1363
17
4
44
2
Cat. No. | Product Name | ||
---|---|---|---|
L8600 | 泛素化化合物库 | 210 compounds | |
210 种泛素化相关的小分子,用于高通量和高内涵筛选; | |||
L1100 | 蛋白酶抑制剂库 | 343 compounds | |
343 种已知的小分子蛋白酶抑制剂的特有集合,可用于高通量筛选和高内涵筛选; | |||
L8500 | HIF-1化合物库 | 1336 compounds | |
1336 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究; | |||
L3800 | NF-κB 通路分子库 | 729 compounds | |
729 个 NF-κB 信号通路相关的小分子化合物的特有集合,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21854 |
Proteasome inhibitor IX
PS-IX,AM114 |
Proteasome | Proteases/Proteasome; Ubiquitination |
Proteasome inhibitor IX (PS-IX) 是 Chalcone 的一种衍生物,对20S 蛋白酶体的胰凝乳蛋白酶样活性有抑制作用,IC50约为 1 μM。它抑制 HCT116 p53+/+细胞生长,IC50为 1.49 μM,显示出有效的抗癌活性。 | |||
T63321 |
20S Proteasome activator 1
|
Proteasome | Proteases/Proteasome; Ubiquitination |
20S Proteasome activator 1 是一种 20S 蛋白酶激活剂,对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的 IC50 分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 通过在细胞系统中翻译来防止致病性 α-synuclein A53T 突变体积累从而减少疾病发生的概率。20S Proteasome activator 1 可用于研究神经退行性疾病。 | |||
T12561 |
Proteasome-IN-1
|
Proteasome | Proteases/Proteasome; Ubiquitination |
Proteasome-IN-1 is an inhibitor of proteasome. | |||
T81371 |
Proteasome-IN-5
|
Proteasome | Proteases/Proteasome; Ubiquitination |
Proteasome-IN-5(compound 5)是一款有效的蛋白酶体抑制剂。 | |||
T72762 |
Proteasome-IN-4
|
Others | Others |
Proteasome-IN-4 是一种良好的非共价 proteasome 抑制剂 (IC50= 8.39 nM)。Proteasome-IN-4 对 RPMI-8226、MM-1S 和 MV-4-11 细胞系具有较强的抗增殖活性。Proteasome-IN-4 可用于癌症研究。 | |||
T81372 |
Proteasome-activating peptide 1
|
||
Proteasome-activating peptide 1 是一种肽,其作用是提升胰凝乳蛋白酶样蛋白酶体(proteasome)的催化活性,有效增强体外及细胞培养环境下的蛋白质降解效率。此外,该肽能阻止肌萎缩侧索硬化症(Amyotrophic Lateral Sclerosis, ALS)细胞模型中蛋白质的过度聚集。 | |||
T71092 |
Proteasome-IN-3
|
Others | Others |
Proteasome-IN-3 is an inhibitor of proteasome-associated DUBs. | |||
T9710 |
Dazcapistat
|
Cysteine Protease | Proteases/Proteasome |
Dazcapistat 是一种有效的 calpain 抑制剂,对 calpain 1、calpain 2 和 calpain 9 的 IC50 值均 <3 μM。 | |||
T62255 |
20S Proteasome-IN-4
|
Others | Others |
20S Proteasome-IN-4 (Compound 7) 是一种能透过血脑屏障的、寄生虫选择性的、具有口服活性的20Sproteasome 抑制剂,对T. b. brucei20S 蛋白酶体的IC50为 6.3 nM。20S Proteasome-IN-4 可用于非洲人类锥虫病的研究。 | |||
T78625 |
Z-Ala-Arg-Arg-AMC
Z-ARR-AMC,Fluorogenic Proteasome Substrate |
Proteasome | Proteases/Proteasome; Ubiquitination |
Z-Ala-Arg-Arg-AMC (FluorogenicProteasomeSubstrate) 作为荧光底物,专用于检测蛋白酶体中的胰蛋白酶样活性。 | |||
T76243 |
Proteasome-activating peptide 1 TFA
|
||
Proteasome-activating peptide 1 TFA 是一种肽类蛋白酶体激活剂,能显著增强胰凝乳蛋白酶样蛋白酶体的催化活性,进而提升体外及培养环境中的蛋白质水解效率。此外,Proteasome-activating peptide 1 TFA 还能有效阻止肌萎缩侧索硬化症细胞模型内的蛋白质聚集现象。 | |||
T6432 |
Calpeptin
|
Apoptosis; Cysteine Protease; Proteasome | Apoptosis; Proteases/Proteasome; Ubiquitination |
Calpeptin 是一种具有细胞穿透性的calpain 抑制剂,也是cathepsin K 抑制剂,其对人血小板 Calpain I 的ID50值为40 nM。 | |||
T81373 |
Proteasome β2c/i-IN-1
|
Proteasome | Proteases/Proteasome; Ubiquitination |
Proteasomeβ2c/i-IN-1(compound 37)为针对β2c和β2i亚基的选择性蛋白酶抑制剂。 | |||
T9090 |
MUN57694
|
Proteasome | Proteases/Proteasome; Ubiquitination |
MUN57694 是 26S 蛋白酶体的抑制剂。 | |||
T7016 |
VR23
|
Apoptosis; Proteasome; Caspase | Apoptosis; Proteases/Proteasome; Ubiquitination |
VR23 是一种蛋白酶体抑制剂,对胰蛋白酶样蛋白酶体、糜蛋白酶样蛋白酶体和半胱天冬酶样蛋白酶体的 IC50 分别是1 nM、50-100 nM 和3 μM。 | |||
T13858 |
RA190
|
Proteasome | Proteases/Proteasome; Ubiquitination |
RA190 能够与泛素受体 RPN13 的半胱氨酸 88 共价结合,并抑制蛋白酶体功能。 | |||
T7814 |
Alloxan monohydrate
|
Proteasome | Proteases/Proteasome; Ubiquitination |
