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C-82 是一种特异性 CBP/β-catenin 拮抗剂。它抑制 β-catenin 和 CBP 之间的结合,并增加 β-catenin 和 p300 之间的结合。
C-82 是一种特异性 CBP/β-catenin 拮抗剂。它抑制 β-catenin 和 CBP 之间的结合,并增加 β-catenin 和 p300 之间的结合。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 3,939 | 现货 | |
5 mg | ¥ 7,939 | 现货 | |
10 mg | ¥ 11,484 | 现货 | |
25 mg | ¥ 17,300 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 10,200 | 现货 |
产品描述 | C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300. |
体外活性 | C-82 inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs. |
体内活性 | PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo, and pre-clinical studies have shown a very acceptable toxicity profile. |
分子量 | 578.66 |
分子式 | C33H34N6O4 |
CAS No. | 1422253-37-9 |
Smiles | [H][C@]12[C@H](C)N(Cc3cccc4cccnc34)C(=O)[C@H](Cc3ccc(O)cc3)N1C(=O)CN(C)N2C(=O)NCc1ccccc1 |
密度 | 1.39 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/ml (95.05 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
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