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Search Results for " epigenetic "

Targets Recommended: Epigenetic Reader Domain Others

148

抑制剂 & 化合物

10

天然产物

5

化合物库

20

重组蛋白

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Cat. No.	Product Name
L1200	表观遗传库		953 compounds
	953 种表观遗传学研究相关的生物活性小分子的特有集合，用于表观遗传学研究及其相关的检测和高通量、高内涵筛选；
L3500	组蛋白修饰化合物库		469 compounds
	469 个组蛋白修饰相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
L8200	抗衰老化合物库		3279 compounds
	3279 个抗衰老化合物的独特集合，可用于高通量筛选和高内涵筛选；
L8300	染色质修饰分子库		250 compounds
	250 种染色质化学修饰相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L2140	癌细胞分化化合物库		406 compounds
	406 个诱导肿瘤细胞分化化合物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

表观遗传库

Cat.No: L1200

Compounds: 953

组蛋白修饰化合物库

Cat.No: L3500

Compounds: 469

抗衰老化合物库

Cat.No: L8200

Compounds: 3279

染色质修饰分子库

Cat.No: L8300

Compounds: 250

癌细胞分化化合物库

Cat.No: L2140

Compounds: 406

Cat. No.	Product Name	Target	Signaling Pathways
T72013	Epigenetic Multiple Ligand	Others	Others
	Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing either apoptosis or granulocytic differentiation.
T82458	Epigenetic factor-IN-1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Epigenetic factor-IN-1（40569Z）是一种针对SIRT7显示出强效结合能力的表观遗传因子抑制剂，常用于肝癌的研究领域。
T15424	GSK1379725A	Epigenetic Reader Domain	Chromatin/Epigenetic
	GSK1379725A 是一种选择性 BPTF 配体，Kd 为 2.8 μM。
T11925	M‑89	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	M-89 可抑制 Menin-MLL 蛋白之间的相互作用，有研究混合谱系白血病的潜力。它是一种强特异性 menin 抑制剂，结合到 menin 的Kd 值为 1.4 nM。
T2072	BET bromodomain inhibitor	Epigenetic Reader Domain	Chromatin/Epigenetic
	BET bromodomain inhibitor 是 BET 的一种有效抑制剂。
T16072	MI-538	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-538是一种menin 和MLL 融合蛋白相互作用的抑制剂，IC50值为 21 nM。
T16321	NI-42	Epigenetic Reader Domain	Chromatin/Epigenetic
	NI-42 是一种用于 BRPF 的结构正交化学探针，是有偏向性的BRPFs 溴结构域 (BRD)抑制剂，BRPF1、2和3的IC50为7.9、48和260 nM; BRPF1、2和3的Kd 值为40、210和940 nM，与非分类 IV BRD 蛋白相比具有很好的选择性。
T3311	GSK6853	Epigenetic Reader Domain	Chromatin/Epigenetic
	GSK6853 是一种强选择性RPF1乙酰赖氨酸抑制剂，pKd 为9.5，其选择性是其它的乙酰赖氨酸的 1600 倍。
T5362	Y06036	Epigenetic Reader Domain	Chromatin/Epigenetic
	Y06036 是一种选择性 BET 抑制剂，具有抗肿瘤活性，可与 BRD4(1)溴结构域结合，Kd 值为 82 nM。
T13363	Y06137	Epigenetic Reader Domain; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Y06137 是一种有效的特异性 BET 抑制剂，对 BRD4(1) 溴结构域的 Kd 为 81 nM。 Y06137可用于去势抵抗性前列腺癌治疗的研究。
T3973	PF-CBP1	Epigenetic Reader Domain	Chromatin/Epigenetic
	PF-CBP1 是一种高选择性的 CREB 结合蛋白 (CREBBP) 溴结构域抑制剂。它抑制 CREBBP (IC50: 125 nM) 和 p300 溴结构域 (IC50: 363 nM)。
T5442	A1874	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	A1874 是一种基于 nutlin 的 BRD4 降解 PROTAC，可诱导细胞中的 BRD4 降解，DC50值为 32 nM。它有效抑制许多癌细胞系的增殖。
T17311	(+)-JQ1 PA	Epigenetic Reader Domain	Chromatin/Epigenetic
	(+)-JQ1 PA 是一种溴结构域和末端外 (BET) 抑制剂 JQ1 的衍生物，IC50 为 10.4 nM。
T9568	SGC-SMARCA-BRDVIII	Epigenetic Reader Domain	Chromatin/Epigenetic
	SGC-SMARCA-BRDVIII 是SMARCA2/4和PB1(5)选择性抑制剂，其Kd 值分别为 35 nM，36 nM 和 13 nM。它还抑制PB1(2)和PB1(3)，Kd 值分别为 3.7 和 2.0 μM。它可阻断 3T3-L1 鼠成纤维细胞的脂肪生成。