Alloxan Monohydrate 是一种能够引起糖尿病的致糖尿病药物。它作为蛋白酶体抑制剂,破坏胰腺中能够分泌胰岛素的B 细胞,导致实验动物患糖尿病。 | |||
T6941 |
PI-1840
PI 1840 |
PARP; Proteasome | Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome; Ubiquitination |
PI-1840 是一种高效的、选择性的蛋白酶体chymotrypsin-like (CT-L)抑制剂,IC50=27nM。 | |||
T0372 |
Gabexate mesylate
甲磺酸加贝酯,FOY |
Factor Xa; Serine Protease; Proteasome | Metabolism; Proteases/Proteasome; Ubiquitination |
Gabexate mesylate (FOY) 是一种非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。 | |||
T8978 |
DD1
3,3'-Diamino-4'-methoxyflavone,HUN85111 |
Proteasome | Proteases/Proteasome; Ubiquitination |
DD1 (HUN85111) 是一种蛋白酶体抑制剂,可诱导人髓系肿瘤选择性凋亡。 | |||
T2122 |
Ixazomib
艾沙佐米,MLN2238 |
Proteasome; Caspase; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination |
Ixazomib (MLN2238) 含硼肽蛋白酶体抑制剂(PI),可抑制 20S 蛋白酶体的糜蛋白酶样蛋白水解 (β5) 位点,IC50为 3.4 nM,Ki 为 0.93 nM。它还抑制半胱天冬酶样 (β1) 和胰蛋白酶样 (β2) 蛋白水解位点,IC50值为 31和3500 nM。 | |||
T2470 |
MDL-28170
Calpain Inhibitor III |
Cysteine Protease; Proteasome | Proteases/Proteasome; Ubiquitination |
MDL-28170 (Calpain Inhibitor III) 是一种选择性的、有效的、具有膜渗透性的半胱氨酸蛋白酶 (calpain)抑制剂,可在全身给药后迅速穿过血脑屏障。它还能阻断γ-secretase。 | |||
T1795 |
Carfilzomib
卡非佐米,PR-171 |
Apoptosis; Proteasome; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination |
Carfilzomib (PR-171) 是一种蛋白酶体抑制剂,与 20S 蛋白酶体的糜蛋白酶不可逆结合。Carfilzomib 具有抗肿瘤活性,可以用于治疗多发性骨髓瘤。 | |||
T17011 |
TCH-165
|
Proteasome | Proteases/Proteasome; Ubiquitination |
TCH-165 是一种蛋白酶体组装的小分子调节剂,可增加游离 20S 水平,进而增强 IDP 蛋白水解。 | |||
T21510 |
PSI
|
Proteasome | Proteases/Proteasome; Ubiquitination |
PSI 是蛋白酶体proteasome 抑制剂。它对原发性渗出性淋巴瘤 (PEL) 细胞的增殖具有抑制作用。它可用于 KSHV 相关淋巴瘤、卡波济氏肉瘤相关疱疹病毒 (KSHV) 感染的研究。 | |||
T8397 |
Ixazomib citrate
枸橼酸艾沙佐米,MLN9708 |
Proteasome; Autophagy | Autophagy; Proteases/Proteasome; Ubiquitination |
Ixazomib citrate (MLN9708) 是 Ixazomib 的前药,是20S 蛋白酶体胰凝乳蛋白酶样蛋白水解β5位点的可逆抑制剂,IC50为3.4 nM 和Ki 为0.93 nM。 | |||
T13273 |
UT-34
|
Androgen Receptor | Endocrinology/Hormones |
UT-34 是选择性的、具有口服活性的泛雄激素受体拮抗剂和降解剂,能够作用于野生型 AR (IC50:211.7 nM)、F876L-AR (IC50:262.4 nM)、W741L-AR (IC50:215.7 nM)。它与配体结合结构域和功能 1结构域结合,并需要泛素蛋白酶体途径来降解AR。它有抗前列腺癌的能力。 | |||
T12579 |
RAMB4
PTP1B-IN-9 |
Proteasome | Proteases/Proteasome; Ubiquitination |
RAMB4 (PTP1B-IN-9) 是一种泛素-蛋白酶体系统(UPS)应激源,是通过抑制 20S 蛋白酶体催化活性物质上游泛素介导的蛋白质降解而产生。它能够在不影响 20S 蛋白酶体催化活性的情况下触发泛素蛋白酶体系统 (UPS) 应激反应。 | |||
T9809 |
E3 ligase Ligand 23
|
Ligand for E3 Ligase | PROTAC |
E3 ligase Ligand 23 是一种 cereblon 结合剂,可通过泛素蛋白酶体降解 Ikaros 或 Aiolos。 | |||
T12079 |
ML604440
|
Proteasome | Proteases/Proteasome; Ubiquitination |
ML604440 是一种特异性的、有效的、细胞可渗透的蛋白酶体 β1i (LMP2) 亚基抑制剂,能够破坏 MHC I 类细胞表面表达,IL-6 分泌以及 naïve T helper 向 17 T helper 细胞的分化。它可以改善实验性结肠炎和 EAE 疾病。 | |||
T39710 |
ARV-471
Vepdegestrant |
Estrogen Receptor/ERR; PROTACs | Endocrinology/Hormones; PROTAC |
ARV-471 (Vepdegestrant) 是一种高效的,口服有效的基于 Cereblon 配体的雌激素受体降解剂 PROTAC 。ARV-471 常用于研究乳腺癌。 | |||
T3695 |
Pepstatin
抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C |
Amino Acids and Derivatives; Proteasome; HIV Protease; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination |
Pepstatin (Pepsin Inhibitor S 735A) 是由放线菌类产生的特异性天冬氨酸蛋白酶抑制剂,可抑制 HIV 蛋白酶的活性。 | |||
T6029 |
ONX-0914
ONX0914,PR-957,ONX 0914 |
Proteasome; HIV Protease; Antibacterial | Microbiology/Virology; Proteases/Proteasome; Ubiquitination |
ONX-0914 (PR-957) 是选择性的低分子量多肽-7(LMP7)的抑制剂,LMP7 是免疫蛋白酶体的类糜蛋白酶亚单位。它是分枝杆菌蛋白酶体的非竞争性不可逆抑制剂,Ki 值为5.2 μM。它通过 HSF-1 介导的 p-TEFb 活化激活潜伏的 HIV-1。 | |||
