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P-Selectin Protein, Human, Recombinant (His)

产品编号 TMPY-02709

别名: GMP140, CD62, CD62P, LECAM3, P-Selectin, GRMP, selectin P (granule membrane protein 140kDa, antigen CD62), PSEL, PADGEM

P-Selectin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.4 kDa and the accession number is AAN06828.1.

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P-Selectin Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 2,520		现货
200 μg	￥ 4,470		5日内发货

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生物活性	Testing in progress
产品描述	P-Selectin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.4 kDa and the accession number is AAN06828.1.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	AAN06828.1
别名	GMP140, CD62, CD62P, LECAM3, P-Selectin, GRMP, selectin P (granule membrane protein 140kDa, antigen CD62), PSEL, PADGEM
蛋白构建	The Human SELP (AAN06828.1) extracellular domain (Met 1-Ala 771) was fused with a polyhistidine tag at the C-terminus.
蛋白纯度	≥ 90 % as determined by SDS-PAGE. ≥ 85 % as determined by SEC-HPLC.
分子量	81.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P selectin is a cell adhesion molecule on the surface of activated endothelial cells. Cellular adhesion molecules are a large family of proteins that attach the cytoskeleton and intracellular signaling cascades with the extracellular environment. SELP is a calcium-dependent receptor for myeloid cells that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes.

参考文献

1. Johnson-Tidey RR, et al. (1994) Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-Am J Pathol. 144(5):952-61. 2. Walcheck B, et al. (1996) Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro. J Clin Invest. 98(5):1081-7. 3. Foreman KE, et al. (1994) C5a-induced expression of P-selectin in endothelial cells. J Clin Invest. 94(3):1147-55.

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Keywords

P-Selectin Protein, Human, Recombinant (His) LECAM 3 GMP140 selectin P LECAM-3 CD62 granule membrane protein 140kDa, antigen CD62 CD62P CD-62 LECAM3 P-Selectin GMP 140 CD 62 GRMP selectin P (granule membrane protein 140kDa, antigen CD62) GMP-140 PSEL PADGEM recombinant recombinant-proteins proteins protein

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