PROTAC Mcl1 degrader-1

Name: PROTAC Mcl1 degrader-1
Brand: TargetMol
SKU: T11975
Price: 359 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T11975Cas号 2163793-38-0

PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.

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PROTAC Mcl1 degrader-1

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产品编号 T11975Cas号 2163793-38-0

规格	价格	库存
1 mg	¥ 4,570	期货
5 mg	¥ 8,150	期货
10 mg	¥ 12,400	期货
50 mg	询价	期货
100 mg	询价	期货

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产品介绍

生物活性

产品描述	PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.
靶点活性	MCL1:0.78 μM

化学信息

分子量	909.84
分子式	C₄₅H₄₅BrN₆O₈S
CAS No.	2163793-38-0

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 50 mg/mL (54.95 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0991 mL	5.4955 mL	10.9909 mL	54.9547 mL
5 mM	0.2198 mL	1.0991 mL	2.1982 mL	10.9909 mL
10 mM	0.1099 mL	0.5495 mL	1.0991 mL	5.4955 mL
20 mM	0.0550 mL	0.2748 mL	0.5495 mL	2.7477 mL
50 mM	0.0220 mL	0.1099 mL	0.2198 mL	1.0991 mL