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Search Results for " oral activity "

Targets Recommended: CDK

269

抑制剂 & 化合物

34

天然产物

1

化合物库

7

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name
L9850	口服活性化合物库		2427 compounds
	2427 种口服活性化合物独特集合，可用于高通量筛选和高内涵筛选

化合物库

口服活性化合物库

Cat.No: L9850

Compounds: 2427

Cat. No.	Product Name	Target	Signaling Pathways
T5405	BI-1347	CDK	Cell Cycle/Checkpoint
	BI-1347 是一种有效的、选择性的 CDK8/cyclinC 抑制剂，IC50值为 1 nM，可抑制肿瘤生存。
T3465	Vesnarinone 维司力农,OPC-8212,Arkin,Piteranometozine	HIV Protease; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Vesnarinone (Arkin) 是一种喹啉酮衍生物，可抑制磷酸二酯酶III 活性，增加钙通量和减小钾通量。
T67991	Iliparcil	Others	Others
	Iliparcil 是一种具有口服活性的抗血栓化合物。
T26914	BTA-9881 BTA9881,AZD9639,AZD-9639,BTA 9881,MEDI-564	RSV	Microbiology/Virology
	BTA-9881 是一种具有口服活性的新型 RSV 融合抑制剂，具有抗病毒活性，可用于研究呼吸道合胞病毒感染。
T23449	TCS 46b	NMDAR	Neuroscience
	TCS 46b 是一种具有口服活性的 NR1A/NR2B NMDA 受体拮抗剂。
T7120	Cefetamet pivoxil hydrochloride 盐酸头孢他美酯,Ro 15-8075	Antibacterial; Antibiotic	Microbiology/Virology
	Cefetamet pivoxil hydrochloride (Ro 15-8075) 是一种可口服的头孢类抗生素。
T34616	Seridopidine ACR-343,ACR 343,ACR343	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Seridopidine (ACR343) 是一种多巴胺能活性调节剂，可作为精神分裂症、帕金森病和抽动秽语综合征的口服疗法。
T12894	SGN-2FF	Others	Others
	SGN-2FF 是一种岩藻糖基化抑制剂，具有口服活性，能够抑制岩藻糖基转移酶的活性，具有抗肿瘤活性。
T9593	Senaparib IMP4297	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Senaparib (IMP4297) 是一种选择性和口服有效的PARP1/2抑制剂，具有强效的抗肿瘤活性。
T67875	DHODH-IN-23	Dehydrogenase	Metabolism
	DHODH-IN-23是一种 DHODH 抑制剂，具有口服活性。DHODH-IN-23常用于对癌症的研究。
T2492	Perifosine NSC 639966,D21266,KRX-0401,哌立福新	Apoptosis; Akt; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Perifosine (KRX-0401) 是一种具有口服活性的烷基磷酸胆碱 Akt 抑制剂，具有抗肿瘤活性。
T33711L	Nolomirole HCl CHF 1035 HCl,CHF 1035,CHF1035,CHF1035 HCl,CHF-1035 HCl,CHF-1035,Nolomirole Hydrochloride	Dopamine Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Nolomirole HCl（CHF 1035）是一种具有口服活性的新型选择性多巴胺激动剂，对去甲肾上腺素的释放有抑制作用，可用于研究轻度慢性心力衰竭。
T16366	NVR 3-778	HBV	Microbiology/Virology
	NVR 3-778 是一种 SBA 类的口服有效HBV CAM 衣壳组装调制剂，具有抗 HBV 活性。
T11410L	GLPG0492	Androgen Receptor	Endocrinology/Hormones
	GLPG0492 是一种非甾体选择性雄激素受体 (androgen receptor) 调节剂。GLPG0492 在肌肉骨骼疾病如肌萎缩和恶病质的研究方面具有潜在的潜力。
T2383	Panobinostat 帕比司他,NVP-LBH589,LBH589	Apoptosis; HIV Protease; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Panobinostat (NVP-LBH589) 是一种广谱的 HDAC 抑制剂 (IC50=5 nM)，具有口服活性和非选择性。Panobinostat 具有抗肿瘤活性，可以诱导细胞凋亡和自噬。
T40287	FATP1-IN-2	Others	Others
	FATP1-IN-2 是一种脂肪酸转运蛋白1 (FATP1) 抑制剂，具有口服活性，可用于研究肥胖和代谢疾病。
T60187	RP-6685	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Polθ), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Polθ. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model [1].
T19705	JTE-907 JTE 907	Cannabinoid Receptor	GPCR/G Protein
	JTE-907 是一种具有高度选择性和口服活性的 CB2 受体反向激动剂。JTE-907在体内展现出抗炎活性。
T13331	WAY127093B racemate	PDE	Metabolism
