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268

抑制剂 & 化合物

9

天然产物

12

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T40379	Bax BH3 peptide (55-74), wild type Bax BH3 peptide (55-74), wild type
	Bax BH3 peptide (55-74), wild type is a 20-amino acid peptide (Bax 1) known for its ability to induce apoptosis in various cell line models.
T9303	MRTX1133	Ras	GPCR/G Protein; MAPK
	MRTX1133 是一种 KRAS G12D 抑制剂 (KD=0.2 pM)，具有强效性、选择性和非共价性。MRTX1133 对 KRAS G12D 突变的肿瘤具有抑制活性，而对 KRAS 野生型肿瘤无抑制活性。
T9246	JNJ-63576253	Androgen Receptor	Endocrinology/Hormones
	JNJ63576253 是具有口服活性的、有效的雄激素受体的完全拮抗剂，在 LNCaP 细胞中对 F877L 突变型 AR 和野生型 AR 的IC50值分别为 37 和 54 nM。它可用于研究去势抵抗性前列腺癌。
T1623	Lopinavir ABT-378,洛匹那韦	SARS-CoV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Lopinavir (ABT-378) 是一种选择性肽模拟 HIV-1 蛋白酶的高效抑制剂。它通过阻止 HIV-1 的成熟而起作用，从而阻断其感染性。它也是 SARS-CoV 3CLpro 的抑制剂。
T8933	JNJ-63576253 free base TRC253,JNJ-63576253	Androgen Receptor	Endocrinology/Hormones
	JNJ-63576253 free base (TRC253) 是具有口服活性的、有效的雄激素受体的完全拮抗剂，在 LNCaP 细胞中对 F877L 突变型 AR 和野生型 AR 的 IC50值分别为 37 和 54 nM。它可用于研究去势抵抗性前列腺癌 (CRPC) 。
T21900	ML-336 (E)-2-((1,4-二甲基哌嗪-2-亚基)氨基)-5-硝基-N-苯基苯甲酰胺	Others	Others
	ML-336 是一种喹唑啉酮类的委内瑞拉马脑炎病毒 (VEEV) 抑制剂，其VEEV TC-83 CPE(IC50:32 nM)、VEEV V3526 CPE(IC50:20 nM)、VEEV 野生型 CPE (IC50:42 nM)，有效抑制 VEEV 诱导的三种病毒株 (V3526、TC-83和野生型) 细胞病变效应。
T2330	Rilpivirine TMC278,R278474,利匹韦林,DB08864	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Rilpivirine (R278474) 是一种二芳基嘧啶衍生物和非核苷逆转录酶抑制剂，具有抗 HIV-1 的抗病毒活性，用于治疗 HIV 感染。
T3184	Kevetrin hydrochloride Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride	Mdm2; p53	Apoptosis
	Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) 是一种小分子，是肿瘤抑制蛋白 p53 的激活剂，具有潜在的抗肿瘤活性。
T39202	CZC-54252 hydrochloride	LRRK2	Autophagy
	CZC-54252 hydrochloride 是 LRRK2 的特异性抑制剂，对野生型和 G2019S LRRK2 的 IC50 分别为 1.85 nM 和 1.28 nM。 CZC-54252 hydrochloride 具有神经保护活性，可减轻 G2019S LRRK2 诱导的人类神经元损伤，EC50 为 1 nM。
T32108	HXJ42 HXJ-42,HXJ 42	Others	Others
	HXJ42 是一种 PP1 类似物，可选择性地有效作用于野生型 ZAP-70 (AS)。
T23182	PPY A	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PPY A 是 T315l 突变体和野生型 Abl 激酶的有效抑制剂（IC50 分别为 9 和 20 nM）。PPY A 还能抑制 Bcr-Abl T315l 突变体或野生型 Bcr-Abl 基因转化细胞的生长。
T13273	UT-34	Androgen Receptor	Endocrinology/Hormones
