Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA) is the R enantiomer of (Rac)-Idroxioleic acid. It is an orally active fatty acid known for its ability to modulate the lipid composition and structure of membranes. With demonstrated antitumor activities, Idroxioleic acid plays a significant role in the field of cancer research.
产品描述 | Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA) is the R enantiomer of (Rac)-Idroxioleic acid. It is an orally active fatty acid known for its ability to modulate the lipid composition and structure of membranes. With demonstrated antitumor activities, Idroxioleic acid plays a significant role in the field of cancer research. |
体外活性 | Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA) inhibited the growth of A549, lung adenocarcinoma cell line with an IC 50 of 252 μM[1]. |
体内活性 | Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA; 400 mg/kg; p.o.; daily; for 21 days) causes a reduction in tumor volume of about 20-25% after 21 days[1]. Animal Model: Male NUDE (Swiss) Crl:NU(Ico)-Foxn1nu mice (5 weeks old, 30-35 g) injected with A549 human lung cancer cells[1]Dosage: 400 mg/kg Administration: p.o.; daily; for 21 days Result: Caused a reduction in tumor volume of about 20-25% after 21 days. |
别名 | (R)-2-Hydroxyoleic acid, (R)-2-OHOA |
分子量 | 298.467 |
分子式 | C18H34O3 |
CAS No. | 182370-45-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Idroxioleic acid 182370-45-2 Others (R)-2-Hydroxyoleic acid 2-OHOA (R)-2-OHOA 2-Hydroxyoleic acid Inhibitor inhibitor inhibit