	WAY127093B racemate 是WAY127093 B 的外消旋体。WAY127093B 是一种磷酸二酯酶IV 抑制剂，在大鼠和豚鼠中具有口服活性。
T1920	Capivasertib AZD5363	Akt; PKA; mTOR; Autophagy	Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Capivasertib (AZD5363) 是一种广谱的 AKT 抑制剂，对 Akt1、Akt2 和 Akt3 均有抑制活性 (IC50=3/7/7 nM)，具有口服活性。Capivasertib 具有抗肿瘤活性，可以用于治疗乳腺癌。
T7897	PK150	Others; Antibacterial	Microbiology/Virology; Others
	PK150 是一种 Sorafenib 类似物，具有抗菌活性。它抑制甲氧西林敏感金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌，万古霉素中介金黄色葡萄球菌的 MIC 分别为 0.3，0.3-1，0.3 µM。
T6189	Mirdametinib PD325901,PD0325901	Apoptosis; MEK; Autophagy	Apoptosis; Autophagy; MAPK
	Mirdametinib (PD325901) 是一种 MEK 抑制剂 (IC50=0.33 nM)，具有选择性、非 ATP 竞争性和口服活性。Mirdametinib 具有抗肿瘤活性，可以抑制 p-ERK1/2 的表达并诱导细胞凋亡。
T2101	Navitoclax ABT-263	BCL	Apoptosis
	Navitoclax (ABT-263) 是一种 Bcl-2 抑制剂，可与 Bcl-xL、Bcl-2、Bcl-w 等蛋白结合 (Ki<1 nM)，具有有效性和口服活性。Navitoclax 具有抗肿瘤活性，可以诱导细胞凋亡。
T15756	Lidorestat IDD-676	Reductase	Endocrinology/Hormones; Metabolism
	Lidorestat (IDD-676) 是一种醛糖还原酶抑制剂(IC50: 5 nM)，具有有效性，选择性和口服活性。Lidorestat 改善神经传导，减少白内障的形成。Lidorestat 可用于治疗慢性糖尿病并发症。
TQ0138	K145 hydrochloride K145盐酸盐	Apoptosis; S1P Receptor	Apoptosis; GPCR/G Protein
	K145 hydrochloride 是选择性的，底物竞争性的和口服有效的SphK2抑制剂，IC50为 4.3 µM，Ki 为 6.4 µM。它可诱导细胞凋亡，显示出强大的抗肿瘤活性。
T30252	AZD1940 UNII-0J0035E9FT,AZD-1940,AZD 1940	Cannabinoid Receptor	GPCR/G Protein
	AZD1940 (UNII-0J0035E9FT)是一种高亲和力的大麻素CB(1)/CB(2)受体激动剂，具有口服活性，应用于口面疼痛的研究。
T36802L	Bisubstrate Inhibitor 78 HCl Bisubstrate Inhibitor 78 HCl(2368247-39-4 Free base)	Others	Others
	Bisubstrate Inhibitor 78 HCl 是一种 NNMT 抑制剂（IC50 = 1.41 μM），具有潜在的抗癌活性，在 100μM 时抑制HSC-2口腔癌细胞增殖。
T21686	CD 1530 CD-1530,CD1530	Retinoid Receptor	Metabolism
	CD 1530 是一种具有选择性和有效性的 RARγ激动剂(Kd:150 nM)，具有潜在的抗癌活性，对秀丽隐杆线虫显示出杀虫活性，可用于研究口腔癌变。
T0078	Lapatinib GSK572016,GW572016,拉帕替尼	EGFR; Ferroptosis; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Lapatinib (GW572016) 是一种 ErbB2 和 EGFR 的抑制剂 (IC50=9.2/10.8 nM)，具有口服活性。Lapatinib 具有抗肿瘤活性，可以用于治疗 HER2 过表达的晚期或转移性乳腺癌。
T67872	VT104	YAP	Stem Cells
	VT104是一种有效的YAP/TAZ 抑制剂，具有口服活性，可用于癌症研究。VT104阻止内源性TEAD1和TEAD3蛋白棕榈酰化。
T2125	Trametinib GSK1120212,曲美替尼,JTP-74057	Apoptosis; MEK; Autophagy	Apoptosis; Autophagy; MAPK
	Trametinib (GSK1120212) 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=0.7/0.9 nM)，具有 ATP 非竞争性和口服活性。Trametinib 可以激活自噬，诱导凋亡。
T0334	Rosiglitazone BRL49653,罗格列酮	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone (BRL49653) 是一种 PPARγ 激动剂、TRPC5 激活剂和 TRPM3 抑制剂，具有口服活性。Rosiglitazone 也是一种降糖剂，是噻唑烷二酮类胰岛素增敏剂。
T11265	Faropenem daloxate 法罗培南酯,Faropenem medoxil	Antibacterial; Antibiotic	Microbiology/Virology
	Faropenem daloxate (Faropenem medoxil) 是β-内酰胺类口服抗生素。
T35862	Cucurbit[8]uril	Others	Others
	Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications.
T12174	Naphthoquine phosphate	Parasite	Microbiology/Virology
	Naphthoquine phosphate 是一种具有口服活性的广谱4-氨基喹啉类抗疟化合物，可能影响病毒进入和进入后复制。Naphthoquine phosphate 具有肝血管中心毒性，常与青蒿素一起使用来治疗疟疾。
T6106	Selinexor (KPT-330) Selinexor,KPT-330,塞利尼索	CRM1	Membrane transporter/Ion channel
