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Search Results for " ligase "

Targets Recommended: E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase Ligand for E3 Ligase

483

抑制剂 & 化合物

7

天然产物

126

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9809	E3 ligase Ligand 23	Ligand for E3 Ligase	PROTAC
	E3 ligase Ligand 23 是一种 cereblon 结合剂，可通过泛素蛋白酶体降解 Ikaros 或 Aiolos。
T17879	E3 ligase Ligand 8	Others; Ligand for E3 Ligase	Others; PROTAC
	E3 ligase Ligand 8 是 E3 泛素连接酶配体。它能够利用 linker 与靶蛋白配体连接，形成 PROTAC 分子。PROTAC 可诱导促癌蛋白发生泛素化降解。
T17870	cIAP1 ligand 1 E3 ligase Ligand 12	Others	Others
	cIAP1 ligand 1 (E3 ligase Ligand 12) 是基于 LCL161 衍生物的细胞凋亡蛋白配体，可募集 IAP 泛素连接酶以降解靶蛋白，可用于和雄激素受体配体欧联开发蛋白降解剂，可用于研究前列腺癌。
T7763	Thalidomide-4-OH Cereblon ligand 2,E3 ligase Ligand 2	Ligand for E3 Ligase	PROTAC
	Thalidomide-4-OH (E3 ligase Ligand 2) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T3103	L67 DNA Ligase Inhibitor	DNA; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	L67 (DNA Ligase Inhibitor) 是一种竞争性人类 DNA 连接酶抑制剂，抑制 DNA 连接酶 I 和 III，IC50为10μM。
T7752	(S,R,S)-AHPC-Me VHL ligand 2,E3 ligase Ligand 1A	Ligand for E3 Ligase	PROTAC
	(S,R,S)-AHPC-Me是基于 (S,R,S)-AHPC 的的 VHL 配体，可用于募集 von Hippel-Lindau (VHL) 蛋白。它可有效降解去势抵抗性前列腺癌细胞中的 BET 蛋白，DC50<1 nM。它可用于合成 ARV-771。
T17871	E3 ligase Ligand 13	Others	Others
	E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
T17872	E3 ligase Ligand 14	Others	Others
	E3 ligase Ligand 14 is a ligand that binds to E3 ubiquitin ligase and can be conjugated to a protein ligand via a linker to create PROTACs. These PROTACs are capable of promoting ubiquitination-mediated degradation of cancer-promoting proteins[1].
T17868	E3 ligase Ligand 10	Others	Others
	E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1].
T7753	Thalidomide-O-COOH Cereblon ligand 3,E3 ligase Ligand 3,TCE35031	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T17877	VH032-cyclopropane-F VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101	Others; Ligand for E3 Ligase	Others; PROTAC
	VH032-cyclopropane-F 是基于 VH032 的 VHL 配体。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子，如 PROTAC 1。PROTAC 1 是 SMARCA2 和 SMARCA4 的部分降解剂。
T13671	(S,R,S)-AHPC-Me hydrochloride VHL ligand 2 hydrochloride,E3 ligase Ligand 1	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein.
T17876	E3 ligase Ligand 18	Others	Others
	E3 ligase Ligand 18 is a ligand that binds to E3 ubiquitin ligase, and it can be chemically attached to a protein ligand through a linker to create PROTACs. The resulting PROTACs function as inducers of ubiquitination-mediated degradation, targeting cancer-promoting proteins[1].
T17880	E3 ligase Ligand 9	Others	Others
	E3 ligase Ligand 9 is a compound that serves as a ligand for E3 ubiquitin ligase. It can be linked to the protein ligand through a linker, forming PROTACs or SNIPERs. These PROTACs are known to induce the degradation of cancer-promoting proteins through ubiquitination-mediated mechanisms[1].
T17919	Thalidomide-O-amido-C6-NH2 TFA E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate,Cereblon Ligand-Linker Conjugates 11 TFA,E3 Ligase Ligand-Linker Conjugates 25 TFA	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物。可用于 PROTAC 的合成分子。
T17916	Pomalidomide-PEG4-C2-NH2 Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22	Others; Ligand for E3 Ligase	Others; PROTAC
	Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体- linker 偶联物，用于 PROTAC 技术中。
T17325	Pomalidomide-PEG4-C-COOH Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) 包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T15189	Thalidomide-O-amido-C4-N3 E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) 是一种 E3 连接酶配体- linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 linker。
T7759	Thalidomide-O-amido-C4-NH2 TFA E3 ligase Ligand-Linker Conjugates 19 TFA,Cereblon Ligand-Linker Conjugates 6 TFA	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Thalidomide-O-amido-C4-NH2 TFA (E3 ligase Ligand-Linker Conjugates 19 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T17918	Thalidomide-O-amido-PEG2-C2-NH2 TFA E3 Ligase Ligand-Linker Conjugates 24 TFA,Cereblon Ligand-Linker Conjugates 10 TFA	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	Thalidomide-O-amido-PEG2-C2-NH2 TFA (E3 Ligase Ligand-Linker Conjugates 24 TFA) 包含基于 Thalidomide 的 cereblon 配体和 2 个单元的 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T7758	Thalidomide-O-amido-PEG3-C2-NH2 TFA E3 ligase Ligand-Linker Conjugates 14 TFA,Cereblon Ligand-Linker Conjugates 3 (TFA)	Others; E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) 包含基于 Thalidomide 的 cereblon 配体和 3 个单元的 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T7760	Thalidomide-O-amido-C3-NH2 TFA Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA	E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase	PROTAC
	Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物，。
T7755	Thalidomide 4-fluoride E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮	IRAK; Ligand for E3 Ligase	Immunology/Inflammation; NF-κB; PROTAC
	Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接，得到 PROTAC IRAK4 degrader-1。
T17909	(S,R,S)-AHPC-PEG3-N3 VHL Ligand-Linker Conjugates 8,VH032-PEG3-N3,E3 ligase Ligand-Linker Conjugates 12	Others; E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T18640	(S,R,S)-AHPC-C4-NH2 hydrochloride VH032-C4-NH2 hydrochloride,E3 ligase Ligand-Linker Conjugates 28,VHL Ligand-Linker Conjugates 13	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-C4-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 28) 是一种合成的 E3 连接酶配体- linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 linker。
T17920	(S,R,S)-AHPC-PEG1-N3 VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) 是 E3 连接酶配体和linker 连接得到的偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 1 个单元 PEG linker。
T17921	(S,R,S)-AHPC-PEG4-N3 VH032-PEG4-N3,VHL Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 4	Others; PROTAC Linker	Others; PROTAC
	(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both commonly employed in PROTAC technology.
T79924	T4 RNA ligase	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	T4 RNA ligase为一RNA连接酶，催化单链DNA分子的连接作用。该酶在酶促低核糖核苷酸合成及RNA 3'端标记过程中应用。
T15190L	(S,R,S)-AHPC-PEG4-NH2 VHL Ligand-Linker Conjugates 4,E3 ligase Ligand-Linker Conjugates 7 Free Base,VH032-PEG4-NH2	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) 是一种合成的 E3 连接酶配体-接头偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 4 单元 PEG 接头。
T17924	(S,R,S)-AHPC-PEG2-NH2 hydrochloride VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 的合成分子。
T17922	(S,R,S)-AHPC-PEG3-NH2 hydrochloride VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) 是一种 E3 ligase ligand-linker conjugate，包含了 (S,R,S)-AHPC-based VHL ligand 和 3-unit PEG linker。
T7756	Pomalidomide-PEG4-Ph-NH2	Ligand for E3 Ligase	PROTAC
	Pomalidomide-PEG4-Ph-NH2 是一种合成的 E3 连接酶配体- linker 偶联物，结合了基于 Pomalidomide 的 cereblon 配体和 4 单元 PEG linker。
T18064	Lenalidomide-Br	Ligand for E3 Ligase	PROTAC
	Lenalidomide-Br 是一种用于 E3 泛素连接酶的 cereblon (CRBN) 配体 Lenalidomide 的类似物，用于 CRBN 蛋白的募集。它能够利用 linker 连接到蛋白质配体上形成 PROTAC，如 PROTAC STAT3 降解剂 SD-36。
T4517	L189	DNA; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	L189 是一种人类 DNA 连接酶抑制剂，抑制 hLigI/III/IV，IC50值分别为5、9 和 5 μM。
T5334	VL285	Others; Ligand for E3 Ligase	Others; PROTAC
	VL285 是VHL 配体，IC50=0.34 μM。
T18831	Thalidomide-propargyl	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-propargyl 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到含 IMiD 的 PROTAC。
T18066	Lenalidomide-OH	Ligand for E3 Ligase	PROTAC
	Lenalidomide-OH 是一种用于 E3 泛素连接酶 (CRBN) 的 cereblon 配体 Lenalidomide 的类似物，用于 CRBN 蛋白的募集。它能够利用 linker 连接到蛋白质配体上形成 PROTAC。
T40503	Thalidomide-5-methyl	Ligand for E3 Ligase	PROTAC
	Thalidomide-5-methyl 是基于 Thalidomide 的 CRBN 配体，可以用于CRBN 的招募。
T17869	cIAP1 ligand 2 E3 ligase Ligand 11	Others	Others
	cIAP1 ligand 2, a derivative of LCL161, is an IAP ligand that can be connected to the ABL ligand for protein via a linker, resulting in the formation of SNIPER.
TQ0121	VH-298	Others; HIF; Ligand for E3 Ligase	Angiogenesis; Chromatin/Epigenetic; Others; PROTAC
	VH-298 是一种高效的 VHL:HIF-α 相互作用抑制剂(Kd:80-90 nM)。它可用于PROTAC 技术中。
T14893	CC-885	Others; Ligand for E3 Ligase	Others; PROTAC
	CC-885 是一种 CRBN 蛋白调节剂，有抗肿瘤的潜能。
T22922	Lenalidomide hemihydrate	TNF; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Lenalidomide hemihydrate 是 Thalidomide 的衍生物，也是具有口服活性免疫调节剂，以分子胶的方式作用。它是泛素 E3 连接酶 cereblon 的配体，通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。
T17908	VHL Ligand-Linker Conjugates 15 E3 Ligase Ligand-Linker Conjugates 56	Others	Others
	VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1].
T0213	Thalidomide Thalomid,沙利度胺,Sedoval	Apoptosis; TNF; Autophagy; Ligand for E3 Ligase; Molecular Glues	Apoptosis; Autophagy; PROTAC
	Thalidomide (Thalomid) 能够抑制 cereblon，即 cullin-4 E3 泛素连接酶复合物 CUL4-RBX1-DDB1 的一部分，Kd 值约为 250 nM，具有免疫调节、抗炎、抗肿瘤作用。它可以作为分子胶来增强底物。
T40019	Thalidomide-5-NH2-CH2-COOH	Others	Others
	Thalidomide-5-NH2-CH2-COOH (compound 114) 是原肌球蛋白受体激酶的选择性抑制剂。它是 E3 连接酶的配体，具有研究一种或多种疾病的潜力。
T17893	cIAP1 Ligand-Linker Conjugates 5 E3 ligase Ligand-Linker Conjugates 39	Others	Others
	cIAP1 Ligand-Linker Conjugates 5 is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 5, is specifically designed for the development of SNIPERs[1].
T17364	AhR Ligand-Linker Conjugates 1 E3 Ligase Ligand-Linker Conjugates 57	Others	Others
	AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be used in the development of SNIPER[1].
T1642	Lenalidomide 来那度胺,CC-5013	Apoptosis; TNF; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Lenalidomide (CC-5013) 是 Thalidomide 的衍生物，也是具有口服活性免疫调节剂，以分子胶的方式作用。它是泛素 E3 连接酶 cereblon (CRBN) 的配体，可通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。
T8824	CRBN modulator-1 WUN29654	Others; Ligand for E3 Ligase	Others; PROTAC
	CRBN modulator-1 (WUN29654) 是一种 Thalidomide 类似物。它是一种 CRBN 调节剂，结合 CRBN 的 IC50=3.5 μM，Ki=0.98 μM。
T17874	Nutlin carboxylic acid MDM2 ligand 1,E3 ligase Ligand 16	Others	Others
	Nutlin Carboxylic Acid (MDM2 ligand 1), derived from Nutlin 3, serves as an MDM2 ligand. It can be attached to a protein ligand via a linker to create PROTACs[1].

