Melinamide

Name: Melinamide
Brand: TargetMol
SKU: T16036
Rating: 4.5 (1 reviews)

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产品编号 T16036Cas号 14417-88-0

别名 甲亚油酰胺, DL-N-(α-Methylbenzyl)linoleamide, AC 223

Melinamide is an amide derivative of an unsaturated long-chain fatty acid and also is an inhibitor of cholesterol absorption (IC50: 20.9 μM).

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产品编号 T16036 别名 甲亚油酰胺, DL-N-(α-Methylbenzyl)linoleamide, AC 223Cas号 14417-88-0

Melinamide is an amide derivative of an unsaturated long-chain fatty acid and also is an inhibitor of cholesterol absorption (IC50: 20.9 μM).

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生物活性

产品描述	Melinamide is an amide derivative of an unsaturated long-chain fatty acid and also is an inhibitor of cholesterol absorption (IC50: 20.9 μM).
靶点活性	Cholesterol:20.9 μM
体外活性	D-Melinamide is found to be a more effective inhibitor than L-Melinamide. DL-Melinamide suppresses acyl CoA: cholesterol acyltransferase activity (ACAT) in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 μM. Kinetic studies indicate that DL-Melinamide is an uncompetitive inhibitor of acyl CoA: cholesterol acyltransferase [2].
体内活性	Melinamide induces a substantial decrease in the enhanced intestinal ACAT activity in diabetic rats but does not affect intestinal cholesterol esterase activity. Melinamide is a new hypocholesterolaemic drug. A marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurs concomitantly with the drug treatment[3].
别名	甲亚油酰胺, DL-N-(α-Methylbenzyl)linoleamide, AC 223