞周期停滞在的 G(2)/M 期，降低预防染色体损伤和癌前病变。Manool 促使大鼠主动脉中由 NO/cGMP 信号通路介导的内皮依赖性血管松弛和血压降低。
T41095	(E)-3-(4-Methoxyphenyl)acrylic acid (E)-3-(4-甲氧基苯基)丙烯酸	Glucosidase	Metabolism
	(E)-3-(4-Methoxyphenyl)acrylic acid 是从 Etlingera pavieana (Pierre ex Gagnep.) R. M. Sm. 的根茎中分离出来的一种小分子化合物。它是一种新型 α-葡萄糖苷酶抑制剂。(E)-3-(4-甲氧基苯基)丙烯酸具有保肝活性、抗失水活性、增强认知效果，并可用于降低血压血糖。
T6S0033	Crotonoside 巴豆苷；异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE	Others; FLT; HDAC	Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors
	Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。它抑制 FLT3 和 HDAC3/6，有治疗急性髓性白血病 (AML)的研究潜力。
T41242	Uric acid sodium 尿酸钠	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Uric acid sodium 是氧自由基 (oxygen radical) 的清除剂，是一种有效的、常见的抗氧化剂，有助于维持机体血压稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS)，如单线态氧和过氧亚硝酸盐，对脂质过氧化有抑制作用，与痛风性关节病的发病机理和草酸钙结石的形成有关。
T8270	Deserpidine 地舍平,Harmonyl	RAAS	Endocrinology/Hormones
	Deserpidine (Harmonyl) 是从 Rauwolfia canescens 的根中分离的生物碱。Deserpidine 与 Reserpine 相关。Deserpidine 是竞争性血管紧张素转化酶抑制剂，可以被用作抗高血压药以及镇定剂。Deserpidine 还减少了肾上腺皮质血管紧张素 II 诱导的醛固酮分泌。
T3123	Allicin	ERK; IL Receptor; Others; IκB/IKK; p38 MAPK; TNF; ROS; Caspase; Antifection	Apoptosis; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; Others; Proteases/Proteasome
	Allicin 具有抗氧化、杀菌、抗癌、抗炎活性，对肠上皮细胞具有抑制性免疫调节作用。 Allicin 能显着抑制胰岛素诱导的血管平滑肌细胞的增殖和迁移，这可能与抑制 ERK 信号通路的激活有关。 Allicin 有利于降低高胆固醇血症大鼠的血液胆固醇、甘油三酯水平和收缩压，它可能有益于影响动脉粥样硬化的两个危险因素——高脂血症和高血压。
T64812	Collagenase Type I Collagenase I,Collagenase Type I (From microorganisms)	Others	Others
	Collagenase Type I 是一种蛋白水解酶，能分解胶原蛋白中的肽键（胶原蛋白是结缔组织的主要结构蛋白）。Collagenase 已被探索作为一种潜在的治疗选择来分解突出的椎间盘物质，从而减少对附近神经的压迫。Collagenase 可能有助于过度疤痕组织的分解和重组，潜在地改善组织功能和外观。Collagenase 具有治疗椎间盘突出、瘢痕疙瘩、脂肪团、脂肪瘤以及佩罗尼氏病和手掌纤维瘤病等方面的潜力。
TN2350	Pingpeimine A	Others	Others
	Pingpeimine A has the effect of expectorating and lowering blood pressure. Derived from Fritillaria sibiricum.
T12789	S-1-Propenyl-L-cysteine	Others	Others
	S-1-Propenyl-L-cysteine, a stereoisomer of S-allyl-l-cysteine, exhibits immunomodulatory effects and has been shown to decrease blood pressure in hypertensive animal models.
TN1367	Alismol 泽泻醇	Potassium Channel; Calcium Channel; PI3K	Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks.
T2S1727	Lycorenine	Antifection	Microbiology/Virology
	Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph
TN2001	Oblongine	Others	Others
	Oblongine chloride may have potential haemodynamic effects, it can cause a dose-dependent reduction of systolic and diastolic blood pressure, and that these effects are not mediated by α²-adrenergic receptor stimulation.
T2S2363	Corydine	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Corydine is the adrenolytic and weak cholinergic agent, it shows antimicrobial, and antineoplastic activities. Corydine shows irritant and respiratory stimulant and CNS depressant activities. Injected intravenously in rabbits corydine produced an initial
TN4616	N-Methyltaxol C	Others	Others
	N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolate
TN1540	Cyanidin-3,5-O-diglucoside chloride	Others	Others
	Cyanidin-3,5-O-diglucoside chloride 具有抗氧化活性。 Cyanidin-3,5-O-diglucoside 抑制高压诱导的 GLAST 降低，可用于青光眼研究。 Cyanidin-3,5-O-diglucoside chloride 在 >40°C 的温度下很容易通过水解和/或氢化降解。
T36915	21-Deoxycortisol	Others	Others
	21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. 1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive...

