130
31
3
14
Cat. No. | Product Name | ||
---|---|---|---|
L2194 | 抗结直肠癌化合物库 | 1545 compounds | |
1545 种与结直肠癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L7900 | 成骨分子库 | 317 compounds | |
317 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L7700 | 神经再生化合物库 | 524 compounds | |
524 种神经再生相关化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9696 |
β-catenin-IN-2
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
β-catenin-IN-2 是有效的β-catenin 抑制剂。β-catenin-IN-2在结直肠癌中有研究的价值。 | |||
T9988 |
Wnt/β-catenin agonist 3
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Wnt/β-catenin agonist 3是一种Wnt/beta-catenin 信号通路激动剂。 | |||
TP1730L |
β-catenin peptide acetate
β-catenin peptide acetate(265669-37-2 free base) |
Others | Others |
β-catenin peptide acetate(265669-37-2 free base) 是一种由 Kb 呈递的天然存在的自身肽,可非常有效地介导 OT-I 胸腺细胞的阳性选择。 | |||
T67884 |
β-catenin modulator IIa-661
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
β-catenin modulator IIa-661是 Wnt 途径小分子抑制剂,具有抗肿瘤活性。 | |||
T41094 |
Wnt/β-catenin agonist 2
|
GSK-3; Wnt/beta-catenin | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells |
Wnt/β-catenin agonist 2激活 Wnt/β-catenin 信号传导,是一种有效的 Wnt 激动剂。 Wnt/β-catenin agonist 2可用于与信号转导相关的疾病研究,与癌症侵袭转移密切相关。 | |||
T39200 |
β-catenin-IN-37
|
Others | Others |
β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively. | |||
TP1730 |
β-catenin peptide
|
||
β-catenin peptide,(βCATp) is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes. | |||
T8400 |
Pamidronic acid
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Pamidronic acid 可用于各种骨吸收类疾病的研究。 | |||
T6868 |
KYA1797K
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
KYA1797K 是一种选择性 Wnt/β-catenin 抑制剂(IC50:0.75 µM)。 | |||
T8710 |
MSAB
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
MSAB 是一种Wnt/β-catenin 信号传导的选择性抑制剂。它能够与 β-catenin 结合,诱导其降解,并能够下调 Wnt/β-catenin 靶基因。它对 Wnt 依赖性癌细胞表现出有效的抗肿瘤特性。 | |||
T7399 |
LF3
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
LF3 是一种典型 Wnt 信号传导的特异性抑制剂,通过破坏 β-catenin 和 TCF4 之间的相互作用(IC50 < 2 μM) | |||
T9182 |
NRX-252262
|
Others; Wnt/beta-catenin | Cytoskeletal Signaling; Others; Stem Cells |
NRX-252262 是 β-Catenin 与同源 E3 ligaseSCFβ-TrCP 的相互作用增强剂,能够诱导 β-catenin 的降解,其 EC50=3.8 nM。 | |||
T1971 |
WAY-262611
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
WAY262611是一种 Wnt/β- 联蛋白激动剂,也是一种Dkk1的抑制剂。它能够增加骨形成速率,在 TCF- 荧光素酶测定实验中的EC50=0.63 μM。 | |||
T15137 |
DK419
|
Wnt/beta-catenin; AMPK | Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells |
DK419 是一种具有口服活性的 Wnt/β-catenin 信号通路抑制剂,IC50 为 0.19 μM。 DK419 降低 Axin2、β-catenin、c-Myc、Cyclin D1 和 Survivin 的蛋白质水平。它还诱导 pAMPK 的产生。 | |||
T12537 |
β-catenin/CBP-IN-1
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin | |||
T60803 |
Wnt/β-catenin agonist 4
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Wnt/β-catenin agonist 4 是一种Wnt的激动剂,可激活Wnt/β-catenin信号,引导信号传输。 | |||
T15677 |
KY1220
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