T4495	dBET1	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	dBET1 是一种由 BRD4 抑制剂 JQ1 与 NSC 527179 衍生物通过 linker 产生的 PROTAC，可诱导 BRD4 降解。它是由Cereblon 配体和BRD4配体相连的PROTAC，其EC50值为 430 nM。
T5440	Dbet57	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	dBET57 是基于 PROTAC 技术的 BRD4 异双功能降解剂，对 BRD4BD1 有显著降解作用，DC50/5h 为 500 nM。
T6668	SGC-CBP30	Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic
	SGC-CBP30 是高选择性CBP/p300溴结构域的有效抑制剂，对CBP 和p300的Kd 值分别为 21 和 32 nM。它强烈减少 Th17 细胞中 IL-17A 的分泌，具有抗炎作用。
T5130	dBET6	Apoptosis; Epigenetic Reader Domain; PROTACs	Apoptosis; Chromatin/Epigenetic; PROTAC
	dBET6 是一种基于 PROTAC 的选择性和细胞渗透性 BET 降解剂，IC50值为 14 nM。它具有抗肿瘤活性。
T6786	BI-9564 BI 9564,BI9564	Epigenetic Reader Domain	Chromatin/Epigenetic
	BI-9564 是一种选择性的且可透过细胞的 BRD9/BRD7溴结构域抑制剂，IC50分别为 75 和 3.4 μM，Kd 为 14 和 239 nM。它对 BET 家族的 IC50值大于 100 μM。
T17350	ACBI1	Apoptosis; Epigenetic Reader Domain; PROTACs	Apoptosis; Chromatin/Epigenetic; PROTAC
	ACBI1 是一种基于PROTAC 技术的 BAF ATPase 亚基SMARCA2和SMARCA4降解剂，也是 PBAF 成员PBRM1的降解剂。它由一个 bromodomain 配体、linker 和 E3 泛素连接酶von Hippel-Lindau 构成，能诱导抗增殖作用和凋亡。
TQ0253	PLX51107	Epigenetic Reader Domain	Chromatin/Epigenetic
	PLX51107 是一种选择性 BET 抑制剂，与 CBP 和 EP300 的结构域相互作用。它对 BRD2、BRD3、BRD4 和 BRDT 的 BD1 结构域的亲和力Kd 值分别为 1.6、2.1、1.7 和 5 nM，BD2 结构域亲和力Kd 值分别为 5.9、6.2、6.1 和 120 nM。
TQ0083	NI-57	Epigenetic Reader Domain	Chromatin/Epigenetic
	NI-57 是溴结构域和植物同源锌指结构域 (BRPF) 蛋白家族的一种抑制剂，对 BRPF1、BRPF2 (BRD1) 和 BRPF3 的 IC50值分别为 3.1、46 和 140 nM。
TQ0058	MI-463	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-463 是一种有口服活性的menin-mLL 相互作用的高效小分子抑制剂，IC50为15.3 nM。
TQ0069	MI-503	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-503 是一种高效且可口服的 menin-mLL 相互作用抑制剂。
T14685	BMS-986158	Epigenetic Reader Domain	Chromatin/Epigenetic
	BMS-986158 是一种BET 抑制剂，在 MDA-MB231 三阴性乳腺癌细胞和 NCI-H211 小细胞肺癌细胞中，对 BET 的IC50分别为 5 和 6.6 nM。
T9749	FHD-286	Epigenetic Reader Domain	Chromatin/Epigenetic
	FHD-286 是 BRM/BRG1 ATPase 的抑制剂，可用于治疗 BAF 相关疾病如急性髓性白血病的研究。
T6783	BI-7273	Epigenetic Reader Domain	Chromatin/Epigenetic
	BI7273 是一种选择性的可细胞透过BRD9抑制剂，IC50和Kd 分别为 19 和 0.75 nM。它对 BRD7 的作用较强，IC50和Kd 值分别为 117 和 0.3 nM。
T19935	XD14	Epigenetic Reader Domain	Chromatin/Epigenetic
	XD14 是BET 抑制剂，其与 BRD2、BRD3 和 BRD4 的结合常数分别为 170 nM、380 nM 和 160 nM。它具有抗肿瘤活性。
T1854	MS436	Epigenetic Reader Domain	Chromatin/Epigenetic
	MS436 是溴结构域抑制剂，作用于 BRD4 BrD1的Ki 为 30 到 50 nM 之间，比作用于 BrD2 选择性高 10 倍。
T2127	OF-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	OF-1 是溴结构域的一种抑制剂，其对TRIM24 和BRPF1B 的IC50值分别为270 mM 和1.2 μM。
T12112	MS402	Epigenetic Reader Domain	Chromatin/Epigenetic
	MS402 是一种新型 BD1 选择性 BET BrD 抑制剂，阻断 Th17 细胞分化并改善小鼠结肠炎，对BRD4(BD1)、BRD4(BD2)、BRD3(BD1)、BRD3(BD2)、BRD2(BD1)和BRD2(BD2)的Ki 分别为 77 、718、110、200、83 和 240 nM。
T4345	CeMMEC1 CeMMEC1 HCl	Epigenetic Reader Domain; Carboxypeptidase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	CeMMEC1 是一种 BRD4 抑制剂，对 TAF1 有很好的亲和力，IC50为0.9 μM。