T8745 |
PROTAC BRAF-V600E degrader-1
Compound 23 |
Raf; PROTACs | MAPK; PROTAC |
PROTAC BRAF-V600E degrader-1 (Compound 23) 选择性地诱导 BRAF-V600E 的降解,而不是野生型 BRAF。 | |||
T6027 |
Delanzomib
德兰佐米,CEP-18770 |
Apoptosis; NF-κB; Proteasome | Apoptosis; NF-κB; Proteases/Proteasome; Ubiquitination |
Delanzomib (CEP-18770) 是一种强效的具有口服活性的蛋白酶体的胰凝乳蛋白酶样活性抑制剂,IC50为 3.8 nM。它抑制NF-κB 活性,诱导癌细胞凋亡,具有很强的抗血管生成和抗癌活性。 | |||
T13554 |
Arimoclomol maleate
BRX-220 |
HSP | Cytoskeletal Signaling; Metabolism |
Arimoclomol maleate (BRX-220) 是一种热休克蛋白 (HSP) 的共诱导剂。它通过增强 Hsp 表达来保护运动神经元,进而通过蛋白酶体-泛素系统直接影响蛋白质聚集和错误折叠装配体的清除 | |||
T10765 |
Eragidomide
CC-90009,Cereblon modulator 1 |
Apoptosis; Ligand for E3 Ligase; Molecular Glues | Apoptosis; PROTAC |
Cereblon modulator 1 是一种 GSPT1 选择性cereblon (CRBN)E3 连接酶调节剂,以分子胶的方式作用。它通过 CRL4CRBN选择性靶向 GSPT1 进行泛素化和蛋白酶体降解。 | |||
T6041 |
Oprozomib
PR-047,奥泼佐米,ONX 0912 |
Proteasome; Autophagy | Autophagy; Proteases/Proteasome; Ubiquitination |
Oprozomib (PR-047) 是一种可口服的选择性肽环氧酮类蛋白酶体抑制剂,诱导多发性骨髓瘤细胞凋亡。它对蛋白酶体 (β5) 和免疫蛋白酶体 (LMP7) 的 IC50分别为 36 和 82 nM。 | |||
T2154 |
MG-132
Z-LLL-al,Z-Leu-Leu-Leu-CHO |
Apoptosis; Proteasome; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination |
MG-132 (Z-Leu-Leu-Leu-al) 是一种 26S 蛋白酶体抑制剂 (IC50=100 nM),具有细胞渗透性、可逆性。MG-132 可作为自噬激活剂,可诱导凋亡。 | |||
T13553 |
Arimoclomol
阿瑞洛莫,BRX-220 free base |
HSP | Cytoskeletal Signaling; Metabolism |
Arimoclomol (BRX-220 free base) 是热休克蛋白 (HSP) 的共诱导剂,可用于治疗肌萎缩侧索硬化症的研究。 | |||
T12628 |
(R)-MG-132
(S,R,S)-(-)-MG-132,N-[(苯基甲氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-D-亮氨酰胺,Z-Leu-D-leu-leu-al |
Proteasome | Proteases/Proteasome; Ubiquitination |
(R)-MG-132 (Z-Leu-D-leu-leu-al) 是一种 MG-132 的对映异构体,是一种蛋白酶体 (proteasome) 抑制剂,细胞毒性比 MG-132 弱,是一种比 MG-132 更有效的proteasome 抑制剂。 | |||
T6583 |
MG-101
ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101,钙蛋白酶抑制剂I |
Cysteine Protease; Proteasome | Proteases/Proteasome; Ubiquitination |
MG-101 (Calpain inhibitor I) 是一种有效的半胱氨酸蛋白酶抑制剂,能够抑制钙蛋白酶I (Ki:190 pM),钙蛋白酶II (Ki:220 pM),组织蛋白酶B (Ki:150 pM)和组织蛋白酶L (Ki:500 pM)。 | |||
T2399 |
Bortezomib
Radiciol,NSC 681239,硼替佐米,MG 341,DPBA,Brotezamide,LDP 341 |
Apoptosis; NF-κB; Proteasome; Autophagy | Apoptosis; Autophagy; NF-κB; Proteases/Proteasome; Ubiquitination |
Bortezomib (LDP 341) 是一种 20S 蛋白酶体抑制剂 (Ki=0.6 nM),具有可逆性和选择性。Bortezomib 具有抗肿瘤活性,可以抑制 NF-κB,可破坏细胞周期、诱导细胞凋亡。 | |||
T61320 |
Immunoproteasome inhibitor 1
|
Others | Others |
Immunoproteasome inhibitor 1 is a highly potent and reversible inhibitor of both immunoproteasome and proteasome activity. It exhibits time-independent inhibitory effects on immunoproteasome subunits β5c, β1i, and β5i, with respective Ki values of 1.18 μM, 0.27 μM, and 1.91 μM. This compound shows promising potential for the treatment of select neoplastic diseases [1]. | |||
T2016 |
MLN9708
Ixazomib Citrate |
Proteasome | Proteases/Proteasome; Ubiquitination |
MLN9708 (Ixazomib Citrate) 抑制 20S 蛋白酶体的糜蛋白酶样蛋白水解 (β5) 位点 (Ki50=0.93 nM, IC50=3.4 nM/)。 MLN9708 的生物活性形式是水溶液或血浆中的 MLN2238。 | |||
T21617 |
MG-115
Z-LL-Nva-CHO |
Proteasome | Proteases/Proteasome; Ubiquitination |
MG-115 (Z-LL-Nva-CHO) 是一种有效且可逆的蛋白酶体抑制剂,对20S 和26S 蛋白酶体的 Ki 值分别为 21 nM 和 35 nM。MG-115 特异性抑制蛋白酶体的胰凝乳蛋白酶样活性,诱导 p53 依赖性细胞凋亡。 | |||
T1932 |
B-AP15
NSC 687852 |
Apoptosis; DUB | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
B-AP15 (NSC-687852) 是 26S 蛋白酶体的去泛素化酶 Usp14 和 UCHL5 的选择性抑制剂。 它阻断 26S 蛋白酶体的去泛素化活性。 | |||
