Timolol hemimaleate

产品编号 T87530Cas号 33305-95-2

别名 MK 950 hemimaleate|||马来酸噻吗洛尔|||(S)-L-714,465 hemimaleate

Timolol hemimaleate ((S)-L-714,465; MK 950) 作为一种β受体阻滞剂，既可用于局部也可用于全身治疗。此药物主要应用于降低开角型青光眼和高眼压症状。此外，Timolol hemimaleate 在治疗婴儿血管瘤、高血压、心肌梗塞、预防偏头痛和心房颤动的研究中也显示出其有效性。它还具备对心脏的保护功能。

Timolol hemimaleate

产品编号 T87530别名 MK 950 hemimaleate, 马来酸噻吗洛尔, (S)-L-714,465 hemimaleateCas号 33305-95-2

规格	价格	库存	数量
10 mg	询价	10-14周
50 mg	询价	10-14周

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产品介绍

生物活性

产品描述	Timolol hemimaleate ((S)-L-714,465; MK 950), a β-blocker, is formulated for both systemic and topical use. It is commonly applied topically to decrease intraocular pressure in cases of open-angle glaucoma and ocular hypertension. Additionally, it is utilized in research for the treatment of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation. Moreover, Timolol has been recognized for its cardioprotective effects [1] [2].
体外活性	Timolol hemimaleate significantly prevents increased lipid peroxidation in the hearts of diabetic rats, induces a balanced ratio between oxidative stress and antioxidant defense, and provides important cardioprotection against diabetes-induced ERS and associated apoptotic effects [3].
体内活性	Timolol hemimaleate exhibits cardioprotective effects in diabetic rats by inhibiting the ERS response [3]. Animal model: 3-month-old male Wistar rats [3]. Dosage: 5 mg/kg. Administration: 5 mg/kg daily for 12 weeks. Result: Demonstrated cardioprotective effects.
别名	MK 950 hemimaleate, 马来酸噻吗洛尔, (S)-L-714,465 hemimaleate