T11136	E-7386 E7386	Epigenetic Reader Domain	Chromatin/Epigenetic
	E-7386 是是一种有口服活性的 CBP/-catenin 调节剂。
T17697	BRD7-IN-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	BRD7-IN-1 是一种修饰的 BI7273 衍生物 (BRD7/9 抑制剂)。BRD7-IN-1 通过与 VHL 配体连接形成 PROTAC VZ185。VZ185 抑制 BRD7/9 的 DC50分别是 4.5 nM 和1.8 nM。
T5417	INCB-057643	Apoptosis; Epigenetic Reader Domain	Apoptosis; Chromatin/Epigenetic
	INCB-057643 是一种有效的、选择性的和口服生物可利用的 BET 抑制剂。
T5434	ARV-825	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	ARV-825 是一种双功能 PROTAC，蛋白水解靶向嵌合体，将 BRD4 募集到 E3 泛素连接酶大脑中，导致 BRD4 在所有测试的 BL 细胞系中快速、有效和延长降解。对 BRD4 的 BD1 和 BD2 结构域具有高亲和力，Kd 值分别为 90 和 28 nM。
T5435	ARV-771	Epigenetic Reader Domain; PROTACs	Chromatin/Epigenetic; PROTAC
	ARV-771 是基于 PROTAC 技术的有效 BET 降解剂，对 BRD2(1)、BRD2(2)、BRD3(1)、BRD3(2)、BRD4 (1) 和 BRD4(2)的 Kd 分别为 34、4.7、8.3、7.6、9.6 和 7.6 nM。
T6021	GSK1324726A I-BET726	Apoptosis; Epigenetic Reader Domain	Apoptosis; Chromatin/Epigenetic
	GSK1324726A (I-BET726) 是一种选择性有效的BET 蛋白抑制剂，高亲和力结合到BRD2、BRD3和BRD4，IC50值分别为 41 nM、31 nM 和 22 nM。
T2252	UNC 669 UNC669	Epigenetic Reader Domain	Chromatin/Epigenetic
	UNC 669是一种有效且特异性的 MBT（恶性脑瘤）抑制剂，是甲基赖氨酸结合结构域的配体，是L3MBTL1和L3MBTL3的抑制剂，IC50分别为 4.2 和 3.1 uM。
T2436	GSK2801	Apoptosis; Epigenetic Reader Domain	Apoptosis; Chromatin/Epigenetic
	GSK2801 是一种有口服活性的和细胞活性的乙酰赖氨酸竞争性BAZ2A 和BAZ2B 溴结构域选择性抑制剂，Kd 值分别为 136 nM 和 257 nM。
T6939	PFI-3 PFI 3	Epigenetic Reader Domain	Chromatin/Epigenetic
	PFI-3是一种选择性，可渗透细胞的SMARCA2/4溴结构域抑制剂，Kd 值为89 nM，可延迟和预防乳腺癌。
T13974	ZL0580	Epigenetic Reader Domain; HIV Protease	Chromatin/Epigenetic; Microbiology/Virology; Proteases/Proteasome
	ZL0580 通过抑制 Tat 反式激活和转录延伸以及通过在 HIV 启动子处诱导抑制性染色质结构来诱导 HIV 抑制。
T3624	A-366 A 366,A366	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	A-366 是一种高选择性的肽竞争性组蛋白甲基转移酶 G9a 抑制剂，对 G9a 和 GLP 的 IC50分别为 3.3 和 38 nM。它比其他 21 种甲基转移酶具有 1000 倍以上的选择性。它是 Spindlin1-H3K4me3相互作用的抑制剂，IC50为182.6 nM。它对人 H3R 表现出很高的亲和力，Ki 值为 17 nM，在组胺能和多巴胺能受体家族的亚群间表现出亚型选择性。
T9703	GSK778	Epigenetic Reader Domain	Chromatin/Epigenetic
	GSK778 是BET 蛋白BD1溴结构域的选择性抑制剂，对BRD2 BD1、BRD3 BD1、BRD4 BD1、BRDT BD1的IC50分别为75 nM，41 nM，41 nM 和143 nM。
T14073	A-485	Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic
	A-485 是 p300/CBP 的一种选择性催化抑制剂，对 p300和 CBP 组蛋白乙酰转移酶的 IC50值分别为 9.8 和 2.6 nM。
T6026	CPI-203 CPI 203,CPI203	Apoptosis; Epigenetic Reader Domain	Apoptosis; Chromatin/Epigenetic
	CPI-203 是一种选择性的，细胞通透的 BET 溴结构域抑制剂，抑制 BRD4，IC50值约为 37 nM。
T5318	666-15 CREB inhibitor	Epigenetic Reader Domain	Chromatin/Epigenetic
	666-15 (CREB inhibitor) 是一种选择性CREB 抑制剂，IC50为 81 nM，可抑制乳腺癌异种移植模型中的肿瘤生长。
T60072	ZL0590	Epigenetic Reader Domain	Chromatin/Epigenetic
	ZL0590 是一种有效的特异性 BD1-BRD4 抑制剂 (IC50 = 90 nM)，具有抗炎活性。
T6828	ZL0420	Epigenetic Reader Domain	Chromatin/Epigenetic
	ZL0420 是有效且选择性的 BET 溴结构域 4 (BRD4) 抑制剂，对 BRD4 的溴结构域 (BD) 具有纳摩尔结合亲和力。ZL0420 对 BRD4 BD1和 BRD4 BD2 的IC50分别为 27 nM 和 32 nM。
T15405	GNE-781	Epigenetic Reader Domain	Chromatin/Epigenetic
	GNE-781 是一种具有口服活性的选择性 CBP 抑制剂，在 TR-FRET 实验中 IC50为 0.94 nM。它还抑制BRET 和BRD4 (1)，IC50分别为 6.2 和 5100 nM，有抗肿瘤活性。