T11742L |
K-7174 dihydrochloride
K7174 2HCl,K-7174 2HCl,K 7174 2HCl |
Proteasome | Proteases/Proteasome; Ubiquitination |
K-7174 dihydrochloride 是具有口服活性的 proteasome 和 GATA 抑制剂,抑制白细胞粘附和炎症因子表达,抑制神经元变性,诱导细胞凋亡。K-7174 dihydrochloride 具有抗肿瘤活性,可用于研究神经精神系统性红斑狼疮和认知功能障碍。 | |||
T10672 |
Capzimin
|
Others | Others |
Capzimin 是蛋白酶体异肽酶 Rpn11 的选择性抑制剂。 | |||
T39214L |
LXE408 fumarate
LXE408 fumarate (1799330-15-6 Free base) |
Proteasome | Proteases/Proteasome; Ubiquitination |
LXE408 fumarate 是一种口服有效的,非竞争性的,动素体选择性蛋白酶体 (proteasome) 抑制剂。LXE408 fumarate 抑制 L. donovani 蛋白酶体 (IC50=0.04 μM) 和 L. donovani (EC50=0.04 μM)。LXE408 fumarate 具有较弱的透过血脑屏障能力。LXE408 fumarate 具有用于内脏利什曼病 (VL) 研究的潜力。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3786 |
Tomatine
lycopersicin,番茄素,番茄碱 |
Apoptosis; Proteasome | Apoptosis; Proteases/Proteasome; Ubiquitination |
Tomatine (lycopersicin) 是从番茄植物中发现的一种糖苷生物碱。它促进神经母细胞瘤细胞中核凋亡诱导因子的上调,还抑制20S 蛋白酶体活性。它以 RIP1 激酶和 caspase 非依赖性的方式引发神经毒性。 | |||
T3028 |
Tripterin
Celastrol,Tripterine,雷公藤红素 |
Apoptosis; Mitophagy; Proteasome; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination |
Tripterin (Celastrol) 属于天然产物,是一种蛋白酶体抑制剂,抑制 20S 蛋白酶体的胰凝乳蛋白酶样活性 (IC50=2.5 μM)。Tripterin 具有抗炎、抗感染和免疫调节的作用。 | |||
T6830 |
Epoxomicin
BU-4061T,BU-4061T,Aids010837,环氧酶素 |
Apoptosis; Proteasome | Apoptosis; Proteases/Proteasome; Ubiquitination |
Epoxomicin (BU-4061T,Aids010837) 是一种含环氧酮的天然产物,可穿越血脑屏障,并具有很强的抗肿瘤和抗炎活性。它是一种选择性不可逆的蛋白酶体抑制剂,抑制类胰凝乳蛋白酶的活性。 | |||
T7917 |
4'-Hydroxychalcone
4-羟基查耳酮,4′-羟基查耳酮,2-Benzal-4-Hydroxyacetophenone |
Proteasome | Proteases/Proteasome; Ubiquitination |
4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) 是从甘草根中分离的一种查尔酮,具有保护肝脏的作用。它能诱导大鼠离体肝线粒体囊泡快速释放钾,并引起其线粒体呼吸控制和氧化磷酸化衰退。它能通过抑制蛋白酶体 (proteasome),抑制TNFα 诱导的 NF-κB 活性。 | |||
T4S21320 |
ISOGINKGETIN
异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮 |
MMP; Others | Others; Proteases/Proteasome |
ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂,也是一种Pre-mRNA Splicing 抑制剂。 | |||
T2745 |
18α-Glycyrrhetinic acid
18-α-甘草次酸,甘草次酸,Enoxolone,Glycyrrhetinic acid |
Apoptosis; NF-κB; Proteasome | Apoptosis; NF-κB; Proteases/Proteasome; Ubiquitination |
18α-Glycyrrhetinic acid (Enoxolone) 是 NF-kB 的抑制剂和蛋白酶体的激活剂,在多细胞生物中起到促进长寿和抗聚集因子的作用。它诱导细胞凋亡。 | |||
T16012 |
Marizomib
NPI-0052,Salinosporamide A,ML858 |
Proteasome | Proteases/Proteasome; Ubiquitination |
Marizomib (ML858) 是一种新型不可逆的脑渗透性泛蛋白酶体 (proteasome) 抑制剂,对 20S 蛋白酶体的 CT-L (β5)、CT-T-laspase 样 (C-L, β1) 和胰蛋白酶样 (T-L, β2) 具有抑制作用, IC50 分别为 3.5, 28, 430 nM。 | |||
T2S1837 |
Steviol
甜菊醇,NSC 226902,Hydroxydehydrostevic acid |
Others | Others |
Steviol (NSC-226902) 是一种甜菊糖甙的主要代谢物。它能降低 AQP2 的表达,并促进 AQP2 的降解,从而减缓肾囊肿的生长。 | |||
T4S1615 |
Sanggenon C
桑根酮C,桑根酮 C,Sanggenone C |
NF-κB | NF-κB |
Sanggenon C (Sanggenone C) 是一种从桑属的根皮中分离得到的黄烷酮 Diels-Alder 加合物化合物。它可抑制NF-κB 活性,抑制 RAW264.7 细胞中诱导型一氧化氮合酶的表达,以及肿瘤坏死因子-α 刺激的细胞粘附和血管细胞粘附分子-1 的表达。 它具有抗氧化和抗炎作用,也有抑制胰脂肪酶作用。 | |||
T15702 |
Lactacystin
|
Proteasome | Proteases/Proteasome; Ubiquitination |
Lactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome inhibitor (IC50: 4.8 μM for 20S proteasome). Lactacystin inhibits cell growth and induces neurite outgrowth and also inhibits the lysosomal enzyme cathepsin A. | |||
TN3228 |
7-Hydroxy-3-(4-hydroxybenzyl)chroman
|
Others | Others |
7-Hydroxy-3-(4-hydroxybenzyl)chroman shows moderate inhibitory activity against a chymotrypsin-like activity of the proteasome. | |||