化合物

E3 ligase Ligand 23

Cat.No: T9809

Target: Ligand for E3 Ligase

E3 ligase Ligand 8

Cat.No: T17879

Target: Others, Ligand for E3 Ligase

Cat.No: T17870

Synonym: E3 ligase Ligand 12

Target: Others

Thalidomide-4-OH

Cat.No: T7763

Synonym: Cereblon ligand 2,E3 ligase Ligand 2

Target: Ligand for E3 Ligase

Cat.No: T3103

Synonym: DNA Ligase Inhibitor

Target: DNA, DNA/RNA Synthesis

(S,R,S)-AHPC-Me

Cat.No: T7752

Synonym: VHL ligand 2,E3 ligase Ligand 1A

Target: Ligand for E3 Ligase

E3 ligase Ligand 13

Cat.No: T17871

Target: Others

E3 ligase Ligand 14

Cat.No: T17872

Target: Others

E3 ligase Ligand 10

Cat.No: T17868

Target: Others

Thalidomide-O-COOH

Cat.No: T7753

Synonym: Cereblon ligand 3,E3 ligase Ligand 3,TCE35031

Target: Others, Ligand for E3 Ligase

VH032-cyclopropane-F

Cat.No: T17877

Synonym: VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-Me hydrochloride

Cat.No: T13671

Synonym: VHL ligand 2 hydrochloride,E3 ligase Ligand 1

Target: Others, Ligand for E3 Ligase

E3 ligase Ligand 18

Cat.No: T17876

Target: Others

E3 ligase Ligand 9

Cat.No: T17880

Target: Others

Thalidomide-O-amido-C6-NH2 TFA

Cat.No: T17919

Synonym: E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate,Cereblon Ligand-Linker Conjugates 11 TFA,E3 Ligase Ligand-Linker Conjugates 25 TFA

Target: Others, Ligand for E3 Ligase

Pomalidomide-PEG4-C2-NH2

Cat.No: T17916

Synonym: Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22

Target: Others, Ligand for E3 Ligase

Pomalidomide-PEG4-C-COOH

Cat.No: T17325

Synonym: Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1

Target: Others, E3 Ligase Ligand-Linker Conjugate

Thalidomide-O-amido-C4-N3

Cat.No: T15189

Synonym: E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4

Target: Others, Ligand for E3 Ligase

Thalidomide-O-amido-C4-NH2 TFA

Cat.No: T7759

Synonym: E3 ligase Ligand-Linker Conjugates 19 TFA,Cereblon Ligand-Linker Conjugates 6 TFA

Target: E3 Ligase Ligand-Linker Conjugate

Thalidomide-O-amido-PEG2-C2-NH2 TFA

Cat.No: T17918

Synonym: E3 Ligase Ligand-Linker Conjugates 24 TFA,Cereblon Ligand-Linker Conjugates 10 TFA

Target: Others, E3 Ligase Ligand-Linker Conjugate

Thalidomide-O-amido-PEG3-C2-NH2 TFA

Cat.No: T7758

Synonym: E3 ligase Ligand-Linker Conjugates 14 TFA,Cereblon Ligand-Linker Conjugates 3 (TFA)