天然产物

2'-O-Methyladenosine

Cat.No: T13482

Target: Endogenous Metabolite

Cat.No: T0022

Synonym: 牛磺酸,2-Aminoethanesulfonic acid

Target: LDL, Endogenous Metabolite, Autophagy

Cat.No: TCS0324

Synonym: 2-N-Pentylfuran,2-正戊基呋喃,2-Amylfuran

Target: Others

DL-Adrenaline Hydrochloride

Cat.No: T1071L

Target: Adrenergic Receptor

Cat.No: T5S0229

Synonym: 4'-Methylnaringenin,异野樱素,异樱花亭

Target: Others

Cat.No: T6S2238

Target: Others

Catharanthine Tartrate(2468-21-5(free base))

Cat.No: T2782L

Target: Calcium Channel

Cat.No: T6S0654

Synonym: 7-Isocorynoxeine,异去氢钩藤碱

Target: 5-HT Receptor

Angiotensin II human

Cat.No: T7040

Synonym: DRVYIHPF,Angiotensin II,Hypertensin II,血管紧张素Ⅱ,Ang II,血管紧张素II

Target: Apoptosis, RAAS

Prostaglandin E2

Cat.No: T5014

Synonym: 地诺前列酮,前列腺素 E2,PGE2,Dinoprostone,Prostaglandin E2 (PGE2)

Target: Endogenous Metabolite, Prostaglandin Receptor

DL-Homocysteine thiolactone hydrochloride

Cat.No: T5968

Synonym: DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐

Target: Endogenous Metabolite

Pseudoginsenoside RT1

Cat.No: T4S1518

Synonym: 拟人参皂苷 RT1,假人参皂苷RT1

Target: Others

Cat.No: T5S1708

Target: Others, Influenza Virus

Cat.No: T21418

Synonym: Linopril,赖诺普利,Zestril,Prinivil,Lisipril

Target: RAAS

Cat.No: TN1465

Target: NOS, 5-HT Receptor, ROS

Cat.No: T3744

Synonym: Veratrumenoic acid,藜芦酸,3,4-Dimethoxybenzoic acid

Target: Reactive Oxygen Species, COX

Cat.No: T0530

Synonym: 2-Phenyl-4-chromanone,4-Flavanone,2,3-Dihydroflavone,黄烷酮,2-Phenylchroman-4-one

Target: Others, Aromatase

Hesperetin 7-O-glucoside

Cat.No: TN1733

Target: Anti-infection, Antibacterial, HMG-CoA Reductase

Cat.No: T3332

Synonym: 异甜菊醇,(-)-Isosteviol

Target: IL Receptor, Potassium Channel, TNF, NF-κB, Reactive Oxygen Species, COX, Topoisomerase

Diammonium Glycyrrhizinate

Cat.No: T0522

Synonym: 甘草酸二铵,Glycyrrhizin

Target: Dehydrogenase

Cat.No: T78479

Target: Others

(E)-3-(4-Methoxyphenyl)acrylic acid

Cat.No: T41095

Synonym: (E)-3-(4-甲氧基苯基)丙烯酸

Target: Glucosidase

Cat.No: T6S0033

Synonym: 巴豆苷；异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE

Target: Others, FLT, HDAC

Uric acid sodium

Cat.No: T41242

Synonym: 尿酸钠

Target: Reactive Oxygen Species

Cat.No: T8270

Synonym: 地舍平,Harmonyl

Target: RAAS

Cat.No: T3123

Target: ERK, IL Receptor, Others, IκB/IKK, p38 MAPK, TNF, ROS, Caspase, Antifection

Collagenase Type I

Cat.No: T64812

Synonym: Collagenase I,Collagenase Type I (From microorganisms)

