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Anti-CD33 Monoclonal Antibody-AF647
还可以产品编号 TMAZ-0119A6
别名 Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67
Anti-CD33 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF.
Anti-CD33 Monoclonal Antibody-AF647
Anti-CD33 Monoclonal Antibody-AF647
还可以产品编号 TMAZ-0119A6 别名 Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67
Anti-CD33 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,811 | 7日内发货 | |
| 50 μg | ¥ 3,018 | 7日内发货 | |
| 100 μg | ¥ 4,527 | 7日内发货 |
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| 产品描述 | Anti-CD33 Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody-AF647 can be used in ELISA, FACS, IF. |
| 别名 | Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67 |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of CD33 overexpressed 340F cells with TMAZ-0119A6, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS, IF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD33 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed: 10611343, PubMed: 11320212, PubMed: 15597323). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed: 7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed: 10887109, PubMed: 28325905). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed: 10206955, PubMed: 10556798, PubMed: 10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed: 10206955, PubMed: 10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed: 15597323) |
| 偶联 | AF647 |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF555 |
| 可提供抗体种类 | 3 |
| 免疫原 | CD33 |
| 抗原种属 | Human |
| 基因ID | 945 |
| Uniprot ID | |
| 研究领域 | Cancer Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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