Target: Others, E3 Ligase Ligand-Linker Conjugate, Ligand for E3 Ligase

Thalidomide-O-amido-C3-NH2 TFA

Cat.No: T7760

Synonym: Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA

Target: E3 Ligase Ligand-Linker Conjugate, Ligand for E3 Ligase

Thalidomide 4-fluoride

Cat.No: T7755

Synonym: E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮

Target: IRAK, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG3-N3

Cat.No: T17909

Synonym: VHL Ligand-Linker Conjugates 8,VH032-PEG3-N3,E3 ligase Ligand-Linker Conjugates 12

Target: Others, E3 Ligase Ligand-Linker Conjugate, Ligand for E3 Ligase

(S,R,S)-AHPC-C4-NH2 hydrochloride

Cat.No: T18640

Synonym: VH032-C4-NH2 hydrochloride,E3 ligase Ligand-Linker Conjugates 28,VHL Ligand-Linker Conjugates 13

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG1-N3

Cat.No: T17920

Synonym: VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG4-N3

Cat.No: T17921

Synonym: VH032-PEG4-N3,VHL Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 4

Target: Others, PROTAC Linker

T4 RNA ligase

Cat.No: T79924

Target: DNA/RNA Synthesis

(S,R,S)-AHPC-PEG4-NH2

Cat.No: T15190L

Synonym: VHL Ligand-Linker Conjugates 4,E3 ligase Ligand-Linker Conjugates 7 Free Base,VH032-PEG4-NH2

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

Cat.No: T17924

Synonym: VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6

Target: Others, E3 Ligase Ligand-Linker Conjugate

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

Cat.No: T17922

Synonym: VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl

Target: Others, E3 Ligase Ligand-Linker Conjugate

Pomalidomide-PEG4-Ph-NH2

Cat.No: T7756

Target: Ligand for E3 Ligase

Lenalidomide-Br

Cat.No: T18064

Target: Ligand for E3 Ligase

Cat.No: T4517

Target: DNA, DNA/RNA Synthesis

Cat.No: T5334

Target: Others, Ligand for E3 Ligase

Thalidomide-propargyl

Cat.No: T18831

Target: Others, Ligand for E3 Ligase

Lenalidomide-OH

Cat.No: T18066

Target: Ligand for E3 Ligase

Thalidomide-5-methyl

Cat.No: T40503

Target: Ligand for E3 Ligase

Cat.No: T17869

Synonym: E3 ligase Ligand 11

Target: Others

Cat.No: TQ0121

Target: Others, HIF, Ligand for E3 Ligase

Cat.No: T14893

Target: Others, Ligand for E3 Ligase

Lenalidomide hemihydrate

Cat.No: T22922

Target: TNF, Ligand for E3 Ligase, Molecular Glues

VHL Ligand-Linker Conjugates 15

Cat.No: T17908

Synonym: E3 Ligase Ligand-Linker Conjugates 56

Target: Others

Cat.No: T0213

Synonym: Thalomid,沙利度胺,Sedoval

Target: Apoptosis, TNF, Autophagy, Ligand for E3 Ligase, Molecular Glues

Thalidomide-5-NH2-CH2-COOH

Cat.No: T40019

Target: Others

cIAP1 Ligand-Linker Conjugates 5

Cat.No: T17893

Synonym: E3 ligase Ligand-Linker Conjugates 39

Target: Others

AhR Ligand-Linker Conjugates 1

Cat.No: T17364

Synonym: E3 Ligase Ligand-Linker Conjugates 57

Target: Others

Cat.No: T1642

Synonym: 来那度胺,CC-5013

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

CRBN modulator-1

Cat.No: T8824

Synonym: WUN29654

Target: Others, Ligand for E3 Ligase

Nutlin carboxylic acid

Cat.No: T17874

Synonym: MDM2 ligand 1,E3 ligase Ligand 16

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4S0181	Hinokiflavone 日本扁柏黄酮,扁柏双黄酮	MMP; BCL; E1/E2/E3 Enzyme	Apoptosis; Proteases/Proteasome; Ubiquitination
	Hinokiflavone 是pre-mRNA 剪接活性的新型调节剂，通过抑制剪接体装配来阻止pre-mRNA 底物的剪接，特别是阻止 B complex 的形成。它是SUMO protease 蛋白酶抑制剂，能够抑制前哨蛋白特异性蛋白酶 1 的活性。
T9352	hydrocotarnine	Others	Others
	hydrocotarnine 是 Cbl 的抑制剂。
T9368	3,4-(Methylenedioxy)cinnamic acid 3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid,3,4-(亚甲二氧)肉桂酸	Others	Others
	3,4-(Methylenedioxy)cinnamic acid (3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid) 是一种植物衍生化合物，首先从芦笋的根中提取，并进一步表征为一种化感化学物质。
T4036	Solasodine Solancarpidine,Purapuridine,澳洲茄铵,Solasodin	Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal	Apoptosis; Microbiology/Virology; Others; Ubiquitination
	Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。
T6S2123	Ginkgolic Acid Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),银杏酸C15:1,银杏酸,Ginkgolic acid C15:1	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	Ginkgolic Acid (Romanicardic acid) 是一种天然化合物，在体外实验中抑制SUMOylation，IC50=3.0 μM。
T2947	Indole-3-carbinol 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol	E1/E2/E3 Enzyme; NF-κB; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p53	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Ubiquitination
	Indole-3-carbinol (I3C) 是樟子松中的一种天然产物，是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂，可抑制 NF-κB 和 IκBα 激酶活化。
T6407	β-Lapachone 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501	IDO; Apoptosis; Topoisomerase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism
	β-Lapachone (ARQ-501) 是一种萘醌类天然产物，是拓扑异构酶 I 抑制剂，通过抑制细胞周期进程来诱导细胞凋亡。