化合物

Epigenetic Multiple Ligand

Cat.No: T72013

Target: Others

Epigenetic factor-IN-1

Cat.No: T82458

Target: Sirtuin

Cat.No: T15424

Target: Epigenetic Reader Domain

Cat.No: T11925

Target: Epigenetic Reader Domain, Histone Methyltransferase

BET bromodomain inhibitor

Cat.No: T2072

Target: Epigenetic Reader Domain

Cat.No: T16072

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T16321

Target: Epigenetic Reader Domain

Cat.No: T3311

Target: Epigenetic Reader Domain

Cat.No: T5362

Target: Epigenetic Reader Domain

Cat.No: T13363

Target: Epigenetic Reader Domain, PKC

Cat.No: T3973

Target: Epigenetic Reader Domain

Cat.No: T5442

Target: Epigenetic Reader Domain, PROTACs

Cat.No: T17311

Target: Epigenetic Reader Domain

SGC-SMARCA-BRDVIII

Cat.No: T9568

Target: Epigenetic Reader Domain

Cat.No: T4495

Target: Epigenetic Reader Domain, PROTACs

Cat.No: T5440

Target: Epigenetic Reader Domain, PROTACs

Cat.No: T6668

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Cat.No: T5130

Target: Apoptosis, Epigenetic Reader Domain, PROTACs

Cat.No: T6786

Synonym: BI 9564,BI9564

Target: Epigenetic Reader Domain

Cat.No: T17350

Target: Apoptosis, Epigenetic Reader Domain, PROTACs

Cat.No: TQ0253

Target: Epigenetic Reader Domain

Cat.No: TQ0083

Target: Epigenetic Reader Domain

Cat.No: TQ0058

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: TQ0069

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T14685

Target: Epigenetic Reader Domain

Cat.No: T9749

Target: Epigenetic Reader Domain

Cat.No: T6783

Target: Epigenetic Reader Domain

Cat.No: T19935

Target: Epigenetic Reader Domain

Cat.No: T1854

Target: Epigenetic Reader Domain

Cat.No: T2127

Target: Epigenetic Reader Domain

Cat.No: T12112

Target: Epigenetic Reader Domain

Cat.No: T4345

Synonym: CeMMEC1 HCl

Target: Epigenetic Reader Domain, Carboxypeptidase, DNA/RNA Synthesis

Cat.No: T11136

Synonym: E7386

Target: Epigenetic Reader Domain

Cat.No: T17697

Target: Epigenetic Reader Domain

Cat.No: T5417

Target: Apoptosis, Epigenetic Reader Domain

Cat.No: T5434

Target: Epigenetic Reader Domain, PROTACs

Cat.No: T5435

Target: Epigenetic Reader Domain, PROTACs

Cat.No: T6021

Synonym: I-BET726

Target: Apoptosis, Epigenetic Reader Domain

Cat.No: T2252

Synonym: UNC669

Target: Epigenetic Reader Domain

Cat.No: T2436

Target: Apoptosis, Epigenetic Reader Domain

Cat.No: T6939

Synonym: PFI 3

Target: Epigenetic Reader Domain

Cat.No: T13974

Target: Epigenetic Reader Domain, HIV Protease

Cat.No: T3624

Synonym: A 366,A366

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T9703

Target: Epigenetic Reader Domain

Cat.No: T14073

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Cat.No: T6026

Synonym: CPI 203,CPI203

Target: Apoptosis, Epigenetic Reader Domain

Cat.No: T5318

Synonym: CREB inhibitor

Target: Epigenetic Reader Domain

Cat.No: T60072

Target: Epigenetic Reader Domain

