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Cat. No. | Product Name | ||
---|---|---|---|
L9420 | 外泌体相关化合物库 | 76 compounds | |
76 种外泌体相关的化合物,可以用于高通量和高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0104B |
Protein A/G Immunomagnetic Beads
Protein A/G 免疫沉淀磁珠 |
Suspension in bottle | IP, Co-IP, ChIP |
C0105 |
Protein A Immunoprecipitation Kit
Protein A 免疫沉淀试剂盒 |
Suspension in bottle | IP, Co-IP, ChIP |
C0104 |
Protein A/G Immunoprecipitation Kit
Protein A/G 免疫沉淀试剂盒 |
Suspension in bottle | IP, Co-IP, ChIP |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1286 |
Carcinoembryonic Antigen CEA
癌胚抗原 |
Others | Others |
Carcinoembryonic Antigen CEA 是一种广谱性肿瘤标志物,是大肠癌组织产生的一种糖蛋白,作为抗原可引起患者的免疫反应。 | |||
TP1830L |
SV40 large T antigen NLS acetate
|
Others | Others |
SV40 large T antigen NLS acetate 是从大 T 抗原残基 47 到 55,使蛋白质进入细胞核。 | |||
TP1830 |
SV40 large T antigen NLS
|
||
SV40 large T antigen NLS is from Large T antigen residue 47 to 55, enables protein import into cell nucleus. This peptide is generated from Large T antigen residue 47 to 55. | |||
TP2183 |
Large T antigen - rhesus polyomavirus 560-568
|
Others | Others |
Large T antigen - rhesus polyomavirus 560-568 has a peptide sequence of Ser-Glu-Phe-Leu-Leu-Glu-Lys-Arg-Ile. T antigen is required for viral DNA replication, transcription, and virion assembly. | |||
T23407 |
surface antigen (208-215) [Hepatitis B Virus]
|
Others | Others |
The nucleocapsid of the hepatitis B virus is covered by an envelope of HBV surface antigen (HBsAg), which has the common, group-specific determinant a. The four major subtypes of HBsAg, adw, adr, ayw and ayr, are generated, and they have been proposed to | |||
TP2270 |
MHC class II antigen (45-57) [Homo sapiens]
|
Others | Others |
MHC class II antigen (45-57) [Homo sapiens] is a peptide with the sequence H2N-Asp-Leu-Asp-Lys-Lys-Glu-Thr-Val-Trp-His-Leu-Glu- Glu-OH, MW= 1868.07. MHC (major histocompatibility complex) class II molecules are found only on antigen-presenting cells and l | |||
T80552 |
Prostate Specific Antigen Substrate
|
||
Prostate Specific Antigen Substrate为前列腺特异性抗原(PSA)的荧光底物,专用于检测PSA的酶活性。 | |||
T81883 |
MAGE-3 Antigen (167-176) (human)
|
||
MAGE-3 Antigen (167-176) (human) 是一个由 MAGE-A3 编码并与 HLA-B44 抗原结合的人类抗原决定簇,包含8个氨基酸的多肽序列。 | |||
T8697 |
ZAP-180013
|
Tyrosine Kinases; Tyrosinase | Proteases/Proteasome; Tyrosine Kinase/Adaptors |
ZAP-180013 是ZAP-70抑制剂,IC50=1.8 μM。它能够抑制 ZAP-70SH2 结构域与基于免疫受体酪氨酸的激活基序的相互作用。 | |||
T3160 |
HUHS015
|
Others | Others |
HUHS015 是高效的PCA-1/ALKBH3抑制剂。它对 PCA-1 作用的IC50值为 0.67 μM。 | |||
T2340 |
AC1NS4RE
|
Tyrosinase | Proteases/Proteasome |
是一种化学合成中的砌块 | |||
T8995 |
NCGC00262650
|
Others; Src | Angiogenesis; Others; Tyrosine Kinase/Adaptors |
NCGC00262650 是 AMA1-RON2 相互作用和 c-Src 酪氨酸激酶活性的抑制剂。 | |||
T27527 |
HBF-0259
HBF 0259 |
Antiviral | Immunology/Inflammation |
HBF-0259 是有效的乙型肝炎病毒 表面抗原分泌选择性抑制剂,在 HepG2.2.15 细胞中的 EC50为 1.5 μM。 | |||
T1938 |
FLT3-IN-2
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
FLT3-IN-2 是 FLT3 抑制剂(IC50<1 μM)。 | |||
T11298 |
FLT3-IN-3
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
FLT3-IN-3 是 FLT3抑制剂,能够抑制 FLT3 WT (IC50:13 nM) 和 FLT3 D835Y (IC50:8 nM) 。 | |||
TP2412 |
Tanurmotide
Human lymphocyte antigen 6k-(101-111)-peptide.,Arg-tyr-cys-asn-leu-glu-gly-pro-pro-ile |
||
Tanurmotide is a bioactive chemical. | |||
T7954 |
YM976
|
PDE | Metabolism |
YM976 是磷酸二酯酶 4 抑制剂(IC50:2.2 nM)。它能够抑制抗原诱导的气道反应,并有抗炎的作用。 | |||
T4428 |
CCT241736
|
FLT; Aurora Kinase | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
CCT241736 是一种口服生物可利用的双重 FLT3/Aurora 激酶抑制剂,还抑制临床相关的 FLT3 耐药突变体,包括 FLT3-ITD 和 FLT3。它是 CCT137690 的高级类似物,是治疗人类恶性肿瘤的临床前开发候选物。 | |||
T4348 |
Syk Inhibitor II
|
5-HT Receptor; Syk | Angiogenesis; GPCR/G Protein; Neuroscience; Tyrosine Kinase/Adaptors |
Syk Inhibitor II 是一种可渗透细胞、具有 ATP 竞争性的嘧啶-甲酰胺化合物,可选择性且可逆地抑制 Syk,IC50为 41 nM。 | |||
T15335 |
FN-1501
|
FLT; CDK | Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
FN-1501 是一种有效的 FLT3 和 CDK 抑制剂,具有抗肿瘤的活性,对 CDK2/cyclin A、CDK4/cyclin D1、CDK6/cyclin D1 和 FLT3 的 IC50值分别为 2.47、0.85、1.96 和 0.28 nM。 | |||
T2272 |
BPR1J-097
BPR1J097 |
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
BPR1-J097 是新型的、强效的FLT3抑制剂 (IC50:11 nM)。 | |||
T6756 |
AMG 925
|
FLT; CDK | Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
AMG 925 是一种选择性FLT3/CDK4双重抑制剂,IC50分别为 1 nM 和 3 nM。 | |||
T4507 |
Chlorphenesin
Adermykon,Chlorophenesin,Gecophen,氯苯甘醚 |