KY1220 通过靶向 Wnt/β-连环蛋白通路,使 β-连环蛋白和 Ras 不稳定。 它在 HEK293 报告细胞中的 IC50 为 2.1 μM。 | |||
T6989 |
SKL2001
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
SKL2001 是一种Wnt/β-catenin 信号通路的激动剂,具有抗肿瘤作用。它能够破坏 Axin/β-catenin 相互作用,稳定细胞内 β-catenin。 | |||
T9151 |
Teplinovivint
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Teplinovivint 是 wnt/β-catenin 信号通路抑制剂。它具有抗炎作用,对用于肌腱病具有潜在的研究价值。 | |||
T7204 |
PNU-74654
|
Apoptosis; Wnt/beta-catenin | Apoptosis; Cytoskeletal Signaling; Stem Cells |
PNU 74654是一种Wnt/β-catenin 通路抑制剂,在NCI-H295 细胞中的IC50值为129.8 μM。 | |||
T5642 |
Tegatrabetan
BC2059 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Tegatrabetan (BC2059) 是β-Catenin 拮抗剂,能够破坏 β-catenin 与转导素 β 样蛋白 1 (TBL1) 结合。 | |||
T6113 |
ICG-001
|
Apoptosis; Epigenetic Reader Domain; Wnt/beta-catenin | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells |
ICG001 是β-catenin/TCF 介导的一种转录抑制剂,选择性地阻断 β-catenin/CBP 相互作用而不干扰 β-catenin/p300 相互作用。它可特异性结合 CREB 蛋白,IC50为3 μM。 | |||
T13344 | Wnt/β-catenin agonist 1 | Others | Others |
Wnt/β-catenin agonist 1 is an agonist of Wnt/β-catenin signalling pathway(EC50 of 0.27 μM). | |||
T3062 |
WIKI4
|
PARP; Wnt/beta-catenin | Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells |
WIKI4 是tankyrase 有效抑制剂,其对TNKS2的IC50值为 26 nM。它有效抑制Wnt/β-catenin 信号传导,其EC50值为 75 nM。它通过抑制TNKS2的酶活性来介导其对Wnt/β-catenin 信号传导的影响。它对 SCLC 细胞具有细胞毒性,其IC50值为 0.02 μM。 | |||
T3635 |
IQ 1
IQ1,IQ-1 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
IQ 1 有多种作用,如保持小鼠ESCs 的多功能性、降低Wnt 刺激的磷酸化、阻止PP2A/Nkd 的相互作用等等。 | |||
T21685 |
CCT 031374 hydrobromide
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
CCT 031374 hydrobromide 是一种 TCF/β-catenin 抑制剂,具有抗肿瘤活性。 | |||
T2413 |
FH535
|
Wnt/beta-catenin; PPAR | Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; Stem Cells |
FH535 是一种具有抗肿瘤活性的Wnt/β-catenin 和PPAR 抑制剂。 | |||
T10904 |
CWP232228
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
CWP232228 是一种高效的、选择性的Wnt/β-catenin 信号通路抑制剂,在细胞核中,拮抗 β-catenin 与 T 细胞因子结合。它能够抑制乳腺癌和肝癌干细胞的生长,抑制肿瘤的形成和转移,且没有毒性。 | |||
T17142 |
Toxoflavin
毒黄素,Xanthothricin,PKF-118-310,Toxoflavine |
Wnt/beta-catenin; Antibacterial; Antibiotic | Cytoskeletal Signaling; Microbiology/Virology; Stem Cells |
Toxoflavin (Xanthothricin) 是一种 TCF4/β-catenin 复合物抑制剂,也是一种 KDM4A 抑制剂,有抗肿瘤和抗菌作用。 | |||
T0470 |
Nefopam hydrochloride
盐酸奈福泮,Fenazoxine hydrochloride,Nefopam HCl |
Wnt/beta-catenin; Sodium Channel | Cytoskeletal Signaling; Membrane transporter/Ion channel; Stem Cells |
Nefopam hydrochloride (Nefopam HCl) 作用于体外和体内间充质细胞β-连环蛋白水平,是一种中枢性但非阿片类缓解中度和重度疼痛。 | |||
T1878 |
XAV-939
XAV939,NVP-XAV939 |
PARP; Wnt/beta-catenin | Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells |
XAV-939 (NVP-XAV939) 是一种 Tankyrase (TNKS) 抑制剂,抑制 TNKS1 和 TNKS2 (IC50=11/4 nM)。XAV-939 可以选择性抑制 Wnt/β-catenin 介导的转录。 | |||
T22884 |
JW 67
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
JW 67 是典型 Wnt 信号通路的抑制剂,IC50为 1.17 μM。它影响由 β- 连环蛋白/GSK-3β/AXIN/APC/CK1 组成的多蛋白复合物,快速降低活性 β- 连环蛋白,随后下调Wnt 靶基因。它也抑制结直肠癌细胞生长。 | |||
T2310 |