	Selinexor (KPT-330) 是一种 CRM1 的小分子抑制剂，具有选择性和口服活性。Selinexor 可以阻滞细胞周期、诱导细胞凋亡，具有抗肿瘤活性，可以用于治疗多发性骨髓瘤。
T1921	Alpelisib BYL-719	PI3K	PI3K/Akt/mTOR signaling
	Alpelisib (BYL-719) 是一种 PI3Kα 抑制剂 (IC50=5 nM)，具有选择性、有效性和口服活性。Alpelisib 以较低活性抑制 PI3Kβ/γ/δ (IC50=250/290/1200 nM)。Alpelisib 具有抗肿瘤活性，对 PIK3CA 突变肿瘤具有靶向性。
T61318	BRD4 Inhibitor-20	Epigenetic Reader Domain	Chromatin/Epigenetic
	BRD4 Inhibitor-20是一种有效的溴结构域蛋白4(BRD4)抑制剂，具有口服活性。BRD4 Inhibitor-20在癌细胞系中具有抗增殖活性，并被用于各种癌症的研究，如结肠癌。
T0520	Lenvatinib 仑伐替尼,E7080	VEGFR; FGFR; c-RET; PDGFR; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Lenvatinib (E7080) 是一种多靶点受体酪氨酸激酶抑制剂，抑制 VEGFR1-3、FGFR1-4、KIT、PDGFR 和 RET 等，具有口服活性。Lenvatinib 对 VEGFR2 和 VEGFR3 的抑制活性最强 (IC50=4/5.2 nM)。Lenvatinib 具有强效抗肿瘤活性。
T61972	Pomaglumetad methionil hydrochloride LY2140023 hydrochloride	GluR	Neuroscience
	Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) (LY2140023 hydrochloride) 是的 LY404039 的蛋氨酸前药，具有口服活性。LY404039是一种选择性 mGlu2/3 受体激动剂。Pomaglumetad methionil hydrochloride 可用于精神分裂症的研究。
T21463	Temozolomide Acid TMZA,3,4-二氢-3-甲基-4-氧代咪唑并[5,1-D]-1,2,3,5-四嗪-8-甲酰胺酸	Others	Others
	Temozolomide Acid (TMZA) 是 temozolomide (TMZ) 的代谢物。TMZ 在体外具有抗癌活性。TMZ 是一种口服烷化剂，用于治疗多形性胶质母细胞瘤 (GBM) 和星形细胞瘤。
T8850	sbp-7455	Autophagy	Autophagy
	SBP-7455 是一种高亲和力，可口服的双重ULK1/ULK2自噬抑制剂，可有效抑制ULK1/2酶活性，可研究三阴性乳腺癌，在 ADP-Glo 分析中的IC50分别为 13 nM 和 476 nM。
T2490	Osimertinib AZD-9291,Mereletinib,奥希替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Osimertinib (AZD-9291) 是一种 EGFR 三代抑制剂，抑制二代 EGFR 抑制剂产生的 T790M 耐药突变，具有不可逆性和口服活性。Osimertinib 具有抗肿瘤活性，用于治疗 EGFR 突变的非小细胞肺癌。
T4990	Cefcapene pivoxil hydrochloride hydrate Cefcapene Pivoxil Hydrochloride,盐酸头孢卡品酯	Antibacterial; Antibiotic	Microbiology/Virology
	Cefcapene pivoxil hydrochloride hydrate 是一种头孢菌素的前药，具有口服活性和广谱抗菌活性。它可研究掌跖脓疱病等感染性疾病。
T11339	Furegrelate sodium U-63557A	PPAR	DNA Damage/DNA Repair; Metabolism
	Furegrelate sodium (U-63557A) 是口服有效的、血栓素合酶选择性抑制剂，抑制人血小板微粒体血栓素 A2 (TxA2) 合酶的 IC50为 15 nM。它正在开发作为抗血小板药物。
T70692	ST7612AA1	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	ST7612AA1 是一种新型有效且可口服的 HDAC 抑制剂，作为作为HIV-1潜伏期再激活剂。ST7612AA1 在体内外实验中低浓度显示出显著的抗肿瘤活性。ST7612AA1 具有潜在的抗癌活性，可用于研究疟疾。
T6961	PX-478 PX-478 2HCl	HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy	Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism
	PX-478 是一种 HIF-1α 抑制剂，具有选择性、口服活性和血脑屏障渗透性。PX-478 具有抗肿瘤活性，还可以保护糖尿病中的胰腺 β 细胞功能，用于 2 型糖尿病的研究。
T72029	CDK8-IN-13	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	CDK8-IN-13是一种 CDK8抑制剂（IC50：51.9 nM），具有强效性、选择性和口服活性。CDK8-IN-13能诱导细胞凋亡，降低了 p-STAT1 S727和p-STAT5 S726的表达。CDK8-IN-13表现出抗肿瘤活性。
T67776	PCSK9-IN-11	Others	Others
	PCSK9-IN-11 (compound 5r) 是口服有效的 PCSK9 抑制剂。 PCSK9-IN-11 在 HepG2 细胞中抑制 PCSK9 转录活性 (IC50= 5.7 μM)。 PCSK9-IN-11 可以增加 LDL 受体 (LDLR) 蛋白水平，可用于动脉粥样硬化研究。
T22263	Bavdegalutamide ARV-110	Androgen Receptor	Endocrinology/Hormones
	Bavdegalutamide (ARV-110) 是一种雄激素受体 (AR) 的 PROTAC 降解剂。 Bavdegalutamide 可用于前列腺癌的研究。 Bavdegalutamide 具有口服活性和选择性，并促进 AR 的泛素化和降解。