Antibacterial; Antifungal; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Chlorphenesin (Chlorophenesin) 是一种抗原相关免疫抑制剂,可抑制 IgE 介导的组胺释放。 它也用作抗真菌剂,用于许多眼保健化妆品中。 | |||
T6138 |
TCS 359
FLT3 Inhibitor |
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
TCS 359 (FLT3 Inhibitor) 是 2-酰基氨基噻吩-3-甲酰胺,是选择性FLT3抑制剂(IC50:42 nM),能够抑制 MV4-11 细胞增殖(IC50:340 nM)。 | |||
T6020 |
Pacritinib
SB1518 |
FLT; Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Pacritinib (SB1518) 是一种野生型 JAK2和 JAK2V617F 突变型抑制剂,IC50分别为 23 和 19 nM。它也抑制 FLT3及其突变型 FLT3D835Y,IC50分别为 22 和 6 nM。 | |||
T3065 |
TG101209
|
Apoptosis; FLT; c-RET; JAK; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
TG101209 是一种选择性有效的 JAK2抑制剂,IC50值为 6 nM。它能抑制 Flt3和RET 的活性,IC50值分别为 25 nM 和 17 nM。 | |||
T9473 |
4SC-203
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
4SC-203 是一种具有潜在的抗肿瘤活性的多激酶抑制剂。它对 FLT3/STK1、 FLT3 的突变形式以及 VEGFRs 具有选择性抑制作用。 | |||
T7673 |
ATH686
ATH 686 |
Apoptosis; FLT | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
ATH686 是一种选择性的,ATP 竞争性的FLT3抑制剂,具有抗白血病作用。它靶向突变 FLT3 蛋白激酶活性,并通过诱导凋亡和抑制细胞周期来抑制具有 FLT3 突变的细胞的增殖。 | |||
T8317 |
5'-Fluoroindirubinoxime
5'-FIO |
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
5'-Fluoroindirubinoxime (5'-FIO) 是一种 Indirubin 的衍生物,是一种 FLT3 的抑制剂(IC50:15 nM)。 | |||
T2640 |
Rebastinib
DCC2036,DCC 2036,DCC-2036 |
Apoptosis; FLT; Bcr-Abl; Src | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Rebastinib (DCC-2036) 是一种口服有效的,非 ATP 竞争性的 Bcr-Abl 抑制剂,作用于 Abl1WT 和 Abl1T315I,IC50分别为 0.8 nM 和 4 nM,还抑制 LYN、SRC、HCK、FGR、FLT3、KDR 和 Tie-2,对 c-Kit 的活性低。Rebastinib 对 Angiopoietin2-Tie2通路具有抑制作用。 | |||
T6115 |
Fostamatinib
R788,福他替尼 |
FLT; Syk; Monoamine Transporter; Adenosine Receptor | Angiogenesis; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors |
Fostamatinib (R788) 是一种口服具有活力的 R406 前药。其中R406 是具有口服活性的,有效的,ATP 竞争性的Syk/FLT3抑制剂(Ki:30 nM,IC50:41 nM),也能够抑制 Lyn (IC50:63 nM) 和 Lck (IC50:37 nM)。 | |||
T16144 |
MRX-2843
UNC2371 |
Others; FLT | Angiogenesis; Others; Tyrosine Kinase/Adaptors |
MRX-2843 (UNC2371) 是ATP 竞争性的、具有口服活性的MERTK 和FLT3酪氨酸激酶抑制剂 (TKI),它们的IC50分别为 1.3 nM 和 0.64 nM。 | |||
T2341 |
KW-2449
KW2449 |
Apoptosis; FGFR; FLT; JAK; Bcr-Abl; Src; c-Kit; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
KW-2449是一种多靶点激酶抑制剂,对FLT3,ABL,ABLT315I 和极光激酶的IC50值分别为6.6,14,4 和 48 nM。 | |||
T3455 |
Merestinib
LY2801653 |
Discoidin Domain Receptor (DDR); FLT; c-Met/HGFR; ROS; ROS Kinase | Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors |
Merestinib (LY2801653) 是一种有效的口服生物可利用的具有抗肿瘤活性的c-Met 抑制剂。 | |||
TQ0235 |
AC710
|
FLT; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
AC710是一种 PDGFR 抑制剂,能够作用于 FLT3 (Kd:0.6),CSF1R (Kd:1.57),KIT (Kd:1),PDGFRα (Kd:1.3) 和 PDGFRβ (Kd:1.0)。 | |||
T4409 |
Gilteritinib
吉列替尼,ASP2215 |
FLT; TAM Receptor; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Gilteritinib (ASP2215) 是一种 FLT3 抑制剂 (IC50=0.29 nM),也是一种 AXL 抑制剂 (IC50=0.73 nM),具有 ATP 竞争性、选择性和口服活性。Gilteritinib 具有抗肿瘤活性,可以用于治疗 FLT3 突变阳性的 AML。 | |||
T38562 |
AKN-028
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
AKN-028 是酪氨酸激酶 FLT3的抑制剂,可剂量依赖性的诱导 FLT3的自磷酸化。 | |||
T6350 |
CHIR-124
CHIR124,CHIR 124 |
Apoptosis; GSK-3; FLT; Chk; PDGFR; Src | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
CHIR-124 是一种选择性 Chk1抑制剂,IC50值为 0.3 nM,可有效抑制 PDGFR 和 FLT3,IC50值分别为 6.6 nM 和 5.8 nM。 | |||
T2620 |
G-749
G749 |
Apoptosis; FLT; c-RET; TAM Receptor; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
G-749 是一种新型 FLT3 抑制剂,对 FLT3 野生型和突变体有持续的抑制作用,IC50值分别为 0.4 nM 和 0.6 nM。它可用于急性髓系白血病的耐药研究。 | |||
T6174 |
R406
R-406 besylate |
Apoptosis; FLT; Syk | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
R406 (R-406 besylate) 是一种具有口服活性的 ATP 竞争性 Syk/FLT3抑制剂,Ki 为 30 nM。它有效抑制 Syk 激酶活性,IC50为 41 nM。它还抑制 Lyn 和 Lck,IC50值分别为 63 nM 和 37 nM。它可减轻免疫复合物介导的炎症。 | |||
T7007 |
UNC2025
mrx-6313,UNC-2025,UNC 2025 |
FLT; TAM Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
UNC2025 (mrx-6313) 是高效的、具有口服活性的、ATP 竞争性的Mer/Flt3双抑制剂,IC50值分别为 0.74 nM 和 0.8 nM。它对MERTK 的选择性比 Axl 高 45 倍(IC50:122 nM;Ki:13.3 nM)。它具有良好的 PK 特性,可用于研究急性白血病。 | |||
T1836 |
AZD2932
|
VEGFR; FLT; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
AZD2932是一种多靶点激酶抑制剂,细胞试验中能够抑制 VEGFR2 (IC50:8 nM),PDGFβ (IC50:4 nM),PDGFβ (IC50:7 nM) 和 PDGFβ (IC50:9 nM)。 | |||
T2638 |
Gandotinib
LY2784544 |
VEGFR; FGFR; FLT; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Gandotinib (LY2784544) 是一种JAK2抑制剂,IC50为 3 nM。它也抑制FLT3、FLT4、FGFR2、TYK2 和 TRKB,IC50分别为 4、25、32、44 和 95 nM。 | |||
T3068 |
AT9283
J-504568 |
Apoptosis; FLT; JAK; Bcr-Abl; Aurora Kinase; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