CHIR-99021
Laduviglusib,CT99021,CHIR-99021 |
GSK-3; Wnt/beta-catenin; Autophagy | Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells |
CHIR-99021 (CT99021) 是一种 Wnt/β-catenin 信号通路激活剂,也是一种 GSK-3α/β抑制剂 (IC50=10/6.7 nM),具有选择性和口服活性。CHIR-99021 可以诱导细胞自噬,可增强小鼠和人类胚胎干细胞的自我更新。 | |||
T16079 |
Mirodenafil
米罗那非,SK3530 |
PDE | Metabolism |
Mirodenafil 是一种磷酸二酯酶5(PDE-5)抑制剂,可用于勃起功能紊乱的研究。 | |||
T39341 |
FCPR03
|
PDE | Metabolism |
FCPR03 是一种特异性磷酸二酯酶 4 (PDE4) 抑制剂,对 PDE4B1、PDE4D7 和 PDE4 催化结构域的 IC50 分别为 31 nM、47 nM 和 60 nM。 FCPR03 具有神经保护、抗炎和抗抑郁样作用。 | |||
T11284 |
FIDAS-3
|
Others; Wnt/beta-catenin; Methionine Adenosyltransferase (MAT) | Chromatin/Epigenetic; Cytoskeletal Signaling; Others; Stem Cells |
FIDAS-3 是一种强效Wnt 抑制剂,也是一种二苯乙烯衍生物,对甲硫氨酸腺苷转移酶 2A (MAT2A) 的IC50为 4.9 μM。它能够与 S-腺苷甲硫氨酸有效竞争MAT2A 结合,并具有抗癌作用。 | |||
T6150 |
TAK-715
|
p38 MAPK; Casein Kinase; JNK | MAPK; Metabolism; Stem Cells |
TAK-715 是一种具有口服活性的p38 MAPK 抑制剂,对 p38α 和 p38β 的IC50分别为 7.1 nM 和200 nM。它抑制酪蛋白激酶 I (CK1δ/ε),调节 Wnt/β-catenin 信号传导的激活,有抗炎活性。 | |||
T10606 |
BRD0705
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
BRD0705 是一种具有旁系选择性的、口服具有活性的GSK3α抑制剂,其 IC50=66 nM,Kd=4.8 μM。 它与 GSK3β (其 IC50=515 nM) 相比,对GSK3α的选择性更高 (8 倍)。它可用于研究急性髓细胞性白血病。 | |||
T11571 |
HLY78
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) 是 Wnt/β-catenin 信号通路的激活剂,通过靶向通道中 Axin 的 DIX 域,增强 Axin-LRP6 交联,诱导 Wnt 信号转导。 | |||
T78120 |
β-catenin-IN-6
|
Others | Others |
β-catenin-IN-6是一种针对Wnt/β-catenin(典型的wingless相关整合位点)通路的抑制剂,能够抑制人类结直肠癌细胞的增殖,并在β-catenin/RK3E小鼠模型上展现出效果。 | |||
T8005 |
Cardiogenol C hydrochloride
2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐,Cardiogenol C HCl,Cardiogenol C |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Cardiogenol C hydrochloride (Cardiogenol C) 是一种细胞渗透性嘧啶诱导剂,能够促使 ESCs 分化为心肌细胞。在有限的可塑性范围内,它可以对已经沿袭的祖细胞类型产生心肌生成效应,是一种心肌生成试剂,在动物模型中可以用作细胞移植研究中提高心脏修复的工具。 | |||
TP1263 |
Fz7-21
(Ac)-LPSDDLEFWCHVMY-NH2 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) 是一种 Frizzled 7 (FZD 7) 受体的肽抑制剂,能够选择性的与FZD7 CRD 亚类结合。它还阻断了WNT3A 介导的β-catenin 在小鼠L 细胞中的稳定作用。它对外源性WNT3A 刺激和转染WNT3A 或WNT1的HEK293细胞Wnt/β-catenin 信号传导有损伤。 | |||
T63212 |
β-catenin-IN-3
|
Others | Others |
β-catenin-IN-3 是选择性的、有效的β- 连环蛋白 (β-catenin) 抑制剂(KD: 54.96 nM),能够靶向 β-catenin 的一个隐变构调控位点,明显降低 β-catenin 驱动的癌细胞的活力。 | |||
TQ0126 |
Mirodenafil dihydrochloride
SK-3530 dihydrochloride,米罗那非二盐酸盐 |
PDE | Metabolism |
Mirodenafil dihydrochloride 是一种磷酸二酯酶5(PDE-5)抑制剂,可作用于勃起功能紊乱的研究。 | |||
T79103 |
β-Catenin modulator-4
|
Others | Others |
β-Cateninmodulator-4 (compound IIa-92) 为恶唑与噻唑类化合物,兼具高效性与选择性,作为β-Catenin调节剂。 | |||
T9025 |
KY19382
2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382,A3051 |
Others; GSK-3; Wnt/beta-catenin | Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Stem Cells |
KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) 是一种具有口服活性的 CXXC5-DVL (IC50:19 nM) 和 GSK3β (IC50:10 nM) 的双重抑制剂。它通过对 CXXC5-DVL 相互作用和 GSK3β 活性的抑制作用激活 Wnt/β-catenin 信号传导。它可用于高脂饮食诱发的代谢性疾病的研究。 | |||
T79102 |