天然产物

Cat.No: T4S0181

Synonym: 日本扁柏黄酮,扁柏双黄酮

Target: MMP, BCL, E1/E2/E3 Enzyme

Cat.No: T9352

Target: Others

3,4-(Methylenedioxy)cinnamic acid

Cat.No: T9368

Synonym: 3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid,3,4-(亚甲二氧)肉桂酸

Target: Others

Cat.No: T4036

Synonym: Solancarpidine,Purapuridine,澳洲茄铵,Solasodin

Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal

Cat.No: T6S2123

Synonym: Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),银杏酸C15:1,银杏酸,Ginkgolic acid C15:1

Target: Others, E1/E2/E3 Enzyme

Indole-3-carbinol

Cat.No: T2947

Synonym: 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol

Target: E1/E2/E3 Enzyme, NF-κB, Aryl Hydrocarbon Receptor, Endogenous Metabolite, p53

Cat.No: T6407

Synonym: 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501

Target: IDO, Apoptosis, Topoisomerase, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00475	DNA ligase Protein, Desulfotalea psychrophila, Recombinant (His) Polydeoxyribonucleotide synthase [NAD(+)],ligA,DNA ligas...	Desulfotalea psychrophila	E. coli
	DNA ligase Protein, Desulfotalea psychrophila, Recombinant (His) is expressed in E. coli.
TMPH-00425	DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His) ligA,DNA ligase,Polydeoxyribonucleotide synthase [N...	Colwellia psychrerythraea	E. coli
	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 42.1 kDa and the accession number is Q47YI0.
TMPH-00647	Lipoate-protein ligase A/LplA Protein, E. coli, Recombinant (His & SUMO) lplA,Lipoate-protein ligase A,Lipoate--protein ...	E. coli	E. coli
	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
TMPH-02461	pylS Protein, Methanosarcina barkeri, Recombinant (His) pylS,Pyrrolysine--tRNA ligase,Pyrrolysine--tRNA(Pyl...	Methanosarcina barkeri	E. coli
	Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG. pylS Protein, Methanosarcina barkeri, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 51.8 kDa and the accession number is Q46E77.
TMPH-00732	RtcB Protein, E. coli, Recombinant (His) rtcB,3'-phosphate/5'-hydroxy nucleic acid ligase,RN...	E. coli	P. pastoris (Yeast)
	GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases.
TMPH-02631	PRKN Protein, Mouse, Recombinant (GST) E3 ubiquitin-protein ligase parkin,Prkn,Parkin RBR ...	Mouse	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det...
TMPH-03281	PRKN Protein, Rat, Recombinant (His & Myc) E3 ubiquitin-protein ligase parkin,Parkin RBR E3 ub...	Rat	Baculovirus Insect Cells
	PRKN Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 55.6 kDa and the accession number is Q9JK66.
TMPY-00361	Pellino-1 Protein, Human, Recombinant (His & GST) pellino E3 ubiquitin protein ligase 1,PRISM	Human	Baculovirus Insect Cells
	PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant cell death and maintaining cellular homeostasis. PELI1 might participate in B-cell maturation or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages.
TMPH-03533	Ddl Protein, S. aureus, Recombinant (His & Myc) ddl,D-alanylalanine synthetase,D-Ala-D-Ala ligase,D...	Staphylococcus aureus	E. coli
	Cell wall formation. Ddl Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.7 kDa and the accession number is P63891.
TMPJ-00732	ASS1 Protein, Human, Recombinant (His) Citrulline--Aspartate Ligase,Argininosuccinate Synt...	Human	E. coli
	Argininosuccinate Synthase (ASS1) is an urea cycle enzyme with a tetrameric structure composed of identical subunits. ASS1 is involved in the synthesis of arginine and catalyzes that condensation of citrulline and aspartate to argininosuccinate using ATP. ASS1 is important to the urea cycle as it catalyzes the important second last step in the arginine biosynthetic pathway. ASS1 mainly expressed in periportal hepatocytes, but also in most other body tissues. A deficiency of ASS1 causes citrullin...
TMPH-02527	ASS1 Protein, Mouse, Recombinant (His & Myc) Ass,Citrulline--aspartate ligase,Ass1,Argininosucci...	Mouse	E. coli
	One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. ASS1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 5...
TMPH-01613	LIPT1 Protein, Human, Recombinant (His) Lipoate biosynthesis protein,Lipoyl amidotransferase LIPT1, ...	Human	E. coli
	Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
TMPH-01263	PRKN Protein, Human, Recombinant (His & SUMO) PRKN,Parkin RBR E3 ubiquitin-protein ligase,E3 ubiq...	Human	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det...
TMPH-02764	ACSL4 Protein, Mouse, Recombinant (His) LACS 4,mACS4,Long-chain-fatty-acid--CoA ligase 4,Ac...	Mouse	E. coli
	ACSL4 Protein, Mouse, Recombinant (His) is expressed in E. coli.
TMPH-02741	IARS1 Protein, Mouse, Recombinant (His & Myc) Isoleucyl-tRNA synthetase,Iars1,Isoleucine--tRNA ligase<...	Mouse	E. coli
	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. IARS1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 16.8 kDa and the accession number is Q8BU30.
TMPH-01262	PRKN Protein, Human, Recombinant (His & Myc) Parkinson juvenile disease protein 2,E3 ubiquitin-protein	Human	Baculovirus Insect Cells