Cat.No: T6828

Target: Epigenetic Reader Domain

Cat.No: T15405

Target: Epigenetic Reader Domain

Cat. No.	Product Name	Target	Signaling Pathways
T6389	Anacardic Acid 漆树酸,6-pentadecylsalicylic Acid,Hydroginkgolic acid	Others; Epigenetic Reader Domain; Histone Acetyltransferase; Antibacterial	Chromatin/Epigenetic; Microbiology/Virology; Others
	Anacardic Acid (6-pentadecylsalicylic Acid) 是从腰果壳中提取液中分离到的酸类物质，是一种组蛋白乙酰转移酶抑制剂，对 p300 和 PCAF 的 IC50值分别为 ∼8.5 μM 和 ∼5 μM。
T1516	Curcumin Diferuloylmethane,Natural Yellow 3,姜黄素,Indian Saffron,Turmeric yellow	Mitophagy; Epigenetic Reader Domain; Ferroptosis; Influenza Virus; Nrf2; Histone Acetyltransferase; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology
	Curcumin (Natural Yellow 3) 属于酚类天然产物，是一种组蛋白乙酰化转移酶 p300/CREB 的抑制剂 (IC50=25 μM)，具有特异性。Curcumin 具有抗肿瘤、抗炎和抗氧化等多种药理活性。
T19127	3-Phosphoglyceric acid	Others	Others
	3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. It is involved in alveolar macrophage epigenetic regulation.
T5270	5-Methylcytosine	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	5-Methylcytosine 是一种存在于真核 DNA 中的甲基化核苷酸碱基。它是由 DNA 甲基转移酶作用形成的表观遗传修饰。
TN2286	Tsugaric acid A	NO Synthase	Immunology/Inflammation
	Tsugaric acid A 能够显著抑制超氧阴离子的形成，还可以保护人类角质形成细胞，使其免受紫外线 B 诱导的损害。
T5255	5-Hydroxymethyluracil 5-(Hydroxymethyl)uracil,5-羟甲基脲嘧啶,Hydroxymethyl Uracil,a-Hydroxythymine	Others; Endogenous Metabolite	Metabolism; Others
	5-(Hydroxymethyl)uracil 是一种氧化性 DNA 损伤的产物，能够增强或抑制细菌 RNA 聚合酶转录的潜在表观遗传标记。
TN1691	Glabrol 光甘草酚,光甘草醇	P450; NF-κB; NO Synthase; Acyltransferase	Immunology/Inflammation; Metabolism; NF-κB
	Glabrol 是分离自甘草根的乙醇提取物中的一种异戊二烯类黄酮，是一种有效且非竞争性的酰基辅酶 A：胆固醇酰基转移酶（ACAT）抑制剂，抑制大鼠肝脏微粒体 ACAT 的IC50为 24.6 μM。
T66903	Gallic Acid Monohydrate	Others	Others
	Gallic acid may be used as a standard in the photometric determination of total phenolics content by Folin-Ciocalteu method with potential role in epigenetic therapy of human cancers.
T13749	L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid	Others	Others
	L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Additionally, it obstructs histone demethylases, thereby encouraging histone methylation.
TN7258	3-Methylcytidine methosulfate	Others	Others
	3-Methylcytidine (methosulfate), a derivative of cytidine, serves as an internal standard for HPLC and is recognized for its epigenetic modification in tRNA, although its cellular role remains unclear. Research has explored its utility as a cancer biomarker, with findings indicating a notable increase in the urine of breast cancer patients.

天然产物

Cat.No: T6389

Synonym: 漆树酸,6-pentadecylsalicylic Acid,Hydroginkgolic acid

Target: Others, Epigenetic Reader Domain, Histone Acetyltransferase, Antibacterial

Cat.No: T1516

Synonym: Diferuloylmethane,Natural Yellow 3,姜黄素,Indian Saffron,Turmeric yellow

Target: Mitophagy, Epigenetic Reader Domain, Ferroptosis, Influenza Virus, Nrf2, Histone Acetyltransferase, HDAC, Autophagy

