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Search Results for " carcinoma "

Targets Recommended: Raf Ras

296

抑制剂 & 化合物

131

天然产物

117

重组蛋白

7

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1892	Kobe2602	Raf; Ras	GPCR/G Protein; MAPK
	Kobe2602 是 Ras-Raf 相互作用抑制剂，具有抗癌化疗活性。它抑制 H-Ras·GTP 与 c-Raf-1 RBD 结合的Ki 值为 149 μM。
T26046	Razoxane	Topoisomerase	DNA Damage/DNA Repair
	Razoxane 是拓扑异构酶 II 的有效抑制剂，具有抗血管生成的作用，在肾细胞癌中具有研究价值。
T9693	TBAP-001	Raf	MAPK
	TBAP-001是RAF 激酶的泛抑制剂，IC50为 62 nM。
T26889	Borofalan(10B) L-4-Boronophenylalanine,4-10硼酸-L-苯丙氨酸	Others	Others
	Borofalan(10B) (L-4-Boronophenylalanine) 具有抗肿瘤作用，可用于研究复发性或局部晚期头颈癌。
T23372	SMIFH2	Others	Others
	SMIFH2 是formin 特异性抑制剂。它利用 Formins 阻碍肌动蛋白聚合，影响肌动蛋白细胞骨架。
T6683	STF-62247 STF 62247	Estrogen/progestogen Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	STF-62247 是一种自噬诱导剂，在 RCC4 和 RCC4/VHL 细胞中的IC50分别为 0.625 μM 和 16 μM。它对 VHL 缺陷型肾细胞癌有选择性的细胞毒性。
T15371	Gardiquimod	TLR; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Gardiquimod 可抑制巨噬细胞和活化的外周血单个核细胞的HIV-1感染。它是一种咪唑喹啉类似物，是一种 TLR7/8 激动剂。
T2282	RPI-1	Others; Phospholipase; c-Met/HGFR; c-RET	Apoptosis; Metabolism; Others; Tyrosine Kinase/Adaptors
	RPI1 是特异性的、口服具有活力的 2-吲哚啉酮Ret 酪氨酸激酶抑制剂，具有抗肿瘤作用。它能够抑制人甲状腺髓样癌 TT 细胞增殖、Ret 酪氨酸磷酸化、Ret 蛋白表达及 PLCgamma、ERKs 和 AKT 的活化。
T8843	APS6-45	MAPK; Ras	GPCR/G Protein; MAPK
	APS6-45 是一种可口服的肿瘤校准抑制剂，可抑制 RAS/MAPK 信号传导并表现出抗肿瘤活性。
T22661	CHM-1	Apoptosis; Others; Microtubule Associated	Apoptosis; Cytoskeletal Signaling; Others
	CHM-1 是细胞凋亡的诱导剂，通过激活 Cdc2 激酶活性在人肝细胞癌中显示出有效的抗肿瘤能力。 CHM-1 在体外和体内抑制微管蛋白聚合。
T8344	CPTH2	Apoptosis; Histone Acetyltransferase	Apoptosis; Chromatin/Epigenetic
	CPTH2 是一种组蛋白乙酰基转移酶抑制剂。它选择性地抑制Gcn5对组蛋白 H3 的乙酰化，通过抑制乙酰转移酶p300 (KAT3B)诱导凋亡并降低透明细胞肾癌细胞系的侵袭性。
T5521	Bropirimine U-54461,溴匹立明	TLR	Immunology/Inflammation
	Bropirimine (U-54461) 是 toll 样受体 7(TLR7)的合成激动剂，可通过 TLR7 介导 IFN-β 的产生抑制破骨细胞前体细胞向破骨细胞分化。它是一种生物反应调节剂，通过诱导淋巴因子起作用，在膀胱和上尿路的原位移行细胞癌中具有抗癌活性。
T2676	PF-04217903	c-Met/HGFR	Tyrosine Kinase/Adaptors
	PF04217903 是一种高效的、 ATP 竞争性的c-Met 激酶抑制剂(Ki=4.8 nM)，相对于 208 个激酶，PF04217903 显示出 1000 倍以上的选择性。它抗血管生成作用。
T1753	D-64131	Microtubule Associated	Cytoskeletal Signaling
	D64131 是一种微管蛋白聚合抑制剂，IC50 值为 0.53 μM。它具有抗丝分裂活性，可用于癌症研究。
T28410	PHPS1 PHPS-1,PHPS 1	Phosphatase	Metabolism
	PHPS1 是 Shp2的选择性抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的 Ki 分别为 0.73，5.8，10.7，5.8 和 0.47 μM。
T12695	RBN-2397	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RBN-2397 是一种有效的、选择性的、具有口服活性的跨物种 NAD+ 竞争性 PARP7 抑制剂，IC50 小于 3 nM。它选择性结合 PARP7 ，Kd 为0.001 μM，可恢复干扰素 I 型信号转导，有用于晚期或转移性实体肿瘤的研究潜力。
T6932	PD168393	Apoptosis; EGFR; FGFR; IGF-1R; PDGFR; PKC; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD168393 是一种细胞渗透性的选择性 EGFR 酪氨酸激酶和 ErbB2的抑制剂。它不可逆转地失活 EGF 受体，IC50值为 0.7 nM，但对胰岛素受体、PDGFR、FGFR 和 PKC 无作用。
T27730	KGP94 KGP-94,KGP 94	Cysteine Protease	Proteases/Proteasome
	KGP94 是一种有效的、选择性的和竞争性的溶酶体内肽酶抑制剂。
TQ0157	EIPA L593754,MH 12-43	Sodium Channel; TRP/TRPV Channel	Membrane transporter/Ion channel
	EIPA (L593754) 是一种有效的TRPP3 channel 抑制剂，IC50为 10.5 μM。EIPA 对Na+/H+交换 (NHE) 和巨噬细胞也有抑制作用。
T12148	N-Desmethyltamoxifen hydrochloride	Estrogen Receptor/ERR; Endogenous Metabolite; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism
	N-Desmethyltamoxifen hydrochloride 是 Tamoxifen 在人体内主要的三苯氧胺代谢物。它是蛋白激酶 C 抑制剂，也是人体 AML 细胞神经酰胺代谢的有效调节因子，可限制神经酰胺糖基化、水解和鞘氨醇磷酸化。
T15771	Lobaplatin D-19466,络铂	DNA Alkylation	DNA Damage/DNA Repair
	Lobaplatin (D-19466) 是一种铂 (II) 复合物的非对映混合物，是一种有前途的抗肿瘤化疗药物，在多种肿瘤类型的患者中具有活性。
T9705	TL-895	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	TL-895 是口服有效的，ATP 竞争性的，以及高度选择性和不可逆的BTK 抑制剂，IC50和Ki 分别为 1.5 nM 和 11.9 nM。TL-895在 JAKi 复发/难治性骨髓纤维化、急性髓系白血病、COVID-19 和癌症方面有研究的价值。
T9616	PD-1/PD-L1-IN-10	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-10 是一种口服有效的PD-1/PD-L1抑制剂 (IC50of 2.7 nM)，显示出抗肿瘤活性。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
T22830	GYY4137 GYY 4137 morpholine salt	Others	Others
	GYY4137 (GYY 4137 morpholine salt) 是一种缓释H2S 供体，具有抗炎和抗癌作用，也具有血管扩张和抗高血压活性。
T6609	NMS-E973	HSP	Cytoskeletal Signaling; Metabolism
	NMS-E973 是一种有效且选择性的 Hsp90 抑制剂，与 Hsp90 结合的 DC50小于 10 nM。它能够穿越血脑屏障，具有抗肿瘤效果。
T7008	Vacquinol-1 Vacquinol 1	JNK	MAPK
	Vacquinol-1 能够激活 MAPK 通路，是MKK4特异性激活剂。它可以诱导肝细胞癌细胞凋亡，在多形性胶质母细胞瘤小鼠模型中特异性诱导人胶质母细胞瘤细胞死亡、减缓肿瘤进展并延长生存期。
T19147	5-ALA benzyl ester hydrochloride Benzyl-ALA hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) 是一种原卟啉前体，可用作光检测器。5-ALA benzyl ester hydrochloride 在结肠癌细胞系中可以诱导原卟啉 IX (PPIX) 的积聚。
T4570	Pipobroman Vercyte,A-8103,Amedel,哌泊溴烷	Others; DNA Alkylator/Crosslinker	DNA Damage/DNA Repair; Others
	Pipobroman (Vercyte) 是一种烷基化剂，是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性，可用于癌症研究。
T2455	PFK-015 PFK15,PFK 015	Glucokinase; Autophagy	Autophagy; Metabolism
	PFK-015 (PFK15) 是一种有效的 PFKFB3 抑制剂，对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性，IC50为20 nM。
T1785	Palbociclib PD 0332991,帕博西尼,帕布昔利布	CDK	Cell Cycle/Checkpoint
	Palbociclib (PD 0332991) 是一种 CDK 抑制剂，抑制 CDK4 和 CDK6 (IC50=11/16 nM)，具有口服活性。Palbociclib 具有抗肿瘤活性，有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T2456	Tivozanib 替沃扎尼,AV-951,KRN951	VEGFR; PDGFR; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Tivozanib (KRN951) 是一种选择性的 VEGFR 1/2/3抑制剂，它们的 IC50值分别为0.21 nM、0.16 nM、0.24 nM。
T21505	Suberoyl bis-hydroxamic acid SBHA,软木肟酸,Suberohydroxamic acid	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Suberoyl bis-hydroxamic acid (SBHA) 是一种竞争性且可透过细胞的HDAC1和HDAC3抑制剂，ID50值分别为 0.25 μM 和 0.30 μM。它使肿瘤细胞易于凋亡并促进线粒体凋亡途径，可研究甲状腺髓样癌。
T1199	Mitotane Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦	Apoptosis; AChR	Apoptosis; Neuroscience
	Mitotane (NCI-C04933) 是 DDD 的同分异构体和 DDT 的衍生物，可作用于肾上腺皮质癌，有抗癌活性。
T0334	Rosiglitazone BRL49653,罗格列酮	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone (BRL49653) 是一种 PPARγ 激动剂、TRPC5 激活剂和 TRPM3 抑制剂，具有口服活性。Rosiglitazone 也是一种降糖剂，是噻唑烷二酮类胰岛素增敏剂。
T6481	Droxinostat NS 41080,4-(4-氯-2-甲基苯氧基)-N-羟基丁酰胺	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Droxinostat (NS 41080) 是HDAC3、HDAC6和HDAC8抑制剂，IC50分别为16.9、2.47和1.46 μM。
T28475	Pyrazoloacridine PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	Pyrazoloacridine (PD 115934) 是一种核酸结合剂，在 K562 细胞中抑制 topo I 和 II 的活性，IC50 为 1.25 μM。 Pyrazoloacridine 具有抗癌活性。
T22443	Triglycidyl isocyanurate Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI	Apoptosis	Apoptosis
	Triglycidyl isocyanurate (Teroxirone) 是一种三氮烯三环氧化合物，可通过 p53的激活抑制非小细胞肺癌细胞的生长。它诱导细胞凋亡，具有抗血管生成和抗肿瘤活性，用于癌症研究。
T1520	Aliskiren hemifumarate 阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B	RAAS; Autophagy	Autophagy; Endocrinology/Hormones
	Aliskiren hemifumarate (CGP60536B) 一种可口服非肽肾素抑制剂，IC50为1.5 nM，具有抗高血压活性。
T9945	MNK8 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione	STAT	JAK/STAT signaling; Stem Cells
	MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) 是一种有效的STAT3抑制剂，降低STAT3与DNA 结合的能力，对肝癌细胞也有良好的生长抑制作用。
T0134	Imiquimod 咪喹莫特,R 837,IMQ,S-26308	SARS-CoV; TLR; Autophagy; HSV	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Imiquimod (R 837) 是一种免疫反应修饰剂，可作为 toll 样受体7 激动剂。它有抗病毒和抗肿瘤作用，可研究外生殖器、肛周疣、癌症和 COVID-19。
T22450	Tyrphostin B44, (+) enantiomer 酪氨酸磷酸化抑制剂AG 835	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin B44, (+) enantiomer 是一种表皮生长因子受体 (EGFR) 激酶抑制剂，IC50 为 0.86 μM，活性低于 (-) 对映体。
T6690	T0901317 N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺	Apoptosis; FXR; Liver X Receptor; ROR	Apoptosis; Metabolism
	T0901317 是一种口服有效且高度选择性的LXR 激动剂，对 LXRα 的EC50为 20 nM。它激活FXR，EC50为 5 μM。它是RORα和RORγ双重反向激动剂，Ki 值分别为 132 nM 和 51 nM。它诱导细胞凋亡，并抑制低密度脂蛋白受体缺失小鼠动脉粥样硬化的发展。
T2008	LY294002 LY 294002,NSC 697286,SF 1101	Apoptosis; DNA-PK; Casein Kinase; PI3K; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	LY294002 (SF 1101) 是一种 PI3K 的广谱抑制剂，抑制 PI3Kα、PI3Kδ 和 PI3Kβ (IC50=0.5/0.57/0.97 μM)。LY294002 也是 DNA-PK 抑制剂 (IC50=1.4 μM) 和 CK2 抑制剂 (IC50=98 nM)。LY294002 可以激活凋亡和自噬。
T3061	Lorlatinib 劳拉替尼,PF-6463922,PF-06463922,Loratinib	Apoptosis; Tyrosine Kinases; ROS; ALK; ROS Kinase	Angiogenesis; Apoptosis; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Lorlatinib (PF-6463922) 是一种具有口服活性，选择性，脑渗透性和 ATP 竞争性的ROS1/ALK 抑制剂，具有抗癌活性。它对 ROS1、野生型 ALK 和 ALKL1196M 的Ki 值分别为 <0.025 nM、<0.07 nM 和 0.7 nM。
T6646	Rosiglitazone hydrochloride 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone hydrochloride (BRL-49653 HCl) 是一种降血糖药物，通过与脂肪细胞中的 PPAR 受体结合来刺激胰岛素分泌。它对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。它也是TRPC5的激活剂和TRPM3的抑制剂。
T6240	Palbociclib Isethionate Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐	CDK	Cell Cycle/Checkpoint
	Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。
T6239	Palbociclib monohydrochloride PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl	CDK	Cell Cycle/Checkpoint
	Palbociclib monohydrochloride (PD 0332991 hydrochloride) 是一种口服的细胞周期蛋白依赖性激酶 (CDK) 抑制剂，具有潜在的抗肿瘤活性。它抑制 CDK4和 CDK6，IC50分别为11 nM，16 nM。它有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T4079	LY-294002 hydrochloride SF 1101,LY 294002,NSC 697286	PI3K	PI3K/Akt/mTOR signaling
	LY-294002 hydrochloride (NSC 697286) 是一种合成的 PI3Kα/δ/β 分子抑制剂（IC50：0.5/0.57/0.97 μM，在无细胞试验中）；在溶液中比 Wortmannin 更稳定，也是自噬体形成的阻断剂。
T5002	Methyl Aminolevulinate Hydrochloride 5-Aminolevulinic acid methyl ester,Methyl δ-aminolevulinate hydrochloride,5-氨基酮戊酸甲酯盐酸盐,Methyl 5-aminolevulinate Hydrochloride,Aminolevulinic acid methyl ester Hydrochloride	Others	Others
	Methyl Aminolevulinate Hydrochloride (5-Aminolevulinic acid methyl ester) 是增敏剂，可用于光动力疗法。Methyl aminolevulinate 是一种前药，可代谢为原卟啉 IX。

