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CP-640186 hydrochloride (CP 640186 HCl) 是膜渗透性的乙酰辅酶A 羧化酶(ACC)抑制剂,抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的IC50为53 nM 和61 nM。
CP-640186 hydrochloride (CP 640186 HCl) 是膜渗透性的乙酰辅酶A 羧化酶(ACC)抑制剂,抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的IC50为53 nM 和61 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 315 | 现货 | |
2 mg | ¥ 453 | 现货 | |
5 mg | ¥ 747 | 现货 | |
10 mg | ¥ 1,190 | 现货 | |
25 mg | ¥ 2,490 | 现货 | |
50 mg | ¥ 3,950 | 现货 | |
100 mg | ¥ 5,630 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 858 | 现货 |
产品描述 | CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431. |
靶点活性 | ACC1:53 nM, ACC2:61 nM |
激酶实验 | Aconitase activities are determined by homogenization of mouse brain tissues on ice at 10% w/v in CellLytic MT Mammalian Tissue Lysis/Extraction buffer, followed by centrifugation at 800×g?for 10?min at 4°C. Tissue lysates (50?μL) are then added to 200?μL of substrate mix (50?mM Tris/HCl pH 7.4, 0.4?mM NADP, 5?mM Na citrate, 0.6?mM MgCl2, 0.1% (v/v) Triton X-100 and 1U isocitrate dehydrogenase) and the reactions are incubated at 37°C for 15?min, followed by spectrophotometric absorbance measurements every minute for 15?min at 340?nm 37°C to determine the reaction slope. Aconitase activities of mouse brain tissues are then normalized to citrate synthase activities, which are determined using a citrate synthase assay kit. |
别名 | 盐酸CP-640186, CP 640186 HCl |
分子量 | 522.08 |
分子式 | C30H36ClN3O3 |
CAS No. | 591778-70-0 |
Smiles | Cl.O=C([C@@H]1CCCN(C1)C1CCN(CC1)C(=O)c1c2ccccc2cc2ccccc12)N1CCOCC1 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (95.77 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
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