Powder: -20°C for 3 years | In solvent: -80°C for 1 year
11-Azidoundecanoic acid,含有叠氮基团的化合物,兼具疏水性,作为生物偶联剂广泛应用。其叠氮基团可通过Staudinger结扎法或Click-chemistry方法进行修饰,为硫辛酸连接酶(LpIA)的特异性标记底物。此外,11-Azidoundecanoic acid作为点击化学试剂,能与含Alkyne基团的分子发生CuAAc反应,或与DBCO、BCN基团的分子进行SPAAC反应。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | 待询 | 待询 | ||
50 mg | 待询 | 待询 |
产品描述 | 11-Azidoundecanoic acid, a click chemistry reagent with an azide group, serves as a hydrophobic bioconjugation linker amenable to further modification via Staudinger ligation or Click chemistry. This compound is recognized as a substrate by lipoic acid ligase (LpIA) for labeling purposes [1] [2]. Additionally, 11-Azidoundecanoic acid can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules and engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules featuring DBCO or BCN groups. |
体外活性 | The microbial lipoic acid ligase (LplA) specifically attaches an alkyl azide to an engineered LplA acceptor peptide (LAP), which then selectively reacts with cyclooctyne conjugates, linking various probes. This method facilitates broad application in biochemical and imaging analyses of cell surface proteins, employing small fluorophores coupled through a concise peptide tag. |
分子量 | 227.308 |
分子式 | C11H21N3O2 |
CAS No. | 118162-45-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
11-Azidoundecanoic acid 118162-45-1 Antibody-drug Conjugate/ADC Related Others ADC Linker Inhibitor inhibitor inhibit