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Anti-CD82 Monoclonal Antibody-PE

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产品编号 TMAZ-0048P
别名 Tetraspanin-27, Suppressor of tumorigenicity 6 protein, Metastasis suppressor Kangai-1, Inducible membrane protein R2, IA4, CD82 antigen, C33 antigen

Anti-CD82 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting CD82. Anti-CD82 Monoclonal Antibody-PE can be used in ELISA, FACS.

Anti-CD82 Monoclonal Antibody-PE

Anti-CD82 Monoclonal Antibody-PE

Rating icon 还可以
产品编号 TMAZ-0048P 别名 Tetraspanin-27, Suppressor of tumorigenicity 6 protein, Metastasis suppressor Kangai-1, Inducible membrane protein R2, IA4, CD82 antigen, C33 antigen

Anti-CD82 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting CD82. Anti-CD82 Monoclonal Antibody-PE can be used in ELISA, FACS.

规格价格库存数量
25 μg¥ 2,1357日内发货
50 μg¥ 3,5587日内发货
100 μg¥ 5,3377日内发货
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产品介绍

生物活性
产品描述
Anti-CD82 Monoclonal Antibody-PE is a Biotin-conjugated rabbit antibody targeting CD82. Anti-CD82 Monoclonal Antibody-PE can be used in ELISA, FACS.
别名Tetraspanin-27, Suppressor of tumorigenicity 6 protein, Metastasis suppressor Kangai-1, Inducible membrane protein R2, IA4, CD82 antigen, C33 antigen
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of CD82 overexpressed 293F cells with TMAZ-0048PBI, which was counjucated with SA-PE (red). The WT 293F control is black line.
应用
ELISA, FACS
推荐剂量
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Single-pass type I membrane
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD82 protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
纯度> 95% as determined by SDS-PAGE.
研究背景Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed: 19497983). Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization (PubMed: 10985391, PubMed: 35538033). Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC (PubMed: 23897813). Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4 (PubMed: 24623721, PubMed: 8757325). Modulates adhesion and suppresses cell migration through other integrins such as the alpha6/ITGA6 and beta1/ITGB1 (PubMed: 15557282, PubMed: 17560548). Decreases cell-associated plasminogen activation by interfering with the interaction between urokinase-type plasminogen activator/PLAU and its receptor PLAUR (PubMed: 15677461). Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Plays a role in TLR9 trafficking to acidified CpG-containing compartments by controlling interaction between TLR9 and VAMP3 and subsequent myddosome assembly (By similarity). Inhibits LPS-induced inflammatory response by preventing binding of LPS to TLR4 on the cell surface (PubMed: 36945827). Plays a role in the activation of macrophages into anti-inflammatory phenotypes (By similarity). Independently of Toll-like receptor (TLR) signaling, is recruited to pathogen-containing phagosomes prior to fusion with lysosomes and thereby participates in antigen presentation (By similarity). Acts also to control angiogenesis and switch angiogenic milieu to quiescent state by binding and sequestering VEGFA and PDGFB to inhibit the signaling they trigger via their respective cell surface receptor (PubMed: 34530889)
偶联与修饰
偶联
PE
其他可选修饰符
Biotin/APC/AF488/AF555/AF647
可提供抗体种类
1
抗原信息
免疫原
CD82
抗原种属
Human
基因ID
3732
Uniprot ID
研究领域
Immunology Research
化学信息
分子量150 kDa
存储&运输
储存方式For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
运输方式For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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