化合物

Cat.No: T1892

Target: Raf, Ras

Cat.No: T26046

Target: Topoisomerase

Cat.No: T9693

Target: Raf

Cat.No: T26889

Synonym: L-4-Boronophenylalanine,4-10硼酸-L-苯丙氨酸

Target: Others

Cat.No: T23372

Target: Others

Cat.No: T6683

Synonym: STF 62247

Target: Estrogen/progestogen Receptor, Autophagy

Cat.No: T15371

Target: TLR, HIV Protease

Cat.No: T2282

Target: Others, Phospholipase, c-Met/HGFR, c-RET

Cat.No: T8843

Target: MAPK, Ras

Cat.No: T22661

Target: Apoptosis, Others, Microtubule Associated

Cat.No: T8344

Target: Apoptosis, Histone Acetyltransferase

Cat.No: T5521

Synonym: U-54461,溴匹立明

Target: TLR

Cat.No: T2676

Target: c-Met/HGFR

Cat.No: T1753

Target: Microtubule Associated

Cat.No: T28410

Synonym: PHPS-1,PHPS 1

Target: Phosphatase

Cat.No: T12695

Target: PARP

Cat.No: T6932

Target: Apoptosis, EGFR, FGFR, IGF-1R, PDGFR, PKC, Autophagy

Cat.No: T27730

Synonym: KGP-94,KGP 94

Target: Cysteine Protease

Cat.No: TQ0157

Synonym: L593754,MH 12-43

Target: Sodium Channel, TRP/TRPV Channel

N-Desmethyltamoxifen hydrochloride

Cat.No: T12148

Target: Estrogen Receptor/ERR, Endogenous Metabolite, PKC

Cat.No: T15771

Synonym: D-19466,络铂

Target: DNA Alkylation

Cat.No: T9705

Target: BTK

PD-1/PD-L1-IN-10

Cat.No: T9616

Target: PD-1/PD-L1

Cat.No: T15017

Target: TLR

Cat.No: T22830

Synonym: GYY 4137 morpholine salt

Target: Others

Cat.No: T6609

Target: HSP

Cat.No: T7008

Synonym: Vacquinol 1

Target: JNK

5-ALA benzyl ester hydrochloride

Cat.No: T19147

Synonym: Benzyl-ALA hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T4570

Synonym: Vercyte,A-8103,Amedel,哌泊溴烷

Target: Others, DNA Alkylator/Crosslinker

Cat.No: T2455

Synonym: PFK15,PFK 015

Target: Glucokinase, Autophagy

Cat.No: T1785

Synonym: PD 0332991,帕博西尼,帕布昔利布

Target: CDK

Cat.No: T2456

Synonym: 替沃扎尼,AV-951,KRN951

Target: VEGFR, PDGFR, Ephrin Receptor

Suberoyl bis-hydroxamic acid

Cat.No: T21505

Synonym: SBHA,软木肟酸,Suberohydroxamic acid

Target: Apoptosis, HDAC

Cat.No: T1199

Synonym: Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦

Target: Apoptosis, AChR

Cat.No: T0334

Synonym: BRL49653,罗格列酮

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Cat.No: T6481

Synonym: NS 41080,4-(4-氯-2-甲基苯氧基)-N-羟基丁酰胺

Target: Apoptosis, HDAC

Pyrazoloacridine

Cat.No: T28475

Synonym: PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934

Target: Apoptosis, Topoisomerase

Triglycidyl isocyanurate

Cat.No: T22443

Synonym: Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI

Target: Apoptosis

Aliskiren hemifumarate

Cat.No: T1520

Synonym: 阿利克仑半富马酸盐,CGP 60536,SPP 100,CGP60536B

Target: RAAS, Autophagy

Cat.No: T9945

Synonym: 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione

Target: STAT

Cat.No: T0134

Synonym: 咪喹莫特,R 837,IMQ,S-26308

Target: SARS-CoV, TLR, Autophagy, HSV

Tyrphostin B44, (+) enantiomer

Cat.No: T22450

Synonym: 酪氨酸磷酸化抑制剂AG 835

Target: EGFR

Cat.No: T6690

Synonym: N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺

Target: Apoptosis, FXR, Liver X Receptor, ROR

Cat.No: T2008

Synonym: LY 294002,NSC 697286,SF 1101

Target: Apoptosis, DNA-PK, Casein Kinase, PI3K, Autophagy

Cat.No: T3061

Synonym: 劳拉替尼,PF-6463922,PF-06463922,Loratinib

Target: Apoptosis, Tyrosine Kinases, ROS, ALK, ROS Kinase

Rosiglitazone hydrochloride

Cat.No: T6646

Synonym: 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Palbociclib Isethionate

Cat.No: T6240

Synonym: Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐

Target: CDK

Palbociclib monohydrochloride

Cat.No: T6239

Synonym: PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl

Target: CDK

LY-294002 hydrochloride

Cat.No: T4079

Synonym: SF 1101,LY 294002,NSC 697286

Target: PI3K

Methyl Aminolevulinate Hydrochloride

Cat.No: T5002

Synonym: 5-Aminolevulinic acid methyl ester,Methyl δ-aminolevulinate hydrochloride,5-氨基酮戊酸甲酯盐酸盐,Methyl 5-aminolevulinate Hydrochloride,Aminolevulinic acid methyl ester Hydrochloride

