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Anti-PDPN Monoclonal Antibody-AF647
产品编号 TMAZ-0063A6
别名 T1-alpha, Aggrus, PA2.26 antigen, Glycoprotein 36, Podoplanin
Anti-PDPN Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting PDPN. Anti-PDPN Monoclonal Antibody-AF647 can be used in ELISA, FACS.
Anti-PDPN Monoclonal Antibody-AF647
Anti-PDPN Monoclonal Antibody-AF647
产品编号 TMAZ-0063A6 别名 T1-alpha, Aggrus, PA2.26 antigen, Glycoprotein 36, Podoplanin
Anti-PDPN Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting PDPN. Anti-PDPN Monoclonal Antibody-AF647 can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 639.74¥ 1,103 | 7日内发货 | |
| 50 μg | ¥ 1,066.04¥ 1,838 | 7日内发货 | |
| 100 μg | ¥ 1,599.06¥ 2,757 | 7日内发货 |
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偶联与修饰
抗原信息
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| 产品描述 | Anti-PDPN Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting PDPN. Anti-PDPN Monoclonal Antibody-AF647 can be used in ELISA, FACS. |
| 别名 | T1-alpha, Aggrus, PA2.26 antigen, Glycoprotein 36, Podoplanin |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of PDPN overexpressed 470F cells with TMAZ-0063A6, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of PDPN protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation (PubMed: 14522983, PubMed: 15231832, PubMed: 17222411, PubMed: 17616532, PubMed: 18215137). Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN (PubMed: 18541721). Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness (PubMed: 17046996, PubMed: 21376833). Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (PubMed: 20962267). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix (PubMed: 19268462). In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion (PubMed: 15515019). Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (PubMed: 25486435). Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels (PubMed: 9651190). Does not have any effect on folic acid or amino acid transport (By similarity) |
| 偶联 | AF647 |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF555 |
| 可提供抗体种类 | 1 |
| 免疫原 | PDPN |
| 抗原种属 | Human |
| 基因ID | 10630 |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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