AT9283 (J-504568) 是一种多靶点激酶抑制剂,抑制多种实体瘤在体内外的生长和存活,有效抑制Aurora A/B,JAK2/3,Abl (T315I),和Flt3,IC50值范围为 1-30 nM。 | |||
T0093L |
Sorafenib
索拉非尼,Bay 43-9006 |
Apoptosis; Raf; VEGFR; FLT; Ferroptosis; PDGFR; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Sorafenib (Bay 43-9006) 是一种多激酶抑制剂,抑制 Raf-1、B-Raf、VEGFR2、VEGFR3、VEGFR4、PDGFRβ、FLT3、c-Kit 等 (IC50=6/22/90/15/20/20/57/58 nM),具有口服活性。Sorafenib 具有抗肿瘤活性,可以诱导细胞自噬和凋亡,也可以激动铁死亡。 | |||
T2054 |
Altiratinib
DCC-2701 |
VEGFR; Tie-2; FLT; Trk receptor; c-Met/HGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂,能够抑制 MET (IC50:2.7 nM),TIE2 (IC50:8 nM),VEGFR2 (IC50:9.2 nM),FLT3 (IC50:9.3 nM),Trk1 (IC50:0.85 nM),Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。 | |||
T9027 |
CA-4948
Emavusertib |
IRAK; FLT | Angiogenesis; Immunology/Inflammation; NF-κB; Tyrosine Kinase/Adaptors |
CA-4948 (Emavusertib) 是一种IRAK4抑制剂,也是一种FLT3抑制剂,具有抗肿瘤作用。 | |||
T2677 |
Crenolanib
ARO 002,CP-868596 |
FLT; PDGFR; Autophagy | Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors |
Crenolanib (ARO 002) 是一种口服生物可利用的 III 型酪氨酸激酶抑制剂,抑制 FLT3和 PDGFRα/β的 IC50分别为 4、11和 3.2 nM。 | |||
T2358 |
ENMD-2076
|
Apoptosis; VEGFR; FGFR; FLT; c-RET; PDGFR; Src; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
ENMD2076是一种多靶点激酶抑制剂,抑制Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1、FGFR2、Src、PDGFRα的IC50值分别为1.86、14、58.2、15.9、92.7、70.8、20.2 and 56.4 nM。 | |||
T2467 |
R406 free base
R406 (free base) |
Apoptosis; FLT; Syk | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
R406 free base (R406(free base)) 是一种具有口服活性的,ATP 竞争性的Syk/FLT3抑制剂,Ki 为 30 nM。它有效抑制 Syk 激酶活性,IC50为 41 nM,可减轻免疫复合物介导的炎症。它还抑制 Lyn 和 Lck,IC50分别为 63 nM 和 37 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T82856 |
Blood group A antigen tetraose type 5
A-Tetrasaccharide |
||
Blood group A antigen tetraose type 5 (A-Tetrasaccharide) 是特定于A型血的四糖,具有阻止抗-A抗体与A型血物质结合的能力。该化合物可通过北极熊乳样本纯化获得。 | |||
TN1025 |
3,29-O-Dibenzoyloxykarounidiol
|
Others | Others |
3,29-O-Dibenzoyloxykarounidiol 是一种苯甲酸三萜烯酯,从 Momordica grosvenori 果实中提取。它能够抑制肿瘤启动子 TPA 诱导的 EB 病毒早期抗原活化。 | |||
T6S0033 |
Crotonoside
巴豆苷;异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE |
Others; FLT; HDAC | Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors |
Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。 它抑制 FLT3 和 HDAC3/6,有治疗急性髓性白血病 (AML)的研究潜力。 | |||
T9371 |
DL-Pyroglutamic acid
|
Others | Others |
DL-Pyroglutamic acid 对乙型肝炎表面抗原表现出强烈的灭活作用。 | |||
T11855 |
Lipopolysaccharides
脂多糖,LPS |
Others | Others |
Lipopolysaccharides (LPS) 是革兰氏阴性细菌细胞壁的一种特有成分,由脂质A、寡糖核心和 O -特异性多糖 (O-antigen) 3个区域组成。Lipopolysaccharides 有利于维持细胞外膜的完整性,保护细菌免受胆汁盐和脂类抗生素的破坏。Lipopolysaccharides 是一种高免疫原性抗原,可以增强免疫反应,可以用于炎症模型构建。 | |||
T41078 |
Lipopolysaccharides, Escherichiacoli
Lipopolysaccharide, E. coli O111:B4 |
Others | Others |
Lipopolysaccharides, Escherichiacoli (E. coli O111:B4) 是革兰氏阴性细菌细胞壁的一种特有成分,由脂质A、寡糖核心和 O -特异性多糖 (O-antigen) 3个区域组成。Lipopolysaccharides, Escherichiacoli 有利于维持细胞外膜的完整性,保护细菌免受胆汁盐和脂类抗生素的破坏。Lipopolysaccharides, Escherichiacoli 是一种高免疫原性抗原,可以增强免疫反应,可以用于炎症模型构建。 | |||
T5771 |
Hypocrellin A
|
Antibacterial; PKC; Parasite | Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology |
Hypocrellin A 是一种天然的PKC 抑制剂,具有光诱导的抗肿瘤、抗真菌和抗病毒活性,还对 MHC 限制性抗原呈递发挥免疫调节作用。 | |||
TN2088 |
Platycodin D2
桔梗皂苷D2 |
IL Receptor; HBV | Immunology/Inflammation; Microbiology/Virology |
Platycodin D2 是分离自桔梗的皂苷类物质,显示除抗癌活性。 | |||
TN1031 |
Poricoic acid B
茯苓酸B,茯苓新酸 B |
Others | Others |
Poricoic acid B 是提取自 Poria cocos 中,拥有抗肿瘤作用。 | |||
T14193 |
α-Galactosylceramide
KRN7000,α-GalCer |
Others | Others |
α-Galactosylceramide (KRN7000) 是一种具有抗肿瘤和免疫刺激作用的合成糖脂。它是一种高效的 NKT 细胞激动剂,可与 CD1d 有效结合。它与 CD1d 的复合物可与 NKT 细胞的 T 细胞抗原受体结合。 | |||
TN7075 |
Linocinnamarin
3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester |
Phospholipase; Syk | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
Linocinnamarin (3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester) 是从 Fragaria ananassa Duch 中分离出来的。 它对抗原刺激脱粒的抑制主要是由于 Syk/磷脂酶 Cgamma (PLCgamma) 途径的失活。 | |||
TN1661 |
Ganoderic acid C2
灵芝酸 C2 |
Reductase; Histamine Receptor; Immunology/Inflammation related | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Ganoderic acid C2 是分离自灵芝的一种三萜化合物, 具有潜在的抗肿瘤生物活性,以及抗组胺、抗衰老和细胞毒性作用。它对rat lens aldose reductase 具有很高的抑制活性,IC50为 3.8 µM。 | |||
TN7432 |
Methyl ganoderate F
|
Others | Others |
Methyl ganoderate F significantly inhibited the induction of Epstein-Barr virus early antigen (EBV-EA). | |||