β-Catenin modulator-3
|
Others | Others |
β-Cateninmodulator-3 (compound IIa-112) 是一种结合了恶唑和噻唑结构的高效选择性β-Catenin调节剂。 | |||
T79101 |
β-Catenin modulator-2
|
Others | Others |
β-Cateninmodulator-2 (compound IIa-130) 是一种融合了恶唑和噻唑结构的化合物,具有高效的β-Catenin选择性调控作用。 | |||
T72829 |
β-catenin-IN-4
|
Others | Others |
β-catenin-IN-4 是一种β-catenin 抑制剂,Ki 值为 0.64 μM。β-catenin-IN-4 降低 cyclin D1 和c-Myc 的蛋白表达水平。 | |||
T78919 |
β-catenin-IN-7
|
Others | Others |
β-catenin-IN-7(Compound 9)为一种β-catenin抑制剂,能够阻断β-catenin与Tcf-4的相互作用,进而抑制Wnt依赖性靶基因的表达,展现出抗癌活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5729 |
L-quebrachitol
L-白雀木醇,(-)-白雀木醇 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
L-Quebrachitol 是一种从多种植物中分离得到的天然产物,能够触发 BMP-2 反应以及 Runx2、MAPK 和 Wnt/β-catenin 信号通路,诱导成骨细胞生成。 | |||
T3925 |
Astragaloside I
黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Astragaloside I (Cyclosieversioside B) 是从黄芪中分离得到天然产物。它可通过 Wnt/β-catenin 信号通路刺激成骨细胞分化,可用于成骨活性研究。 | |||
TQ0215 |
Salinomycin sodium salt
盐霉素钠,Sodium salinomycin,Salinomycin sodium |
Apoptosis; Wnt/beta-catenin; Antibacterial; Antibiotic; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Microbiology/Virology; Stem Cells |
Salinomycin sodium salt (Sodium salinomycin) 是钾离子载体抗生素,是作用于 Wnt/Fzd/LRP 复合物的Wnt/β-catenin 信号传导抑制剂,能阻断 Wnt 诱导的 LRP6 磷酸化,导致 LRP6 蛋白降解。它选择性抑制人肿瘤干细胞。 | |||
TN1079 |
Deoxyelephantopin
|
NF-κB | NF-κB |
Deoxyelephantopin 是来自Elephantopus scaber 的,具有生物活性的天然倍半萜烯内酯,能够抑制NF-κB,MAPK,PI3K/Akt 和β-catenin 信号传导。它可广泛用于癌症方面的研究。 | |||
T5679 |
(E)-Ferulic acid
trans-Ferulic acid,反式阿魏酸,(E)-Coniferic acid |
BCL; Ferroptosis; Wnt/beta-catenin; Endogenous Metabolite | Apoptosis; Cytoskeletal Signaling; Metabolism; Stem Cells |
(E)-Ferulic acid ((E)-Coniferic acid) 是阿魏酸的异构体,阿魏酸是在植物细胞壁中丰富存在的芳香族天然产物。 它引起 β-catenin 的磷酸化,导致其蛋白酶体降解,增加促凋亡因子 Bax 的表达,降低促生存因子的表达。它在人肺癌细胞系 H1299 中发挥抗增殖和抗迁移作用。 | |||
TN1413 |
Atranorin
荔枝素,巴美灵,荔枝素 |
Endogenous Metabolite; NO Synthase; Ras | GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism |
Atranorin 是地衣的次生代谢产物,具有显着的抗伤害、抗炎和氧化还原活性,对 H(2)O(2) 诱导的氧化应激下的细胞具有细胞保护作用。 | |||
T5S1058 |
Triptonide
雷公藤内酯酮,PG 492,NSC 165677 |
Apoptosis; Wnt/beta-catenin; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Stem Cells |
Triptonide (PG 492) 是从雷公藤中鉴定出的一种天然产物,是一种 Wnt 信号抑制剂,其 IC50约为 0.3 nM。它具有免疫抑制、抗炎、避育、神经保护和抗淋巴瘤作用。 | |||
TN7036 |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
(9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) 是一种从玛卡中分离得到的玛卡酰胺。它能够激活典型的Wnt/β‐catenin 信号通路,诱导间充质干细胞成骨分化和随后的骨形成,可用于研究骨质疏松症。 | |||
TL0008 |
Gigantol
|
Wnt/beta-catenin; Glucosidase | Cytoskeletal Signaling; Metabolism; Stem Cells |
Gigantol 是一种联苄基化合物,从几种药用兰花中获得,是一种Wnt/β-catenin 通路抑制剂,具有抗肿瘤活性。 | |||
TN6508 |
Trachelogenin
(-)-Trachelogenin |
Virus Protease; c-Myc; HCV Protease; Wnt/beta-catenin | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells |
Trachelogenin ((-)-Trachelogenin) 分离自Combretum fruticosum,是一种 HCV 进入抑制剂 具有抗增殖作用,其机制与影响β-Catenin 信号通路中的 β-Catenin、c-Myc 和 GSK3 等关键蛋白的磷酸化有关,且呈浓度依赖性。Trachelogenin具有抗病毒、抗炎和镇痛活性,在 HCVcc 和 HCVpp 模型中的 IC50 分别为 0.325 和 0.259 μg/mL。 | |||
