658
175
4
103
30
Cat. No. | Product Name | ||
---|---|---|---|
L7000 | 活性脂质化合物库 | 385 compounds | |
385 种生物活性小分子化合物,用于高通量、高内涵筛选; | |||
L2510 | 脂代谢化合物库 | 492 compounds | |
492 个脂代谢相关的化合物集合,可用于高通量和高内涵筛选; | |||
L1120 | AMPK靶向分子库 | 80 compounds | |
80 个靶向AMPK 的分子集合,可用于高通量和高内涵筛选; | |||
L2540 | 肠道微生物代谢化合物库 | 614 compounds | |
614 种肠道微生物代谢物的集合,可以用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13896 |
Soya fatty acids
|
Others | Others |
Soya fatty acids is a class of polyunsaturated fatty acids isolated from soybean. | |||
T85012 |
10,13-epoxy-11-methyl-Octadecadienoic Acid
F2 Furan Fatty Acid |
Others | Others |
T85253 |
12,15-epoxy-13-methyl-12,14-Eicosadienoic Acid
Furan Fatty Acid F5 |
Others | Others |
12,15-Epoxy-13-methyl-12,14-eicosadienoic acid, a furan fatty acid first identified in northern pike (E. lucius), exhibits elevated levels in the liver of starving cod. | |||
T85151 |
12:0 N-Biotinyl Fatty Acid
N-Biotinyl Dodecanoic Acid |
Others | Others |
12:0 N-Biotinyl fatty acid, a biotinylated derivative of lauric acid, serves as an intermediate for synthesizing N-biotinylated phenylarsonous acids. | |||
T8642 |
4-CMTB
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
4-CMTB 是选择性的游离脂肪酸受体 2(FFA2/GPR43)的激动剂以及正变构调节剂 (pEC50=6.38)。 | |||
T85146 |
11-Hexadecenoic Acid
C16:1 (cis-11/trans-11) Fatty Acid |
Others | Others |
11-Hexadecenoic acid, a monounsaturated fatty acid, comprises both 11-cis-hexadecenoic acid and 11-trans-hexadecenoic acid. These isoforms are present in ewe milk fat and their concentrations increase when the diet is supplemented with lipids from linseed, sunflower, olive, or fish oils. Additionally, 11-trans-hexadecenoic acid is found in intramuscular fat of both male and female foals. The product is a blend of the 11-cis and 11-trans forms. [Matreya, LLC. Catalog No. 1208] | |||
T6043 |
PF-3845
|
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
PF3845 是一种有效的、选择性的和不可逆的脂肪酸酰胺水解酶(FAAH)抑制剂,Ki 为 230 nM。它是将 FAAH 的丝氨酸亲核试剂氨基甲酸酯化的共价抑制剂,可以减少疼痛感、炎症和焦虑或抑郁。 | |||
T11557 |
FASN-IN-3
|
Fatty Acid Synthase | Metabolism |
FASN-IN-3 是脂肪酸合酶抑制剂。 | |||
T7947 |
FT113
|
Fatty Acid Synthase | Metabolism |
FT113 是口服具有活力的脂肪酸合酶抑制剂,对全长重组人 FASN 酶的 IC50=213 nM。在 BT474 细胞中,它抑制 FASN 的特性,IC50=90 nM。它具有抗增殖作用,在体内和体外实验中,都具有抗癌作用。 | |||
T0686 |
Orlistat
Ro-18-0647,奥利司他,Tetrahydrolipstatin |
Apoptosis; Others; Fatty Acid Synthase | Apoptosis; Metabolism; Others |
Orlistat (Tetrahydrolipstatin) 是一种不可逆的胰腺和胃脂肪酶抑制剂,也是一种脂肪酸合成酶抑制剂,可研究肥胖症,具有抗动脉粥样硬化作用。 | |||
T17181 |
TVB-3664
|
Fatty Acid Synthase | Metabolism |
TVB-3664 是一种具有口服具有活力的、选择性的、可逆的、具有高生物利用度的脂肪酸合酶抑制剂,其对人和老鼠棕榈酸酯合成的IC50分别为 18 nM 和 12 nM。可显著抑制微管蛋白棕榈酰化和 mRNA 表达。 | |||
T2684 |
JNJ-1661010
JNJ1661010,Takeda-25,JNJ 1661010 |
FAAH | Metabolism; Neuroscience |
JNJ-1661010 (Takeda-25) 是一种有效的、选择性的、可以穿透血脑屏障的脂肪酸酰胺水解酶 (FAAH) 抑制剂,对大鼠和人 FAAH 的 IC50分别为 34 和 33 nM,可用于缓解疼痛的研究。 | |||
T17180 |
TVB-3166
|
Apoptosis; Others; Fatty Acid Synthase | Apoptosis; Metabolism; Others |
TVB-3166 是一种口服有效的,可逆和选择性脂肪酸合成酶 (FASN) 抑制剂,对于 FASN 和细胞棕榈酸酯合成的IC50分别为 42 nM 和 81 nM。它诱导细胞凋亡,抑制体内异种移植肿瘤生长。 | |||
T9967 |
MAGL-IN-5
|
Lipid | Metabolism |
MAGL-IN-5 是一种非选择性脂肪酶抑制剂。 | |||
T28353 |
PDP-EA
|
FAAH | Metabolism; Neuroscience |
PDP-EA 是脂肪酸酰胺水解酶 (FAAH) 的激活剂,可增强 FAAH 的酰胺水解酶活性。 | |||
T21729 |
(±)-Lisofylline
|
Others | Others |
(±)-Lisofylline 是一种对映异构体特异性、烷基取代的甲基黄嘌呤,在下调白细胞活化方面具有特异性和有效的活性。它是一种抗炎剂。 | |||
T7796 |
TUG-1375
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
TUG-1375 是游离脂肪酸受体 2 (FFA2/GPR43) 激动剂(pKi:6.69)。它对 FFA3,FFA4,PPARα,PPARγ,PPARδ,LXRα 或 LXRβ 无作用。 | |||
T15810 |
LY2922470
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
LY2922470 是选择性口服有效的GPR40激动剂,作用于 人 GPR40、小鼠 GPR40、大鼠 GPR40 的EC50值分别为 7 nM、1 nM、3 nM。它可降低血糖水平,同时显著增加胰岛素和 GLP-1,有潜力用于 2 型糖尿病的研究。 | |||
T7688 |
4-Nonylphenylboronic acid
|
FAAH | Metabolism; Neuroscience |
4-Nonylphenylboronic acid 是 FAAH 的抑制剂。 | |||
T3433 |
TUG-891
TUG 891,TUG891 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
TUG-891 是一种选择性的长链游离脂肪酸受体 4 (FFA4/GPR120) 的激动剂。 | |||
T7798 |
FGH10019
FGH-10019 |
NPC1L1; Fatty Acid Synthase | Membrane transporter/Ion channel; Metabolism |
FGH10019 是固醇调节元件结合蛋白 (SREBP) 抑制剂,IC50=1 μM。 | |||
T12580 |
PTUPB
|
COX; Epoxide Hydrolase | Immunology/Inflammation; Metabolism; Neuroscience |
PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。 | |||
T8646 |
URB937
|
FAAH | Metabolism; Neuroscience |
URB937 是一种口服具有活性的、外周限制的FAAH 抑制剂,IC50=26.8 nM,可增加 anandamide 水平,但不能影响脑内 FAAH 水平 (无法透过血脑屏障)。 | |||
T3215 |
JNJ-42165279
JNJ42165279 |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
JNJ-42165279 是一种 FAAH 抑制剂,抑制 hFAAH 和 rFAAH,IC50分别为70 ± 8 nM 和 313 ± 28 nM。它对其他酶、离子通道、转运蛋白和受体具有高度选择性。 | |||
T2338 |
JZL195
|
FAAH; Lipase; Autophagy | Autophagy; Metabolism; Neuroscience |
JZL195 是一种选择性有效的脂肪酸酰胺水解酶和单酰甘油脂肪酶双重抑制剂,IC50s 分别为 2 和 4 nM。 | |||
T9808 |
Tetradecylthioacetic acid
|
PPAR | DNA Damage/DNA Repair; Metabolism |
Tetradecylthioacetic acid 是一种合成脂肪酸,在 β 位具有硫取代。这种修饰使 TTA 无法进行完全的 β-氧化并增加其生物活性,包括激活过氧化物酶体增殖物激活受体 (PPAR),优先选择 PPARα。 | |||
T2601 |
Vidofludimus
SC12267,4sc-101 |
Dehydrogenase; DNA/RNA Synthesis; Interleukin | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism |
Vidofludimus (SC12267) 是一种新型的二氢乳清酸脱氢酶 (DHODH) 小分子抑制剂,可在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。 | |||
T11458 |
GPR40/FFAR1 modulator 1
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
GPR40/FFAR1 modulator 1是一种针对Gq偶联的游离脂肪酸受体1 (GPR40/FFAR1) 的激动剂以及异构调节剂。 | |||
T29350 |
2-Hexyldecanoic acid