化合物

Cat.No: T5405

Target: CDK

Cat.No: T3465

Synonym: 维司力农,OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

Cat.No: T67991

Target: Others

Cat.No: T26914

Synonym: BTA9881,AZD9639,AZD-9639,BTA 9881,MEDI-564

Target: RSV

Cat.No: T23449

Target: NMDAR

Cefetamet pivoxil hydrochloride

Cat.No: T7120

Synonym: 盐酸头孢他美酯,Ro 15-8075

Target: Antibacterial, Antibiotic

Cat.No: T34616

Synonym: ACR-343,ACR 343,ACR343

Target: Dopamine Receptor

Cat.No: T12894

Target: Others

Cat.No: T9593

Synonym: IMP4297

Target: PARP

Cat.No: T67875

Target: Dehydrogenase

Cat.No: T2492

Synonym: NSC 639966,D21266,KRX-0401,哌立福新

Target: Apoptosis, Akt, Autophagy

Cat.No: T33711L

Synonym: CHF 1035 HCl,CHF 1035,CHF1035,CHF1035 HCl,CHF-1035 HCl,CHF-1035,Nolomirole Hydrochloride

Target: Dopamine Receptor, Norepinephrine

Cat.No: T16366

Target: HBV

Cat.No: T11410L

Target: Androgen Receptor

Cat.No: T2383

Synonym: 帕比司他,NVP-LBH589,LBH589

Target: Apoptosis, HIV Protease, HDAC, Autophagy

Cat.No: T40287

Target: Others

Cat.No: T60187

Target: DNA/RNA Synthesis

Cat.No: T19705

Synonym: JTE 907

Target: Cannabinoid Receptor

WAY127093B racemate

Cat.No: T13331

Target: PDE

Cat.No: T1920

Synonym: AZD5363

Target: Akt, PKA, mTOR, Autophagy

Cat.No: T7897

Target: Others, Antibacterial

Cat.No: T6189

Synonym: PD325901,PD0325901

Target: Apoptosis, MEK, Autophagy

Cat.No: T2101

Synonym: ABT-263

Target: BCL

Cat.No: T15756

Synonym: IDD-676

Target: Reductase

K145 hydrochloride

Cat.No: TQ0138

Synonym: K145盐酸盐

Target: Apoptosis, S1P Receptor

Cat.No: T30252

Synonym: UNII-0J0035E9FT,AZD-1940,AZD 1940

Target: Cannabinoid Receptor

Bisubstrate Inhibitor 78 HCl

Cat.No: T36802L

Synonym: Bisubstrate Inhibitor 78 HCl(2368247-39-4 Free base)

Target: Others

Cat.No: T21686

Synonym: CD-1530,CD1530

Target: Retinoid Receptor

Cat.No: T0078

Synonym: GSK572016,GW572016,拉帕替尼

Target: EGFR, Ferroptosis, Autophagy

Cat.No: T67872

Target: YAP

Cat.No: T2125

Synonym: GSK1120212,曲美替尼,JTP-74057

Target: Apoptosis, MEK, Autophagy

Cat.No: T0334

Synonym: BRL49653,罗格列酮

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Faropenem daloxate

Cat.No: T11265

Synonym: 法罗培南酯,Faropenem medoxil

Target: Antibacterial, Antibiotic

Cucurbit[8]uril

Cat.No: T35862

Target: Others

Naphthoquine phosphate

Cat.No: T12174

Target: Parasite

Selinexor (KPT-330)

