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Anti-CD82 Monoclonal Antibody-AF488
产品编号 TMAZ-0048A4
别名 Tetraspanin-27, IA4, C33 antigen, CD82 antigen, Metastasis suppressor Kangai-1, Inducible membrane protein R2, Suppressor of tumorigenicity 6 protein
Anti-CD82 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD82. Anti-CD82 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
Anti-CD82 Monoclonal Antibody-AF488
Anti-CD82 Monoclonal Antibody-AF488
产品编号 TMAZ-0048A4 别名 Tetraspanin-27, IA4, C33 antigen, CD82 antigen, Metastasis suppressor Kangai-1, Inducible membrane protein R2, Suppressor of tumorigenicity 6 protein
Anti-CD82 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD82. Anti-CD82 Monoclonal Antibody-AF488 can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,238.3¥ 2,135 | 7日内发货 | |
| 50 μg | ¥ 2,063.64¥ 3,558 | 7日内发货 | |
| 100 μg | ¥ 3,095.46¥ 5,337 | 7日内发货 |
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产品介绍
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偶联与修饰
抗原信息
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| 产品描述 | Anti-CD82 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD82. Anti-CD82 Monoclonal Antibody-AF488 can be used in ELISA, FACS. |
| 别名 | Tetraspanin-27, IA4, C33 antigen, CD82 antigen, Metastasis suppressor Kangai-1, Inducible membrane protein R2, Suppressor of tumorigenicity 6 protein |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of CD82 overexpressed 293F cells with TMAZ-0048A4BI, which was counjucated with SA-PE (red). The WT 293F control is black line. |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD82 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed: 19497983). Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization (PubMed: 10985391, PubMed: 35538033). Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC (PubMed: 23897813). Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4 (PubMed: 24623721, PubMed: 8757325). Modulates adhesion and suppresses cell migration through other integrins such as the alpha6/ITGA6 and beta1/ITGB1 (PubMed: 15557282, PubMed: 17560548). Decreases cell-associated plasminogen activation by interfering with the interaction between urokinase-type plasminogen activator/PLAU and its receptor PLAUR (PubMed: 15677461). Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Plays a role in TLR9 trafficking to acidified CpG-containing compartments by controlling interaction between TLR9 and VAMP3 and subsequent myddosome assembly (By similarity). Inhibits LPS-induced inflammatory response by preventing binding of LPS to TLR4 on the cell surface (PubMed: 36945827). Plays a role in the activation of macrophages into anti-inflammatory phenotypes (By similarity). Independently of Toll-like receptor (TLR) signaling, is recruited to pathogen-containing phagosomes prior to fusion with lysosomes and thereby participates in antigen presentation (By similarity). Acts also to control angiogenesis and switch angiogenic milieu to quiescent state by binding and sequestering VEGFA and PDGFB to inhibit the signaling they trigger via their respective cell surface receptor (PubMed: 34530889) |
| 偶联 | AF488 |
| 其他可选修饰符 | Biotin/APC/PE/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | CD82 |
| 抗原种属 | Human |
| 基因ID | 3732 |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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