	UT-34 是选择性的、具有口服活性的泛雄激素受体拮抗剂和降解剂，能够作用于野生型 AR (IC50:211.7 nM)、F876L-AR (IC50:262.4 nM)、W741L-AR (IC50:215.7 nM)。它与配体结合结构域和功能 1结构域结合，并需要泛素蛋白酶体途径来降解AR。它有抗前列腺癌的能力。
T4565	Tafamidis 他发米帝司甲葡胺,氯苯唑酸,Fx-1006A	Others	Others
	Tafamidis (Fx-1006A) 是选择性的transthyretin (TTR)稳定剂，对野生型 WT-TTR 、突变型同源四聚体 V30M-TTR、V122I-TTR 的活性相当，它们的EC50值为2.7-3.2 μM。它对淀粉样蛋白的生成具有抑制作用。
T6824	EAI045	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EAI045是突变体EGFR 的变构抑制剂，在10 μM ATP 时抑制EGFR、EGFRL858R、EGFRT790M 和 EGFRL858R/T790M 的IC50值分别为1.9、0.019、0.19 和 0.002 μM。
T21946	BIMU 8	5-HT Receptor	GPCR/G Protein; Neuroscience
	BIMU 8 是 5-HT4 的选择性激动剂，对野生型 5HT4 受体、T3.36A 和 W6.48A 突变体 5-HT4 的 EC50 分别为 18 nM、77 nM 和 540 nM。
T2620	G-749 G749	Apoptosis; FLT; c-RET; TAM Receptor; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	G-749 是一种新型 FLT3 抑制剂，对 FLT3 野生型和突变体有持续的抑制作用，IC50值分别为 0.4 nM 和 0.6 nM。它可用于急性髓系白血病的耐药研究。
T2050	PF-06447475	LRRK2	Autophagy
	PF-06447475是一种高效、特异性的脑渗透性 LRRK2 抑制剂，IC50值为3 nM。
T12097	Morphothiadin GLS4,莫非赛定	HBV	Microbiology/Virology
	Morphothiadin (GLS4) 是一种有效的抑制野生型和阿德福韦耐药 HBV 复制的抑制剂，IC50值为 12 nM。
T5139	CZC-25146 hydrochloride	LRRK2	Autophagy
	CZC-25146 hydrochloride 是一种有效、特异性和代谢稳定的 LRRK2 抑制剂，对野生型 LRRK2 和 G2019S LRRK2 的 IC50 分别为 4.76 和 6.87 nM。
T6008	CNX-2006 CNX 2006,CNX2006	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	CNX-2006 是一种新型的不可逆突变选择性 EGFR 抑制剂，对 EGFRT790M 的IC50值小于 20 nM。
T4257	Belizatinib TSR-011	Trk receptor; ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	Belizatinib (TSR-011) 是可口服的ALK 和 TRKA、TRKB、TRKC 双重抑制剂，对野生型重组 ALK 的IC50值为0.7 nM。
T32490	L-161240 L-161,240	Antibacterial	Microbiology/Virology
	L-161240 是一种与脂质A生物合成有关的抗菌剂，在DEACET测定IC50值为 30 nM，并且对野生型大肠杆菌的MIC值为1-3μg/ mL。
T8970	ML162	Ferroptosis; GPX; Glutathione Peroxidase	Apoptosis; Metabolism; oxidation-reduction
	ML162 是一种共价谷胱甘肽过氧化物酶 4 抑制剂。它选择性抑制表达突变 RAS 癌基因的细胞系。
T15617	JNJ-38877618 OMO-1	c-Met/HGFR	Tyrosine Kinase/Adaptors
	JNJ-38877618 (OMO-1)是一种口服有活性的 Met 激酶选择性抑制剂，其对野生型和突变体的 IC50值分别为2和3 nM。
T7338L	DHBP 紫外线吸收剂,Benzoresorcinol	Others	Others
	DHBP (Benzoresorcinol) 是一种 WalKR TCS 激活剂。它通过靶向行走和选择性地促进纽曼野生型菌株的溶葡萄球菌素诱导的裂解活性起作用。
T2153	1-NM-PP1 PP1 Analog II,1 nM-PP1	Serine/threonin kinase; CDK; Src	Angiogenesis; Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors
	1-NM-PP1 (PP1 Analog II) 是一种有效的Src 家族激酶抑制剂，是一种细胞渗透性 PP1 类似物，对 v-Src-as1 与 c-Fyn-as1 的IC50值分别为 4.3 nM、3.2 nM。