3-Phosphoglyceric acid

Cat.No: T19127

Target: Others

5-Methylcytosine

Cat.No: T5270

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Tsugaric acid A

Cat.No: TN2286

Target: NO Synthase

5-Hydroxymethyluracil

Cat.No: T5255

Synonym: 5-(Hydroxymethyl)uracil,5-羟甲基脲嘧啶,Hydroxymethyl Uracil,a-Hydroxythymine

Target: Others, Endogenous Metabolite

Cat.No: TN1691

Synonym: 光甘草酚,光甘草醇

Target: P450, NF-κB, NO Synthase, Acyltransferase

Gallic Acid Monohydrate

Cat.No: T66903

Target: Others

L-2-Hydroxyglutaric acid

Cat.No: T13749

Synonym: (S)-2-Hydroxyglutaric acid

Target: Others

3-Methylcytidine methosulfate

Cat.No: TN7258

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00365	GALNT7 Protein, Human, Recombinant (His) GalNAcT7,polypeptide N-acetylgalactosaminyltransferase 7,GAL...	Human	HEK293 Cells
	GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either discrete genetic perturbation or epigenetic dysregulation. GALNT7 acts as a glycosyltransferase in protein O-glycosylation, involving in the occurrence and development of CRC. GALNT7 silencing significantly attenuated the proliferation, clonogenicity and migration of LSCC cells a...
TMPY-02030	CD82 Protein, Human, Recombinant (His) CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,TSPAN27,ST6,IA4,GR1...	Human	HEK293 Cells
	CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud...
TMPY-00150	IGF2/IGF-II Protein, Human, Recombinant PP9974,胰岛素样生长因子,C11orf43,IGF-II,insulin-like growth factor 2	Human	P. pastoris (Yeast)
	Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br...
TMPY-02378	14‑3‑3 theta/YWHAQ Protein, Human, Recombinant (GST) tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activati...	Human	E. coli
	The recently identified 14-3-3 tau, whose corresponding gene name is YWHAQ, is in a hypoxia-treated human trophoblast cell line. YWHAQ may play a role in epigenetic regulation of placental genes in the onset of Preeclampsia (PE). Moreover, there was a closer relationship between blood pressure and methylation levels of the YWHAQ promoter.
TMPH-00095	HDT2 Protein, Arabidopsis thaliana, Recombinant (His) Histone deacetylase HDT2,Histone deacetylase 2b,HD-tuins pro...	Arabidopsis thaliana	P. pastoris (Yeast)
	Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDT2 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.3 kDa and the accession number is Q56WH4.
TMPH-02908	AICDA Protein, Mouse, Recombinant (His & Myc) Single-stranded DNA cytosine deaminase,Cytidine aminohydrola...	Mouse	E. coli
	Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
TMPJ-00694	BRD4 Protein, Human, Recombinant (His & Flag) MCAP,HUNK1,HUNKI,bromodomain-containing protein 4	Human	E. coli
	Bromodomain-containing protein 4 (BRD4) is a member of the BET class chromatin reader proteins that bind acetylated histones and play a key role in transcriptional regulation and transmission of epigenetic memory. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. BRD bromodomains serve as recognition motifs for ...
TMPH-01472	HDAC11 Protein, Human, Recombinant (GST) HDAC11,Histone deacetylase 11	Human	E. coli
	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC11 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 66....
TMPJ-00986	CTCF Protein, Human, Recombinant Transcriptional Repressor CTCF,CCCTC-Binding Factor,CTCFL Pa...	Human	E. coli
	Transcriptional Repressor CTCF (CTCF) belongs to the CTCF Zinc-Finger Protein family. CTCF contains twelve C2H2-type zinc fingers and interacts with CHD8. CTCF is widely expressed in many tissues, and it is absent in primary spermatocytes. CTCF is involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. CTCF plays an essential role in oocyte and preimplantation embryo development by activating or rep...
TMPK-00710	Claudin-4 Protein-VLP, Human, Recombinant Claudin4,CLDN4,Claudin-4,CPETR1,CPE-R,WBSCR8,CPE R	Human	HEK293 Cells
	Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs in...
TMPH-02175	TAF5L Protein, Human, Recombinant (GST) TAF5L,TAF5-like RNA polymerase II p300/CBP-associated factor...	Human	E. coli
	Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state.
TMPH-01088	CBX5 Protein, Human, Recombinant (His & Myc) HP1 alpha,CBX5,Heterochromatin protein 1 homolog alpha,Chrom...	Human	E. coli
	Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. CBX5 Protein...
TMPY-03332	PRTFDC1 Protein, Human, Recombinant (His) HHGP,PRTFDC1,phosphoribosyl transferase domain containing 1	Human	E. coli
	PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis. PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse and has important implications for unraveling the molecular etiology of lesch-Nyhan disease(LND). LND is a sever...
TMPH-01235	APOBEC3A Protein, Human, Recombinant (His & SUMO) A3A,APOBEC3A,DNA dC->dU-editing enzyme APOBEC-3A,Phorbolin-1	Human	E. coli
	DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a rol...
TMPJ-00790	GSN Protein, Human, Recombinant (mFc) ADF,Actin-depolymerizing factor,Brevin,Gelsolin,GSN,AGEL	Human	HEK293 Cells
	Gelsolin is a calcium-activated actin filament severing and capping protein found in many cell types and as a secreted form in the plasma of vertebrates. Gelsolin is composed of six of these domains, termed G1-6. Some reaseraches show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. The difference in the expression levels of cytoplasmic and plasma gelsolin suggests that these two different form...
TMPY-00519	Gastrokine 1 Protein, Human, Recombinant (His) UNQ489/PRO1005,CA11,foveolin,BRICD1,AMP18,gastrokine 1,FOV	Human	Baculovirus Insect Cells
	Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in gastric cancer. GKN1-mediated inhibition of APP processing might represent a new approach for the prevention and therapy of Alzheimer's disease (AD). In the presence of GKN2, GKN1 loses its ability to decrease cell proliferation, induce apoptosis, and inhibit epigenetic alterati...
TMPY-02979	HMGN3 Protein, Human, Recombinant (His) PNAS-24,TRIP7,PNAS-25,high mobility group nucleosomal bindin...	Human	E. coli
	HMGN3 belongs to the HMGN family and is expressed in the kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate, and uterus. Members of the HMGN family bind to nucleosomes without any specificity for the underlying DNA sequence. They affect the global and local structure of chromatin, as well as the levels of histone modifications, and thus play a role in epigenetic regulation of gene expression. HMGN3 regulates the expression of the glucose transporter ...
TMPY-02957	DYDC2 Protein, Human, Recombinant (GST) DPY30 domain containing 2	Human	E. coli
	DPY30 domain containing 2 belongs to the dpy-30 family. Dumpy-30 family members act as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. MTF-1 plays a key role in transition metal detoxification and homeostasis. It binds to metal response elements (MREs). Two candidate dMTF-1 interactors are related to the small regulatory protein Dumpy-30 (Dpy-30) of the worm C. elegans. Dpy-30 is the founding member of a protein family inv...
TMPY-01657	SUV420H2 Protein, Human, Recombinant (His & GST) suppressor of variegation 4-20 homolog 2 (Drosophila),KMT5C	Human	E. coli
	Histone-lysine N-methyltransferase SUV42H2, also known as Suppressor of variegation 4-2 homolog 2, Su(var)4-2 homolog 2, Lysine N-methyltransferase 5C, SUV42H2 and KMT5C, is nucleus protein that belongs to the histone-lysine methyltransferase family and Suvar4-2 subfamily. SUV42H2 is a histone methyltransferase that specifically trimethylates 'Lys-2' of histone H4. H4 'Lys-2' trimethylation represents a specific tag for epigenetic transcriptional repression. SUV42H2 mainly functions in pericentr...
TMPY-00585	Annexin A8 Protein, Human, Recombinant (His) ANX8,annexin A8	Human	E. coli
	We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA8 mRNA is expressed in low-proliferative isolated pubertal mouse mammary ductal epithelium and after enforced involution, but not in isolated highly proliferative terminal end buds (TEB) or during pregnancy. ANXA8 as a potential mediator of quiescence in the normal mouse mammary ...