Target: Others

Cat.No: TN2350

Target: Others

S-1-Propenyl-L-cysteine

Cat.No: T12789

Target: Others

Cat.No: TN1367

Synonym: 泽泻醇

Target: Potassium Channel, Calcium Channel, PI3K

Cat.No: T2S1727

Target: Antifection

Cat.No: TN2001

Target: Others

Cat.No: T2S2363

Target: IL Receptor, Antifection

N-Methyltaxol C

Cat.No: TN4616

Target: Others

Cyanidin-3,5-O-diglucoside chloride

Cat.No: TN1540

Target: Others

21-Deoxycortisol

Cat.No: T36915

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04552	AKT1 Protein, Human, Recombinant (His) RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1,RAC,...	Human	Baculovirus Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac...
TMPH-00670	MscL Protein, E. coli O157:H7, Recombinant (B2M & His) mscL,Large-conductance mechanosensitive channel	E. coli	E. coli
	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. MscL Protein, E. coli O157:H7, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 29.0 kDa and the accession number is P0A743.
TMPY-02378	14‑3‑3 theta/YWHAQ Protein, Human, Recombinant (GST) tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activati...	Human	E. coli
	The recently identified 14-3-3 tau, whose corresponding gene name is YWHAQ, is in a hypoxia-treated human trophoblast cell line. YWHAQ may play a role in epigenetic regulation of placental genes in the onset of Preeclampsia (PE). Moreover, there was a closer relationship between blood pressure and methylation levels of the YWHAQ promoter.
TMPH-01979	SFTPB Protein, Human, Recombinant SFTPB,Pulmonary surfactant-associated protein B,6 kDa protei...	Human	P. pastoris (Yeast)
	Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. SFTPB Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 8.7 kDa and the accession number is P07988.
TMPJ-00504	Serpin A8 Protein, Human, Recombinant (His) AGT and SERPINA8,Angiotensinogen,Serpin A8	Human	HEK293 Cells
	Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the encoding gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
TMPH-02835	PDGFD Protein, Mouse, Recombinant (His & SUMO) Platelet-derived growth factor D,Pdgfd,Spinal cord-derived g...	Mouse	E. coli
	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including inf...
TMPH-02881	Renin-2 Protein, Mouse, Recombinant (His) Ren2,Renin-2,Submandibular gland renin,Angiotensinogenase	Mouse	E. coli
	Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Its function in the salivary gland is not understood. Renin-2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.0 kDa and the accession number ...
TMPH-00985	NPR3 Protein, Human, Recombinant (His) Atrial natriuretic peptide receptor type C,Atrial natriureti...	Human	E. coli
	Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. NPR3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-...
TMPH-03250	NPR3 Protein, Rat, Recombinant (His & SUMO) Npr3,Atrial natriuretic peptide receptor 3,Atrial natriureti...	Rat	E. coli
	Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. NPR3 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system wi...
TMPJ-00475	Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His) Tissue Kallikrein,Kidney/Pancreas/Salivary Gland Kallikrein,...	Human	HEK293 Cells
	Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262). The function of KLK1 is to cleave Kininogen in order to release the vasoactive Kinin peptide (Lysyl-Bradykinin or Bradykinin). The Kinin peptide controls blood pressure reduction, vasodilation, smooth muscle relaxation and contraction, pain induction and inflammation. KLK1 also plays ...
TMPJ-01061	Nucleobindin-2 Protein, Human, Recombinant NUCB2,NEFA,Gastric cancer antigen Zg4,Nesfatin-1,Prepronesfa...	Human	E. coli
	Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage. Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic islets β-cells, gastric endocrine cells and adipocytes. Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner. Nesfatin-1 may ...
TMPH-00780	CACNA1C Protein, Guinea Pig, Recombinant (His) CACNA1C,CACNL1A1,CACH2,CACN2,Voltage-dependent L-type calciu...	Guinea pig	E. coli
	Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressur...
TMPY-02248	Myocilin Protein, Human, Recombinant (His) myocilin, trabecular meshwork inducible glucocorticoid respo...	Human	HEK293 Cells
	Myocilin, also known as Trabecular meshwork-induced glucocorticoid response protein, MYOC, and GLC1A, is a protein that contains one olfactomedin-like domain. Myocilin / MYOC may participate in the obstruction of fluid outflow in the trabecular meshwork. Myocilin / MYOC is expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, and other tissues. Myocilin / MYOC is expressed predominantly in the retina. In normal eyes, it is found in the ...
TMPY-02081	PDE2A Protein, Human, Recombinant (aa 215-900, His) phosphodiesterase 2A, cGMP-stimulated,cGSPDE,PED2A4,PDE2A1,C...	Human	Baculovirus Insect Cells
	cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac ...
TMPY-01027	Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His) carnitine palmitoyltransferase 1B (muscle),AV080368,Mcp-1	Mouse	HEK293 Cells
	Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared w...