T60542	BTK-IN-16	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	BTK-IN-16 是一种潜在的野生型 BTK 和 C481S 突变体的抑制剂。BTK-IN-16 可用于研究由BTK 引起的各种自身免疫性疾病和癌症。
T3053	CZC-25146 CHEMBL2397014	LRRK2	Autophagy
	CZC-25146 (CHEMBL2397014) 是一种有效、特异性和代谢稳定的 LRRK2 抑制剂，对野生型 LRRK2 和 G2019S LRRK2 的 IC50 分别为 4.76 和 6.87 nM。
T21648	CP-31398 dihydrochloride CP 31398 dihydrochloride	p53	Apoptosis
	CP-31398 dihydrochloride 是一种 p53 稳定剂，可稳定 p53 的活性构象并促进具有突变型或野生型 p53 的癌细胞系中的 p53 活性。
T71857	GTP-14564	FLT; Tyrosine Kinases	Angiogenesis; Tyrosine Kinase/Adaptors
	GTP-14564是一种新型酪氨酸激酶抑制剂，对 wt-FLT3和ITD-FLT3也具有抑制作用。GTP-14564 在 3μ m 处抑制表达 ITD-FLT3 的白细胞介素-3 非依赖性 Ba/F1 的生长，而需要高 30 倍的 GTP-14564 浓度来抑制表达野生型 FLT3 的 Ba/F3 的 FLT3 配体依赖性生长（wt-FLT3）。
T1803	GNF-5 GNF 5	SARS-CoV; Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	GNF-5是 Bcr-Abl 的特异性非 ATP 竞争性抑制剂，IC50为0.22uM。它是 GNF-2 的类似物，具有改进的药代动力学特性。
T12428L	PF-06726304	Histone Methyltransferase	Chromatin/Epigenetic
	PF-06726304 是选择性EZH2有效抑制剂，具有强抗肿瘤生长活性。它抑制野生型和 Y641N 突变型 EZH2，Ki 分别为 0.7 和 3.0 nM。
T2662	Alda-1 Alda 1	Apoptosis; Dehydrogenase	Apoptosis; Metabolism
	Alda-1是一种 ALDH2 激动剂，是野生型 ALDH21 和亚洲 E487K 突变体 ALDH22 形式的线粒体醛脱氢酶 2 的细胞渗透激活剂。
T22980	MIRA-1 p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor	DNA/RNA Synthesis; p53	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	MIRA-1 (WRN Helicase Inhibitor) 是马来酰亚胺类似物。它可以恢复p53依赖的转录转激活诱导 p53 突变细胞凋亡，具有抗肿瘤作用。
T60081	BV02 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid	Others	Others
	BV02 是 14-3-3 蛋白-蛋白相互作用的抑制剂，可用于治疗慢性粒细胞白血病的研究。 BV02 破坏表达 IM 抗性 T315I 突变和 IM 敏感的野生型 Bcr-Abl 的造血细胞。
T3659	Zorifertinib AZD3759	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Zorifertinib (AZD3759) 是一种可口服的中枢神经系统渗透性 EGFR 抑制剂，对 EGFRwt、EGFRL858R 和 EGFRexon 19Del，IC50分别为 0.3、0.2 和 0.2 nM。
T5172	AZ304	c-Fms; Raf; p38 MAPK; Autophagy	Autophagy; MAPK; Tyrosine Kinase/Adaptors
	AZ304 是一种 ATP 竞争性双 BRAF 激酶抑制剂，有效抑制 BRAF (WT)、BRAF (V600E) 和野生型 CRAF，IC50值分别为79、38和68 nM。具有抗肿瘤活性。它对 p38 和 CSF1R 也有抑制作用，IC50值分别为 6 nM 和 35 nM。
T8882	Vodobatinib K-0706	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Vodobatinib (K-0706) 是第三代具有口服活性的Bcr-Abl1酪氨酸激酶抑制剂，IC50=7 nM，对大多数 BCR-ABL1 点突变体具有活性，但对 BCR-ABL1T315I 无活性。它可用于研究慢性粒细胞白血病 (CML)。
T37042	SCH529074 SCH 529074	p53	Apoptosis