T75624 |
Sadopeptins B
|
Others | Others |
Sadopeptins B 是一种天然产物,可以从 Streptomycessp 中分离出来。Sadopeptins B 是一种有效的蛋白酶体抑制剂。 | |||
TN1354 |
Aaptamine
|
c-Myc; TNF; p53 | Apoptosis; Cell Cycle/Checkpoint |
Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner. | |||
T10238 |
Aclacinomycin A hydrochloride
盐酸阿柔比星,Aclarubicin hydrochloride |
Proteasome | Proteases/Proteasome; Ubiquitination |
Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II. | |||
T75623 |
Sadopeptins A
|
Others | Others |
Sadopeptins A 是一种天然产物,可以从 Streptomycessp 中分离出来。Sadopeptins A 是一种有效的蛋白酶体抑制剂。 | |||
T75488 |
Leptosphaerodione
|
Others | Others |
Leptosphaerodione,可从 Remotididymellasp. 中分离得到,是一种有效的泛素-蛋白酶体系统 (UPS) 抑制剂。Leptosphaerodione 在 HeLa 细胞中具有细胞毒性,IC50为 3.2 μM。抗肿瘤剂。 | |||
T79941 |
Antimycin A2c
|
Apoptosis | Apoptosis |
Anticanceragent 141(compound AE)是一种针对HPV感染宫颈癌具有抑制作用的抗霉素生物碱。该化合物能够抑制宫颈癌HeLa细胞的增殖并导致细胞周期在S期停滞。Anticanceragent 141破坏线粒体功能,诱导caspase依赖性细胞凋亡,并激活ROS介导的泛素依赖性蛋白酶体系统,进而引起E6/E7癌蛋白的降解。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00002 |
PSMD3 Protein, Human, Recombinant (His)
PSMD3,26S proteasome regulatory subunit S3,26S ... |
Human | P. pastoris (Yeast) |
PSMD3 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 63 kDa; 70 kDa, reducing conditions and the accession number is O43242. | |||
TMPH-00849 |
PSMD14 Protein, Human, Recombinant (His & MBP)
26S proteasome non-ATPase regulatory subunit 14,PSM... |
Human | Baculovirus Insect Cells |
PSMD14 Protein, Human, Recombinant (His & MBP) is expressed in Baculovirus insect cells with N-MBP and C-6xHis tag. The predicted molecular weight is 79.2 kDa and the accession number is O00487. | |||
TMPJ-00703 |
Gankyrin Protein, Human, Recombinant
PSMD10,Gankyrin,26S Proteasome Non-ATPase Regulator... |
Human | E. coli |
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis. | |||
TMPY-00607 |
PSMB6 Protein, Mouse, Recombinant (His)
proteasome (prosome, macropain) subunit, β type, 6,... |
Mouse | E. coli |
PSMB6 subunit belongs to the 20S proteasomal subunit family, which plays an importance role in the antigen presentation by MHC class I molecular. Proteasome subunit beta type 6 (PSMB6) is a member of 20S proteasomal subunit family, which forms the proteolytic core of 26S proteasome. PSMB6 knockdown decreased cellular viability under DM treatment. PSMB6 is associated with DM resistance in mosquitoes and that proteasome inhibitors such as MG-132 or bortezomib are suitable for use as a DM synergist... | |||
TMPY-04078 |
PSMA3 Protein, Human, Recombinant (His)
HC8,PSC3,proteasome (prosome, macropain) subunit, α... |
Human | E. coli |
PSMA3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30.7 kDa and the accession number is AAH29402.1. | |||
TMPH-01927 |
PSMB2 Protein, Human, Recombinant (GST)
Proteasome subunit beta type-2,Multicatalytic endop... |
Human | E. coli |
PSMB2 Protein, Human, Recombinant (GST) is expressed in E. coli. | |||
TMPY-03610 |
PSME2 Protein, Human, Recombinant (His)
REGβ,proteasome (prosome, macropain) activator subu... |
Human | E. coli |
PSME2, also known as PA28b, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit... | |||
TMPH-01928 |
PSMB8 Protein, Human, Recombinant (His & Myc & SUMO)
Proteasome subunit beta type-8,Proteasome ... |
Human | E. coli |
PSMB8 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli. | |||
TMPY-03612 |
PSME1 Protein, Human, Recombinant (His)