Pentadecane-7-carboxylic Acid,Isopalmitic Acid,7-Pentadecanecarboxylic acid,C16 Guerbet fatty acid,2-Hexyldecansaeure |
Others | Others |
2-Hexyldecanoic acid is a biochemical. | |||
T2351 |
Fasiglifam
TAK875 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
Fasiglifam (TAK875) 是一种可口服的选择性GPR40激动剂,EC50值为 72 nM。 | |||
TQ0020 |
AMG 837 calcium hydrate
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
AMG 837 calcium hydrate 是口服有效的 GPR40/FFA1部分激动剂,抑制 [3H]AMG 837 与人类 FFA1受体的特异性结合,pIC50为 8.13。AMG 837 calcium hydrate 可增强啮齿动物的胰岛素分泌并降低葡萄糖水平。 | |||
T7482 |
3-chloro-5-hydroxybenzoic Acid
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
3-Chloro-5-hydroxybenzoic acid 是一种口服具有活力的乳酸受体GPR81选择性激动剂,对人 GPR81 的EC50为 16 μM。肥胖小鼠模型中,它表现出良好的体内脂肪分解作用。 | |||
T4323 |
PF-04457845
PF04457845,PF 04457845 |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
PF-04457845 是一种非常有效的选择性 FAAH 抑制剂,作用于 rFAAH 和 hFAAH,IC50分别为 7.4±0.62 nM 和 7.2±0.63 nM。 | |||
T9722 |
YTX-465
|
Stearoyl-CoA Desaturase (SCD) | Metabolism |
YTX-465 是有效的硬脂酰辅酶 A 去饱和酶 (Ole1/SCD) 抑制剂,抑制 Ole1 和 SCD1的IC50=分别为 0.039 μM 和 30.4 μM。YTX-465在帕金森病和其他突触核蛋白病领域有研究的价值。 | |||
T9266 |
Fatostatin
|
Lipid; Fatty Acid Synthase | Metabolism |
Fatostatin A 是一种SREBP 活化的特异性抑制剂,能够抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合,抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤活性,能抑制ob/ob 小鼠的高血糖。它抑制细胞中成脂基因的转录。 | |||
T11267 |
FASN-IN-1
TVB-2460 |
Fatty Acid Synthase | Metabolism |
FASN- in -1是一种有效的、特异性的脂肪酸合成酶(FASN)抑制剂,是一种专门设计用于靶向和抑制FASN 活性的化合物,是一种参与脂肪酸合成的酶,可抑制FASN 活性可以破坏脂肪酸的产生,并可能影响各种细胞过程。 | |||
T8927 |
WWL 154
WWL-154 |
FAAH | Metabolism; Neuroscience |
WWL 154 是一种丝氨酸水解酶 (SH) 和脂肪酸酰胺水解酶 FAAH-4 抑制剂。 | |||
T7092 |
NADPH tetrasodium salt
|
Others; Ferroptosis; Endogenous Metabolite | Apoptosis; Metabolism; Others |
NADPH tetrasodium salt 是电子受体烟酰胺腺嘌呤二核苷酸磷酸的还原形式,在各种生物反应中充当电子供体。NADPH tetrasodium salt 也是一种内源性铁死亡抑制剂。 | |||
T4534 |
BMS-309403
|
FABP | Metabolism |
BMS309403 是有效的、选择性脂肪细胞脂肪酸结合蛋白 aFABP 抑制剂。它可改善载脂蛋白 E 缺乏症小鼠和培养的人内皮细胞的内皮功能。它能够与蛋白质内部的脂肪酸结合口袋相互作用,竞争性地抑制内源性脂肪酸的结合。 | |||
T3354 |
BIA 10-2474
BIA10-2474 |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
BIA 10-2474 是一种长效可逆的脂肪酸酰胺水解酶抑制剂,与人类内源性大麻素系统相互作用,可增加中枢神经系统和外周组织,对大鼠大脑不同区域的 IC50值为50至70mg/kg。它用于治疗焦虑症、帕金森氏病和多发性硬化症、高血压或肥胖症的慢性疼痛。 | |||
T15802 |
LY2183240
|
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
LY2183240 是大麻素摄取阻滞剂。它是内源性大麻素降解酶脂肪酸酰胺水解酶的有效共价抑制剂。它抑制脂肪酸酰胺水解酶 (FAAH) 活性,IC50 为12.4 nM。它也抑制其他几种脑丝氨酸水解酶,对 MAG 脂肪酶、bh6 和 KIAA1363 的 IC50分别为 5.3、0.09 和 8.2 nM。 | |||
T1325 |
Carprofen
卡洛芬,Ridamyl,Imadyl,Rimadyl |
FAAH; COX; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; Neuroscience |
Carprofen (Ridamyl) 是多靶点FAAH/COX 抑制剂,能够抑制 COX-2,COX-1 和 FAAH 的活性,IC50值分别为 3.9 μM,22.3 μM 和 78.6 μM。它是一种丙酸衍生物和非甾体抗炎药,具有抗炎、镇痛和解热活性。 | |||
T7127 |
DC260126
|
Apoptosis; GPR | Apoptosis; Endocrinology/Hormones; GPCR/G Protein |
DC260126 是一种 GPR40 (FFAR1)拮抗剂,对棕榈酸酯诱导的内质网应激和凋亡有保护作用。它剂量依赖性地抑制亚油酸、油酸、棕榈油酸和月桂酸刺激的 GPR40 介导的 Ca2+升高,IC50分别 6.28、5.96、7.07和4.58 μM。 | |||
T22027 |
AH-7614
AH 7614 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
AH-7614 (AH 7614) 是一种选择性的游离脂肪酸受体 4(FFA4/GPR120) 拮抗剂,对人和大小鼠 FFA4 的pIC50值分别为 7.1、8.1 和 8.1。它能够阻断多不饱和 ω-6 脂肪酸亚油酸和 FFA4 激动剂的作用。 | |||
T4312 |
GPR120 Agonist 2
GPR120 receptor agonist |
GPR | Endocrinology/Hormones; GPCR/G Protein |
GPR120 Agonist 2 是一种选择性 GPR120激动剂。 | |||
T15413 |
GPR120 Agonist 3
GPR120-IN-1 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
GPR120 Agonist 3 (GPR120-IN-1) 是一种有效的、选择性的 Gpr120激动剂,logEC50为 −7.62。 | |||
T7832 |
Ibrolipim
NO-1886 |
LPL Receptor | GPCR/G Protein |
Ibrolipim (NO-1886) 是口服具有活力的脂蛋白脂肪酶 (LPL) 激活剂。它能够降低血浆甘油三酸酯,增加高密度脂蛋白胆固醇水平,具有肾保护和降血脂的作用。 | |||
T22967 |
MEDICA16
MEDICA 16 |
GPR; Others; ATP Citrate Lyase | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Others |
MEDICA16 是 GPR40 的特异性激动剂以及 GPR120 的部分激动剂。 MEDICA16 是一种 ATP-柠檬酸裂解酶抑制剂,可显着降低腓肠肌中的细胞内 TG 含量,同时增加胰岛素敏感性。 | |||
T12437 |
PF429242 dihydrochloride
|
S1P Receptor | GPCR/G Protein |
PF429242 dihydrochloride 是一种可逆的竞争性 SREBP 位点 1 蛋白酶抑制剂,IC50值为175 nM。 | |||
T1889 |
CP-640186
CP 640186 |
Acetyl-CoA Carboxylase | Metabolism |
CP-640186 是一种有效的乙酰辅酶 A 羧化酶 (ACC)抑制剂,抑制大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50分别为 53 nM 和 61 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0260 |
Cerulenin
|
Antibiotic; Antifungal; Fatty Acid Synthase | Metabolism; Microbiology/Virology |
Cerulenin 是广泛使用的天然脂肪酸合成酶抑制剂。它是由真菌Cephalosporium caeruleus 产生的。它抑制拓扑异构酶I 催化活性并增强 SN-38 诱导的细胞凋亡。它具有抗真菌和抗肿瘤活性。 | |||
TN4662 |
Nonanal
|
Others | Others |
Nonanal 是木材腐烂真菌的生长因子。 Nonanal 是松梢甲虫的潜在引诱剂。 | |||
T8276 |
Methyl palmitoleate
|
Others | Others |
Methyl palmitoleate 是棕榈油酸的类似物,也是一种脂肪酸甲酯,具有细胞保护性和促进生长性。 | |||
T8192 |
Pentacosanoic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Pentacosanoic acid 是戊酸的共轭酸,是 25 碳长链饱和脂肪酸。 | |||
T2824 |
Pedunculoside
|
Others; Fatty Acid Synthase | Metabolism; Others |
Pedunculoside 是从 Ilex rotunda Thunb 中提取的,通过对脂质形成和脂肪酸 β-氧化的调节而发挥降脂作用。 | |||
T14862 |
Caprylic/Capric Triglyceride
|
Others | Others |
Caprylic/Capric Triglyceride 是一种从分离的植物油中提取的甘油三酯和酯,以及从椰子油和棕榈仁油中提取的脂肪酸。它具有良好的氧化稳定性,可用作食品添加剂及用于化妆品。 | |||
T7529 |
Yamogenin
山药 |
Others | Others |
Yamogenin 是一种薯蓣皂素的非对映异构体。它通过抑制 HepG2 肝细胞中脂肪酸合成的基因表达来抑制甘油三酸酯 (TG) 的积累。它在萤光素酶配体测定中拮抗肝脏 X 受体 (LXR) 的激活。 | |||
T13719 |
Hexadecanal
Palmitaldehyde,十六醛 |
Endogenous Metabolite | Metabolism |
Hexadecanal (Palmitaldehyde) 是存在于动物体内的游离脂肪醛。 | |||
T5567 |
Tetradecanedioic acid
十四烷二酸,Tetradecanedicarboxylate |