	SCH529074 是 p53 的选择性激活剂 (Ki = 1 μM)，可用于非小细胞肺癌的研究。 SCH529074 恢复突变 p53 功能并中断 HDM2 介导的野生型 p53 泛素化。
T22106	MLS-573151	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	MLS-573151 是 GTPase Cdc42 的选择性抑制剂，EC50 为 2 μM。它通过阻止 GTP 与 Cdc42 的结合来发挥作用。
T4414	Eprenetapopt APR-246,PRIMA-1Met	Apoptosis; Others; Ferroptosis; p53; Autophagy	Apoptosis; Autophagy; Others
	Eprenetapopt (PRIMA-1Met) 是一种在 TP53突变细胞中恢复野生型 p53功能的小分子，可引发肿瘤细胞凋亡，还抑制硒蛋白硫氧还蛋白还原酶 1。
T11438	GNE-1858	Others; MAPK	MAPK; Others
	GNE-1858 是高效的 ATP 竞争性造血祖细胞激酶-1抑制剂，能够抑制野生型(IC50:1.9 nM)、活性模拟突变株 HPK1-TSEE (IC50:1.9 nM)、 HPK1-SA (IC50:4.5 nM)的活性。
T22324	Ensartinib hydrochloride Ensartinib dihydrochloride,X-396 dihydrochloride	Others; Trk receptor; c-Met/HGFR; ALK	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	Ensartinib hydrochloride (X-396 dihydrochloride) 是双重的 ALK/MET 抑制剂，IC50分别 <0.4 nM 和 0.74 nM。
T11163	EGFR-IN-9	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-9 是一种有效的 EGFR 激酶抑制剂，对于野生型 EGFR 激酶和双重突变型 EGFR 激酶 (L858R/T790M) 的 IC50 分别为 7 nM 和 28 nM。EGFR-IN-9 具有抗肿瘤活性。
T17002	Tazemetostat hydrobromide E-7438 hydrobromide,氢溴酸泰泽司他,EPZ-6438 hydrobromide	Histone Methyltransferase	Chromatin/Epigenetic
	Tazemetostat hydrobromide (E-7438 hydrobromide) 是口服的EZH2选择性抑制剂。它抑制含有 PRC2 复合体的野生型 EZH2 的活性，Ki 为 2.5 nM。它还抑制 EZH1，IC50为 392 nM。
T15704	Lagociclovir MIV-210	HBV	Microbiology/Virology
	Lagociclovir (MIV-210) 是一种核苷类似物，是一种可用治疗 HBV82的抗病毒化合物，可抑制野生型乙型肝炎病毒 (HBV) 在永久表达 HBV 的人肝癌细胞系中的复制。
T17257L	WR99210 hydrochloride(47326-86-3 free base) WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine	Others	Others
	WR99210 hydrochloride 是恶性疟原虫二氢叶酸还原酶 (pfDHFR) 的有效抑制剂，pfDHFR 是主要的疟疾药物靶点。它对野生型、双突变体和四突变体二氢叶酸还原酶具有亚纳摩尔效力。
T3506	Nazartinib 那扎替尼,EGF816,NVS-816	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Nazartinib (EGF816) 是一种共价、不可逆、突变选择性 EGFR 抑制剂，对激活 mt (L858R, ex19del) 和 T790M mt 具有纳摩尔抑制效力，在体外其选择性比野生型 (wt) EGFR 高 60 倍。
T21995	XAP044	GluR	Neuroscience
	XAP044 是高效的选择性mGlu7拮抗剂。代谢型谷氨酸受体亚型 7 是哺乳动物 CNS 中神经传递的重要突触前调节剂。它在啮齿动物行为测试中表现出较好的大脑暴露、广谱抗应激、抗抑郁以及抗焦虑作用。
T5462	Almonertinib HS-10296,阿美替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Almonertinib (HS-10296) 是EGFR 激活突变抑制剂和EGFR T790M 耐受突变抑制剂，对 EGFR 致敏和 T790M 耐药突变具有高选择性，用于非小细胞肺癌的研究。它对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性，对野生型的抑制作用较弱。