重组蛋白

AKT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04552

Species: Human

Expression System: Baculovirus Insect Cells

MscL Protein, E. coli O157:H7, Recombinant (B2M & His)

Cat.No: TMPH-00670

Species: E. coli

Expression System: E. coli

14‑3‑3 theta/YWHAQ Protein, Human, Recombinant (GST)

Cat.No: TMPY-02378

Species: Human

Expression System: E. coli

SFTPB Protein, Human, Recombinant

Cat.No: TMPH-01979

Species: Human

Expression System: P. pastoris (Yeast)

Serpin A8 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00504

Species: Human

Expression System: HEK293 Cells

PDGFD Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02835

Species: Mouse

Expression System: E. coli

Renin-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02881

Species: Mouse

Expression System: E. coli

NPR3 Protein, Human, Recombinant (His)

Cat.No: TMPH-00985

Species: Human

Expression System: E. coli

NPR3 Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03250

Species: Rat

Expression System: E. coli

Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His)

Cat.No: TMPJ-00475

Species: Human

Expression System: HEK293 Cells

Nucleobindin-2 Protein, Human, Recombinant

Cat.No: TMPJ-01061

Species: Human

Expression System: E. coli

CACNA1C Protein, Guinea Pig, Recombinant (His)

Cat.No: TMPH-00780

Species: Guinea pig

Expression System: E. coli

Myocilin Protein, Human, Recombinant (His)

Cat.No: TMPY-02248

Species: Human

Expression System: HEK293 Cells

PDE2A Protein, Human, Recombinant (aa 215-900, His)

Cat.No: TMPY-02081

Species: Human

Expression System: Baculovirus Insect Cells

Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01027

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T19185	Aldosterone-d8 醛固酮 D8,Aldosterone D8	Others	Others
	Aldosterone D8, a deuterium-labeled variant of Aldosterone produced in the adrenal zona glomerulosa, regulates blood pressure.
T13282	Valsartan-d9 CGP-48933 D9,缬沙坦 D9	Others	Others
	Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.
T12300	Olmesartan-d4 RNH-6270 D4,奥美沙坦 D4	Others	Others
	Olmesartan D4 is the deuterium labeled Olmesartan. Olmesartan is an antagonist of angiotensin II receptor (AT1R) used to treat high blood pressure.
T69598	Isoproterenol-d7 HCl
	Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively). It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectom...
TMIJ-0183	Terazosin-d8
	Terazosin-d8 是 Terazosin 的氘代化合物。Terazosin 的 CAS 号为 63590-64-7。
T35591	Guanfacine-13C,15N3 Guanfacine-13C,15N3
	Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin...
TMIJ-0077	Clevidipine-d7
	Clevidipine-d7 是 Clevidipine 的氘代化合物。Clevidipine 的 CAS 号为 167221-71-8。Clevidipine butyrate 是一种二氢吡啶 L 型钙通道阻滞剂，IC50为7.1 nM。它对血管平滑肌有选择性，可用于降低血压。
TMIJ-0497	Lacidipine-d10
	Lacidipine-d10 是 Lacidipine 的氘代化合物。Lacidipine 的 CAS 号为 103890-78-4。Lacidipine 是一种L型钙离子通道阻断剂。
T71065	Quinapril-d5
	Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con...
TMIJ-0042	Metoprolol-d7 Hydrochloride
	Metoprolol-d7 Hydrochloride 是 Metoprolol Hydrochloride 的氘代化合物。Metoprolol Hydrochloride 的 CAS 号为 56392-18-8。Metoprolol 是一种选择性 β1 受体阻滞剂。Metoprolol 用于治疗高血压、因心脏血流不畅而引起的胸痛以及许多心率异常快的疾病。
T70990	ADMA-d6
	NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Da...
T36059	Dichlorphenamide-13C6 Dichlorphenamide-13C6
	Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induc...
T70883	Moexipril-d5
	Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) ...
T70186	Methazolamide-d6
	Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re...
T71402	Nicorandil-d4
	Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =...
T69600	Spermidine-d6
	Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki...

同位素标记化合物

Cat.No: T19185

Synonym: 醛固酮 D8,Aldosterone D8

Target: Others

Cat.No: T13282

Synonym: CGP-48933 D9,缬沙坦 D9

Target: Others

Cat.No: T12300

Synonym: RNH-6270 D4,奥美沙坦 D4

Target: Others

Isoproterenol-d7 HCl

Cat.No: T69598

Cat.No: TMIJ-0183

Guanfacine-13C,15N3

Cat.No: T35591

Synonym: Guanfacine-13C,15N3

Cat.No: TMIJ-0077

Cat.No: TMIJ-0497

Cat.No: T71065

Metoprolol-d7 Hydrochloride

Cat.No: TMIJ-0042

Cat.No: T70990

Dichlorphenamide-13C6

Cat.No: T36059

Synonym: Dichlorphenamide-13C6

Cat.No: T70883

Methazolamide-d6

Cat.No: T70186

Cat.No: T71402

Cat.No: T69600

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