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Azido-PEG3-chloroacetamide is a polyethylene glycol (PEG)-based linker. It serves as a crucial component in the synthesis of proteolysis-targeting chimeras (PROTACs), facilitating efficient conjugation between target protein-recruiting ligands and E3 ubiquitin ligase binders.
Azido-PEG3-chloroacetamide is a polyethylene glycol (PEG)-based linker. It serves as a crucial component in the synthesis of proteolysis-targeting chimeras (PROTACs), facilitating efficient conjugation between target protein-recruiting ligands and E3 ubiquitin ligase binders.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100 mg | 询价 | 期货 | |
500 mg | 询价 | 期货 |
产品描述 | Azido-PEG3-chloroacetamide is a polyethylene glycol (PEG)-based linker. It serves as a crucial component in the synthesis of proteolysis-targeting chimeras (PROTACs), facilitating efficient conjugation between target protein-recruiting ligands and E3 ubiquitin ligase binders. |
体外活性 | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
别名 | Azido-PEG3-chloroacetamide |
分子量 | 294.74 |
分子式 | C10H19ClN4O4 |
CAS No. | 604766-23-6 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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