化合物

Bax BH3 peptide (55-74), wild type

Cat.No: T40379

Synonym: Bax BH3 peptide (55-74), wild type

Cat.No: T9303

Target: Ras

Cat.No: T9246

Target: Androgen Receptor

Cat.No: T1623

Synonym: ABT-378,洛匹那韦

Target: SARS-CoV, HIV Protease

JNJ-63576253 free base

Cat.No: T8933

Synonym: TRC253,JNJ-63576253

Target: Androgen Receptor

Cat.No: T21900

Synonym: (E)-2-((1,4-二甲基哌嗪-2-亚基)氨基)-5-硝基-N-苯基苯甲酰胺

Target: Others

Cat.No: T2330

Synonym: TMC278,R278474,利匹韦林,DB08864

Target: HIV Protease, Reverse Transcriptase

Kevetrin hydrochloride

Cat.No: T3184

Synonym: Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride

Target: Mdm2, p53

CZC-54252 hydrochloride

Cat.No: T39202

Target: LRRK2

Cat.No: T32108

Synonym: HXJ-42,HXJ 42

Target: Others

Cat.No: T23182

Target: Bcr-Abl

Cat.No: T13273

Target: Androgen Receptor

Cat.No: T4565

Synonym: 他发米帝司甲葡胺,氯苯唑酸,Fx-1006A

Target: Others

Cat.No: T6824

Target: EGFR

Cat.No: T21946

Target: 5-HT Receptor

Cat.No: T2620

Synonym: G749

Target: Apoptosis, FLT, c-RET, TAM Receptor, Aurora Kinase

Cat.No: T2050

Target: LRRK2

Cat.No: T12097

Synonym: GLS4,莫非赛定

Target: HBV

CZC-25146 hydrochloride

Cat.No: T5139

Target: LRRK2

Cat.No: T6008

Synonym: CNX 2006,CNX2006

Target: EGFR

Cat.No: T4257

Synonym: TSR-011

Target: Trk receptor, ALK

Cat.No: T32490

Synonym: L-161,240

Target: Antibacterial

Cat.No: T8970

Target: Ferroptosis, GPX, Glutathione Peroxidase

Cat.No: T15617

Synonym: OMO-1

Target: c-Met/HGFR

Cat.No: T7338L

Synonym: 紫外线吸收剂,Benzoresorcinol

Target: Others

Cat.No: T2153

Synonym: PP1 Analog II,1 nM-PP1

Target: Serine/threonin kinase, CDK, Src

Cat.No: T60542

Target: BTK

Cat.No: T3053

Synonym: CHEMBL2397014

Target: LRRK2

CP-31398 dihydrochloride

Cat.No: T21648

Synonym: CP 31398 dihydrochloride

Target: p53

Cat.No: T71857

Target: FLT, Tyrosine Kinases

Cat.No: T1803

Synonym: GNF 5

Target: SARS-CoV, Bcr-Abl

Cat.No: T12428L

Target: Histone Methyltransferase

Cat.No: T2662

Synonym: Alda 1

Target: Apoptosis, Dehydrogenase

Cat.No: T22980

Synonym: p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor

Target: DNA/RNA Synthesis, p53

Cat.No: T60081

Synonym: 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid

Target: Others

Cat.No: T3659

Synonym: AZD3759

Target: EGFR

Cat.No: T5172

Target: c-Fms, Raf, p38 MAPK, Autophagy

Cat.No: T8882

Synonym: K-0706

Target: Bcr-Abl

Cat.No: T37042

Synonym: SCH 529074

Target: p53

Cat.No: T22106

Target: CDK, Ras

Cat.No: T4414

Synonym: APR-246,PRIMA-1Met

Target: Apoptosis, Others, Ferroptosis, p53, Autophagy

Cat.No: T11438

Target: Others, MAPK

Ensartinib hydrochloride

Cat.No: T22324

Synonym: Ensartinib dihydrochloride,X-396 dihydrochloride

