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Immunoproteasome activator 1 (compound A) 作为一种高选择性的免疫蛋白酶体激活剂,能显著地促进MHC-I结合肽的呈递,增幅达到超过100倍。该化合物通过与蛋白酶体的结构亚单位PSMA1结合,并进一步促使蛋白酶体激活物PA28α/β (PSME1/PSME2) 与免疫蛋白酶体的有效结合,从而发挥其作用。
Immunoproteasome activator 1 (compound A) 作为一种高选择性的免疫蛋白酶体激活剂,能显著地促进MHC-I结合肽的呈递,增幅达到超过100倍。该化合物通过与蛋白酶体的结构亚单位PSMA1结合,并进一步促使蛋白酶体激活物PA28α/β (PSME1/PSME2) 与免疫蛋白酶体的有效结合,从而发挥其作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome. |
分子量 | 401.46 |
分子式 | C24H23N3O3 |
CAS No. | 901728-48-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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