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3020	Sclareol	Apoptosis; Others	Apoptosis; Others
	Sclareol 是一种从快乐鼠尾草中分离出来的拉丹型二萜，对多种人类 Y 细胞系具有生长抑制和细胞毒活性，诱导细胞凋亡。
T3862	Irigenin	NF-κB; Integrin	Cytoskeletal Signaling; NF-κB
	Irigenin 可通过特异性和选择性地阻断 Extra Domain A 域的 C-C 环上α9β1和α4β1整合素结合位点，介导其抗转移作用。可通过增强胃癌细胞中促凋亡分子的表达来敏化 TRAIL 诱导的凋亡，具有抗癌作用。
T11363	Ganoderic acid F	Others	Others
	Ganoderic acid F 是一种灵芝酸。它具有抗肿瘤和抗转移的活性，与抑制血管生成和涉及细胞增殖和细胞死亡，致癌作用，氧化应激，钙信号传导和内质网应激的蛋白质改变等机制相关。
T2786	Oxysophocarpine 氧化槐树碱,氧卡地平	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Oxysophocarpine 是提取自海藻的生物碱。它对中枢神经系统和周围神经系统具有神经保护作用和抗伤害感受作用。
T6670	Silymarin Silybin B,水飞蓟素	SARS-CoV	Microbiology/Virology
	Silymarin (Silybin B) 是一种多酚类黄酮，是从水飞蓟或水飞蓟的种子中提取的一种 SARS-CoV-2 主蛋白酶抑制剂。它可降低肿瘤细胞的增殖，血管生成以及胰岛素抵抗，用于预防和治疗肝脏疾病，有潜力研究 COVID-19 。
T13741	Isoviolanthin 异佛莱心苷,异佛来心苷	Others	Others
	Isoviolanthin 是一种黄酮类苷类化合物，提取自铁皮石斛叶中。它能减少 TGF-β1 处理的 HCC 细胞的迁移和入侵能力，对正常细胞没有毒性影响，对转移性肝癌晚期具有潜在的研究价值。
T5S1133	Ganoderic acid D 灵芝酸D,灵芝酸 D	Apoptosis; Sirtuin	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Ganoderic acid D 是高度氧化的四环三萜，是灵芝的主要活性成分，可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程，包括结肠癌细胞中的葡萄糖摄取，乳酸、丙酮酸和乙酰辅酶的产生。
TN1968	N-Feruloyloctopamine N-Feruloyloctopamine,N-阿魏酰章鱼胺	p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	N-Feruloyloctopamine 是从木本曼陀罗提取的一种天然产物，有抗氧化作用，可显著降低Akt 和p38 MAPK 磷酸化水平。
TN1019	Beta-mangostin β-Mangostin,beta-倒捻子素	Apoptosis; Antibacterial; Parasite	Apoptosis; Microbiology/Virology
	Beta-mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮类天然产物，有抗癌和抗菌活性，对结核分枝杆菌的 MIC 值为 6.25 μg/mL。它在体外有抗疟活性，对恶性疟原虫的 IC50值为 3.00 μg/mL。
T0314	Hexylresorcinol 己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol	Apoptosis; Tyrosinase; Antibacterial; Parasite	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Hexylresorcinol (4-Hexylresorcinol) 是在植物中发现的一种天然产物，具有抗菌、驱虫、防腐和抗肿瘤活性。它是一种可逆、非竞争性的 α-葡萄糖苷酶抑制剂，有抗 DNA 氧化损伤的保护作用。它可诱导鳞癌细胞凋亡。
T13475	β-Aminopropionitrile 3-氨基丙腈,3-Aminopropionitrile,BAPN	Others; Endogenous Metabolite	Metabolism; Others
	β-Aminopropionitrile (3-Aminopropionitrile) 是赖氨酰氧化酶的特异性抑制剂。
T6485	Embelin NSC 91874,恩贝酸,恩贝酸/恩贝灵,Emberine,Embelic acid	Apoptosis; NF-κB; Lipoxygenase; IAP; Prostaglandin Receptor; Autophagy	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; NF-κB
	Embelin (Embelic acid) 是从日本 Ardisia 草药中分离出来的一种非肽类细胞渗透性XIAP 抑制剂，诱导口腔鳞癌细胞自噬和凋亡。它阻断 NF-kappaB 信号通路，从而抑制 NF-kappaB 调节的抗凋亡和转移基因产物。在高水平 XIAP 的前列腺癌细胞中抑制细胞生长，诱导凋亡，并激活 caspase-9。
T7203	Oglufanide 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH	VEGFR; HCV Protease; Endogenous Metabolite	Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂，可抑制血管内皮生长因子，可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。
T12581	Puerarin-4'-O-β-D-glucopyranoside Puerarin4'-O-glucoside,葛根素-4'-Β-D-葡萄糖苷	Others	Others
	Puerarin-4'-O-β-D-glucopyranoside (Puerarin4'-O-glucoside) 是一种从葛根 (PLR) 中提取的异黄酮。它具有雌激素活性和抗 MCF-7 人乳腺癌细胞增殖作用。
T1511	Daunorubicin hydrochloride Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类化合物，一种拓扑异构酶 II (Topo II) 抑制剂。Daunorubicin hydrochloride 可以抑制 DNA 和 RNA 的合成，具有抗肿瘤活性。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 属于生物碱类天然产物，可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。
T7849	Norspermine	Others	Others
	Norspermine 是一种多胺类似物，用于治疗非小细胞肺癌和乳腺癌。
TN3548	Bulleyanin	Others	Others
	Bulleyanin 是从 isodon species (Labiatae) 中分离出来的一种物质。
TN1757	Hypophyllanthin 叶下珠次素,(7S,8S,9R)-9-(3,4-二甲氧基苯基)-6,7,8,9-四氢-4-甲氧基-7,8-双(甲氧基甲基)萘并[1,2-D]-1,3-二恶茂	Potassium Channel; Calcium Channel; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Hypophyllanthin 是珠子草中的一种木脂素，能直接抑制 P-gp 的活性，具有很强的抗炎活性。
T1660	Silibinin 水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I	Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Silibinin (Silybin) 是水飞蓟的主要活性成分，具有抗癌和化疗预防作用，能抑制细胞增殖和迁移。
TN7217	4,6-Benzilidine-D-Glucose	Others	Others
	4,6-Benzilidine-D-Glucose 是一种临床抗肿瘤化合物，在化学诱导肝细胞癌大鼠中显示出抗肿瘤活性。
T1709	2'-Deoxyinosine Guanine deoxyriboside,Deoxyinosine,2'-脱氧肌苷	Others; Endogenous Metabolite	Metabolism; Others
	2'-Deoxyinosine (Guanine deoxyriboside) 具有抑制人癌细胞株生长的活性，并发现其与嘌呤核苷磷酸化酶缺乏有关。
TN1405	Arnicolide D 山金车内酯 D,山金车内酯D	Akt; Caspase; PI3K; STAT; mTOR	Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯，以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期，激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。
T3051	Theaflavin-3-gallate 茶黄素-3-没食子酸酯,茶黄素 3-没食子酸酯,茶黄素 -3-没食子酸,Theaflavine-3-Gallate	Others	Others
	Theaflavin-3-gallate (Theaflavine-3-Gallate) 是红茶茶黄素单体，是红茶生物学上重要的活性成分，对健康有益。它以时间和浓度依赖性方式与还原型谷胱甘肽直接反应。它充当促氧化剂并在癌细胞中诱导氧化应激。
T5040	Medroxyprogesterone 甲羟孕酮,甲孕酮	Estrogen/progestogen Receptor; Progesterone Receptor	Endocrinology/Hormones; Others
	Medroxyprogesterone 是一种合成的人孕酮变体，是孕酮受体激动剂，用于治疗肾癌。在兽医实践中用作发情调节剂。
T3425	Polyphyllin G 重楼皂苷VII,Polyphyllin VII,Polyphyllin VII,Y-0166,重楼皂苷G	Others	Others
	Polyphyllin G (Polyphyllin VII) 是从Paris yunnanensis 的根茎中分离出来的，具有抗菌活性，抑制革兰氏阳性和革兰氏阴性细菌的生长。它是polyphyllin 家族的主要成员，对肺癌、乳腺癌、结直肠癌、宫颈癌、肝细胞癌和骨肉瘤等多种癌症具有很强的抗癌活性。
T6S1373	Casticin Quercetagetin 3,6,7,4'-Tetramethyl Ether,Vitexicarpin,蔓荆子黄素	STAT	JAK/STAT signaling; Stem Cells
	Casticin (Vitexicarpin) 是从蔓荆子中得到的一种甲氧基黄酮，可抑制STAT3的活化，具有抗有丝分裂和抗炎活性。
