Dichlorphenamide disodium is a specific, orally active carbonic anhydrase inhibitor. It effectively reduces intraocular pressure by impeding the secretion of aqueous humor. Notably, dichlorphenamide disodium holds potential for glaucoma research [1].

Dichlorphenamide disodium can reduce IOP locally in male albino rabbits [1]. Animal Model: Male albino rabbits (approximately 2.5 kg) [1] Dosage: 50 μL 10% aqueous solutions of dichlorphenamide sodium or 2 mg/kg, 6 mg/kg Administration: Eye drop of 50 μL or Oral gavage of 2 mg/kg or 6 mg/kg，5 hours Result: Showed significant decrease in IOP at 30 min by instilling into eyes and decrease in IOP only at 1 h by orally after drug administration. And demonstrated that drug levels were significantly higher in the iris ciliary body and lower in the serum by instilling compared to oral administration.