TN3416 |
Angelol M
|
Others | Others |
Angelol M shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells. | |||
TN2417 |
Furomollugin
5-羟基萘并[1,2-B]呋喃-4-甲酸甲酯,呋喃大叶茜草素 |
Antifection | Microbiology/Virology |
Furomollugin has antiviral activity, it can strongly suppress the secretion of hepatitis B surface antigen (HBsAg), with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells. | |||
TN4750 |
Periglaucine A
|
HBV | Microbiology/Virology |
Periglaucine A inhibits hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells. | |||
TN4751 |
Periglaucine B
|
HBV | Microbiology/Virology |
Periglaucine B can inhibit hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells. | |||
TN5878 |
7,2',4'-Trihydroxy-5-methoxy-3-phenylcoumarin
|
||
7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells. | |||
TN2500 |
1,5,15-Tri-O-methylmorindol
|
Others | Others |
1,5,15-Tri-O-methylmorindol has effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA. | |||
TN3309 |
9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid
|
Others | Others |
9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. | |||
TN3699 |
Corchoionoside C
|
Antifection; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Corchoionoside C has antioxidant activity, shows strong scavenging activities on DPPH radical, it also shows weak antifungal activity. Corchoionosides A, B, and C inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction. | |||
T81813 |
Methyl lucidenate Q
|
||
Methyl lucidenate Q,一种灵芝甲酯,展现了显著的抑制作用于EBV-EA诱导活性。 | |||
T79976 |
Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside
|
HBV | Microbiology/Virology |
Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside 作为一种抗HBV剂,在Hep G2.2.15细胞系上能够抑制HBsAg和HBeAg的分泌,其IC50值分别约为1.67 mM和>2.15 mM。 | |||
T79975 |
Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside
|
HBV | Microbiology/Virology |
Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside(化合物1)是一种具有抗HBV活性的木脂素类化合物。该化合物对HBV表面抗原(HBsAg)的IC50为0.58 mM,而对HBV e抗原(HBeAg)的IC50 > 2.4 mM。其可从八角茴香中提取分离。 | |||
TN2926 |
3-Epicabraleahydroxylactone
|
Others | Others |
3-Epicabraleahydroxylactone has anti-tumor promoting effect, it has anti-carcinogenic activity by the inhibitory effect on the induction of Epstein-Barr virus early antigen(EBV-EA) by the tumor promoter. | |||
TN4421 |
Latisxanthone C
|
Others | Others |
Latisxanthone C shows inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, it may be a valuable antitumor promoter. | |||
TN3321 |
9-Methoxy-alpha-lapachone
|
Others | Others |
9-Methoxy-alpha-lapachone has antitumor-promoting effect, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein- Barr virus early antigen (EBV-EA) activation in Raji cells. | |||
T14368 |
Azadirachtin B
|
Others | Others |
Azadirachtin B, a limonoid derived from the seed kernels of Azadirachta indica, exhibits a broad spectrum of biochemical activities, including insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral, and osteogenic effects. It is effective against the Epstein-Barr virus early antigen (EBV-EA), enhances alkaline phosphatase (ALP) activity, and promotes osteoblast differentiation[1][2][3]. | |||
TN5578 |
Abieta-8,11,13-triene-7,15,18-triol
|
||
Abieta-8,11,13-triene-7alpha,15,18-triol,7alpha,8alpha,13beta,14beta-diepoxyabietan-18-oic acid, and 18-nor-abieta-8,11,13-triene-4alpha,7alpha,15-triol may have inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tum | |||
T38838 |
QS-21
Stimulon,QS-21 |
Others | Others |
QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1. | |||
T82855 |
Blood group A pentasaccharide
A-Pentasaccharide |
||
A-Pentasaccharide 是一种尿液中的寡糖,具有抑制抗 A 抗体与 A 型血物质结合的功能。 | |||
TN3736 | Cycloart-25-ene-3,24-diol | Others | Others |
(24R)-Cycloart-25-ene-3beta,24-diol may be an anti-tumor promoter, it exhibits inhibitory effects on both Epstein-Barr virus early antigen (EBV-EA) and (+/-)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3- hexemide (NOR 1) activation. | |||
TN2928 |
Pygenic acid A
3-Epicorosolic acid,脓毒酸A |
||
3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid shows both potent α-glucosidase and pro | |||
TN2839 |
2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay o | |||
TN3019 |
4,9-Dihydroxy-alpha-lapachone
|
Others | Others |
4,9-Dihydroxy-alpha-lapachone has antitumor-promoting effects, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells. 4,9-Dihydroxy-alpha-l | |||
TN4999 |
Serratenediol
|