Others; Endogenous Metabolite | Metabolism; Others |
Tetradecanedioic acid (Tetradecanedicarboxylate) 是一种长链脂肪酸,属于内源性代谢物的一种。它能够作为有机阴离子转运多肽介导的药物-药物相互作用的候选生物标志物。 | |||
TN6953 |
Lignoceric Acid
二十四烷酸,tetracosanoic acid |
Endogenous Metabolite | Metabolism |
Lignoceric Acid (tetracosanoic acid) 是一种 24 碳饱和 (24:0) 脂肪酸,在发育中的大脑中合成,也是一种木质素生产的副产品。它能够用于研究 Zellweger 脑-肝-肾综合征和肾上腺脑白质营养不良。 | |||
T10857 |
Coenzyme A
|
Endogenous Metabolite | Metabolism |
Coenzyme A 是所有活细胞中必需的辅助因子,由泛酸,三磷酸腺苷和半胱氨酸合成的。Coenzyme A 与过氧化物酶 5 共价结合导致其过氧化物酶活性完全抑制,通过 DTT 还原能够逆转。Coenzyme A 及其硫酯衍生物是主要分解代谢,合成代谢途径和基因表达调控的关键参与者。 | |||
T2919 |
Sesamin
Fagarol,Fsesamin,芝麻素 |
Others | Others |
Sesamin 是多不饱和脂肪酸生物合成中的选择性delta 5 去饱和酶抑制剂,是在芝麻油中存在丰富的木脂素。它对脑缺血具有有效的神经保护作用。 | |||
T9512 |
Linoleyl alcohol
CIS,CIS-9,12-OCTADECADIENOL,亚麻醇 |
Others | Others |
Linoleyl alcohol (CIS,CIS-9,12-OCTADECADIENOL) 是一种脂肪醇,是一种没有α-羧基的 Linoleic acid 的结构类似物。 | |||
T7967 |
Methyl behenate
山楂酸甲酯,山嵛酸甲酯 |
Others | Others |
Methyl behenate 是一种从 Aspidopterys obcordata Lemsl 的植物中分离出来的天然脂肪酸甲酯。 | |||
T3324 |
Lycorine
Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱 |
Apoptosis; Virus Protease; Antibacterial; AChR; Fatty Acid Synthase | Apoptosis; Metabolism; Microbiology/Virology; Neuroscience |
Lycorine (Narcissine) 是从金眼科植物科中提取的一种天然生物碱。它是一种具有口服活性的SCAP 抑制剂,Kd 值 15.24 nM。它也是黑色素瘤血管生成抑制剂,有用于前列腺癌和代谢疾病的研究潜力。 | |||
T5S0246 |
Pseudoprotodioscin
山药 |
Others; Fatty Acid Synthase | Metabolism; Others |
Pseudoprotodioscin 是一种呋喃葡糖苷,抑制SREBP1/2和microRNA 33a/b 水平,降低胆固醇和甘油三酯合成相关的基因表达。 | |||
T2859 |
Biochanin A
4-Methylgenistein,鹰嘴豆芽素A,Olmelin |
EGFR; FAAH; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors |
Biochanin A (4-Methylgenistein) 是一种从红三叶车轴草中分离出来的异黄酮衍生物,具有抗癌特性。它是脂肪酸酰胺水解酶抑制剂,作用于小鼠、大鼠和人 FAAH,IC50分别为 1.8、1.4 和 2.4 μM。 | |||
TJS0387 |
Desoxyrhaponticin
去氧土大黄苷,Deoxyrhapontin,脱氧土大黄苷,Deoxyrhaponticin |
Apoptosis; Fatty Acid Synthase | Apoptosis; Metabolism |
Desoxyrhaponticin (Deoxyrhaponticin) 是来自西藏营养食品唐古特大黄中的一种二苯乙烯苷。它是脂肪酸合成酶抑制剂,抑制细胞内 FAS 活性,下调人乳腺癌 MCF-7细胞中 FAS 的表达。它是控制糖尿病餐后高血糖的潜在药物。 | |||
T11590 |
(-)-Hydroxycitric acid
Garcinia acid,(-)-羟基柠檬酸 |
ATP Citrate Lyase | Metabolism |
(-)-Hydroxycitric acid (Garcinia acid) 是Garcinia cambogia 果皮中的主要酸。它是 ATP 柠檬酸裂解酶的竞争性抑制剂,能够抑制脂肪酸的合成,减少脂肪生成,控制食物摄入,从而减轻体重。 | |||
T7647 |
Eicosadienoic acid
二十碳二烯酸,11,14-二十碳二烯酸C20:2 |
Endogenous Metabolite | Metabolism |
Eicosadienoic acid 是天然存在的 n-6 多不饱和脂肪酸,主要再动物组织中获得。 | |||
T0846 |
L-Carnitine
L(-)-Carnitine,Levocarnitine,左旋肉碱 |
Endogenous Metabolite; Fatty Acid Synthase | Metabolism |
L-Carnitine (L(-)-Carnitine) 是一种人内源性分子,在人体内以蛋氨酸和赖氨酸为底物进行生物合成,并参与脂肪酸代谢。L-Carnitine 将长链脂肪酰辅酶A 转运到线粒体。L-Carnitine 能够改善许多先天性代谢错误的代谢失衡。 | |||
T5368 |
Eicosapentaenoic Acid
|
Histone Demethylase; Others; Endogenous Metabolite | Chromatin/Epigenetic; Metabolism; Others |
Eicosapentaenoic Acid 是一种 ω-3 脂肪酸。 | |||
TN1965 |
N-Benzyllinolenamide
N-苄基-(9Z,12Z,15Z)-十八碳三烯酰胺,N-Benzyllinolenamide |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
N-Benzyllinolenamide 是从玛卡中得到的一种生物碱,是脂肪酰胺水解酶抑制剂,IC50 为 41.8 μM。 | |||
T10024 |
1-Octanol
Octanol,正辛醇 |
Calcium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
1-Octanol (Octanol) 是一种饱和脂肪醇,是一种 T 型钙通道抑制剂,对天然 T 电流的IC50为 4 μM。它是一种具有类似柴油特性的极具吸引力的生物燃料。 | |||
T3121 |
Betulin
Trochol,betulinic alcohol,betuline,betulinol,桦木醇,Betulol,白桦脂醇 |
Apoptosis; Endogenous Metabolite; Lipid; Fatty Acid Synthase | Apoptosis; Metabolism |
Betulin (betulinol) 是从桦树树皮中分离出来的一种天然三萜,是 SREBP 抑制剂。 | |||
T7464 |
3,3-Dimethylglutaric acid
3,3-二甲基戊二酸,3,3-Dimethylpentanedioate |
Others; Endogenous Metabolite | Metabolism; Others |
3,3-Dimethylglutaric acid (3,3-Dimethylpentanedioate) 是一种甲基支化脂肪酸,是一种人尿中偶见的内源性代谢物。 | |||
T19180 |
Adrenic Acid
二十二碳四烯酸,廿二碳四烯酸,cis-7,10,13,16-Docosatetraenoic acid |
Endogenous Metabolite | Metabolism |
Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) 是一种天然的多不饱和脂肪酸,主要存在于肾上腺,肾脏,大脑和脉管系统中。Adrenic Acid 能够调节肾上腺皮质血管的血管紧张度。Adrenic Acid 也是非酒精性脂肪肝疾病的炎症增强剂。 | |||
T3919 |
Ginsenoside Rb2
Ginsenoside C,人参皂苷 Rb2,人参皂苷Rb2 |
GPR; Others; Influenza Virus; Endogenous Metabolite | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Others |
Ginsenoside Rb2 (Ginsenoside C) 是人参提取物中的一种主要生物活性成分,具有抗病毒活性,可上调 GPR120 基因表达。 | |||
T12139 |
N-(3-Methoxybenzyl)Palmitamide
N-(3-甲氧基苄基)十六碳酰胺,玛卡酰胺杂质5 |
FAAH | Metabolism; Neuroscience |
N-(3-Methoxybenzyl)Palmitamide 是FAAH 抑制剂,可用于研究疼痛,炎症和中枢神经系统退行性疾病。 | |||
T3S2105 |
N-Benzylpalmitamide
Macamide 1,玛卡酰胺 B,N-苄基十六烷酰胺,N-Benzylhexadecanamide |
Others; FAAH; Autophagy | Autophagy; Metabolism; Neuroscience; Others |
N-Benzylpalmitamide (Macamide 1) 是从玛卡中得到的一种生物碱,可以时间依赖性方式抑制脂肪酸酰胺水解酶,有治疗疼痛、炎症和中枢神经系统退行性疾病的研究潜力。 | |||
T3950 |
Tridecanoic acid
n-Tridecoic Acid,n-Tridecanoic Acid,十三酸,Tridecylic Acid |
Others; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology; Others |
Tridecanoic acid (Tridecylic Acid) 是一种存在于乳制品中的 13 碳饱和脂肪酸,也是正十六烷厌氧生物降解的产物。 它是磷脂酶 A2 的底物,可作为抗粘剂和抗生物膜剂,用于研究细菌感染。它抑制大肠杆菌的持久性和生物膜形成。 | |||
T3322 |
trans-Chalcone
Chalcone,反-查耳酮,查尔酮,Cinnamophenone,Chalkone |
Apoptosis; Others; Antifungal; Fatty Acid Synthase | Apoptosis; Metabolism; Microbiology/Virology; Others |
trans-Chalcone (Chalkone) 是从 Aronia melanocarpa 果皮中分离出来的一种天然产物,是类黄酮前体的双酚核心结构。它是脂肪酸合酶和 α-淀粉酶的抑制剂,具有抗真菌和抗癌活性。 | |||
T19676 |
Tributyrin
NSC661583,NSC 661583,NSC-661583,甘油三丁酸酯 |
Apoptosis | Apoptosis |
Tributyrin (Glyceryl tributyrate) 是一种中性短链脂肪酸甘油三酯,是一种稳定且吸收迅速的丁酸前药。 它通过生物膜扩散并被细胞内脂肪酶代谢,在体内将有效的丁酸直接释放到细胞中,有抗增殖、促凋亡和诱导分化作用。 | |||
T1286 |
Vincamine
