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Anti-CD84 Monoclonal Antibody-AF488
产品编号 TMAZ-0049A4
别名 Leukocyte differentiation antigen CD84, SLAM family member 5, Signaling lymphocytic activation molecule 5, Hly9-beta, Cell surface antigen MAX.3
Anti-CD84 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD84. Anti-CD84 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
Anti-CD84 Monoclonal Antibody-AF488
Anti-CD84 Monoclonal Antibody-AF488
产品编号 TMAZ-0049A4 别名 Leukocyte differentiation antigen CD84, SLAM family member 5, Signaling lymphocytic activation molecule 5, Hly9-beta, Cell surface antigen MAX.3
Anti-CD84 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD84. Anti-CD84 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,349.66¥ 2,327 | 7日内发货 | |
| 50 μg | ¥ 2,249.24¥ 3,878 | 7日内发货 | |
| 100 μg | ¥ 3,373.86¥ 5,817 | 7日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-CD84 Monoclonal Antibody-AF488 is a Biotin-conjugated rabbit antibody targeting CD84. Anti-CD84 Monoclonal Antibody-AF488 can be used in ELISA, FACS, IF. |
| 别名 | Leukocyte differentiation antigen CD84, SLAM family member 5, Signaling lymphocytic activation molecule 5, Hly9-beta, Cell surface antigen MAX.3 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of CD84 overexpressed 293F cells with TMAZ-0049A4BI, which was counjucated with SA-PE (red). The WT 293F control is black line. |
| 应用 | ELISA, FACS, IF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD84 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in PBS. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed: 11564780, PubMed: 12115647, PubMed: 12928397, PubMed: 12962726, PubMed: 16037392) Required for a prolonged T-cell: B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed: 22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed: 29434592) |
| 偶联 | AF488 |
| 其他可选修饰符 | Biotin/APC/PE/AF555/AF647 |
| 可提供抗体种类 | 2 |
| 免疫原 | CD84 |
| 抗原种属 | Human |
| 基因ID | 8832 |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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