T4S1796 |
Heterophyllin B
|
PI3K | PI3K/Akt/mTOR signaling |
Heterophyllin B 是一种活性环肽,从 Pseudostellaria heterophylla 中分离得到,可用于研究食管癌。 | |||
T8229 |
5,7,3',4'-Tetramethoxyflavone
木犀草素四甲醚,3,4,5,7-四甲氧基黄酮 |
Antibacterial; Parasite; Antifungal | Microbiology/Virology |
5,7,3',4'-Tetramethoxyflavone (TMF), a prominent polymethoxyflavone (PMF) derived from M. exotica, displays a range of notable bioactivities. These include anti-malarial, anti-fungal, anti-mycobacterial, and anti-inflammatory properties. Moreover, TMF specifically targets β-catenin signaling to exhibit chondroprotective activity. | |||
T3330 |
trans-Trimethoxyresveratrol
trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,白藜芦醇三甲醚,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
trans-Trimethoxyresveratrol (MR-3) 是一种 Resveratrol(RSV) 的衍生物,与Resveratrol(RSV)相比,它可能是一个更有效的抗炎、抗血管新生的化合物。 | |||
T2818 |
Methyl Vanillate
|
Reactive Oxygen Species; Wnt/beta-catenin; Endogenous Metabolite | Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells |
Methyl vanillate 是一种枳椇属植物中的提取物,是Wnt/β-catenin 信号通路活化剂,是一种香草酸的甲酯。它具有抗氧化作用。 | |||
T0906 |
Salinomycin
盐霉素,Procoxacin |
Wnt/beta-catenin; Antibacterial | Cytoskeletal Signaling; Microbiology/Virology; Stem Cells |
Salinomycin (Procoxacin)是一种多醚类钾离子载体抗生素,特异性抑制革兰氏阳性细菌生长。Salinomycin 作为Wnt/β-连环蛋白信号通路的有效抑制剂,阻断Wnt诱导的LRP6磷酸化。此外,Salinomycin (Procoxacin)对人类癌症干细胞显示出选择性活性。 | |||
TL0007 |
Bisdemethoxycurcumin
双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin |
Epigenetic Reader Domain; Wnt/beta-catenin | Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells |
Bisdemethoxycurcumin (Curcumin III) 是一种具有抗炎及抗氧化作用的姜黄素。 | |||
TN1103 |
Diphyllin
山荷叶素,二叶草素 |
ATPase; Proton pump; Influenza Virus; HIV Protease | Membrane transporter/Ion channel; Microbiology/Virology; Proteases/Proteasome |
Diphyllin 是一种从Justicia procumbens 中分离的芳基萘木脂素,是HIV-1的有效抑制剂,IC50 为 0.38 μM。它是V-ATPase 抑制剂,IC50值为 17 nM,可抑制人破骨细胞中的溶酶体酸化。它抑制NO 产生,IC50值为 50 μM ,具有抗癌和抗炎活性。 | |||
T3391 |
Corosolic acid
Corsolic acid,2α-Hydroxyursolic acid,科罗索酸,Glucosol,Colosolic acid,Colosic acid |
FAK; Autophagy | Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Corosolic acid (Colosic acid) 是从大花紫薇中提取的一种天然产物,具有抗肿瘤活性。 | |||
T5S0754 |
Isoquercetin
3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷 |
NF-κB; Wnt/beta-catenin; NO Synthase | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; Stem Cells |
Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚,具有抗氧化,抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性,氧化应激和炎症反应。它具有高生物利用度和低毒性,是预防糖尿病妊娠出生缺陷的有希望的候选药物。 | |||
T4S1943 |
Kirenol
奇壬醇,奇任醇,Kirel |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的,具有抗氧化、抗炎、抗过敏、抗关节炎活性,可用于缓解疼痛的研究。 | |||
T2771 |
Orcinol glucoside
Sakakin,苔黑酚葡萄糖苷 |
Antioxidant | oxidation-reduction |
Orcinol glucoside (Sakakin) 是一种提取自莪术中的活性成分,具有抗抑郁活性。它能诱导 MSC 转化为成骨细胞,并通过 Wnt/β-catenin 信号通路阻断脂肪形成。 | |||
