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Rpn11-IN-1
还可以产品编号 T16795Cas号 2084867-65-0
别名 Capzimin intermediate
Rpn11-IN-1 is an effective and selective inhibitor of proteasome subunit Rpn11 (IC50: 390 nM).
Rpn11-IN-1
还可以产品编号 T16795 别名 Capzimin intermediateCas号 2084867-65-0
Rpn11-IN-1 is an effective and selective inhibitor of proteasome subunit Rpn11 (IC50: 390 nM).
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 10,600 | 6-8周 | |
| 50 mg | ¥ 13,800 | 6-8周 | |
| 100 mg | ¥ 17,500 | 6-8周 |
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生物活性
化学信息
| 产品描述 | Rpn11-IN-1 is an effective and selective inhibitor of proteasome subunit Rpn11 (IC50: 390 nM). |
| 靶点活性 | RPN11:390 nM |
| 体内活性 | Rpn11-IN-1 blocks the proliferation of tumor cells in culture. Rpn11 is a Zn2+-dependent metalloisopeptidase that hydrolyzes ubiquitin from tagged proteins that are trafficked to the proteasome for degradation. Rpn11-IN-1 has an IC50 of 2.1 μM and 3.8 μM against 293T and A549 cells, respectively. When inhibition of Rpn11-IN-1 against Rpn11 is measured in the presence of Zn(cyclen)2+ (100 μM), a significant loss in activity against Rpn11 is observed (IC50=77.4 μM vs. 0.39 μM). The observed IC50 value shift is attributed to the ability of Zn(cyclen)2+ to compete/titrate Rpn11-IN-1 away from Rpn11 [1]. |
| 别名 | Capzimin intermediate |
| 分子量 | 315.41 |
| 分子式 | C15H13N3OS2 |
| CAS No. | 2084867-65-0 |
| 密度 | 1.373 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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