重组蛋白

GALNT7 Protein, Human, Recombinant (His)

Cat.No: TMPY-00365

Species: Human

Expression System: HEK293 Cells

CD82 Protein, Human, Recombinant (His)

Cat.No: TMPY-02030

Species: Human

Expression System: HEK293 Cells

IGF2/IGF-II Protein, Human, Recombinant

Cat.No: TMPY-00150

Species: Human

Expression System: P. pastoris (Yeast)

14‑3‑3 theta/YWHAQ Protein, Human, Recombinant (GST)

Cat.No: TMPY-02378

Species: Human

Expression System: E. coli

HDT2 Protein, Arabidopsis thaliana, Recombinant (His)

Cat.No: TMPH-00095

Species: Arabidopsis thaliana

Expression System: P. pastoris (Yeast)

AICDA Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02908

Species: Mouse

Expression System: E. coli

BRD4 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-00694

Species: Human

Expression System: E. coli

HDAC11 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01472

Species: Human

Expression System: E. coli

CTCF Protein, Human, Recombinant

Cat.No: TMPJ-00986

Species: Human

Expression System: E. coli

Claudin-4 Protein-VLP, Human, Recombinant

Cat.No: TMPK-00710

Species: Human

Expression System: HEK293 Cells

TAF5L Protein, Human, Recombinant (GST)

Cat.No: TMPH-02175

Species: Human

Expression System: E. coli

CBX5 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01088

Species: Human

Expression System: E. coli

PRTFDC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03332

Species: Human

Expression System: E. coli

APOBEC3A Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01235

Species: Human

Expression System: E. coli

GSN Protein, Human, Recombinant (mFc)

Cat.No: TMPJ-00790

Species: Human

Expression System: HEK293 Cells

Gastrokine 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00519

Species: Human

Expression System: Baculovirus Insect Cells

HMGN3 Protein, Human, Recombinant (His)

Cat.No: TMPY-02979

Species: Human

Expression System: E. coli

DYDC2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02957

Species: Human

Expression System: E. coli

SUV420H2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01657

Species: Human

Expression System: E. coli

Annexin A8 Protein, Human, Recombinant (His)

Cat.No: TMPY-00585

Species: Human

Expression System: E. coli

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