Angiopac,Oxybral,Devincan,Novicet,Equipur,长春胺,Perval |
GPR; Others | Endocrinology/Hormones; GPCR/G Protein; Others |
Vincamine (Perval) 是从长春花中提取的单萜类吲哚生物碱,可作为外周血管扩张剂,对脑微血管循环有选择性的血管调节作用。它可改善体内葡萄糖稳态,对 2 型糖尿病具有研究潜力。它是GPR40激动剂,通过改善 β 细胞功能障碍和促进葡萄糖刺激型胰岛素分泌发挥 β 细胞保护作用。 | |||
T4P2931 |
Linoleic acid
9,12-octadecadienoic acid,亚油酸,α-亚油酸,acidelinoleique,9,12-Linoleic acid |
Others; Endogenous Metabolite | Metabolism; Others |
Linoleic acid (9,12-octadecadienoic acid) 是一种多不饱和脂肪酸,存在于坚果、种子和植物性油中。它是膜磷脂的一部分,作为膜流动性的结构成分来维持表皮透皮水屏障。它通过氧化作用引起血红蛋白和红细胞损伤。 | |||
T4S1173 |
Agrimol B
仙鹤草酚B,仙鹤草酚 B |
Sirtuin; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Agrimol B 是从仙鹤草中分离得到的一种多酚衍生物,可抑制脂肪形成,降低PPARγ的表达,诱导SIRT1易位和表达。 | |||
T3P2904 |
α-Linolenic acid
Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸 |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
α-Linolenic acid (Alpha-Linolenic Acid) 是一种必需脂肪酸,人体无法合成,从种子油中分离得到。它可调节 PI3K/Akt 信号传导,影响血栓形成过程。它具有抗心律失常的特性,并且与心血管疾病和癌症等有关。 | |||
T4859 |
1-Monomyristin
rac-Glycerol 1-myristate,Glyceryl myristate,1-肉豆蔻酸单甘油酯,肉豆寇酸单甘油酯,Monomyristin,2,3-Dihydroxypropyl tetradecanoate |
Others; FAAH; Endogenous Metabolite; Antibacterial; Autophagy; Antifungal | Autophagy; Metabolism; Microbiology/Virology; Neuroscience; Others |
1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) 是从 Serenoa repens 中提取的,抑制脂肪酸酰胺水解酶活性(IC50=18 μM) 和 2-油酰甘油的水解 (IC50=32 μM)。它对白色念珠菌有抗真菌活性,对金黄色葡萄球菌和聚集性放线菌有抗菌活性。 | |||
TQ0251 |
(Z)-2-decenoic acid
(Z)-dec-2-enoic acid,(Z)-2-癸烯酸,cis-2-Decenoic acid,cis-dec-2-enoic acid |
Others | Others |
(Z)-2-decenoic acid (cis-dec-2-enoic acid) 是一种由铜绿假单胞菌产生的不饱和脂肪酸。它能够诱导一系列革兰氏阴性细菌(包括铜绿假单胞菌)和革兰氏阳性细菌形成的生物膜发生分散反应。它能够抑制生物膜发育。 | |||
T4S1421 |
Praeruptorin B
Praeruptorin D,(+)-川白芷内酯 |
NPC1L1; Fatty Acid Synthase | Membrane transporter/Ion channel; Metabolism |
Praeruptorin B 是一种固醇调控元件结合蛋白(SREBPs)的抑制剂。 | |||
T9514 |
1-Dodecanol
|
Endogenous Metabolite | Metabolism |
1-Dodecanol 是内源性代谢产物的一种。 | |||
T5246 |
Trans-2-butene-1,4-dicarboxylic acid
trans-2-Butene-1,4-dicarboxylic Acid,3-Hexenedioic Acid,trans-3-Hexenedioic Acid,β-Hydromuconic Acid,反式-2-丁烯-1,4-二甲酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Trans-2-butene-1,4-dicarboxylic acid (3-Hexenedioic Acid) 是内源性代谢产物的一种。 | |||
T8049 |
Pentadecanoic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Pentadecanoic acid 是一个具有 15 个碳主链的饱和脂肪酸。 | |||
T5223 |
Heneicosanoic acid
二十一碳酸,Heneicosylic Acid,C21:0 |
Others; Endogenous Metabolite | Metabolism; Others |
Heneicosanoic acid (C21:0) 是广泛存在于动植物中的长链饱和脂肪酸。 | |||
T5369 |
Docosahexaenoic Acid
Cervonic acid,DHA |
Others; Endogenous Metabolite | Metabolism; Others |
Docosahexaenoic Acid 属于天然产物,是一种 ω-3 脂肪酸,在脑和视网膜中较为丰富。Docosahexaenoic Acid 对大脑的生长和功能发育至关重要。 | |||
T8032 |
4-Pentenoic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
4-Pentenoic acid 是内源性代谢产物的一种。 | |||
T8111 |
Triacontanoic Acid
蜂花酸,Melissic acid A |
Others | Others |
Triacontanoic Acid (Melissic acid A) 是一种超长链脂肪酸。 | |||
T6359 |
1-Hexadecanol
鲸蜡醇,Cetanol,cetyl alcohol,Hexadecan-1-ol,1-十六烷醇 |
Others; Endogenous Metabolite | Metabolism; Others |
1-Hexadecanol (Hexadecan-1-ol) 是一种脂肪醇,是亲脂性底物。 | |||
T5295 |
1-Hydroxyoctadecane
硬脂醇,1-Octadecanol,Stearyl alcohol,Octadecanol |
Others; Endogenous Metabolite | Metabolism; Others |
1-Hydroxyoctadecane (OctadecanolOctadecanol) 是内源性代谢产物的一种。 | |||
T18927 |
Br-Mmc
4-Bromomethyl-7-methoxycoumarin,4-溴甲基-7-甲氧基香豆素 |
Others | Others |
Br-Mmc (4-Bromomethyl-7-methoxycoumarin) 常用于荧光标记,可测定含有羧基的化合物。它能够利用 TLC 或 HPLC 测定脂肪酸含量。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03291 |
FABP3 Protein, Rat, Recombinant (His & Myc)
Fabp3,Fatty acid-binding protein 3,Heart-type f... |
Rat | HEK293 Cells |
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. | |||
TMPY-06686 |
FASN Protein, Mouse, Recombinant (His)
fatty acid synthase,FAS,A630082H08Rik |
Mouse | E. coli |
FASN Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 34.23 kDa and the accession number is P19096. | |||
TMPJ-01073 |
FABP5 Protein, Human, Recombinant (His)
Fatty Acid-Binding Protein Epidermal,PA-FABP,FABP5,... |
Human | E. coli |
Fatty acid-binding protein 5 (FABP5) is a cytoplasm protein that belongs to the fatty-acid binding protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids. FABP5 can be expressed in keratinocytes, and is highly expressed in psoriatic skin. FABP5 has been shown to be involved in keratinocyte differentiation. FABP5 has high specificity for fatty acids, the highest affinity for C18 chain... | |||
TMPH-00889 |
FADS2 Protein, Human, Recombinant (His & SUMO)
Delta(6) fatty acid desaturase,FADS2,Fatty... |
Human | E. coli |
FADS2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.9 kDa and the accession number is O95864. | |||
TMPJ-00785 |
FABP3 Protein, Human, Recombinant (His)
H-FABP,FABP11,Fatty Acid-Binding Protein Heart,MDGI... |
Human | E. coli |
Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-types. They form 14-15 kDa proteins and are thought to p... | |||
TMPY-06683 |
FASN Protein, Human, Recombinant (His)
OA-519,fatty acid synthase,FAS,SDR27X1 |
Human | E. coli |
FASN Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 35.26 kDa and the accession number is P49327. | |||
TMPH-00933 |
ADTRP Protein, Human, Recombinant (His & Myc)
Fatty acid esters of hydroxy fatty acids h... |
Human | E. coli |
ADTRP Protein, Human, Recombinant (His & Myc) is expressed in in vitro E. coli expression system. | |||
TMPH-00433 |
Ex-FABP Protein, Coturnix coturnix japonica, Recombinant (His & Myc)