BCL; PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanolic acid. Serratenediol can promote | |||
T38394 |
PSMα3
|
Others | Others |
PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation process induced by TLR2 or TLR4. Additionally, PSMα3 inhibits the production of both pro- and anti-inflammatory cytokines and decreases antigen uptake. Notably, PSMα3 is a significant virulence factor released by the most pathogenic strains of methicillin-resistant Staphylococcus... | |||
T75567 |
Cabenoside D
|
Others | Others |
Cabenoside D(化合物 8)是从苔藓根的甲醇提取物中分离的一种三萜苷,显示出对12-O-十四烷酰基激素-13-乙酸酯(TPA)诱导的小鼠炎症的抗炎活性,并能抑制TPA促使的Epstein-Barr病毒(EBV)早期抗原(EBV-EA)激活。 | |||
T35434 |
β-Cembrenediol
|
Others | Others |
β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate. β-CBT inhibits induction of the early antigen of Epstein-Barr virus (EA-EBV) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro (IC50 = 21.9 μM). It inhibits tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation in vivo. β-CBT is also released into soil by flue-cured tobacco plants and exerts autotoxicity as well as phytotoxic activity against L.... | |||
T79977 |
Maceneolignan A
|
Others | Others |
Maceneolignan A,一种可从肉豆蔻(肉豆蔻科)假种皮分离的天然产品,有能力抑制RBL-2H3细胞内β-己糖胺酶释放,其IC50值为48.4 μM。同样,Maceneolignan A对抗原激活的RBL-2H3细胞中TNF-α释放的抑制作用,其IC50为63.7 μM。 | |||
T5157 |
9,13-Epidioxy-8(14)-abieten-18-oic acid
|
Others | Others |
9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory... | |||
TN4592 |
Murrangatin
|
IL Receptor; TNF; COX; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, | |||
T37272 |
9(S),12(S),13(S)-TriHOME
|
Others | Others |
9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME... | |||
TN2511 |
Britannilactone diacetate
1,6-O,O-Diacetylbritannilactone |
IL Receptor; PARP; ROS; MAPK; Caspase; JAK; JNK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; JAK/STAT signaling; MAPK; Proteases/Proteasome; Stem Cells |
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro | |||
TN4277 |
Isocupressic acid
|
cAMP; P450; PKA | GPCR/G Protein; Metabolism; Tyrosine Kinase/Adaptors |
Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial ce | |||
TN3607 |
Catalpalactone
|
cAMP | GPCR/G Protein |
Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by | |||
TN4140 |
Glochidiol
|
Others | Others |
Glochidiol exhibits strong inhibitory effects against all three human tumor cell lines (MCF-7, NCI-H-460 and SF-268), it exerts its antiproliferative activity through the involvement of apoptosis. It exhibits a strong inhibitory effect on mouse skin tumor | |||
TN7505 |
Thujopsene
NSC 44707 |
Others | Others |
Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 µg/ml and Ki of 0.8 µM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 µg/ml. It also suppresses antigen-induced β-hexosaminidase release in IgE-se... | |||
T75566 |
11-Oxomogroside II A1
|
Others | Others |
11-Oxomogroside II A1(化合物 7)是一种从罗汉果乙醇提取物中分离的氧化葫芦苷,对12-O-十四烷酰基激素-13-乙酸酯(TPA)诱导的Epstein-Barr病毒(EBV)早期抗原(EBV-EA)活化具有抑制效果,并对一氧化氮(NO)供体(+/-)-(E)-甲基-2-[(E)羟基亚氨基]-5-硝基-6-甲氧基-3-己酰胺(NOR 1)的活化也展示出轻微的抑制作用。 | |||
TN2977 |
3-O-trans-p-Coumaroyltormentic acid
|
Caspase; Antifection | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, an... | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02698 |
CD14 Protein, Human, Recombinant (His)
CD14 antigen,monocyte differentiation antigen |
Human | HEK293 Cells |
CD14 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P08571. | |||
TMPH-03640 |
34 kDa membrane antigen Protein, Treponema pallidum, Recombinant (His & Myc)
34 kDa membrane antigen,Pathogen-specific membrane ... |
Treponema pallidum | E. coli |
This antigen is a pathogen-specific membrane immunogen. 34 kDa membrane antigen Protein, Treponema pallidum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.1 kDa and the accession number is P19478. | |||
TMPH-03724 |
F1 capsule antigen Protein, Yersinia pestis, Recombinant (His)
F1 capsule antigen,caf1 |
Yersinia pestis | P. pastoris (Yeast) |
F1 capsule antigen Protein, Yersinia pestis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 17.6 kDa and the accession number is P26948. | |||
TMPH-03763 |
Major egg antigen Protein, Schistosoma mansoni, Recombinant (His)
p40,Major egg antigen |
Schistosoma mansoni | E. coli |
Major egg antigen Protein, Schistosoma mansoni, Recombinant (His) is expressed in E. coli with N-terminal 6xHis tag. The predicted molecular weight is 43.4 kDa. Accession number: P12812 | |||