proteasome (prosome, macropain) activator subunit 1... |
Human | E. coli |
PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit... | |||
TMPK-01530 |
HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
MHC,LMP-2,PSMB9,LMP2,Macropain chain 7,Proteasome c... |
Human | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPK-01534 |
Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human&Mouse, MHC (His & Avi)
RING12,PSMB9,Proteasome chain 7,RMF,LMP-2,LMP2,MHC,... |
Human & Mouse | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPK-01503 |
HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Monomer Protein, Human, MHC (His & Avi)
Macropain chain 7,LMP-2,RING12,LMP2,RMF,MHC,PSMB9,Protea... |
Human | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPK-01535 |
Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human&Mouse, MHC (His & Avi)
Macropain chain 7,LMP2,Proteasome chain 7,RING12,PS... |
Human & Mouse | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPK-01502 |
HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Monomer Protein, Human, MHC (His & Avi), Biotinylated
PSMB9,LMP2,Macropain chain 7,MHC,Proteasome chain 7... |
Human | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPK-01533 |
HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human, MHC (His & Avi)
MHC,LMP2,RING12,PSMB9,Macropain chain 7,Proteasome ... |
Human | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPK-01542 |
HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human, MHC (His & Avi)
RMF,PSMB9,Proteasome chain 7,RING12,LMP2,LMP-2,MHC,... |
Human | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPK-01498 |
HLA-A*11:01&B2M&LMP2 (SSCSSCPLTK) Tetramer Protein, Human, MHC (His & Avi)
Proteasome chain 7,MHC,RING12,RMF,LMP2,LMP-2,PSMB9,... |
Human | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPY-03614 |
PSME3 Protein, Human, Recombinant (His)
PA28G,PA28-gamma,HEL-S-283,REG-GAMMA,proteasome (pr... |
Human | E. coli |
PSME3, also known as PA28-gamma, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase su... | |||
TMPH-03757 |
TPP2 Protein, Human, Recombinant (E. coli, His & Myc)
TPP2,Tripeptidyl-peptidase II,Tripeptidyl-peptidase 2,Tripep... |
Human | E. coli |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. TPP2 Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.8 kDa and the accession number is P29144. | |||
TMPH-02250 |
TPP2 Protein, Human, Recombinant (His & Myc)
Tripeptidyl-peptidase II,Tripeptidyl aminopeptidase,Tripepti... |
Human | Baculovirus Insect Cells |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. | |||
TMPH-02953 |
TPP2 Protein, Mouse, Recombinant (His & Myc)
Tripeptidyl aminopeptidase,Tripeptidyl-peptidase 2,Tripeptid... |
Mouse | Baculovirus Insect Cells |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. TPP2 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 28.3 kDa and the accession number is Q64514. | |||
TMPH-03762 |
TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc)
Tpp2,Tripeptidyl-peptidase 2,Tripeptidyl aminopeptidase,Trip... |
Mouse | E. coli |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 29.5 kDa and the accession number is Q64514. | |||
TMPH-02284 |
USP26 Protein, Human, Recombinant (His)
USP26,Deubiquitinating enzyme 26,Ubiquitin thioesterase 26,U... |
Human | E. coli |
Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway. | |||
TMPH-02300 |
