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Anti-CD46 Monoclonal Antibody-Biotin

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产品编号 TMAZ-0191B
别名 Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein

Anti-CD46 Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-Biotin can be used in ELISA, FACS, IF.

Anti-CD46 Monoclonal Antibody-Biotin

Anti-CD46 Monoclonal Antibody-Biotin

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产品编号 TMAZ-0191B 别名 Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein

Anti-CD46 Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-Biotin can be used in ELISA, FACS, IF.

规格价格库存数量
25 μg¥ 2,0397日内发货
50 μg¥ 3,3987日内发货
100 μg¥ 5,0977日内发货
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产品介绍

生物活性
产品描述
Anti-CD46 Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-Biotin can be used in ELISA, FACS, IF.
别名Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of CD46 overexpressed 322F cells with TMAZ-0191B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
ELISA, FACS, IF
推荐剂量
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD46 protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
纯度> 95% as determined by SDS-PAGE.
研究背景Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity|(Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells|(Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3|(Microbial infection) Acts as a receptor for cultured Measles virus|(Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6|(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed: 11260136, PubMed: 11971006, PubMed: 7708671, PubMed: 9379894)
偶联与修饰
偶联
Biotin
其他可选修饰符
APC/PE/AF488/AF555/AF647
可提供抗体种类
4
抗原信息
免疫原
CD46
抗原种属
Human
基因ID
4179
Uniprot ID
研究领域
Drug Target
化学信息
分子量150 kDa
存储&运输
储存方式For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
运输方式For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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