Cat.No: T6106

Synonym: Selinexor,KPT-330,塞利尼索

Target: CRM1

Cat.No: T1921

Synonym: BYL-719

Target: PI3K

BRD4 Inhibitor-20

Cat.No: T61318

Target: Epigenetic Reader Domain

Cat.No: T0520

Synonym: 仑伐替尼,E7080

Target: VEGFR, FGFR, c-RET, PDGFR, c-Kit

Pomaglumetad methionil hydrochloride

Cat.No: T61972

Synonym: LY2140023 hydrochloride

Target: GluR

Temozolomide Acid

Cat.No: T21463

Synonym: TMZA,3,4-二氢-3-甲基-4-氧代咪唑并[5,1-D]-1,2,3,5-四嗪-8-甲酰胺酸

Target: Others

Cat.No: T8850

Target: Autophagy

Cat.No: T2490

Synonym: AZD-9291,Mereletinib,奥希替尼

Target: EGFR

Cefcapene pivoxil hydrochloride hydrate

Cat.No: T4990

Synonym: Cefcapene Pivoxil Hydrochloride,盐酸头孢卡品酯

Target: Antibacterial, Antibiotic

Furegrelate sodium

Cat.No: T11339

Synonym: U-63557A

Target: PPAR

Cat.No: T70692

Target: HIV Protease

Cat.No: T6961

Synonym: PX-478 2HCl

Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy

Cat.No: T72029

Target: Apoptosis, CDK

Cat.No: T67776

Target: Others

Bavdegalutamide

Cat.No: T22263

Synonym: ARV-110

Target: Androgen Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T7938	Quinidine 奎尼丁,奎宁树	Parasite	Microbiology/Virology
	Quinidine 是一种抗心律失常剂，也是 K+通道的有效阻断剂，其 IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂，也可研究疟疾。
T0687	Simvastatin 辛伐他汀,MK-0733,MK 733	Apoptosis; Mitophagy; Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Simvastatin (MK 733) 是一种 HMG-CoA 还原酶抑制剂 (Ki=0.2 nM)，具有口服活性。Simvastatin 具有降血脂活性，可以抑制肝脏产生胆固醇，还可以用于预防心血管疾病。
T8125	Quinidine sulfate dihydrate 硫酸奎尼宁,硫酸奎尼丁二水合物,Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate	P450	Metabolism
	Quinidine sulfate dihydrate (Pitayine Sodium) 是抗心律失常剂，能够阻断 K+通道(IC50:19.9 μM)。它是细胞色素 P450db 的选择性抑制剂，可用于研究疟疾。
T20198	Potassium gluconate Kalium-beta,Kalium Gluconate,Kaon elixir,Kaon,Potassium D-gluconate,HSDB 3165,K-Iao	Endogenous Metabolite; Antifungal	Metabolism; Microbiology/Virology
	Potassium gluconate (Potassium D-gluconate) 是一种具有口服活性和螯合性质的氧化型羧酸，具有杀菌活性。
T8263	3,4'-Dihydroxyflavone	Influenza Virus	Microbiology/Virology
	3,4'-Dihydroxyflavone 是一种口服活性黄酮类化合物，具有抗甲型流感病毒的抗病毒活性。
T1687	Doxycycline Vibramycin,多西环素,Doxiciclina,Doxytetracycline,Doxycyclinum,强力霉素	MMP; ribosome; Antibacterial; Antibiotic; Parasite	Microbiology/Virology; Proteases/Proteasome
	Doxycycline (Doxiciclina) 属于四环素类抗生素，是一种广谱的金属蛋白酶 (MMP) 抑制剂，具有口服活性。Doxycycline 具有抗菌活性和抗肿瘤活性。
T1687L	Doxycycline (hyclate) Doxycycline hydrochloride hemiethanolate hemihydrate,盐酸强力霉素,WC2031,Doxycycline hyclate	MMP; ribosome; Antibacterial; Antibiotic	Microbiology/Virology; Proteases/Proteasome
	Doxycycline hyclate (WC2031) 属于四环素类抗生素，是一种广谱的金属蛋白酶 (MMP) 抑制剂，具有口服活性。Doxycycline hyclate 具有抗菌活性和抗肿瘤活性。
T1508	Decitabine Dacogen,NSC 127716,地西他滨,Deoxycytidine,5-Aza-2'-deoxycytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA Methyltransferase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Decitabine (Deoxycytidine) 是脱氧胞苷类似物，一种 DNA 甲基转移酶抑制剂，具有口服活性。Decitabine 具有抗肿瘤活性和抗代谢活性。Decitabine 诱导细胞周期阻滞和凋亡。
T3400	Bakuchiol	p38 MAPK; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK
	Bakuchiol 是一种从补骨脂种子中提取的植物雌激素，具有抗肿瘤和抗蠕虫特性，以及细胞毒活性和抗菌活性。
T5S2245	Alisol C 23-acetate 泽泻醇 C-23-醋酸酯,Alisol C monoacetate	Others	Others
	Alisol C 23-acetate (Alisol C monoacetate) 是一种提取自东方泽泻中的天然产物，可以显著减少迟发型超敏反应。
T5746	Dictamine Dictamnine,Dectamine,白鲜碱	Apoptosis; Anti-infection; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology
	Dictamine (Dectamine) 显示抗胆碱酯酶、抗炎、致突变、抗菌和抗真菌活性。它具有在人子宫颈、结肠和口腔癌细胞中发挥细胞毒性的能力。
T6564	Leupeptin Hemisulfate 亮肽素	Serine Protease; Cysteine Protease	Proteases/Proteasome
	Leupeptin hemisulfate 是一种蛋白酶抑制剂，具有细胞膜渗透性、可逆性、竞争性和口服活性。Leupeptin hemisulfate 可以抑制 Cathepsin B、Cathepsin H、Cathepsin L 的活性，阻断两性溶酶体的融合。Leupeptin hemisulfate 还具有抗炎活性。
TN7238L	Sanguinarine citrate Sanguinarium citrate,Sanguinarin citrate,Pseudochelerythrine citrate	Antibiotic	Microbiology/Virology
	Sanguinarine citrate (Pseudochelerythrine chloride) 是一种来源于 Sanguinaria Canadensis 的生物碱，具有抗菌、抗炎和镇痛活性，可用于治疗口腔炎、牙龈出血和喉炎等口腔炎症疾病。
T1181	Gefitinib ZD1839,吉非替尼	EGFR; Tyrosine Kinases; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Gefitinib (ZD1839) 是一种 EGFR 一代抑制剂，具有口服活性，抑制 EGFR 19 Del 和 L858R 突变。Gefitinib 具有抗肿瘤活性，用于治疗 EGFR 突变的非小细胞肺癌。Gefitinib 用药会产生 EGFR C797S 耐药突变。
T1678	Nystatin Stamycin,Fungicidin,制霉菌素,Nystavescent	Apoptosis; Antibiotic; Antifungal	Apoptosis; Microbiology/Virology
	Nystatin (Fungicidin) 属于多烯类抗真菌抗生素，对酵母和支原体有效，具有口服活性。Nystatin 可以用于治疗皮肤和口咽念珠菌感染。