T4S1796	Heterophyllin B	PI3K	PI3K/Akt/mTOR signaling
	Heterophyllin B 是一种活性环肽，从 Pseudostellaria heterophylla 中分离得到，可用于研究食管癌。
T2S1975	Ponicidin 冬凌草乙素,Rubescensine B	Apoptosis; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Ponicidin (Rubescensine B) 是来源于冬凌草的一种二萜，具有免疫调节、抗炎、抗病毒和抗癌作用。它可诱导胃癌细胞凋亡，降低 JAK2 和 STAT3 的磷酸化水平。
TQ0275	LysoPC(14:0/0:0)	Others; Endogenous Metabolite	Metabolism; Others
	LysoPC(14:0/0:0) 是一种溶血磷脂，它是单甘油磷脂，其中甘油取代位点被磷酸胆碱占据。LysoPC(14:0/0:0) 有抗痉挛作用。
T5746	Dictamine Dictamnine,Dectamine,白鲜碱	Apoptosis; Anti-infection; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology
	Dictamine (Dectamine) 显示抗胆碱酯酶、抗炎、致突变、抗菌和抗真菌活性。它具有在人子宫颈、结肠和口腔癌细胞中发挥细胞毒性的能力。
TN1644	Flavanomarein	Others	Others
	Flavanomarein 是Coreopsis tinctoria Nutt 的主要黄酮类化合物，对糖尿病性肾病具有保护作用。它具有很好的抗氧化，降糖，降压和降血脂作用。
T5590	2-(4-Methoxyphenyl)acetic acid 4-Methoxyphenylacetic acid,对甲氧基苯乙酸	Others; Endogenous Metabolite	Metabolism; Others
	2-(4-Methoxyphenyl)acetic acid 是血浆代谢物，具有高度敏感性和特异性，能够作为区分非小细胞癌患者和健康对照组之间的生物指标。
T5646	Cinnamic acid 3-Phenylacrylic acid,β-Phenylacrylic acid,肉桂酸	Endogenous Metabolite	Metabolism
	Cinnamic acid (β-Phenylacrylic acid) 在癌症干预中具有潜在的应用价值，对胶质母细胞瘤，黑色素瘤，前列腺癌，肺癌细胞的IC50=1-4.5 mM。
T5S0506	Rotundic acid Rutundic acid,铁冬青酸	Apoptosis; Others; p38 MAPK; Akt; mTOR	Apoptosis; Cytoskeletal Signaling; MAPK; Others; PI3K/Akt/mTOR signaling
	Rotundic acid (Rutundic acid) 是一种从圆形肠球菌中获得的三萜类天然产物，具有抗炎和保护心脏的能力。它可通过 AKT/mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。
T1284	Megestrol acetate SC10363,醋酸甲地孕酮,BDH1298	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; HIV Protease; Autophagy	Autophagy; Endocrinology/Hormones; Microbiology/Virology; Others; Proteases/Proteasome
	Megestrol acetate (BDH1298) 是具有口服活性的合成孕激素。它还具有抗雄激素特性，可用于治疗厌食症和恶病质。
T4S0553	Theaflavin-3'-Gallate 茶黄素-3-没食子酸酯,Theaflavin 2B,THEAFLAVIN 3'-O-GALLATE,茶黄素-3'-没食子酸酯	Others	Others
	Theaflavin-3'-Gallate (Theaflavin 2B) 是红茶茶黄素单体，是红茶生物学上重要的活性成分，对健康有益。它以时间和浓度依赖性方式与还原型谷胱甘肽直接反应。它充当促氧化剂并在癌细胞中诱导氧化应激。
TQ0194	trans-Vaccenic acid TVA,（11E)-octadec-11-enoic acid,11E)-octadec-11-enoic acid	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	trans-Vaccenic acid 是前体物质，可在瘤胃中合成饱和脂肪酸，在组织水平合成共轭亚油酸。trans-Vaccenic acid 通过线粒体介导的凋亡途径抑制人鼻咽癌细胞增殖并诱导其凋亡
TN1721	Gypenoside L	ERK; p38 MAPK; Calcium Channel; NF-κB; ROS	Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Metabolism; NF-κB
	Gypenoside L 是存在于绞股蓝中的一种皂苷，可增加 SA-β-半乳糖苷酶活性，促进衰老相关分泌细胞因子的产生。它还可以激活p38和ERK MAPK 通路和NF-κB 通路以诱导衰老，具有抗肿瘤和抗炎活性。
T3902	Atractylenolide III 白术内酯 III,ICodonolactone,8β-Hydroxyasterolide	Apoptosis	Apoptosis
	Atractylenolide III (ICodonolactone) 是白术根茎主要成分，通过诱导细胞色素 c 的释放、上调 Bax 的表达和易位凋亡诱导因子，是治疗人肺癌的潜力。
TN1854	Lasiodin 毛栲利素,Lasiokaurin	P450; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Proteases/Proteasome
	Lasiodin (Lasiokaurin) 是一种来自植物香茶菜的二帖化合物，可抑制 NPC 细胞增殖。 Lasiodin 具有抗氧化、抗肿瘤活性和抗菌活性，可诱导细胞周期组长和凋亡，诱导细胞迁移和侵袭，可用于研究鼻咽癌
TN3048	4-Methoxycinnamaldehyde p-Methoxycinnamaldehyde	RSV	Microbiology/Virology
	4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde) 是 Agastache rugosa 的一种活性成分。4-Methoxycinnamaldehyde 对人喉癌细胞系中的呼吸道合胞病毒 (RSV) 具有细胞保护活性，有助于控制 RSV 感染诱发的疾病，IC50 约为 0.055 μg/mL。
T2S0837	Astragalus Polysacharin 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole,黄芪多糖,89250-26-0	TAM Receptor	Tyrosine Kinase/Adaptors
	2-(Chloromethyl)-4-(4-nitrophenyl)thiazole 是一种从黄芪 (Astragalus propinquus) 中提取得到的天然产物。2-(Chloromethyl)-4-(4-nitrophenyl)thiazole 具有抗癌活性，通过抑制肿瘤相关巨噬细胞 (TAM) 的 M2 极化在肝细胞癌 (HCC) 中显示除抗肿瘤活性。
T6S0117	Avicularin Fenicularin,扁蓄苷	ERK	MAPK
	Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中，它通过抑制 ERK 信号通路产生抗炎活性。
T7044	Norepinephrine 去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol	MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome
	Norepinephrine (Levophed) 属于生物碱类天然产物，是一种神经递质，一种肾上腺素能受体 (AR) 的激动剂，对 α1、α2 和 β1 AR 具有激活活性。Norepinephrine 被用作抗休克的血管活性剂。
T3S0081	Oxypeucedanin (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin	Potassium Channel	Membrane transporter/Ion channel
	Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物，分离自Angelica dahurica。它是选择性开放通道阻滞剂，可抑制hKv1.5通道电流，IC50值为 76 nM。它延长心脏动作电位持续时间，是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。
TN6694	5,6-Benzoflavone β-Naphthoflavone,beta-NF	Antioxidant	oxidation-reduction
	5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体，可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性，抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴，抑制 LPS 诱导的炎症，抑制TNF-α诱导的ICAM-1和VCAM-1表达，可用于研究神经退行性疾病。
T3S0737	Flavokawain A 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A	Apoptosis; p38 MAPK	Apoptosis; MAPK
	Flavokawain A (Flavokavain A) 是 kava 提取物中的查耳酮，是一种抗癌试剂，具有抗肿瘤活性。它通过 Bax 蛋白依赖和线粒体依赖的凋亡途径诱导细胞凋亡，有潜力用于膀胱癌的相关研究。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。
TN1880	Lucidenic acid B Lucidenicacid B	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Lucidenic acid B (Lucidenicacid B) 是从灵芝中提取得到的天然化合物，可诱导caspase-9 和 caspase-3 的活化和 PARP 的裂解，可通过线粒体介导诱导人白血病细胞凋亡。 Lucidenic acid B通过灭活MAPK / ERK信号转导途径和降低NF-kappaB和AP-1的结合活性来抑制PMA诱导的人肝癌细胞侵袭。。Lucidenic acid B 对细胞周期和坏死细胞没有影响。
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天然产物