	PRKN Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 55.6 kDa and the accession number is O60260.
TMPJ-00855	GLUL Protein, Human, Recombinant (His) GLUL,GS,Glutamine Synthetase,Glutamate-Ammonia Ligase	Human	E. coli
	Glutamine Synthetase reglutes intracellular concentration of glutamate. Glutamine Synthetase catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is an important source of energy and that takes part in cell prolifetation, inhibition of apoptosis, and cell signaling. Glutamine Synthetase is expressed during early fetal stages, and has a role in maintaining body PH by removing ammonia from circulation. Mutations in the GLUL gene are related to congenital glutamine deficiency.
TMPY-01654	ITCH Protein, Human, Recombinant (aa 526-903) itchy E3 ubiquitin protein ligase,NAPP1,dJ468O1.1,A...	Human	E. coli
	E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and contains four WW domains. ITCH acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-...
TMPH-03409	4CL Protein, Rhodobacter capsulatus, Recombinant (His) 4-coumarate--CoA ligase,pcl,EC:6.2.1.12,4-coumaroyl...	Rhodobacter capsulatus	E. coli
	Converts p-coumaric acid into p-coumaryl CoA. This is necessary for the activation of the photoactive yellow protein (PYP) chromophore. 4CL Protein, Rhodobacter capsulatus, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 47.0 kDa and the accession number is O69140.
TMPH-01265	PELI3 Protein, Human, Recombinant (His) PELI3,E3 ubiquitin-protein ligase pellino homolog 3	Human	E. coli
	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. PELI3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 54.8 kDa and the access...
TMPH-00438	GLUL Protein, Cricetulus griseus, Recombinant (His) Glutamine synthetase,GLUL,Glutamate--ammonia ligase...	Chinese hamster	E. coli
	GLUL Protein, Cricetulus griseus, Recombinant (His) is expressed in E. coli.
TMPH-02279	YARS1 Protein, Human, Recombinant (GST) Tyrosine--tRNA ligase, cytoplasmic,Tyrosyl-tRNA syn...	Human	E. coli
	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). YARS1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 86.0 kDa and the accession number is P54577.
TMPJ-01122	KARS Protein, Human, Recombinant (His) Lysine--tRNA Ligase,Lysyl-tRNA Synthetase,LysRS,KAR...	Human	HEK293 Cells
	Lysine-tRNA ligase, also known as Lysyl-tRNA synthetase, LysRS, KARS and KIAA0070, belongs to the class-II aminoacyl-tRNA synthetase family. The N-terminal cytoplasmic domain (1-65) is a functional tRNA-binding domain, which is required for nuclear localization, is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization and is required for interaction with HIV-1 GAG and incorporation into virions. KARS c...
TMPH-00629	Gamma-GCS Protein, E. coli, Recombinant (His & SUMO) Glutamate--cysteine ligase,Gamma-ECS,gshA,Gamma-glu...	E. coli	E. coli
	N/A. Gamma-GCS Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 74.3 kDa and the accession number is P0A6W9.
TMPH-03740	DCL Protein, Bacillus subtilis, Recombinant (His) DCL,D-alanine--poly(phosphoribitol) ligase subunit ...	Bacillus subtilis	E. coli
	Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the...
TMPH-01565	IARS Protein, Human, Recombinant (His & Myc) Isoleucine--tRNA ligase, cytoplasmic,Isoleucyl-tRNA...	Human	E. coli
	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
TMPH-00796	gltX1 Protein, Helicobacter pylori, Recombinant (His) Glutamyl-tRNA synthetase 1,gltX1,Glutamate--tRNA ligase<...	Helicobacter pylori	P. pastoris (Yeast)
	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
TMPH-01266	RNF13 Protein, Human, Recombinant (His) RING finger protein 13,E3 ubiquitin-protein ligase ...	Human	E. coli
	RNF13 Protein, Human, Recombinant (His) is expressed in E. coli with N-terminal 10xHis tag. The predicted molecular weight is 26.2 kDa. Accession number: O43567
TMPH-01273	TRIP12 Protein, Human, Recombinant (His & Myc) Thyroid receptor-interacting protein 12,E3 ubiquitin-protein...	Human	E. coli
	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damag...
TMPJ-01035	UBE2G2 Protein, Human, Recombinant (GST) Ubiquitin-Conjugating Enzyme E2 G2,Ubiquitin-Protein Lig...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked ...
TMPH-01269	SMURF2 Protein, Human, Recombinant (His) SMAD ubiquitination regulatory factor 2,E3 ubiquitin-protein...	Human	E. coli
	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable com...
TMPH-03508	IpaH9.8 Protein, Shigella flexneri, Recombinant (His) E3 ubiquitin-protein ligase ipaH9.8,ipaH9.8,Invasio...	Shigella flexneri	P. pastoris (Yeast)
	Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell. IpaH9.8 Protein, Shigella flexneri, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 64.0 kDa and the accession number is D2AJU0.
TMPH-02488	ACSS2 Protein, Mouse, Recombinant (His) Propionate--CoA ligase,AceCS1,Acyl-activating enzym...	Mouse	E. coli
	Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity. ACSS2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82.9 kDa and the accession number is Q9QXG4.