Extracellular fatty acid-binding protein,Lipocalin ... |
Coturnix coturnix japonica | E. coli |
Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor. Ex-FABP Protein, Coturnix coturnix japonica, Recombinant (His & Myc) is expr... | |||
TMPJ-00671 |
FABP7 Protein, Human, Recombinant (His)
Fatty Acid-Binding Protein 7,Mammary-Derived Growth... |
Human | E. coli |
Fatty Acid-Binding Protein 7 (FABP7) is a cytoplasm protein that belongs to the Fatty-acid Binding Protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids. FABP7 is predominately expressed in brain and neural tissues. FABP7 is involved in fatty acid uptake and intracellular transport and is important in brain development. FABP7 plays a critical role in the transport of a so far unknow... | |||
TMPY-01878 |
L-FABP Protein, Human, Recombinant (His)
fatty acid binding protein 1, liver,FABPL,L-FABP |
Human | E. coli |
Fatty acid-binding protein, liver, also known as Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, FABP1 and FABPL,is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is t... | |||
TMPY-02051 |
FABP2 Protein, Human, Recombinant (His)
MGC133132,fatty acid binding protein 2,FABPI,I-FABP |
Human | E. coli |
Fatty acid binding protein (FABP) is one of the intracellular proteins, with a low molecular weight of approximately 15 kDa, that plays important roles in the transportation and metabolism of long-chain fatty acids. FABP family proteins could be used as tissue specific injury marker based on the following characteristics of FABP. The intestinal fatty acid binding protein (I-FABP), or fatty acid-binding protein 2 (FABP2), an intracellular protein expressed only in the intestine, involved in the a... | |||
TMPY-01482 |
FABP4 Protein, Mouse, Recombinant (His)
ALBP/Ap2,Lbpl,422/aP2,Ap2,fatty acid binding protei... |
Mouse | HEK293 Cells |
FABP4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is P04117. | |||
TMPY-02239 |
FABP3 Protein, Human, Recombinant
O-FABP,M-FABP,FABP11,MDGI,fatty acid binding protei... |
Human | E. coli |
FABP3 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P05413. | |||
TMPY-02174 |
FABP5 Protein, Human, Recombinant
PA-FABP,E-FABP,fatty acid binding protein 5 (psoria... |
Human | E. coli |
Fatty acid-binding protein, also known as Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog, E-FABP and FABP5, is a cytoplasm protein which Belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid-binding proteins ( FABPs ) are postulated to serve as lipid shuttles that solubilize hydrophobic fatty acids and deliver them to appropriate intracellular sites. E-FABP / FABP5 is pre... | |||
TMPY-00605 |
FABP3 Protein, Mouse, Recombinant
Fabph1,Fabph-1,Fabph4,fatty acid binding protein 3,... |
Mouse | E. coli |
FABP3 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14.8 kDa and the accession number is P11404. | |||
TMPH-03520 |
ACP Protein, S. aureus, Recombinant (His & SUMO)
acpP,Cytosolic-activating factor,Fatty acid synthas... |
Staphylococcus aureus | E. coli |
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced. ACP Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 24.5 kDa and the accession number is P0A001. | |||
TMPY-01118 |
SLC27A4/FATP4 Protein, Human, Recombinant (His)
FATP4,IPS,solute carrier family 27 (fatty acid tran... |
Human | HEK293 Cells |
SLC27A4/ATG4B complex might act as a new potential therapeutic target of lung tumor chemotherapy. The solute carrier 27A (SLC27A) gene family encodes fatty acid transport proteins (FATPs) and includes 6 members. Autism spectrum disorders (ASD) are now recognized as disorders caused by impaired early brain development, it is possible that functional abnormalities of SLC27A genes may contribute to the pathogenesis of ASD. The expression of SLC27A3 and SLC27A4 in human neural stem cells derived fro... | |||
TMPY-02103 |
FABP4 Protein, Human, Recombinant (29 Ala/Thr, His)
HEL-S-104,fatty acid binding protein 4, adipocyte,A... |
Human | E. coli |
FABP4 Protein, Human, Recombinant (29 Ala/Thr, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 16 kDa and the accession number is P15090. | |||
TMPY-03276 |
BLBP Protein, Human, Recombinant
fatty acid binding protein 7, brain,FABPB,MRG,B-FAB... |
Human | E. coli |
BLBP, also known as FABP7, is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP7 binds DHA with the highest affinity among all of the FABPs. FABPs may play roles in fatty acid uptake, transport, and metabolism. BLBP is expressed, during development, in radial glia by the activation of notch receptors. It was shown that reelin induces FABP7 expre... | |||
TMPH-03518 |
ACP Protein, S. aureus, Recombinant (GST)
acpP,Fatty acid synthase acyl carrier protein,Acyl ... |
Staphylococcus aureus | E. coli |
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced. ACP Protein, S. aureus, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 35.5 kDa and the accession number is P0A001. | |||
TMPH-03431 |
ACC1 Protein, S. cerevisiae, Recombinant (aa 217-775, His)
Acetyl-CoA carboxylase,ACC,Fatty acid synthetase 3,... |
Saccharomyces cerevisiae | E. coli |
Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole. ACC1 Protein, S. cerevisiae, Recombinant (aa 217-775, His) is expressed in E. coli expression system with N-10xHis tag. The predicted m... | |||
TMPH-03432 |
ACC1 Protein, S. cerevisiae, Recombinant (aa 2-581, His)
mRNA transport-defective protein 7,Acetyl-CoA carboxylase, |