RAD23A Protein, Human, Recombinant (His)
UV excision repair protein RAD23 homolog A,RAD23A |
Human | E. coli |
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucle... | |||
TMPJ-01386 |
STUB1 Protein, Human, Recombinant
Carboxy Terminus of Hsp70-Interacting Protein,STIP1 Homology... |
Human | E. coli |
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.... | |||
TMPH-01203 |
DCAF16 Protein, Human, Recombinant (His & Myc)
C4orf30,DCAF16,DDB1- and CUL4-associated factor 16 |
Human | E. coli |
Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. DCAF16 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.2 kDa and the accession number is Q9NXF7. | |||
TMPH-02282 |
Ubiquilin-1 Protein, Human, Recombinant (His & Myc)
Ubiquilin-1,UBQLN1,Protein linking IAP with cytoskeleton 1 |
Human | E. coli |
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its in... | |||
TMPH-01522 |
HIV-2 (subtype A, isolate ROD) Protein Vpx (His)
vpx,Viral protein X,X ORF protein,Protein Vpx |
HIV-2 | P. pastoris (Yeast) |
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by... | |||
TMPJ-01310 |
TRIM5 Protein, Human, Recombinant (His)
RNF88,Tripartite motif-containing protein 5,RING finger prot... |
Human | E. coli |
Tripartite motif-containing Motif 5 is a protein that in humans is encoded by the TRIM5 gene.It is a 493 amino acids protein that belongs to the TRIM/RBCC family.It contains 1 B box-type zinc finger, 1 B30.2/SPRY domain and 1 RING-type zinc finger. TRIM5 present in the cytoplasm recognizes motifs within the capsid proteins and interferes with the uncoating process, therefore preventing successful reverse transcription and transport to the nucleus of the viral genome. The exact mechanism of actio... | |||
TMPH-00775 |
IFN gamma Protein, Goat, Recombinant (His & Myc)
Interferon gamma,IFNG |
Goat | E. coli |
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activati... | |||
TMPJ-01131 |
UBE2V2 Protein, Human, Recombinant (His)
Enterocyte Differentiation-Associated Factor 1,Vitamin D3-In... |
Human | E. coli |
Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains and which leads to protein degradation by the proteasome. UBE2V2 mediates transcriptional activation of target genes. It plays a role in the control of progress through the cell cycle and... | |||
TMPJ-00661 |
PDCD5 Protein, Human, Recombinant (His)
Programmed Cell Death Protein 5,Protein TFAR19,TFAR19,PDCD5,... |
Human | E. coli |
Programmed Cell Death Protein 5 (PDCD5) is a member of the PDCD5 family. PDCD5 is expressed in tumor cells during apoptosis, independent of apoptosis-inducing stimuli. This protein may function in the process of apoptosis. PDCD5 is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 may play an important regulator of K (lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its pr... | |||
TMPJ-01013 |
VCP Protein, Human, Recombinant (His)
TER ATPase,Transitional Endoplasmic Reticulum ATPase,15S Mg(... |
Human | E. coli |
Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin... | |||
TMPY-03870 |
EDEM2 Protein, Human, Recombinant (His)
UNQ573/PRO1135,ER degradation enhancer, mannosidase alpha-li... |
Human | HEK293 Cells |
EDEM2, also known as C2orf31, belongs to a family of proteins involved in ER-associated degradation (ERAD) of glycoproteins. In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome. Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal. In humans there are a total of three EDEM ... | |||