T3803 |
Specnuezhenide
特女贞苷,Nuzhenide,Nuezhenide |
Others; NF-κB; Wnt/beta-catenin | Cytoskeletal Signaling; NF-κB; Others; Stem Cells |
Specnuezhenide (Nuezhenide) 是分离自女贞子的果实中。它可抑制 NF-κB 和 wnt/β-catenin 信号传导,进而抑制 IL-1β 诱导的软骨细胞炎症。它可在骨关节炎 (OA) 大鼠模型中发挥抗炎作用。 | |||
T3S0153 |
Xanthatin
苍耳亭,叶黄制菌素 |
Apoptosis; VEGFR; Lipoxygenase; Wnt/beta-catenin; Antibacterial | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Stem Cells; Tyrosine Kinase/Adaptors |
Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物,可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL,对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。 | |||
T1716 |
Echinacoside
|
Reactive Oxygen Species; Wnt/beta-catenin | Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells |
Echinacoside 是一种从Cistanche salsa 中分离的苯乙醇类化合物,抑制Wnt/β-catenin 信号通路。它能够激活 Trk 受体及其下游信号通路而起到神经保护作用,还具有显著的抗骨质疏松作用。 | |||
T40643 |
Prodigiosin hydrochloride
盐酸灵菌红素,Prodigiosine hydrochloride |
Others | Others |
Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this compound possesses antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties. | |||
T23645 |
Aeroplysinin 1
NSC170364,Aeroplysinin I,NSC 170364,NSC-170364 |
Others | Others |
Aeroplysinin I is an antibacterial compound from the sponge. It has cytotoxic activity against colon cancer cells by promoting β-catenin degradation. | |||
T1033L |
Monensin
Elancoban,Rumensin,莫能菌素 |
Others | Others |
Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with deregulated Wnt signaling. | |||
TN3468 |
Atractylochromene
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer. | |||
TN2371 |
Isoliquiritin
新异甘草苷,Neoisoliquiritin |
Others | Others |
Neoisoliquiritigenin, isolated from Spatholobus suberectus, inhibits cell proliferation and induces cell apoptosis in breast cancer by directly binding to GRP78 to regulate the β-catenin pathway | |||
T75621 |
Secalonic acid D
|
Others | Others |
Secalonic acid D 是一种抗肿瘤细胞的有毒化合物。Secalonic acid D 可以从Aspergillus aculeatus 的代谢产物中分离得到。Secalonic acid D 激活GSK3-β,并降解β-catenin。因此,Secalonic acid D 下调c-Myc 表达,使细胞周期停滞在 G1 期,诱导细胞凋亡 (apoptosis)。 | |||
TN2775 |
2-Methoxystypandrone
|
MMP; BCL; IκB/IKK; GSK-3; TNF; NOS; NF-κB; Wnt/beta-catenin; COX; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02205 |
Beta-Catenin Protein, Human, Recombinant (His & GST)
catenin beta 1,armadillo,CTNNB,MRD19,catenin |
Human | Baculovirus Insect Cells |
Beta-Catenin Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 113 kDa and the accession number is P35222-1. | |||
TMPY-02985 |
Beta-Catenin Protein, Mouse, Recombinant (His & GST)
catenin β1,Bfc,Mesc,catenin beta ... |
Mouse | Baculovirus Insect Cells |
Beta-Catenin Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 113 kDa and the accession number is Q02248. | |||
TMPK-00925 |
Noggin/NOG Protein, Mouse, Recombinant
NOG,SYM1,SYNS1,Noggin |
Mouse | HEK293 Cells |
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt. Noggin/NOG... | |||