TN4234	Hydrangenol	NOS; NF-κB; Nrf2; NO Synthase; Antifection; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; NF-κB
	Hydrangenol 是一种天然产物，可从绣球花 (Hydrangea serrata) 的叶中分离。Hydrangenol 是口服有效的抗光老化化合物，可以预防皱纹的形成。Hydrangenol 可以降低 MMP 和炎症细胞因子的表达，增加保湿因子和抗氧化基因的水平。
T3834	8-Epideoxyloganic acid 8-表去氧马钱酸	ROS; Immunology/Inflammation related	Immunology/Inflammation
	8-Epideoxyloganic acid 是从 Incarvillea delavayi 中分离得到的一种环烯醚萜苷。它具有微弱的缓解疼痛活性。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
T1326	Gentamicin sulfate SCH9724,Gentamycin sulfate,NSC-82261,硫酸庆大霉素	ribosome; DHFR; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Gentamicin sulfate (SCH9724) 是一种广谱的氨基糖苷类抗生素，具有口服活性。Gentamicin sulfate 可以用于抑制敏感生物体中的蛋白质合成。
T1079	Metronidazole Flagyl,Metronidazol,甲硝唑,Anagiardil	Apoptosis; NADPH; Hydrogenase; Antibacterial; Antibiotic; Parasite; Antifection	Apoptosis; Metabolism; Microbiology/Virology
	Metronidazole (Metronidazol) 是一种合成的硝基咪唑衍生物，一种抗生素和抗原虫剂，具有口服活性和血脑屏障渗透性。Metronidazole 可用于治疗或预防厌氧菌引起的系统或局部感染。
T1011	Itraconazole 伊曲康唑,R51211	P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells
	Itraconazole (R51211) 属于三唑类天然产物，是一种抗真菌剂，具有口服活性。Itraconazole 是一种 Hedgehog 信号通路拮抗剂，一种 oxysterol-binding protein (OSBP) 抑制剂，也是一种细胞色素 P-450 依赖性酶的抑制剂。
TMA0955	Thunberginol C	Antifection	Microbiology/Virology
	Thunberginol C exhibits antimicrobial activity against oral bacteria. It shows antiallergic activity in the in vitro bioassay using the Schults-Dale reaction in sensitized guinea pig bronchial muscle.
TN3726	Cudraflavone B	IκB/IKK; MAO; ROS; Akt; COX; PI3K; Nrf2; Autophagy	Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity. It may be a lead for the development of a potential candidate for human oral squamous cell carcinoma cells.
TN2738	2,6-Dimethoxy-1-acetonylquinol	Antifection	Microbiology/Virology
	2,6-Dimethoxy-1-acetonylquinol shows varying degrees of in vitro antimalarial activity against Plasmodium falciparum. It is devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line.
T82737	Chitobiose
	Chitobiose为壳寡糖，为β-1,4-氨基葡萄糖二聚体，具备口服活性及较高的抗氧化活性。
TN3686	Coccinic acid	Others	Others
	Coccinic acid shows inhibitory effects against colorectal carcinoma HCT-15 and oral epithelial cell line KB-3-1.Mixture of coccinic acid and anwuweizonic acid shows significant inhibitory activity against human decidual cells and rat luteal cells in vitro
TN1526	Corydalmine	P450; Antifection	Metabolism; Microbiology/Virology
	Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spore germination of all the fungi at 100 to 1500 ppm. l-Corydalmine also exhibits potent analgesic activity in preclinical models, it is under development as an oral analgesic agent.
TN4194	Heliangin	IL Receptor; TNF; NF-κB; MAPK; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB
	Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-ÎºB pathway on LPS-induced RAW 264.7 cells. Heliangin has anti-cancer activity, it exhibits cytotoxicity against human oral epidermoid (
T83407	2',3'-Dihydroxy-4',6'-dimethoxychalcone
	2',3'-Dihydroxy-4',6'-dimethoxychalcone 能够抑制β淀粉样蛋白(Aβ42)的纤维化与聚集，并具有口服活性，在大脑中可进行检测。
T73653	Pexiganan	Others	Others
	Pexiganan（MSI 78 free base），maganin 2 的合成类似物，是一种具有口服活性的广谱强效抗菌肽，主要用于研究糖尿病足溃疡等相关感染。
TN4519	Mesuaxanthone A 胡桐，海棠木	Others	Others
	Mesuaxanthone A and mesuaxanthone B are two yellow pigments.They produce varying degrees of C.N.S. depression characterised by ptosis, sedation, decreased spontaneous motor activity, loss of muscle tone, potentiation of pentobarbitone sleeping time and et
TN4585	Moronic acid	HIV Protease; Antifection; HSV	Microbiology/Virology; Proteases/Proteasome
	Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186) and was modified to develop more potent anti-AIDS agents. Moronic acid is a new structural lead for anti-EBV drug development, can substantially reduce the numbers of EBV particles produced by the cells after lytic induction. Morolic and moronic acids have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an...
T82773	Catechin 7-O-β-D-glucopyranoside
	Catechin 7-O-beta-D-glucopyranoside 是发现于Ulmus davidiana和Paeonia obovata的具有口服活性的天然化合物。该化合物显示出明显的抗氧化与抗炎活性，能改善线粒体功能障碍，有望成为肠道炎症性疾病研究中的潜在用途。
TN4437	Licorisoflavan A	MMP; IL Receptor; NF-κB; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; NF-κB; Proteases/Proteasome
	Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis.L