TMPY-05850 |
CEACAM6 Protein, Cynomolgus, Recombinant (His)
carcinoembryonic antigen-related cell adhesion mole... |
Cynomolgus | HEK293 Cells |
CEACAM6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.3 kDa and the accession number is XP_005589488.1. | |||
TMPY-02543 |
PCNA Protein, Human, Recombinant (His)
ATLD2,proliferating cell nuclear antigen |
Human | Baculovirus Insect Cells |
Proliferating Cell Nuclear Antigen (PCNA) is a protein only expressed in normal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established functions for PCNA is its role as the processivity factor for DNA polymerase delta and epsilon. PCNA tethers the polymerase catalytic unit to the DNA template for rapid and processive DNA synthesis. Two forms of PCNA exist in cells: (i) a detergent-insoluble trimeric form stably associated with the replic... | |||
TMPH-00810 |
Hepatitis delta virus genotype I (HDV) Large delta antigen Protein (His & Myc)
p27,Large delta antigen |
HDV | P. pastoris (Yeast) |
Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication. Hepatitis delta virus genotype I (HDV) Large delta antigen Protein (His & Myc) is expressed i... | |||
TMPH-03723 |
F1 capsule antigen Protein, Yersinia pestis, Recombinant (E. coli, His)
caf1,F1 capsule antigen |
Yersinia pestis | E. coli |
F1 capsule antigen Protein, Yersinia pestis, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.6 kDa and the accession number is P26948. | |||
TMPH-00811 |
Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc)
Small delta antigen,p24 |
HDV | P. pastoris (Yeast) |
Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome. Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc) is expressed in yeast with N-6xHi... | |||
TMPY-05050 |
CEACAM5 Protein, Cynomolgus, Recombinant (His)
carcinoembryonic antigen-related cell adhesion mole... |
Cynomolgus | HEK293 Cells |
CEACAM5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.5 kDa and the accession number is XP_005589491.1. | |||
TMPY-00971 |
CEACAM6 Protein, Human, Recombinant (His)
NCA,CD66c,CEA,CEAL,carcinoembryonic antigen-related... |
Human | HEK293 Cells |
CEACAM6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199. | |||
TMPY-01180 |
CD86 Protein, Human, Recombinant (His)
CD86 antigen,B70,B7.2,B7-2,CD28LG2,LAB72 |
Human | HEK293 Cells |
CD86 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P42081-3. | |||
TMPY-03235 |
BST2 Protein, Human, Recombinant (His)
bone marrow stromal cell antigen 2,CD317,TETHERIN |
Human | HEK293 Cells |
BST2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is Q10589. | |||
TMPY-00369 |
LY6D Protein, Human, Recombinant (mFc)
E48,lymphocyte antigen 6 complex, locus D,Ly-6D |
Human | HEK293 Cells |
LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. The expression of LY6D is induced in MCF10A cells by X-ray irradiation. The induction of LY6D expression is triggered through a pathway regulated by ATM, CHK2, and p53. This method is a new Ab-directed proteomic strategy for the analysis of membrane protein... | |||
TMPY-01647 |
CEACAM5 Protein, Human, Recombinant (His)
CD66e,CEA,carcinoembryonic antigen-related cell adh... |
Human | HEK293 Cells |
CEACAM5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.8 kDa and the accession number is A0A024R0K5. | |||
TMPH-03319 |
IL-17A Protein, Rat, Recombinant (His)
Cytotoxic T-lymphocyte-associated antigen 8,Interle... |
Rat | E. coli |
IL-17A Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.0 kDa and the accession number is Q61453. | |||
TMPY-00322 |
DEC-205 Protein, Human, Recombinant (His)
GP200-MR6,CD205,CLEC13B,lymphocyte antigen 75,LY-75... |
Human | HEK293 Cells |
LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways implicated in cell proliferation and metabolism, while pathways associated with cell signaling and adhesion, complement activation, and immune response were mostly suppressed. Moreover, LY75 suppression had an opposite effect on EOC cell lines with the epithelial phenotype (A2780s a... | |||
TMPJ-00103 |
CD28 Protein, Human/Cynomolgus, Recombinant (His)
CD28 antigen,CD28 molecule,T-cell-specific surface ... |
Human,Cynomolgus | HEK293 Cells |
CD28 Protein, Human/Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is P10747. | |||
TMPJ-00211 |
CD47 Protein, Human, Recombinant (His)
MER6,Integrin-Associated Protein,Leukocyte Surface Antig... |
Human | HEK293 Cells |
CD47 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-45 KDa and the accession number is Q08722. | |||