Cat.No: T3020

Target: Apoptosis, Others

Cat.No: T3862

Target: NF-κB, Integrin

Ganoderic acid F

Cat.No: T11363

Target: Others

Oxysophocarpine

Cat.No: T2786

Synonym: 氧化槐树碱,氧卡地平

Target: Prostaglandin Receptor

Cat.No: T6670

Synonym: Silybin B,水飞蓟素

Target: SARS-CoV

Cat.No: T13741

Synonym: 异佛莱心苷,异佛来心苷

Target: Others

Ganoderic acid D

Cat.No: T5S1133

Synonym: 灵芝酸D,灵芝酸 D

Target: Apoptosis, Sirtuin

N-Feruloyloctopamine

Cat.No: TN1968

Synonym: N-Feruloyloctopamine,N-阿魏酰章鱼胺

Target: p38 MAPK, Akt

Cat.No: TN1019

Synonym: β-Mangostin,beta-倒捻子素

Target: Apoptosis, Antibacterial, Parasite

Hexylresorcinol

Cat.No: T0314

Synonym: 己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol

Target: Apoptosis, Tyrosinase, Antibacterial, Parasite

β-Aminopropionitrile

Cat.No: T13475

Synonym: 3-氨基丙腈,3-Aminopropionitrile,BAPN

Target: Others, Endogenous Metabolite

Cat.No: T6485

Synonym: NSC 91874,恩贝酸,恩贝酸/恩贝灵,Emberine,Embelic acid

Target: Apoptosis, NF-κB, Lipoxygenase, IAP, Prostaglandin Receptor, Autophagy

Cat.No: T7203

Synonym: 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH

Target: VEGFR, HCV Protease, Endogenous Metabolite

Puerarin-4'-O-β-D-glucopyranoside

Cat.No: T12581

Synonym: Puerarin4'-O-glucoside,葛根素-4'-Β-D-葡萄糖苷

Target: Others

Daunorubicin hydrochloride

Cat.No: T1511

Synonym: Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy, ADC Cytotoxin

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Cat.No: T7849

Target: Others

Cat.No: TN3548

Target: Others

Hypophyllanthin

Cat.No: TN1757

Synonym: 叶下珠次素,(7S,8S,9R)-9-(3,4-二甲氧基苯基)-6,7,8,9-四氢-4-甲氧基-7,8-双(甲氧基甲基)萘并[1,2-D]-1,3-二恶茂

Target: Potassium Channel, Calcium Channel, P-gp

Cat.No: T1660

Synonym: 水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I

Target: Reactive Oxygen Species, Autophagy

4,6-Benzilidine-D-Glucose

Cat.No: TN7217

Target: Others

2'-Deoxyinosine

Cat.No: T1709

Synonym: Guanine deoxyriboside,Deoxyinosine,2'-脱氧肌苷

Target: Others, Endogenous Metabolite

Cat.No: TN1405

Synonym: 山金车内酯 D,山金车内酯D

Target: Akt, Caspase, PI3K, STAT, mTOR

Theaflavin-3-gallate

Cat.No: T3051

Synonym: 茶黄素-3-没食子酸酯,茶黄素 3-没食子酸酯,茶黄素 -3-没食子酸,Theaflavine-3-Gallate

Target: Others

Medroxyprogesterone

Cat.No: T5040

Synonym: 甲羟孕酮,甲孕酮

Target: Estrogen/progestogen Receptor, Progesterone Receptor

Cat.No: T3425

Synonym: 重楼皂苷VII,Polyphyllin VII,Polyphyllin VII,Y-0166,重楼皂苷G

Target: Others

Cat.No: T6S1373

Synonym: Quercetagetin 3,6,7,4'-Tetramethyl Ether,Vitexicarpin,蔓荆子黄素

Target: STAT

Heterophyllin B

Cat.No: T4S1796

Target: PI3K

Cat.No: T2S1975

Synonym: 冬凌草乙素,Rubescensine B

Target: Apoptosis, JAK, STAT

LysoPC(14:0/0:0)

