Clobutinol has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research [1] [2] [3].

Clobutinol significantly inhibits the voltage-gated outward current in hERG-expressing cells at 10 μM[1]. Clobutinol (0-1000 μM) inhibits the outward current in hERG transfected cells with an IC 50 value of 1.9 μM [1].

Clobutinol (1-20 mg/kg; i.v. once) has no significant effect on the airway of guinea-pigs [2]. Clobutinol (1 and 10 mg/kg; i.v. once) affects heart rate and mean blood pressure of guinea pigs [3]. Animal Model: Anaesthetized guinea-pigs [2] Dosage: 1-20 mg/kg Administration: Intravenous injection; 1-20 mg/kg once Result: Showed no obvious effect on the airways, but affected the cardiovascular system considerably with a high dose. Animal Model: Anesthetized closed-chest guinea pigs [3] Dosage: 1 and 10 mg/kg Administration: Intravenous injection; 1 and 10 mg/kg once Result: Decreased the heart rate with a dose of 1 mg/kg, and decreased the heart rate and mean blood pressure with a dose of 10 mg/kg.