Target: Others, Trk receptor, c-Met/HGFR, ALK

Cat.No: T11163

Target: EGFR

Tazemetostat hydrobromide

Cat.No: T17002

Synonym: E-7438 hydrobromide,氢溴酸泰泽司他,EPZ-6438 hydrobromide

Target: Histone Methyltransferase

Cat.No: T15704

Synonym: MIV-210

Target: HBV

WR99210 hydrochloride(47326-86-3 free base)

Cat.No: T17257L

Synonym: WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine

Target: Others

Cat.No: T3506

Synonym: 那扎替尼,EGF816,NVS-816

Target: EGFR

Cat.No: T21995

Target: GluR

Cat.No: T5462

Synonym: HS-10296,阿美替尼

Target: EGFR

Cat. No.	Product Name	Target	Signaling Pathways
T7970	7-Ethoxycoumarin	Others	Others
	7-Ethoxycoumarin 是细胞色素 P450(CYP) 的底物，现已被应用于多种 CYP 的功能表征。
T3769	Tenuifolin	Others; Beta-Secretase; AChE	Neuroscience; Others
	Tenuifolin 是一种从远志中分离出的三萜，能够抑制β-secretase 以减少 Aβ 蛋白分泌，具有神经保护作用。它可通过降低 AChE 活性来改善衰老小鼠的学习和记忆能力，有潜力用于阿尔茨海默氏病的研究。
T11509	Guanfu base H Atisinium chloride	Others	Others
	Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM).
TN5012	Shizukaol C	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. <br/> 2. Shizukaol C has significant cytotoxicities against C8166 cells. <br/>
TN7557	Heronamide C	Others	Others
	Heronamide C, a polyketide macrolactam antifungal agent synthesized by marine Actinomycetes, exhibits selective toxicity by inhibiting growth and promoting abnormal cell wall material accumulation in wild-type fission yeast cells (MIC = 0.13-0.28 μM), without affecting Gram-positive bacteria or human cancer cell lines, HeLa and MDA-MB-231. At 20 μM, it triggers reversible morphological alterations, notably the development of large intracellular structures, in HeLa cells.
TN7544	(−)-Voacangarine (−)-Voacristine,NSC 306219	Others	Others
	(–)-Voacangarine, an indole alkaloid isolated from V. africana, exhibits cytotoxicity towards various cell lines including HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 with IC50 values of 20 µg/ml. Additionally, it demonstrates cytostatic effects on wild-type S. cerevisiae and is cytotoxic to Δrad3-e5 and Δrad6-1 mutant strains of S. cerevisiae, which have defects in DNA strand break repair and the mutagenic repair pathway, respectively.
T72172	4,6-O-Ethylidene-α-D-glucose Ethylidene-glucose	Others	Others
	4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物，是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂，对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。
T74516	CI-39	Others	Others
	CI-39 是一种抗病毒天然产物。CI-39 是一种 NNRTI (非核苷类逆转录酶抑制) 抗病毒剂，对野生型HIV 的EC50为 3.40 µM，CC50>30 µM。CI-39 抑制HIV-1RT DNA 聚合酶和核糖核酸酶 H 活性。
TN5011	Shizukaol B	ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; HIV Protease; DNA/RNA Synthesis; Prostaglandin Receptor; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimul

天然产物

7-Ethoxycoumarin

Cat.No: T7970

Target: Others

Cat.No: T3769

Target: Others, Beta-Secretase, AChE

Cat.No: T11509

Synonym: Atisinium chloride

Target: Others

Cat.No: TN5012

Target: HIV Protease, Antifection

Cat.No: TN7557

Target: Others

(−)-Voacangarine

Cat.No: TN7544

Synonym: (−)-Voacristine,NSC 306219

Target: Others

4,6-O-Ethylidene-α-D-glucose

Cat.No: T72172

Synonym: Ethylidene-glucose

Target: Others

Cat.No: T74516

Target: Others

Cat.No: TN5011

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, HIV Protease, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04152	RAB7A Protein, Rat, Recombinant (His) RAB7A, member RAS oncogene family,Rab7	Rat	E. coli
	RAB7A is a ubiquitous small GTPase, which controls transport to late endocytic compartments. Silencing or overexpression of wild type RAB7A changed the soluble/insoluble rate of peripherin indicating that RAB7A is important for peripherin organization and function. Besides, disease-causing RAB7A mutant proteins bind more strongly to peripherin and their expression causes a significant increase in the amount of soluble peripherin. The altered interaction between disease-causing RAB7A mutants and ...
TMPK-00081	FGF-7/KGF Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated FGF-7,成纤维细胞生长因子,HBGF-7,KGF	Human	E. coli
	The expression patterns of mRNAs encoding Fibroblast Growth Factor-7 (FGF-7) and its high affinity receptor suggested that FGF-7 signaling may play a role in regulating ureteric bud growth.t Results of these studies demonstrate that the developing ureteric bud and mature collecting system of FGF-7-null kidneys is markedly smaller than wild type. FGF-7 levels modulate the extent of ureteric bud growth during development and the number of nephrons that eventually form in the kidney.
TMPY-03603	AHSP Protein, Human, Recombinant ERAF,alpha hemoglobin stabilizing protein,α hemoglobin stabi...	Human	E. coli
	AHSP, also known as ERAF, is a conserved mammalian erythroid protein which belongs to the AHSP family. It is expressed in blood and bone marrow. AHSP facilitates the production of Hemoglobin A by stabilizing free α-globin. It rapidly binds to ferrous α with association (k'(AHSP)) and dissociation (k(AHSP)) rate constants of ≈1 μm(-1) s(-1) and .2 s(-1), respectively, at pH 7.4 at 22 ℃. A small slow phase was observed when AHSP binds to excess ferrous αCO. This slow phase appears to be due to cis...
TMPY-03606	ECSIT Protein, Human, Recombinant (His) ECSIT signalling integrator,SITPEC	Human	E. coli
	ECSIT is an adapter protein of the toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. It bridges TRAF6 to MEKK-1. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECS...
TMPJ-00981	PTX3 Protein, Mouse, Recombinant (His) alpha-induced protein 5,pentraxin 3, long,pentaxin-related g...	Mouse	HEK293 Cells
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator...
TMPY-03465	Flagellin Protein, Listeria monocytogenes, Recombinant (His) flaA	Listeria monocytogenes	E. coli
	The role of flagella and motility in the attachment of the foodborne pathogen Listeria monocytogenes to various surfaces is mixed with some systems requiring flagella for an interaction and others needing only motility for cells to get to the surface. In nature this bacterium is a saprophyte and contaminated produce is an avenue for infection. Previous studies have documented the ability of this organism to attach to and colonize plant tissue. Motility mutants were generated in three wild ...
TMPY-05062	NRG2 Protein, Human, Recombinant (His) DON1,HRG2,NTAK	Human	HEK293 Cells
	Neuregulin-2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, neuregulin-2 induces the growth and differentiation of epithelial, neuronal, glial and other types of cells. A mutation in NRG2 disrupted the induction of nitrate-responsive genes after nitrate treatment by an ammonium-independent mechanism. The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted ...
TMPY-01125	MDMX Protein, Human, Recombinant (His) MRP1,MDM4, p53 regulator,HDMX,MDMX	Human	E. coli
	MDM4 (MDM4 Regulator Of P53, also known as MDMX) is a Protein Coding gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows structural similarity to p53-binding protein MDM2. MDM4 is a promising target for cancer therapy, as it is undetectable in most normal adult tissues but often upregulated in cancer cells to dampen p53 tumor-suppressor function. MDM4, an essential negative regulator of the P53 tumor ...
TMPY-02003	FH/Fumarate Hydratase Protein, Human, Recombinant (His) fumarate hydratase,MCL,LRCC,MCUL1,FMRD,HLRCC	Human	E. coli
	Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. Fumarate Hydratase is similar to some thermostable class II fumarases and func...
TMPY-02376	BNIP3L Protein, Human, Recombinant BCL2/adenovirus E1B 19kDa interacting protein 3-like,NIX,BNI...	Human	E. coli
	The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to the endoplasmic reticulum and Golgi apparatus of wild-type newborn mouse lenses and is contained within mitochondria, endoplasmic reticulum and Golgi apparatus isolated from adult mouse liver. As the cells become packed with keratin bundles, Bnip3L expression triggers mitophagy to...
TMPY-01479	SPG3A Protein, Human, Recombinant (GST) HSN1D,atlastin GTPase 1,FSP1,atlastin1,GBP3,SPG3,SPG3A,AD-FS...	Human	Baculovirus Insect Cells
	Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 5-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and...
TMPY-02072	HSF1 Protein, Human, Recombinant (His) HSTF1,heat shock transcription factor 1	Human	E. coli
	Heat shock factor protein 1, also known as heat shock transcription factor 1, HSF1, and HSTF1, is a cytoplasm and nucleus protein that belongs to the HSF family. HSF1 is the major transcription factor of HSPs (heat shock proteins) in response to various stresses. Wild type HSF1 (heat shock transcriptional factor 1) is normally inactive. HSF1 / HSTF1 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable...