TMPY-02709 |
P-Selectin Protein, Human, Recombinant (His)
GMP140,CD62,CD62P,LECAM3,P-Selectin,GRMP,selectin P (granule... |
Human | HEK293 Cells |
P-Selectin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.4 kDa and the accession number is AAN06828.1. | |||
TMPY-04123 |
CEACAM1 Protein, Human, Recombinant (His & hFc)
CEACAM‑1,carcinoembryonic antigen-related cell adhe... |
Human | HEK293 Cells |
CEACAM1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 71.4 kDa and the accession number is P13688-8. | |||
TMPY-01850 |
CEACAM3 Protein, Human, Recombinant (His)
W282,W264,CEA,CD66D,CGM1,MGC119875,carcinoembryonic anti... |
Human | HEK293 Cells |
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexp... | |||
TMPY-00381 |
PSMA Protein, Human, Recombinant (His)
FGCP,GCP2,PSMA,GCPII,NAALAdase,folate hydrolase (prostate-sp... |
Human | HEK293 Cells |
PSMA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.86 kDa and the accession number is Q04609-1. | |||
TMPJ-00113 |
CD79B Protein, Human, Recombinant (hFc)
Immunoglobulin-Associated B29 Protein,B-Cell-Specific Glycop... |
Human | HEK293 Cells |
CD79B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 45-65 KDa and the accession number is P40259. | |||
TMPY-00476 |
ITGB1 Protein, Human, Recombinant (His)
VLAB,integrin, beta 1 (fibronectin receptor, beta polypeptid... |
Human | HEK293 Cells |
ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. This gene encodes a beta subunit, which is a type 1 transmembrane protein of the integrin beta chain family. ITGB1 is a heterodimeric cell-surface receptor involved in cell functions such as proliferation, migration, invasion, and survival. ITGB1 has been recognized to play a major role in tumor growth, invasion, and metastasis. Using luciferase assays, the researcher identified ITGB1 as a direct target of miR-134. ITGB1 is a direct targe... | |||
TMPY-03562 |
CD86 Protein, Cynomolgus, Rhesus, Recombinant (hFc)
CD86 antigen |
Cynomolgus,Rhesus | HEK293 Cells |
CD86 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.2 kDa and the accession number is Q9BDM4. | |||
TMPY-02016 |
CD86 Protein, Rat, Recombinant (His)
CD86 antigen |
Rat | HEK293 Cells |
CD86 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is A0A9K3Y6P6. | |||
TMPH-01659 |
MAGEA4 Protein, Human, Recombinant (A173T, His & Myc)
MAGE-41 antigen,MAGE-4 antigen,Melanoma-as... |
Human | E. coli |
Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis. | |||
TMPY-03646 |
CD86 Protein, Cynomolgus, Rhesus, Recombinant (His)
CD86 antigen |
Cynomolgus,Rhesus | HEK293 Cells |
CD86 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.2 kDa and the accession number is Q9BDM4. | |||
TMPJ-01172 |
IL-17 Protein, Mouse, Recombinant (His)
CTLA8,IL-17,IL-17A,Interleukin-17A,CTLA-8,Cytotoxic T-Lympho... |
Mouse | HEK293 Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumato... | |||
TMPH-01656 |
MAGEA12 Protein, Human, Recombinant (His & Myc)
Cancer/testis antigen 1.12,MAGEA12,MAGE-12 anti... |
Human | E. coli |
Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. | |||
TMPH-01657 |
MAGEA3 Protein, Human, Recombinant (His & Myc)
Melanoma-associated antigen 3,MAGE-3 antigen |
Human | E. coli |
MAGEA3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.8 kDa and the accession number is P43357. | |||
TMPH-01658 |
MAGEA4 Protein, Human, Recombinant (His)
MAGEA4,Melanoma-associated antigen 4,MAGE-4 ant... |
Human | HEK293 Cells |
Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis. | |||
TMPH-01654 |
MAGEA1 Protein, Human, Recombinant (His)
Antigen MZ2-E,MAGE-1 antigen,Cancer/testis... |
Human | P. pastoris (Yeast) |
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. MAGEA1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 36.3 kDa and the accession number... | |||
TMPH-02766 |
LY6E Protein, Mouse, Recombinant (B2M & His)
Thymic shared antigen 1,Stem cell antigen ... |
Mouse | E. coli |
LY6E Protein, Mouse, Recombinant (B2M & His) is expressed in E. coli. | |||
TMPH-01655 |
MAGEA10 Protein, Human, Recombinant (His)
Cancer/testis antigen 1.10,MAGE-10 antigen... |
Human | E. coli |
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. MAGEA10 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 46.3 kDa and the accession number is P43363. | |||
TMPJ-01242 |
CD160 Protein, Mouse, Recombinant (His)
CD160 antigen,Cd160 |
Mouse | HEK293 Cells |