天然产物

Cat.No: T7938

Synonym: 奎尼丁,奎宁树

Target: Parasite

Cat.No: T0687

Synonym: 辛伐他汀,MK-0733,MK 733

Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy

Quinidine sulfate dihydrate

Cat.No: T8125

Synonym: 硫酸奎尼宁,硫酸奎尼丁二水合物,Chinidin Sodium,β-quinine Sodium,Pitayine Sodium,Quinidine sulfate

Target: P450

Potassium gluconate

Cat.No: T20198

Synonym: Kalium-beta,Kalium Gluconate,Kaon elixir,Kaon,Potassium D-gluconate,HSDB 3165,K-Iao

Target: Endogenous Metabolite, Antifungal

3,4'-Dihydroxyflavone

Cat.No: T8263

Target: Influenza Virus

Cat.No: T1687

Synonym: Vibramycin,多西环素,Doxiciclina,Doxytetracycline,Doxycyclinum,强力霉素

Target: MMP, ribosome, Antibacterial, Antibiotic, Parasite

Doxycycline (hyclate)

Cat.No: T1687L

Synonym: Doxycycline hydrochloride hemiethanolate hemihydrate,盐酸强力霉素,WC2031,Doxycycline hyclate

Target: MMP, ribosome, Antibacterial, Antibiotic

Cat.No: T1508

Synonym: Dacogen,NSC 127716,地西他滨,Deoxycytidine,5-Aza-2'-deoxycytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA Methyltransferase

Cat.No: T3400

Target: p38 MAPK, DNA/RNA Synthesis, Autophagy

Alisol C 23-acetate

Cat.No: T5S2245

Synonym: 泽泻醇 C-23-醋酸酯,Alisol C monoacetate

Target: Others

Cat.No: T5746

Synonym: Dictamnine,Dectamine,白鲜碱

Target: Apoptosis, Anti-infection, Antibacterial, Antifungal

Leupeptin Hemisulfate

Cat.No: T6564

Synonym: 亮肽素

Target: Serine Protease, Cysteine Protease

Sanguinarine citrate

Cat.No: TN7238L

Synonym: Sanguinarium citrate,Sanguinarin citrate,Pseudochelerythrine citrate

Target: Antibiotic

Cat.No: T1181

Synonym: ZD1839,吉非替尼

Target: EGFR, Tyrosine Kinases, Autophagy

Cat.No: T1678

Synonym: Stamycin,Fungicidin,制霉菌素,Nystavescent

Target: Apoptosis, Antibiotic, Antifungal

Cat.No: TN4234

Target: NOS, NF-κB, Nrf2, NO Synthase, Antifection, Autophagy

8-Epideoxyloganic acid

Cat.No: T3834

Synonym: 8-表去氧马钱酸

Target: ROS, Immunology/Inflammation related

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Gentamicin sulfate

Cat.No: T1326

Synonym: SCH9724,Gentamycin sulfate,NSC-82261,硫酸庆大霉素

Target: ribosome, DHFR, Antibacterial, Antibiotic

Cat.No: T1079

Synonym: Flagyl,Metronidazol,甲硝唑,Anagiardil

Target: Apoptosis, NADPH, Hydrogenase, Antibacterial, Antibiotic, Parasite, Antifection