Cat.No: TQ0275

Target: Others, Endogenous Metabolite

Cat.No: T5746

Synonym: Dictamnine,Dectamine,白鲜碱

Target: Apoptosis, Anti-infection, Antibacterial, Antifungal

Cat.No: TN1644

Target: Others

2-(4-Methoxyphenyl)acetic acid

Cat.No: T5590

Synonym: 4-Methoxyphenylacetic acid,对甲氧基苯乙酸

Target: Others, Endogenous Metabolite

Cat.No: T5646

Synonym: 3-Phenylacrylic acid,β-Phenylacrylic acid,肉桂酸

Target: Endogenous Metabolite

Cat.No: T5S0506

Synonym: Rutundic acid,铁冬青酸

Target: Apoptosis, Others, p38 MAPK, Akt, mTOR

Megestrol acetate

Cat.No: T1284

Synonym: SC10363,醋酸甲地孕酮,BDH1298

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, HIV Protease, Autophagy

Theaflavin-3'-Gallate

Cat.No: T4S0553

Synonym: 茶黄素-3-没食子酸酯,Theaflavin 2B,THEAFLAVIN 3'-O-GALLATE,茶黄素-3'-没食子酸酯

Target: Others

trans-Vaccenic acid

Cat.No: TQ0194

Synonym: TVA,（11E)-octadec-11-enoic acid,11E)-octadec-11-enoic acid

Target: Apoptosis, Endogenous Metabolite

Cat.No: TN1721

Target: ERK, p38 MAPK, Calcium Channel, NF-κB, ROS

Atractylenolide III

Cat.No: T3902

Synonym: 白术内酯 III,ICodonolactone,8β-Hydroxyasterolide

Target: Apoptosis

Cat.No: TN1854

Synonym: 毛栲利素,Lasiokaurin

Target: P450, PARP, Caspase

4-Methoxycinnamaldehyde

Cat.No: TN3048

Synonym: p-Methoxycinnamaldehyde

Target: RSV

Astragalus Polysacharin

Cat.No: T2S0837

Synonym: 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole,黄芪多糖,89250-26-0

Target: TAM Receptor

Cat.No: T6S0117

Synonym: Fenicularin,扁蓄苷

Target: ERK

Cat.No: T7044

Synonym: 去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol

Target: MMP, Endogenous Metabolite, Adrenergic Receptor, Autophagy

Cat.No: T3S0081

Synonym: (+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin

Target: Potassium Channel

5,6-Benzoflavone

Cat.No: TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

Cat.No: T3S0737

Synonym: 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A

Target: Apoptosis, p38 MAPK

Cat.No: T6S1699

Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Target: Lipoxygenase, Autophagy