CD160 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 20-25 KDa and the accession number is Q8VC80. | |||
TMPY-00697 |
CD14 Protein, Human, Recombinant (hFc)
CD14 molecule,CD14 antigen,monocyte differentiation... |
Human | HEK293 Cells |
CD14 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.4 kDa and the accession number is P08571. | |||
TMPH-02767 |
LY6E Protein, Mouse, Recombinant (His & SUMO)
Ly6e,Lymphocyte antigen 6E,Stem cell antigen |
Mouse | P. pastoris (Yeast) |
LY6E Protein, Mouse, Recombinant (His & SUMO) is expressed in yeast with N-6xHis-SUMO tag. The predicted molecular weight is 24.8 kDa and the accession number is Q64253. | |||
TMPJ-00329 |
CD19 Protein, Rhesus macaque, Recombinant (hFc)
B-Lymphocyte Antigen CD19,CD19,Differentiation ... |
Rhesus | HEK293 Cells |
CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Sr... | |||
TMPJ-00147 |
FOLR1 Protein, Human, Recombinant (hFc)
Folate receptor 1,Folate receptor,Folate receptor alpha,FOLR... |
Human | HEK293 Cells |
FOLR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-75 kDa and the accession number is P15328. | |||
TMPJ-00626 |
CD160 Protein, Rhesus macaque, Recombinant (hFc)
CD160,CD160 antigen |
Rhesus | HEK293 Cells |
CD160 Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-65 KDa and the accession number is G7MG20. | |||
TMPH-01048 |
CEACAM5 Protein, Human, Recombinant (E398K, His)
Carcinoembryonic antigen-related cell adhesion mole... |
Human | HEK293 Cells |
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. CEACAM5... | |||
TMPJ-00627 |
CD160 Protein, Rhesus macaque, Recombinant (His)
CD160,CD160 antigen |
Rhesus | HEK293 Cells |
CD160 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 16-30 KDa and the accession number is G7MG20. | |||
TMPH-01846 |
PNMA2 Protein, Human, Recombinant (His)
Paraneoplastic antigen Ma2,Onconeuronal antigen... |
Human | E. coli |
PNMA2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.1 kDa and the accession number is Q9UL42. | |||
TMPJ-00959 |
B7-2 Protein, Rabbit, Recombinant (His)
CD86,T-lymphocyte activation antigen CD86,Activatio... |
Rabbit | HEK293 Cells |
B7-2 Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-70 KDa and the accession number is P42071. | |||
TMPH-02991 |
Alpha-crystallin Protein, Mycobacterium bovis, Recombinant (E. coli, His)
14 kDa antigen,Acr,16 kDa antigen,HSP 16.3 |
Mycobacterium bovis | E. coli |
Acts as a chaperone. Alpha-crystallin Protein, Mycobacterium bovis, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.1 kDa and the accession number is P0A5B8. | |||
TMPH-02990 |
Alpha-crystallin Protein, Mycobacterium bovis, Recombinant (His)
14 kDa antigen,Acr,16 kDa antigen,HSP 16.3 |
Mycobacterium bovis | Baculovirus Insect Cells |
Acts as a chaperone. Alpha-crystallin Protein, Mycobacterium bovis, Recombinant (His) is expressed in Baculovirus insect cells with C-9xHis tag. The predicted molecular weight is 18.1 kDa and the accession number is P0A5B8. | |||
TMPH-00535 |
Epstein-Barr virus (strain B95-8) BHRF1 Protein (His)
Nuclear antigen,Apoptosis regulator BHRF1,Early |
EBV | E. coli |
Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell. | |||
TMPK-01385 |
CRTAM Protein, Canine, Recombinant (His)
CRTAM,CD355 antigen,CD355 |
Canine | HEK293 Cells |
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Pr... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIH-0065 |
Acalabrutinib-d4
|
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Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。 | |||
TMIH-0025 |
13C-d3-AOH1996
|
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13C-d3-AOH1996 是 AOH1996 的 13C 和氘代化合物。AOH1996 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体,靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用,导致 DNA 复制应激,诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用,可抑制肿瘤细胞生长。 | |||
TMIH-0091 |
AOH-d3
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AOH-d3 是 AOH 的氘代化合物。AOH 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体,靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用,导致 DNA 复制应激,诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用,可抑制肿瘤细胞生长。 | |||
T38356 |
1,2-Dipalmitoyl-13C-sn-glycero-3-PC
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1,2-Dipalmitoyl-13C-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC by GC- or LC-MS. 1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.1,2,3,4 It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.3 Incorporation... |