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Anti-CD46 Monoclonal Antibody
产品编号 TMAZ-0191
别名 Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein
Anti-CD46 Monoclonal Antibody is a rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody can be used in ELISA, FACS, IF.
Anti-CD46 Monoclonal Antibody
Anti-CD46 Monoclonal Antibody
产品编号 TMAZ-0191 别名 Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein
Anti-CD46 Monoclonal Antibody is a rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody can be used in ELISA, FACS, IF.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 811.42¥ 1,399 | 7日内发货 | |
| 50 μg | ¥ 973.24¥ 1,678 | 7日内发货 | |
| 100 μg | ¥ 1,362.42¥ 2,349 | 7日内发货 |
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偶联与修饰
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| 产品描述 | Anti-CD46 Monoclonal Antibody is a rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody can be used in ELISA, FACS, IF. |
| 别名 | Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of CD46 overexpressed 322F cells with TMAZ-0191, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS, IF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD46 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity|(Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells|(Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3|(Microbial infection) Acts as a receptor for cultured Measles virus|(Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6|(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed: 11260136, PubMed: 11971006, PubMed: 7708671, PubMed: 9379894) |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF555/AF647 |
| 可提供抗体种类 | 4 |
| 免疫原 | CD46 |
| 抗原种属 | Human |
| 基因ID | 4179 |
| Uniprot ID | |
| 研究领域 | Drug Target |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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