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Anti-CD47 Monoclonal Antibody-AF647
产品编号 TMAZ-0052A6
别名 Protein MER6, Antigenic surface determinant protein OA3, Leukocyte surface antigen CD47, Integrin-associated protein
Anti-CD47 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting CD47. Anti-CD47 Monoclonal Antibody-AF647 can be used in ELISA, FACS.
Anti-CD47 Monoclonal Antibody-AF647
Anti-CD47 Monoclonal Antibody-AF647
产品编号 TMAZ-0052A6 别名 Protein MER6, Antigenic surface determinant protein OA3, Leukocyte surface antigen CD47, Integrin-associated protein
Anti-CD47 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting CD47. Anti-CD47 Monoclonal Antibody-AF647 can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,523.66¥ 2,627 | 7日内发货 | |
| 50 μg | ¥ 2,539.24¥ 4,378 | 7日内发货 | |
| 100 μg | ¥ 3,808.86¥ 6,567 | 7日内发货 |
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生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-CD47 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting CD47. Anti-CD47 Monoclonal Antibody-AF647 can be used in ELISA, FACS. |
| 别名 | Protein MER6, Antigenic surface determinant protein OA3, Leukocyte surface antigen CD47, Integrin-associated protein |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of CD47 overexpressed 293F cells with TMAZ-0052A6BI, followed by goat anti-rabbit IgG-ABflo 647 (red). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD47 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Adhesive protein that mediates cell-to-cell interactions (PubMed: 11509594, PubMed: 15383453). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed: 19004835, PubMed: 7691831, PubMed: 8550562). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed: 11509594, PubMed: 15383453, PubMed: 19004835, PubMed: 27742621, PubMed: 32679764, PubMed: 7691831, PubMed: 8550562). Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed: 27742621). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (PubMed: 11509594). Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (PubMed: 15383453). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed: 32679764). In response to THBS1, negatively modulates wound healing (By similarity). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (PubMed: 7691831). May prevent premature elimination of red blood cells (By similarity) |
| 偶联 | AF647 |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF555 |
| 可提供抗体种类 | 1 |
| 免疫原 | CD47 |
| 抗原种属 | Human |
| 基因ID | 961 |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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