Saccharomyces cerevisiae | E. coli |
Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole. ACC1 Protein, S. cerevisiae, Recombinant (aa 2-581, His) is expressed in E. coli expression system with N-10xHis tag. The predicted mol... | |||
TMPH-00572 |
ACP Protein, E. coli, Recombinant (His & SUMO)
acpP,Fatty acid synthase acyl carrier protein,Cytos... |
E. coli | E. coli |
Carrier of the growing fatty acid chain in fatty acid biosynthesis. | |||
TMPH-03519 |
ACP Protein, S. aureus, Recombinant (His)
Cytosolic-activating factor,Fatty acid synthase acy... |
Staphylococcus aureus | P. pastoris (Yeast) |
Carrier of the growing fatty acid chain in fatty acid biosynthesis. Is able to confer high methicillin resistance to S.aureus when overproduced. ACP Protein, S. aureus, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 10.5 kDa and the accession number is P0A001. | |||
TMPH-02491 |
SCD1 Protein, Mouse, Recombinant (His & Myc)
Stearoyl-CoA desaturase 1,Scd1,Delta(9)-desaturase 1,Fat... |
Mouse | E. coli |
SCD1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.4 kDa and the accession number is P13516. | |||
TMPY-02249 |
FABP6 Protein, Human, Recombinant
I-BABP,I-BAP,ILLBP,I-15P,ILBP3,I-BALB,ILBP,fatty ac... |
Human | E. coli |
Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Isoform2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform1of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isof... | |||
TMPH-01325 |
FAAH2 Protein, Human, Recombinant (His)
Amidase domain-containing protein,Anandamide amidohydrolase ... |
Human | E. coli |
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. FAAH2 Protein, Human, Recombinant (His) is expressed in E. coli e... | |||
TMPH-03448 |
EHT1 Protein, S. cerevisiae, Recombinant (His)
EHT1,Ethanol hexanoyl transferase 1,Alcohol O-acetyltransfer... |
Saccharomyces cerevisiae | E. coli |
Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification. EHT1 Protein, S. cerevisiae, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 57.3 kDa and the accession number is P38295. | |||
TMPJ-00292 |
CD36 Protein, Human, Recombinant (hFc)
FATCHDS7,Glycoprotein IIIb,SCARB3,CD36,Fatty acid t... |
Human | HEK293 Cells |
Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition rece... | |||
TMPH-00160 |
Cytochrome P450 BM-3 Protein, Bacillus megaterium, Recombinant (His & Myc)
cyp102A1,Bifunctional cytochrome P450/NADPH--P450 reductase,... |
Bacillus megaterium | E. coli |
Cytochrome P450 BM-3 Protein, Bacillus megaterium, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-02764 |
ACSL4 Protein, Mouse, Recombinant (His)
LACS 4,mACS4,Long-chain-fatty-acid--CoA ligase 4,Ac... |
Mouse | E. coli |
ACSL4 Protein, Mouse, Recombinant (His) is expressed in E. coli. | |||
TMPH-02825 |
ACOX1 Protein, Mouse, Recombinant (Myc)
AOX,Peroxisomal fatty acyl-CoA oxidase,EC:1.3.3.6,P... |
Mouse | E. coli |
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway.; Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length.; Is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA. | |||
TMPH-00955 |
ALOX12 Protein, Human, Recombinant (His)
Polyunsaturated fatty acid lipoxygenase ALOX12,LOG1... |
Human | E. coli |
ALOX12 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPJ-00529 |
FABP6 Protein, Human, Recombinant (His)
Ileal Lipid-Binding Protein,I-BABP,Intestinal Bile Acid-Bind... |
Human | E. coli |
Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine to the ileum where it is involved in the enterohepatic circulation of bile acids. FABP6 forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level)... | |||
TMPY-02481 |
ACOX1 Protein, Human, Recombinant (His)
PALMCOX,ACOX,SCOX,acyl-CoA oxidase 1, palmitoyl |
Human | Baculovirus Insect Cells |
Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a... | |||
TMPH-02646 |
Erythroferrone Protein, Mouse, Recombinant (His)
Erythroferrone,Myonectin,Erfe,Complement C1q tumor necrosis ... |
Mouse | P. pastoris (Yeast) |
Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Erythroferrone Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted m... | |||
TMPH-03524 |
KAS III Protein, S. aureus, Recombinant (His & Myc)
3-oxoacyl-[acyl-carrier-protein] synthase 3,3-oxoacyl-[acyl-... |
Staphylococcus aureus | E. coli |
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids. KAS III Protein, S. au... | |||
TMPH-01634 |
MLYCD Protein, Human, Recombinant (His & Myc)
MLYCD,Malonyl-CoA decarboxylase, mitochondrial |
Human | E. coli |
Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic ... | |||
TMPH-02618 |
CYP2E1 Protein, Mouse, Recombinant (His)
Cyp2e1,Cytochrome P450 2E1,Cytochrome P450-J,4-nitrophenol 2... |
Mouse | E. coli |
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be invo... | |||
TMPH-03755 |
Ppard Protein, Human, Recombinant (His)
NUCI,Peroxisome proliferator-activated receptor delta,PPARD,... |
Human | E. coli |
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by... | |||
TMPY-01140 |
ACOT13/THEM2 Protein, Human, Recombinant (His)
THEM2,HT012,ACOT13,PNAS-27,acyl-CoA thioesterase 13 |
Human | E. coli |
The metabolites of fatty acyl-Coenzyme A (CoA) and metabolic enzymes contribute to lipid biosynthesis, signal transduction, and gene transcription. Members of the acyl-CoA thioesterase (Acot) gene family hydrolyze fatty acyl-CoAs, but their biological functions remain incompletely understood. Thioesterase superfamily member 2 (Them2; synonym Acot13) is enriched in oxidative tissues, associated with mitochondria, and relatively specific for long chain fatty acyl-CoA substrates. Using Them2(-/-) m... | |||