Lucidenic acid B

Cat.No: TN1880

Synonym: Lucidenicacid B

Target: Apoptosis, Caspase

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00381	PIGR Protein, Human, Recombinant (hFc) Polymeric Immunoglobulin Receptor,Poly-Ig Receptor,Hepatocel...	Human	HEK293 Cells
	PIGR binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
TMPJ-00705	BCAS2 Protein, Human, Recombinant (His, T7) BCAS2,DNA Amplified in Mammary Carcinoma 1 Protein,...	Human	E. coli
	Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell lines. BCAS2 is a component of the spliceosome, taking part in the removal of introns from mRNA precursors. BCAS2 interacts with estrogen receptor alpha and beta, thyroid hormone receptor beta, peroxisome proliferator-activated receptor gamma. BCAS2 functions as an ER co-activator ...
TMPH-02100	Serpin B4 Protein, Human, Recombinant (His & SUMO) Leupin,Squamous cell carcinoma antigen 2,Serpin B4,...	Human	E. coli
	May act as a protease inhibitor to modulate the host immune response against tumor cells. Serpin B4 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 60.9 kDa and the accession number is P48594.
TMPH-01706	Mucin-16/MUC16 Protein, Human, Recombinant (His) Ovarian carcinoma antigen CA125,Ovarian cancer-rela...	Human	HEK293 Cells
	Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Mucin-16/MUC16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30.5 kDa and the accession number is Q8WXI7.
TMPH-01363	Galectin-8/LGALS8 Protein, Human, Recombinant (GST) Po66 carbohydrate-binding protein,LGALS8,Prostate carcin...	Human	E. coli
	Galectin-8/LGALS8 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 62.8 kDa and the accession number is O00214.
TMPJ-01093	HYAL1 Protein, Human, Recombinant (His) LUCA1,Hyaluronoglucosaminidase-1,HYAL1,LuCa-1,Hyal-1,Hyaluro...	Human	HEK293 Cells
	Hyaluronidase-1 (HYAL1) is a secreted lysosomal hyaluronidase that belongs to the glycosyl hydrolase 56 family. HYAL1 contains one EGF-like domain and is highly expressed in the liver, kidney, and heart, but it is weakly expressed in the lung, placenta, and skeletal muscle. HYAL1 is thought to be involved in cell proliferation, migration, and differentiation. It may play a role in promoting tumor progression and blocking the TGFB1-enhanced cell growth. Mutations in HYAL1 are associated with muco...
TMPJ-01362	UBAP1 Protein, Human, Recombinant (His) Nasopharyngeal Carcinoma-Associated Gene 20 Protein...	Human	E. coli
	Ubiquitin-Associated Protein 1 (UBAP1) belongs to the UBA domain family. Members of this family are related to ubiquitin and the ubiquitination pathway. Because of their cytogenetic location, this UBA domain family member is being studied as a putative target for mutation in nasopharyngeal carcinomas. UBAP1 is highly expressed in the heart, brain, placenta, lung, skeletal muscle, liver, and pancreas. UBAP1 consists of two UBA domains and one UMA domain. The ubiquitin associated domain is through...
TMPJ-00155	Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated Polymorphic epithelial mucin,KL-6,Cancer antigen 15-3,PEMT,P...	Human	HEK293 Cells
	Mucin-1, is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1 exclusively located in the apical domain of the plasma membrane ...
TMPJ-00654	LGALS8 Protein, Human, Recombinant Prostate Carcinoma Tumor Antigen 1,Po66-CBP,Galecti...	Human	E. coli
	The Galectin family of proteins, with specificity for Nacetyllactosaminecontaining glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs). They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide, galectins can also be...
TMPH-02094	STK11 Protein, Human, Recombinant (His & SUMO) Liver kinase B1,Renal carcinoma antigen NY-REN-19,S...	Human	E. coli
	STK11 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 64.3 kDa and the accession number is Q15831.
TMPH-01705	Mucin-1/MUC1 Protein, Human, Recombinant (Isoform 8, His) Peanut-reactive urinary mucin,Isoform 8 of Mucin-1,Cancer an...	Human	E. coli
	Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8.
TMPJ-00797	LDHB Protein, Human, Recombinant (His) LDH-B,Renal Carcinoma Antigen NY-REN-46,LDH-H,LDH H...	Human	E. coli
	L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LDH-B is an oxidoreductase that catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. It converts pyruvate to lactate when oxygen is absent or in short supply and it performs the reverse reaction during the Cori cycle in the liver....
TMPH-01278	ENOX2 Protein, Human, Recombinant (His & Myc) Cytosolic ovarian carcinoma antigen 1,Ecto-NOX disu...	Human	E. coli
	May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biol...
TMPH-01429	HSP90AA1 Protein, Human, Recombinant (His) Lipopolysaccharide-associated protein 2,Heat shock 86 kDa,Re...	Human	E. coli
	HSP90AA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.0 kDa and the accession number is P07900.
TMPH-01277	ENOX2 Protein, Human, Recombinant ENOX2,APK1 antigen,Cytosolic ovarian carcinoma anti...	Human	E. coli
	May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biol...
TMPJ-00724	LDHA Protein, Human, Recombinant (His) LDH-M,Renal Carcinoma Antigen NY-REN-59,Cell Prolif...	Human	E. coli
	L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region, a central catalytic site, and at least nine utilized Lys acetylation and two Tyr phosphorylation sites. LDHA belongs to the lactate dehydrogenase family, expressed predominantly in muscle tissue. LDHA mutations have been linked to exertional myoglobinuria.
TMPH-01781	NSMCE3 Protein, Human, Recombinant (His) Necdin-like protein 2,MAGE-G1 antigen,Non-structural mainten...	Human	E. coli
	NSMCE3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38.4 kDa and the accession number is Q96MG7.
TMPJ-01108	SMAD4 Protein, Human, Recombinant (His) DPC4,SMAD 4,Deletion Target in Pancreatic Carcinoma...	Human	E. coli
	SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. SMAD4 may act as a tumo...
TMPH-02246	TGS1 Protein, Human, Recombinant (His & SUMO) CLL-associated antigen KW-2,Cap-specific guanine-N2 methyltr...	Human	E. coli
	Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
TMPJ-00928	Serpin B3 Protein, Human, Recombinant (C-His) SCCA1,serpin peptidase inhibitor, clade B (ovalbumin), membe...	Human	HEK293 Cells
	Serpin B3 Protein, Human, Recombinant (C-His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 41-50 KDa and the accession number is P29508.
TMPJ-00929	Serpin B3 Protein, Human, Recombinant (N-His) SCCA-1,Serpin B3,serine (or cysteine) proteinase inhibitor, ...	Human	E. coli
	Serpin B3 Protein, Human, Recombinant (N-His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 40-55 KDa and the accession number is P29508.
TMPJ-00755	CRYAB Protein, Human, Recombinant (His) α(B)-Crystallin,Alpha(B)-Crystallin,Heat Shock Protein Beta-...	Human	E. coli
	α Crystallin B Chain (CRYAB) is a cytoplasmic protein that belongs to the small heat shock protein (HSP20) family. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. Alpha crystallins acts as molecular chaperones and hold them in in large soluble aggregates. CRYAB is expressed widely in many tissues and or...
TMPJ-00345	IGF2BP-2 Protein, Human, Recombinant (His) IGF-II mRNA-Binding Protein 2,IGF2 mRNA-Binding Protein 2,He...	Human	E. coli
	Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains and two RRM (RNA recognition motif) domains. IGF2BP2 binds to the 5'-UTR of the Insulin-Like Growth Factor 2 (IGF2) mRNA. This binding is isoform-specific. IGF2BP2 may regulate translation of target mRNAs. Genetic variation at the IGF2BP2 gene has been associated with type 2 diabetes (T2D) by genome-wide association studies and by replicat...
TMPH-02027	RETNLB Protein, Human, Recombinant (His) Colon carcinoma-related gene protein,Colon and smal...	Human	E. coli
	Probable hormone. RETNLB Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 13.4 kDa and the accession number is Q9BQ08.
TMPJ-01010	PLA2G16 Protein, Human, Recombinant (His) Renal Carcinoma Antigen NY-REN-65,HRAS-Like Suppres...	Human	E. coli
	Group XVI Phospholipase A1/A2 (PLA2G16) belongs to the H-rev 107 family. PLA2G16 is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas. PLA2G16 is involved in the regulation of differentiation and survival. PLA2G16 regulates adipocyte lipolysis and release of fatty acids through a G-protein coupled pathway involving prostaglandin and EP3. It has also been reported to play a crucial role in the development of obesity in mouse models.
TMPH-01297	DDR1 Protein, Human, Recombinant (aa 21-417, His) EDDR1,MCK-10,Epithelial discoidin domain-containing receptor...	Human	HEK293 Cells
	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell...
TMPH-00856	RPSA Protein, Human, Recombinant (His & Myc) 67 kDa laminin receptor,RPSA,Laminin-binding protein precurs...	Human	E. coli
	RPSA Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.7 kDa and the accession number is P08865.
TMPY-00545	Dermcidin Protein, Human, Recombinant (hFc) AIDD,PIF,HCAP,dermcidin,DCD-1,DSEP	Human	HEK293 Cells
	Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely diagnoses. Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis ...
TMPJ-01465	GM-CSF/CSF2 Protein, Human, Recombinant (E. coli) Colony-Stimulating Factor,CSF2,CSF,Sargramostim,集落刺激因子,Molgr...	Human	E. coli
	Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryo...
TMPY-01897	PRSS3 Protein, Human, Recombinant (His) PRSS4,TRY4,TRY3,RP11-176F3.3,T9,MTG,protease, serine 3	Human	HEK293 Cells
	Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their ...
TMPY-00566	CCL18 Protein, Human, Recombinant (His) PARC,CCL18,CKb7,DC-CK1,chemokine (C-C motif) ligand 18,MIP-4...	Human	P. pastoris (Yeast)
	CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. (CCL18) is predominantly secreted by M2-tumor associated macrophages (TAMs) a...
TMPY-04483	IRAK4 Protein, Human, Recombinant (His) IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...	Human	Baculovirus Insect Cells
	Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ...
TMPK-01203	TNFRSF19 Protein, Human, Recombinant (hFc) AW123854,TRADE,TAJ α,AL023044,TAJ-α,Taj,TAJ alpha,Toxicity a...	Human	HEK293 Cells
	A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for nasopharyngeal carcinoma and other cancers, functions as a potent inhibitor of the TGFβ signaling pathway. TNFRSF19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.22 kDa and the accession number is Q9NS6...
TMPK-01204	TNFRSF19 Protein, Human, Recombinant (His) Taj,TAJ-α,Toxicity and JNK inducer,TAJ-alpha,TRADE,Troy,AW12...	Human	HEK293 Cells
	A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for nasopharyngeal carcinoma and other cancers, functions as a potent inhibitor of the TGFβ signaling pathway. TNFRSF19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 16.55 kDa and the accession number is Q9NS6...
TMPJ-00056	AG-2 Protein, Human, Recombinant (His) HPC8,AG2,AG-2,hAG-2,Anterior Gradient Protein 2 Homolog,AGR2...	Human	HEK293 Cells
	Anterior Gradient 2 (AGR2) is an 18-21 kDa member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells, such as small intestine goblet, prostate epithelium, enteroendocrine cells, and multiple carcinoma cell types. AGR2 forms transient disulfide linkages with molecules destined for secretion, possibly aiding protein folding. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of E...
TMPK-01543	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi) LAGE2A,ESO1CTAG,LAGE-2,CTAG1,CT6.1,MHC,MY-ESO-1,NY-ESO-1,CTA...	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01499	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein, Human, MHC (His & Avi) ESO1CTAG,LAGE-2,CTAG1B,LAGE2A,MY-ESO-1,CT6.1,NY-ESO-1,CTAG1,...	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01497	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled MY-ESO-1,MHC,ESO1CTAG,NY-ESO-1,CTAG1,LAGE2A,LAGE-2,CT6.1,CTA...	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01500	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi) CTAG1,CT6.1,CTAG1B,LAGE2A,MY-ESO-1,LAGE-2,MHC,NY-ESO-1,ESO1C...	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01539	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi), Biotinylated CTAG1B,CT6.1,MY-ESO-1,LAGE2A,NY-ESO-1,MHC,LAGE-2,ESO1CTAG,CT...	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01449	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi) MHC,CT6.1,CTAG1,LAGE-2,MY-ESO-1,NY-ESO-1,ESO1CTAG,LAGE2A,CTA...	Human	E. coli
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPY-02712	Serpin B3 Protein, Human, Recombinant (His) T4-A,HsT1196,serpin peptidase inhibitor, clade B (ovalbumin)...	Human	Baculovirus Insect Cells
	SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be...
TMPK-00373	FAP Protein, Human, Recombinant (hFc) FAPA,SIMP,DPPIV,FAPα,FAP,Seprase,FAPalpha,DPPIVA,APCE	Human	HEK293 Cells
	Fibroblast activation protein (FAP) is a serine protease that has been reported in fibroblasts and some carcinoma cells, which correlates with poor patient outcomes. FAP can be induced under hypoxia which is also vital in the malignant behaviors of cancer cells. FAP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 112.3 kDa and the accession number is Q12884-1.
TMPK-01546	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi) MHC,CT6.1,CTAG1,MY-ESO-1,ESO1CTAG,CTAG1B,NY-ESO-1,LAGE-2,LAG...	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01513	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi), Biotinylated CT6.1,LAGE2A,MHC,CTAG1B,CTAG1,ESO1CTAG,MY-ESO-1,LAGE-2,NY-ES...	Human	HEK293 Cells
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-01448	HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (E. coli, His & Avi) MHC,LAGE-2,NY-ESO-1,ESO1CTAG,MY-ESO-1,CTAG1B,CTAG1,CT6.1,LAG...	Human	E. coli
	NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy.
TMPK-00923	FAP Protein, Mouse, Recombinant (His) FAPα,FAPalpha,DPPIVA,APCE,SIMP,FAP,DPPIV,FAPA,Seprase	Mouse	HEK293 Cells
	Fibroblast activation protein (FAP) is a serine protease that has been reported in fibroblasts and some carcinoma cells, which correlates with poor patient outcomes. FAP can be induced under hypoxia which is also vital in the malignant behaviors of cancer cells. FAP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 86.4 kDa and the accession number is P97321-1.
TMPK-01282	FAP Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated FAPα,DPPIVA,SIMP,APCE,DPPIV,Seprase,FAP,FAPA,FAPalpha	Cynomolgus	HEK293 Cells
	Fibroblast activation protein (FAP) is a serine protease that has been reported in fibroblasts and some carcinoma cells, which correlates with poor patient outcomes. FAP can be induced under hypoxia which is also vital in the malignant behaviors of cancer cells. FAP Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 88 kDa and the accession number is A0A2K5VGF4.
TMPJ-00703	Gankyrin Protein, Human, Recombinant PSMD10,Gankyrin,26S Proteasome Non-ATPase Regulatory Subunit...	Human	E. coli
	Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
TMPK-01268	Complement C2 Protein, Cynomolgus, Recombinant (His) C2,CO2,Complement C2,C3/C5 convertase,ARMD14	Cynomolgus	HEK293 Cells
	Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to healthy controls, and C2 was associated with TNM stages. Higher C2 expression was significantly associated with better prognosis, and multivariate analysis showed that C2 was also an independent factor for the prognosis of HCC.
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重组蛋白