TMPJ-01053	UBE2I Protein, Human, Recombinant (GST) SUMO-Protein Ligase,Ubiquitin-Conjugating Enzyme E2...	Human	E. coli
	SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However, instead of conjugating ubiquitin, UBC9 conjugates a ubiquitin homologue, Small Ubiquitin-Like Modifier 1 (SUMO-1). The conjugation of ubiquitin requires the activities of ubiquitin-activating (E1) and conjugating (E2) enzymes. It is suggested that UBC9 might play a role in DNA repair and perhaps even in aging.
TMPH-00085	SIZ1 Protein, Arabidopsis thaliana, Recombinant (His) E3 SUMO-protein ligase SIZ1,SIZ1,E3 SUMO-protein tr...	Arabidopsis thaliana	E. coli
	E3 SUMO protein ligase involved in regulation processes. Mediates SUMO/ attachment to PHR1, a MYB transcriptional activator controlling the phosphate deficiency responses. Functions as an upstream negative regulator of salicylic acid (SA) accumulation and subsequent SA-mediated systemic acquired resistance (SAR) signaling. Probably not involved in jasmonic acid (JA)-mediated defense response. Participates in abiotic stress-induced sumoylation. Controls heat shock-induced SUMO1 and SUMO2 conjugat...
TMPK-01001	RNF43 Protein, Mouse, Recombinant (hFc) Rnf43,RING finger protein 43,RING-type E3 ubiquitin transfer...	Mouse	HEK293 Cells
	RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
TMPY-02950	WWP2 Protein, Human, Recombinant (His & GST) WW domain containing E3 ubiquitin protein ligase 2,...	Human	Baculovirus Insect Cells
	WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-6...
TMPY-03510	Cbl-c Protein, Human, Recombinant (His & GST) Cbl proto-oncogene C, E3 ubiquitin protein ligase,C...	Human	Baculovirus Insect Cells
	CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. Cbl-c is a member of the Cbl family of E3 ubiquitin ligases. Expression of Cbl-c gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for Cbl-c g...
TMPJ-00989	MTHFS Protein, Human, Recombinant (His) 5-formyltetrahydrofolate cyclo-ligase,10-methenyl-t...	Human	E. coli
	5-formyltetrahydrofolate cyclo-ligase (MTHFS) belongs to the 5-formyltetrahydrofolate cyclo-ligase family. It is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, contributes to tetrahydrofolate metabolism. MTHFS helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. An increased activity of the encoded protein can result in an increas...
TMPH-01270	TRAIP Protein, Human, Recombinant (His) E3 ubiquitin-protein ligase TRAIP,TRAF-interacting ...	Human	E. coli
	E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm...
TMPJ-01403	UBE2D4 Protein, Human, Recombinant (GST) Ubiquitin-Conjugating Enzyme E2 D4,Ubiquitin-Protein Lig...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational protein modification, protein K6-linked ubiquitination, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, and protein K63-linked ubiquitination. UBE2D4 regulate of protein metabolic process...
TMPY-06026	VHL Protein, Human, Recombinant (His & Avi) RCA1,HRCA1,pVHL,VHL1,von Hippel-Lindau tumor suppressor, E3 ...	Human	E. coli
	VHL Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 27.5 kDa and the accession number is A0A024R2F2.
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc) RING finger protein 8,RNF8,E3 ubiquitin-protein ligase	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...
TMPH-03391	TRIM2 Protein, Rat, Recombinant (His) Trim2,Tripartite motif-containing protein 2,E3 ubiquitin-pro...	Rat	E. coli
	E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. TRIM2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.5 kDa and the accession number is D3ZQG6.
TMPH-01261	NEDD4L Protein, Human, Recombinant (GST) NEDD4L,HECT-type E3 ubiquitin transferase NED4L,Nedd4-2,E3 u...	Human	E. coli
	NEDD4L Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 138.5 kDa and the accession number is Q96PU5.
TMPH-01259	AMFR Protein, Human, Recombinant (His) Autocrine motility factor receptor,AMF receptor,gp78,RNF45,R...	Human	E. coli
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add...
TMPJ-00985	UBE2A Protein, Human, Recombinant (GST, His) RAD6A,HR6A,Ubiquitin-Protein Ligase A,UBE2A,hHR6A,U...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2A catalyzes the covalent attachment of ubiquitin to other proteins. UBE2A is re...
TMPH-01260	AMFR Protein, Human, Recombinant (hFc) gp78,RNF45,AMF receptor,RING finger protein 45,E3 ubiquitin-...	Human	HEK293 Cells
	E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add...
TMPJ-01047	UBE2H Protein, Human, Recombinant (GST) UBE2H,UbcH2,Ubiquitin-Conjugating Enzyme E2 H,Ubiquitin-Prot...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. It has been shown to conjugate ubiquitin to histone H2A in an E3 dependent manner in ...
TMPJ-01198	UBE2R2 Protein, Human, Recombinant (His) UBC3B,Ubiquitin-Conjugating Enzyme E2-CDC34B,CDC34B,Ubiquiti...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, UBE2R2 catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. It may be involved in degradation of katenin.
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重组蛋白