TMPJ-00834 |
ACADM Protein, Human, Recombinant (His)
ACADM,Medium-Chain Specific Acyl-CoA Dehydrogenase Mitochond... |
Human | E. coli |
Medium-Chain Specific Acyl-CoA Dehydrogenase (ACADM) is a mitochondrial fatty acid beta-oxidation that belongs to the acyl-CoA dehydrogenase family. ACADM is a homotetramer enzyme that catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. ACADM is specific for acyl chain lengths of 4 to 16. It is essential for converting these particular fatty acids to energy, especially during fasting periods. Defects in ACADM cause medium-chain acyl-CoA dehydrogenase deficiency, a ... | |||
TMPK-00764 |
Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (hFc)
Apolipoprotein A-II(1-76),Apolipoprotein A-II,Apo-AII,APOA2,... |
Human | HEK293 Cells |
APOA2 is a protein implicated in triglyceride, fatty acid and glucose metabolism. In pigs, the APOA2 gene is located on pig chromosome 4 (SSC4) in a QTL region affecting fatty acid composition, fatness and growth traits. Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 36.1 kDa and the accession number is P02652. | |||
TMPK-00795 |
Apolipoprotein A-II/APOA2 Protein, Mouse, Recombinant (hFc)
APOA2,Apolipoprotein A-II(1-76),Apolipoprotein A-II,Apolipop... |
Mouse | HEK293 Cells |
APOA2 is a protein implicated in triglyceride, fatty acid and glucose metabolism. In pigs, the APOA2 gene is located on pig chromosome 4 (SSC4) in a QTL region affecting fatty acid composition, fatness and growth traits. Apolipoprotein A-II/APOA2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 36.2 kDa and the accession number is P09813. | |||
TMPH-01410 |
GPR84 Protein, Human, Recombinant (hFc)
G-protein coupled receptor 84,GPR84,Inflammation-related G-p... |
Human | P. pastoris (Yeast) |
Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system. GPR84 Protein, Human, Recom... | |||
TMPH-02822 |
PNLIP Protein, Mouse, Recombinant (His & SUMO)
Pancreatic triacylglycerol lipase,Pnlip |
Mouse | E. coli |
Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones. PNLIP Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 65.8 kDa and the accession number is Q6P8U6. | |||
TMPH-03711 |
PPAR gamma Protein, Xenopus laevis, Recombinant (His)
Nuclear receptor subfamily 1 group C member 3,Peroxisome pro... |
Xenopus laevis | E. coli |
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm. | |||
TMPH-03337 |
MGLL Protein, Rat, Recombinant (His)
Mgll,Monoacylglycerol lipase,Monoglyceride lipase |
Rat | P. pastoris (Yeast) |
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. MGLL Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.8 kDa and the accession nu... | |||
TMPH-00564 |
FabG Protein, E. coli, Recombinant (His & Myc)
Beta-Ketoacyl-acyl carrier protein reductase,fabG,Beta-ketoa... |
E. coli | E. coli |
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. | |||
TMPH-02716 |
HADH Protein, Mouse, Recombinant (His & SUMO)
Short-chain 3-hydroxyacyl-CoA dehydrogenase,Hydroxyacyl-coen... |
Mouse | E. coli |
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. HADH Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T35791 |
Palmitic acid-13C
|
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Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ... | |||
T40141 |
Palmitic acid-13C16 sodium
Palmitic acid-13C16 sodium |
||
Palmitic acid-13C16 sodium, a 13C-labeled form of the naturally occurring saturated fatty acid Palmitic acid sodium, is prevalent in animals and plants. This compound can trigger the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells. | |||
T35698 |
Octanoic Acid-13C
|
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Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d... | |||
T40980 |
Palmitic acid-13C2
Palmitic acid-13C2 |
||
Palmitic acid-13C2 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. | |||
T39423 |
Palmitic acid-13C sodium
|
||
Sodium palmitate-13C is the 13C-labeled variant of palmitic acid, a long-chain saturated fatty acid prevalent in animals and plants. This compound has been shown to induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in mouse granulosa cells. | |||
T35695 |
Oleic Acid-13C
|
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Oleic acid-13C is intended for use as an internal standard for the quantification of oleic acid by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.1,2 It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1 Oleic acid inhibits collagen-stimulated platelet aggregation by approximate... | |||
TMIJ-0379 |
Eicosapentaenoic Acid-d5
|
||
Eicosapentaenoic Acid-d5 是 Eicosapentaenoic Acid 的氘代化合物。Eicosapentaenoic Acid 的 CAS 号为 10417-94-4。Eicosapentaenoic Acid 是一种 ω-3 脂肪酸。 | |||
TMIJ-0090 |
L-Carnitine-d9
|
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L-Carnitine-d9 是 L-Carnitine 的氘代化合物。L-Carnitine 的 CAS 号为 541-15-1。L-carnitine 是一种人内源性分子,在人体内以蛋氨酸和赖氨酸为底物进行生物合成,并参与脂肪酸代谢。L-Carnitine 将长链脂肪酰辅酶A转运到线粒体。L-Carnitine 能够改善许多先天性代谢错误的代谢失衡。 | |||
T36149 |
13C C16 Sphingomyelin (d18:1/16:0)
|
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13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in or... | |||
TMIJ-0049 |
4-Methylpentanoic-d11 acid
|