重组蛋白

RAB7A Protein, Rat, Recombinant (His)

Cat.No: TMPY-04152

Species: Rat

Expression System: E. coli

FGF-7/KGF Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00081

Species: Human

Expression System: E. coli

AHSP Protein, Human, Recombinant

Cat.No: TMPY-03603

Species: Human

Expression System: E. coli

ECSIT Protein, Human, Recombinant (His)

Cat.No: TMPY-03606

Species: Human

Expression System: E. coli

PTX3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00981

Species: Mouse

Expression System: HEK293 Cells

Flagellin Protein, Listeria monocytogenes, Recombinant (His)

Cat.No: TMPY-03465

Species: Listeria monocytogenes

Expression System: E. coli

NRG2 Protein, Human, Recombinant (His)

Cat.No: TMPY-05062

Species: Human

Expression System: HEK293 Cells

MDMX Protein, Human, Recombinant (His)

Cat.No: TMPY-01125

Species: Human

Expression System: E. coli

FH/Fumarate Hydratase Protein, Human, Recombinant (His)

Cat.No: TMPY-02003

Species: Human

Expression System: E. coli

BNIP3L Protein, Human, Recombinant

Cat.No: TMPY-02376

Species: Human

Expression System: E. coli

SPG3A Protein, Human, Recombinant (GST)

Cat.No: TMPY-01479

Species: Human

Expression System: Baculovirus Insect Cells

HSF1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02072

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0549	Tafamidis-d3
	Tafamidis-d3 是 Tafamidis 的氘代化合物。Tafamidis 的 CAS 号为 594839-88-0。Tafamidis 是选择性的transthyretin (TTR)稳定剂，对野生型 WT-TTR 、突变型同源四聚体 V30M-TTR、V122I-TTR 的活性相当，它们的EC50值为2.7-3.2 μM。它对淀粉样蛋白的生成具有抑制作用。

同位素标记化合物

Cat.No: TMIH-0549

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