TMPK-00744 |
LRP-6 Protein, Human, Recombinant (mFc)
DCAD2,LRP-6,FLJ90421,LRP6,FLJ90062 |
Human | HEK293 Cells |
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte activation, detachment, and transition to myofibroblasts in vivo in response to kidney injury, resulting in attenuated fibrogenesis, capillary rarefaction, and inflammation.LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it ... | |||
TMPK-01001 |
RNF43 Protein, Mouse, Recombinant (hFc)
Rnf43,RING finger protein 43,RING-type E3 ubiquitin transfer... |
Mouse | HEK293 Cells |
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation. | |||
TMPK-00157 |
DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated
hDkk-1,SK,Dkk1,Dickkopf-related 1,Dickkopf-1,Dkk-1,hDkk1 |
Human | HEK293 Cells |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 38.69 kDa and the accession number is O94907. | |||
TMPK-00155 |
DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi)
hDkk-1,Dickkopf-1,Dkk1,hDkk1,SK,Dkk-1,Dickkopf-related 1 |
Human | HEK293 Cells |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 38.69 kDa and the accession number is O94907. | |||
TMPK-00743 |
LGR-5 Protein, Human, Recombinant (hFc)
G-protein coupled receptor HG38,G-protein coupled receptor 4... |
Human | HEK293 Cells |
G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker and prognostic indicator that can promote EMT by activating the Wnt/β-catenin pathway and would thus be a novel therapeutic target for glioma. | |||
TMPK-00156 |
DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi)
Dickkopf-1,Dkk1,hDkk-1,hDkk1,Dkk-1,SK,Dickkopf-related 1 |
Human | HEK293 Cells |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 40.25 kDa and the accession number is O94907. | |||
TMPK-00158 |
DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated
hDkk1,Dkk1,Dickkopf-1,Dkk-1,Dickkopf-related 1,SK,hDkk-1 |
Human | HEK293 Cells |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 40.25 kDa and the accession number is O94907. | |||
TMPK-01304 |
Kremen-2 Protein, Cynomolgus, Recombinant (His)
KREMEN2,KRM2,Dickkopf receptor 2,Kremen-2 |
Cynomolgus | HEK293 Cells |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy. Kremen-2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian c... | |||
TMPK-01093 |
Kremen-2 Protein, Mouse, Recombinant (His)
KRM2,KREMEN2,Dickkopf receptor 2,Kremen-2 |
Mouse | HEK293 Cells |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy. Kremen-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells ... | |||
TMPK-01106 |
Kremen-2 Protein, Human, Recombinant (His)
KRM2,KREMEN2,Kremen-2,Dickkopf receptor 2 |
Human | HEK293 Cells |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy. Kremen-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells ... | |||
TMPK-00926 |
Noggin/NOG Protein, Mouse, Recombinant (His & Flag)
SYNS1,NOG,SYM1,Noggin |
Mouse | HEK293 Cells |
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt. Noggin/NOG... |