Secretin (swine), a neuroendocrine hormone first identified as secreted by S cells in the duodenal mucosa, is a 27-amino acid peptide targeting secretin receptors. Present in all mature enteroendocrine cell subsets, it is stimulated by fatty acids and promotes pancreatic secretion of water and bicarbonate. Secretin has diverse effects on organ systems and is utilized in research on the digestive system, central nervous system, and energy metabolism [1] [2].

秘丁素（猪源）（10^-7 M、10^-6 M；24至72小时及7天）通过与秘丁素受体（SR）相互作用促进胆汁生长，而敲除SR会通过下调cAMP依赖性信号传导降低胆汁增生[2]。

秘丁肽（swine）（每日每公斤体重2.5纳摩尔，采用渗透微型泵注射，持续1周）通过调节小鼠microRNA 125b及microRNA let7a的表达，刺激胆管细胞增殖[2]。