TMPY-01865 |
BLMH Protein, Mouse, Recombinant (His)
Bh,bleomycin hydrolase,Bmh,AI035728 |
Mouse | E. coli |
The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The papain superfamily member bleomycin hydrolase (BLMH) is a neutral cysteine protease with structural similarity to a 20S proteasome. Bleomycin (BLM), a clinically used glycopeptide antica... | |||
TMPH-01269 |
SMURF2 Protein, Human, Recombinant (His)
SMAD ubiquitination regulatory factor 2,E3 ubiquitin-protein... |
Human | E. coli |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable com... | |||
TMPY-04389 |
MAP3K8 Protein, Human, Recombinant (GST)
TPL2,MEKK8,EST,ESTF,COT,Tpl-2,c-COT,AURA2,mitogen-activated ... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase kinase subfamily. MAP3K8 is expressed in several normal tissues and human tumor-derived cell lines. Isoform 1 of MAP3K8 is activated specifically during the S and G2/M phases of the... | |||
TMPJ-01100 |
UBE2V1 Protein, Human, Recombinant (His)
TRAF6-Regulated IKK Activator 1 Beta Uev1A,P/OKcl.19,TRAF6-R... |
Human | E. coli |
Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inactive on its own. However, in the cytoplasm UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13, which mediates the synthesis Lys63-linked Ubiquitin chains and is required for NF-kappa B activation. UBE2V1 is required for UBE2N (Ubc13)/UBE2V1 Complex-dependent Ly... | |||
TMPH-01664 |
OMA1 Protein, Human, Recombinant (His & SUMO)
Overlapping with the m-AAA protease 1 homolog,OMA1,Metallopr... |
Human | E. coli |
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Also acts as a regulator of apoptosis: upon BAK and BAX ag... | |||
TMPH-01531 |
IKBKB Protein, Human, Recombinant (His)
Serine/threonine protein kinase IKBKB,Nuclear factor NF-kapp... |
Human | Baculovirus Insect Cells |
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu... | |||
TMPH-01532 |
IKBKB Protein, Human, Recombinant (E. coli, His)
Nuclear factor NF-kappa-B inhibitor kinase beta,Serine/threo... |
Human | E. coli |
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu... | |||
TMPH-01270 |
TRAIP Protein, Human, Recombinant (His)
E3 ubiquitin-protein ligase TRAIP,TRAF-interacting protein,T... |
Human | E. coli |
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm... | |||
TMPH-02632 |
TRIM21 Protein, Mouse, Recombinant (E. coli, His)
Trim21,52 kDa ribonucleoprotein autoantigen Ro/SS-A,Triparti... |
Mouse | E. coli |
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr... | |||
TMPH-02633 |
TRIM21 Protein, Mouse, Recombinant (His)
Tripartite motif-containing protein 21,E3 ubiquitin-protein ... |
Mouse | Baculovirus Insect Cells |
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIH-0025 |
13C-d3-AOH1996
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13C-d3-AOH1996 是 AOH1996 的 13C 和氘代化合物。AOH1996 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体,靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用,导致 DNA 复制应激,诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用,可抑制肿瘤细胞生长。 | |||
TMIH-0091 |
AOH-d3
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AOH-d3 是 AOH 的氘代化合物。AOH 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体,靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用,导致 DNA 复制应激,诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用,可抑制肿瘤细胞生长。 |