DNA ligase Protein, Desulfotalea psychrophila, Recombinant (His)

Cat.No: TMPH-00475

Species: Desulfotalea psychrophila

Expression System: E. coli

DNA ligase Protein, Colwellia psychrerythraea, Recombinant (His)

Cat.No: TMPH-00425

Species: Colwellia psychrerythraea

Expression System: E. coli

Lipoate-protein ligase A/LplA Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00647

Species: E. coli

Expression System: E. coli

pylS Protein, Methanosarcina barkeri, Recombinant (His)

Cat.No: TMPH-02461

Species: Methanosarcina barkeri

Expression System: E. coli

RtcB Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00732

Species: E. coli

Expression System: P. pastoris (Yeast)

PRKN Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02631

Species: Mouse

Expression System: E. coli

PRKN Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03281

Species: Rat

Expression System: Baculovirus Insect Cells

Pellino-1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-00361

Species: Human

Expression System: Baculovirus Insect Cells

Ddl Protein, S. aureus, Recombinant (His & Myc)

Cat.No: TMPH-03533

Species: Staphylococcus aureus

Expression System: E. coli

ASS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00732

Species: Human

Expression System: E. coli

ASS1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02527

Species: Mouse

Expression System: E. coli

LIPT1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01613

Species: Human

Expression System: E. coli

PRKN Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01263

Species: Human

Expression System: E. coli

ACSL4 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02764

Species: Mouse

Expression System: E. coli

IARS1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02741

Species: Mouse

Expression System: E. coli

PRKN Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01262

Species: Human

Expression System: Baculovirus Insect Cells

GLUL Protein, Human, Recombinant (His)

Cat.No: TMPJ-00855

Species: Human

Expression System: E. coli

ITCH Protein, Human, Recombinant (aa 526-903)

Cat.No: TMPY-01654

Species: Human

Expression System: E. coli

4CL Protein, Rhodobacter capsulatus, Recombinant (His)

Cat.No: TMPH-03409

Species: Rhodobacter capsulatus

Expression System: E. coli

PELI3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01265

Species: Human

Expression System: E. coli

GLUL Protein, Cricetulus griseus, Recombinant (His)

Cat.No: TMPH-00438

Species: Chinese hamster

Expression System: E. coli

YARS1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02279

Species: Human

Expression System: E. coli

KARS Protein, Human, Recombinant (His)

Cat.No: TMPJ-01122

Species: Human

Expression System: HEK293 Cells

Gamma-GCS Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00629

Species: E. coli

Expression System: E. coli

DCL Protein, Bacillus subtilis, Recombinant (His)

Cat.No: TMPH-03740

Species: Bacillus subtilis

Expression System: E. coli

IARS Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01565

Species: Human

Expression System: E. coli

gltX1 Protein, Helicobacter pylori, Recombinant (His)

Cat.No: TMPH-00796

Species: Helicobacter pylori

Expression System: P. pastoris (Yeast)

RNF13 Protein, Human, Recombinant (His)

Cat.No: TMPH-01266

Species: Human

Expression System: E. coli

TRIP12 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01273

Species: Human

Expression System: E. coli

UBE2G2 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01035

Species: Human

Expression System: E. coli

SMURF2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01269

Species: Human

Expression System: E. coli

IpaH9.8 Protein, Shigella flexneri, Recombinant (His)

Cat.No: TMPH-03508

Species: Shigella flexneri

Expression System: P. pastoris (Yeast)

ACSS2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02488

Species: Mouse

Expression System: E. coli

UBE2I Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01053

Species: Human

Expression System: E. coli

SIZ1 Protein, Arabidopsis thaliana, Recombinant (His)

Cat.No: TMPH-00085

Species: Arabidopsis thaliana

Expression System: E. coli

RNF43 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01001

Species: Mouse

Expression System: HEK293 Cells

WWP2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02950

Species: Human

Expression System: Baculovirus Insect Cells

Cbl-c Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03510

Species: Human

Expression System: Baculovirus Insect Cells

MTHFS Protein, Human, Recombinant (His)

Cat.No: TMPJ-00989

Species: Human

Expression System: E. coli

TRAIP Protein, Human, Recombinant (His)

Cat.No: TMPH-01270

Species: Human

Expression System: E. coli

UBE2D4 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01403

Species: Human

Expression System: E. coli

VHL Protein, Human, Recombinant (His & Avi)

Cat.No: TMPY-06026

Species: Human

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01267

Species: Human

Expression System: E. coli

TRIM2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03391

Species: Rat

Expression System: E. coli

NEDD4L Protein, Human, Recombinant (GST)

Cat.No: TMPH-01261

Species: Human

Expression System: E. coli

AMFR Protein, Human, Recombinant (His)

Cat.No: TMPH-01259

Species: Human

Expression System: E. coli

UBE2A Protein, Human, Recombinant (GST, His)

Cat.No: TMPJ-00985

Species: Human

Expression System: E. coli

AMFR Protein, Human, Recombinant (hFc)

Cat.No: TMPH-01260

Species: Human

Expression System: HEK293 Cells

UBE2H Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01047

Species: Human

Expression System: E. coli

UBE2R2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01198

Species: Human

Expression System: E. coli

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