Cat.No: T1011

Synonym: 伊曲康唑,R51211

Target: P450, Hedgehog/Smoothened, Antibiotic, Autophagy, Antifungal

Cat.No: TMA0955

Target: Antifection

Cat.No: TN3726

Target: IκB/IKK, MAO, ROS, Akt, COX, PI3K, Nrf2, Autophagy

2,6-Dimethoxy-1-acetonylquinol

Cat.No: TN2738

Target: Antifection

Cat.No: T82737

Cat.No: TN3686

Target: Others

Cat.No: TN1526

Target: P450, Antifection

Cat.No: TN4194

Target: IL Receptor, TNF, NF-κB, MAPK, Prostaglandin Receptor

2',3'-Dihydroxy-4',6'-dimethoxychalcone

Cat.No: T83407

Cat.No: T73653

Target: Others

Mesuaxanthone A

Cat.No: TN4519

Synonym: 胡桐，海棠木

Target: Others

Cat.No: TN4585

Target: HIV Protease, Antifection, HSV

Catechin 7-O-β-D-glucopyranoside

Cat.No: T82773

Licorisoflavan A

Cat.No: TN4437

Target: MMP, IL Receptor, NF-κB, DNA/RNA Synthesis

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01061	FGF-10 Protein, Human, Recombinant fibroblast growth factor 10,KGF2	Human	E. coli
	Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 pla...
TMPJ-00042	TSLP Protein, Human, Recombinant TSLP,Thymic stromal lymphopoietin	Human	E. coli
	Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing . lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral...
TMPJ-00764	Catalase/CAT Protein, Human, Recombinant CAT,Catalase	Human	E. coli
	Catalase (CAT) is a member of the catalase family. It exists as a homotetramer that occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Catalase is localized in the peroxisome. Catalase promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells, and normal and transformed fibroblast cells. Defects in CAT are the cause of acatalasemia which is characterized by absence of ...
TMPY-03332	PRTFDC1 Protein, Human, Recombinant (His) HHGP,PRTFDC1,phosphoribosyl transferase domain containing 1	Human	E. coli
	PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis. PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse and has important implications for unraveling the molecular etiology of lesch-Nyhan disease(LND). LND is a sever...
TMPJ-01207	UPP1 Protein, Human, Recombinant (His) UPP1,Uridine Phosphorylase 1,UPP1 Protein	Human	E. coli
	Uridinephosphorylase 1 (UPP1) is a member of the family of pentosyltransferase. UPP1 catalyses the reversible phosphorolysis of uridine to uracil. The expression levels and the enzymatic activity of UPP1 are higher in human solid tumors than in adjacent normal tissues. The high level of UPP1 expression in some tumors makes it a potential prognosticfactor for some cancers, such as oral squamous cell carcinoma. UPP1 is important for the homeostatic regulation of intracellular and plasma uridine c...
TMPY-02391	SUMO1 Protein, Human, Recombinant (His) small ubiquitin-like modifier 1,SMT3C,SMT3,SMT3H3,UBL1,SENP2...	Human	E. coli
	Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX act...
TMPY-02220	HRAS Protein, Human, Recombinant (His) HAMSV,Harvey rat sarcoma viral oncogene homolog,C-H-RAS,C-HA...	Human	Baculovirus Insect Cells
	HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family, and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Defects in HRAS are the cause of faciocutaneoskeletal syndrome (FCSS). FCSS is a rare condition characterized by prenatally increase...

重组蛋白

FGF-10 Protein, Human, Recombinant

Cat.No: TMPY-01061

Species: Human

Expression System: E. coli

TSLP Protein, Human, Recombinant

Cat.No: TMPJ-00042

Species: Human

Expression System: E. coli

Catalase/CAT Protein, Human, Recombinant

Cat.No: TMPJ-00764

Species: Human

Expression System: E. coli

PRTFDC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03332

Species: Human

Expression System: E. coli

UPP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01207

Species: Human

Expression System: E. coli

SUMO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02391

Species: Human

Expression System: E. coli

HRAS Protein, Human, Recombinant (His)

Cat.No: TMPY-02220

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0003	Ribociclib-d6
	Ribociclib-d6 是 Ribociclib 的氘代化合物。Ribociclib 的 CAS 号为 1211441-98-3。Ribociclib (LEE011) 是一种细胞周期蛋白依赖性激酶 CDK4/6 抑制剂 (IC50=10/39 nM)，具有特异性和口服活性。Ribociclib 具有抗肿瘤活性，可以阻滞细胞周期，抑制肿瘤细胞增殖。
TMIJ-0272	Sarpogrelate-d3 HCl
	Sarpogrelate-d3 HCl 是 Sarpogrelate HCl 的氘代化合物。Sarpogrelate HCl 的 CAS 号为 135159-51-2。Sarpogrelate hydrochloride 是一种选择性5-HT2R拮抗剂，可用于研究与血栓形成有关的血管疾病，对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi值分别为 8.52、6.57 和 7.43。
T35698	Octanoic Acid-13C
	Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d...

同位素标记化合物

Cat.No: TMID-0003

Sarpogrelate-d3 HCl

Cat.No: TMIJ-0272

Octanoic Acid-13C

Cat.No: T35698

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