NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption.

NP213 is against T. rubrum NCPF0118, which shows different MIC values against T. rubrum NCPF0118, and the MICs vary depending on the source of the keratin. NP213 (2-3 hours; 0-8 μg/ml) has great activity against clinically relevant yeast, including candida spp, Cryptococcus app, and Trichosporon spp. For all 122 yeast isolates, with the median MIC100 values of 1-2 μg/ml. NP213 (500-1000 μg/mL; 18 hours) enhances the number of PI-stained T. rubrum NCPF0118 cells in samples. These results shows that NP213 is fungicidal and the mechanisms of action involved membrane permeabilization. The MIC values are 16-32 mg/L, 125 mg/L, and 250 mg/L for NP213 in 1640 media containing human nail Keratin, human skin Keratin, and Lamb's wool Keratin, respectively[1][3].

NP213 is tolerated and efficacious and exhibits a half-life of approximately 4.5 h, in Murine models of acute disseminated candidiasis. NP213 (25 mg/kg) is well tolerated in mice [3].