Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.

Pretreatment with Unoprostone (0.01, 0.1, 1 μM; 1 hour before H2O2 treatment) prevents H2O2-induced cell death in a concentration-dependent manner, and the effect is significant at 0.1 μM and 1 μM concentrations[1]. Pretreatment with Unoprostone at a concentration of 0.1 to 3 μM can prevent light-induced cell death in a concentration-dependent manner; the effect is significant at 1 and 3 μM. Unoprostone reduces the morphological change, and it significantly inhibits the low mitochondrial membrane potential and cell death induced by light irradiation[1]. Unoprostone has prostaglandin F2α receptors (FP) binding affinity (Ki of 3.86 μM)[2].