PIGR Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00381

Species: Human

Expression System: HEK293 Cells

BCAS2 Protein, Human, Recombinant (His, T7)

Cat.No: TMPJ-00705

Species: Human

Expression System: E. coli

Serpin B4 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02100

Species: Human

Expression System: E. coli

Mucin-16/MUC16 Protein, Human, Recombinant (His)

Cat.No: TMPH-01706

Species: Human

Expression System: HEK293 Cells

Galectin-8/LGALS8 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01363

Species: Human

Expression System: E. coli

HYAL1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01093

Species: Human

Expression System: HEK293 Cells

UBAP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01362

Species: Human

Expression System: E. coli

Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated

Cat.No: TMPJ-00155

Species: Human

Expression System: HEK293 Cells

LGALS8 Protein, Human, Recombinant

Cat.No: TMPJ-00654

Species: Human

Expression System: E. coli

STK11 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02094

Species: Human

Expression System: E. coli

Mucin-1/MUC1 Protein, Human, Recombinant (Isoform 8, His)

Cat.No: TMPH-01705

Species: Human

Expression System: E. coli

LDHB Protein, Human, Recombinant (His)

Cat.No: TMPJ-00797

Species: Human

Expression System: E. coli

ENOX2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01278

Species: Human

Expression System: E. coli

HSP90AA1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01429

Species: Human

Expression System: E. coli

ENOX2 Protein, Human, Recombinant

Cat.No: TMPH-01277

Species: Human

Expression System: E. coli

LDHA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00724

Species: Human

Expression System: E. coli

NSMCE3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01781

Species: Human

Expression System: E. coli

SMAD4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01108

Species: Human

Expression System: E. coli

TGS1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02246

Species: Human

Expression System: E. coli

Serpin B3 Protein, Human, Recombinant (C-His)

Cat.No: TMPJ-00928

Species: Human

Expression System: HEK293 Cells

Serpin B3 Protein, Human, Recombinant (N-His)

Cat.No: TMPJ-00929

Species: Human

Expression System: E. coli

CRYAB Protein, Human, Recombinant (His)

Cat.No: TMPJ-00755

Species: Human

Expression System: E. coli

IGF2BP-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00345

Species: Human

Expression System: E. coli

RETNLB Protein, Human, Recombinant (His)

Cat.No: TMPH-02027

Species: Human

Expression System: E. coli

PLA2G16 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01010

Species: Human

Expression System: E. coli

DDR1 Protein, Human, Recombinant (aa 21-417, His)

Cat.No: TMPH-01297

Species: Human

Expression System: HEK293 Cells

RPSA Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00856

Species: Human

Expression System: E. coli

Dermcidin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00545

Species: Human

Expression System: HEK293 Cells

GM-CSF/CSF2 Protein, Human, Recombinant (E. coli)

Cat.No: TMPJ-01465

Species: Human

Expression System: E. coli

PRSS3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01897

Species: Human

Expression System: HEK293 Cells

CCL18 Protein, Human, Recombinant (His)

Cat.No: TMPY-00566

Species: Human

Expression System: P. pastoris (Yeast)

IRAK4 Protein, Human, Recombinant (His)

Cat.No: TMPY-04483

Species: Human

Expression System: Baculovirus Insect Cells

TNFRSF19 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01203

Species: Human

Expression System: HEK293 Cells

TNFRSF19 Protein, Human, Recombinant (His)

Cat.No: TMPK-01204

Species: Human

Expression System: HEK293 Cells

AG-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00056

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01543

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01499

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01497

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01500

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01539

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi)

Cat.No: TMPK-01449

Species: Human

Expression System: E. coli

Serpin B3 Protein, Human, Recombinant (His)

Cat.No: TMPY-02712

Species: Human

Expression System: Baculovirus Insect Cells

FAP Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00373

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01546

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01513

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (E. coli, His & Avi)

Cat.No: TMPK-01448

Species: Human

Expression System: E. coli

FAP Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00923

Species: Mouse

Expression System: HEK293 Cells

FAP Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01282

Species: Cynomolgus

Expression System: HEK293 Cells

Gankyrin Protein, Human, Recombinant

Cat.No: TMPJ-00703

Species: Human

Expression System: E. coli

Complement C2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01268

Species: Cynomolgus

Expression System: HEK293 Cells

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Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0521	Silibinin-d3
	Silibinin-d3 是 Silibinin 的氘代化合物。Silibinin 的 CAS 号为 22888-70-6。Silibinin 是水飞蓟的主要活性成分，具有抗癌和化疗预防作用，能抑制细胞增殖和迁移。
TMID-0133	Medroxyprogesterone-d3
	Medroxyprogesterone-d3 是 Medroxyprogesterone 的氘代化合物。Medroxyprogesterone 的 CAS 号为 520-85-4。Medroxyprogesterone 是一种合成的人孕酮变体，是孕酮受体激动剂，用于治疗肾癌。在兽医实践中用作发情调节剂。
TMIJ-0025	Megestrol Acetate-d3
	Megestrol Acetate-d3 是 Megestrol Acetate 的氘代化合物。Megestrol Acetate 的 CAS 号为 595-33-5。Megestrol acetate 是具有口服活性的合成孕激素。它还具有抗雄激素特性，可用于治疗厌食症和恶病质。
T69395	Nicotinamide-d4
	Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl...
T71293	Nifuroxazide-d4
	Nifuroxazide-d4 is intended for use as an internal standard for the quantification of nifuroxazide by GC- or LC-MS. Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay and decreases viability of U266 and INA-6 myeloma cells, which have constitutive S...
T69966	Roxadustat-d5
	Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ...
T35520	Aflatoxin G1-13C17 Aflatoxin G1-13C17
	Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to ducklings (LD50= 1.18 mg/kg).2It induces hepatocellular carcinoma tumor formation and lethality in rats when administered at doses of 1.4 and 3 mg/animal, respectively. Aflatoxin G1also inhibits liver and kidney succinate dehydrogenase and fumarase, as well as kidney cytochrome oxidase...

同位素标记化合物

Cat.No: TMIH-0521

Medroxyprogesterone-d3

Cat.No: TMID-0133

Megestrol Acetate-d3

Cat.No: TMIJ-0025

Nicotinamide-d4

Cat.No: T69395

Nifuroxazide-d4

Cat.No: T71293

Cat.No: T69966

Aflatoxin G1-13C17

Cat.No: T35520

Synonym: Aflatoxin G1-13C17

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