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Anti-PODXL Monoclonal Antibody

产品编号 TMAZ-0170
别名 Podocalyxin, Gp200, GCTM-2 antigen, Podocalyxin-like protein 1

Anti-PODXL Monoclonal Antibody is a rabbit antibody targeting PODXL. Anti-PODXL Monoclonal Antibody can be used in ELISA, FACS.

Anti-PODXL Monoclonal Antibody

Anti-PODXL Monoclonal Antibody

纯度: 无数据
产品编号 TMAZ-0170 别名 Podocalyxin, Gp200, GCTM-2 antigen, Podocalyxin-like protein 1

Anti-PODXL Monoclonal Antibody is a rabbit antibody targeting PODXL. Anti-PODXL Monoclonal Antibody can be used in ELISA, FACS.

规格价格库存数量
25 μg¥ 1,063.72¥ 1,8347日内发货
50 μg¥ 1,276¥ 2,2007日内发货
100 μg¥ 1,785.82¥ 3,0797日内发货
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产品介绍

生物活性
产品描述
Anti-PODXL Monoclonal Antibody is a rabbit antibody targeting PODXL. Anti-PODXL Monoclonal Antibody can be used in ELISA, FACS.
别名Podocalyxin, Gp200, GCTM-2 antigen, Podocalyxin-like protein 1
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of PODXL overexpressed 377F cells with TMAZ-0170, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
ELISA, FACS
推荐剂量
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Secreted
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of PODXL protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
纯度> 95% as determined by SDS-PAGE.
研究背景Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Biotin/APC/PE/AF488/AF555/AF647
可提供抗体种类
2
抗原信息
免疫原
PODXL
抗原种属
Human
基因ID
5420
Uniprot ID
研究领域
Drug Target
化学信息
分子量150 kDa
存储&运输
储存方式For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
运输方式For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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