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4-Methylpentanoic-d11 acid 是 4-Methylpentanoic acid 的氘代化合物。4-Methylpentanoic acid 的 CAS 号为 646-07-1。4-Methylpentanoic acid 是一种短链脂肪酸 (SCFA). | |||
T35789 |
Palmitic acid-1-13C
|
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Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 |1. Santos, M.J., López-Jurado, M., Llopis, J., et a... | |||
T35697 |
Lauric Acid-13C
|
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Lauric acid-13C is intended for use as an internal standard for the quantification of lauric acid by GC- or LC-MS. Lauric acid is a medium-chain saturated fatty acid. It has been found at high levels in coconut oil.1Lauric acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.2 | |||
TMID-0264 |
Docosanoic-7,7,8,8-d4 Acid
|
||
Docosanoic-7,7,8,8-d4 Acid 是 Docosanoic Acid 的氘代化合物。Docosanoic Acid 的 CAS 号为 112-85-6。Docosanoic acid 是一种较难吸收的饱和脂肪酸,能提高人类胆固醇水平。 | |||
T70882 |
Orlistat-d3
|
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Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit... | |||
TMIJ-0373 |
Biotin-d2
|
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Biotin-d2 是 Biotin 的氘代化合物。Biotin 的 CAS 号为 58-85-5。Biotin 是一种水溶性B族维生素,是细胞生长、脂肪酸产生以及脂肪和氨基酸代谢所必需的。 | |||
T35790 |
Palmitic acid-1,2,3,4-13C4
Palmitic Acid-13C (C1, C2, C3, and C4 labeled) |
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Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula... | |||
TMID-0040 |
Palmitoyl L-Carnitine-d3 Hydrochloride
|
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Palmitoyl L-Carnitine-d3 Hydrochloride 是 Palmitoyl L-Carnitine Hydrochloride 的氘代化合物。Palmitoyl L-Carnitine Hydrochloride 的 CAS 号为 18877-64-0。L-Palmitoylcarnitine chloride (Palmitoyl-L-carnitine chloride)是一种脂肪酸代谢产物,具有抗血栓形成的作用,通过抵消tMCAO模型中的脑内血栓形成来保护小鼠免受缺血性中风。L-Palmitoylcarnitine chloride抑制心脏中的Na/K泵,抑制 FeCl 3诱导的动脉血栓形成,减轻了短暂性大脑中动脉闭塞(tMCAO)小鼠模型的脑内血栓形成和炎症。 | |||
TMID-0177 |
Palmitic acid-16,16,16-d3
|
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Palmitic acid-16,16,16-d3 是 Palmitic acid 的氘代化合物。Palmitic acid 的 CAS 号为 57-10-3。Palmitic acid 是在动物、植物和微生物中发现的最常见的饱和脂肪酸,具有抗肿瘤活性。它可诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 和 CCAAT/增强子结合蛋白同源蛋白的表达。 | |||
TMIJ-0094 |
Trimetazidine-d8 Dihydrochloride
|
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Trimetazidine-d8 Dihydrochloride 是 Trimetazidine Dihydrochloride 的氘代化合物。Trimetazidine Dihydrochloride 的 CAS 号为 13171-25-0。Trimetazidine dihydrochloride 是细胞保护性抗缺血剂,也用作缺血性心脏病或心绞痛的血管扩张剂,具有抗氧化,抗炎,抗伤害和胃保护作用。它可通过抑制脂肪酸代谢提高心肌葡萄糖利用率。 | |||
TMIJ-0051 |
Hexanoic-d11 acid
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Hexanoic-d11 acid 是 Hexanoic acid 的氘代化合物。Hexanoic acid 的 CAS 号为 142-62-1。Caproic acid 是一种无色油状液体,闻起来像奶酪。它是一种天然存在于各种动物脂肪和油中的脂肪酸。它是一种抗性引发诱导剂,可保护番茄植物免受灰霉病菌的侵害。 | |||
TMIJ-0377 |
Thiamine Hydrochloride-13C4
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Thiamine Hydrochloride-13C4 是 Thiamine Hydrochloride 的 13C 的标记化合物。Thiamine Hydrochloride 的 CAS 号为 67-03-8。Thiamine hydrochloride 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。 | |||
TMIJ-0050 |
Butyricacid-d7
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Butyricacid-d7 是 Butyricacid 的氘代化合物。Butyricacid 的 CAS 号为 107-92-6。Butyric acid 是一种从许多乳制品中分离出来的脂肪酸,具有抗癌活性。 它抑制组蛋白去乙酰化酶 (HDAC) 并诱导胶质瘤细胞凋亡和 G1 期细胞周期停滞。此外,它在低剂量时刺激上皮细胞增殖,在高剂量时抑制增殖。 | |||
T69395 |
Nicotinamide-d4
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Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl... | |||
TMID-0120 |
Valproic Acid-d15
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Valproic Acid-d15 是 Valproic Acid 的氘代化合物。Valproic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂,可抑制HDAC1的活性,同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。 | |||
TMIJ-0163 |
Valproic Acid-d4
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Valproic Acid-d4 是 Valproic Acid 的氘代化合物。Valproic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂,可抑制HDAC1的活性,同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。 | |||
TMIJ-0431 |
2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid
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2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid 是 2-pentanoic Acid 的氘代化合物。2-pentanoic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂,可抑制HDAC1的活性,同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。 | |||
TMIJ-0047 |
Isobutyric-d6 acid
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Isobutyric-d6 acid 是 Isobutyric acid 的氘代化合物。Isobutyric acid 的 CAS 号为 79-31-2。Isobutyric acid 是一种羧酸或短链脂肪酸,具有特征性的汗味。通过微生物(肠道)代谢产生少量异丁酸。在某些食物或发酵饮料中也可能发现少量。 | |||
TMIJ-0053 |
2-Methylpropionic-d7 acid
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2-Methylpropionic-d7 acid 是 2-Methylpropionic acid 的氘代化合物。2-Methylpropionic acid 的 CAS 号为 79-31-2。Isobutyric acid 是一种羧酸或短链脂肪酸,具有特征性的汗味。通过微生物(肠道)代谢产生少量异丁酸。在某些食物或发酵饮料中也可能发现少量。 | |||
TMIJ-0054 |
Propionic-2,2-d2 acid
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Propionic-2,2-d2 acid 是 Propionic acid 的氘代化合物。Propionic acid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中,并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中,作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。 | |||
TMIJ-0052 |
Propionicacid-d5
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Propionicacid-d5 是 Propionicacid 的氘代化合物。Propionicacid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中,并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中,作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。 |