首页 工具
登录
购物车

搜索结果

Search Results for " polymerase "
Targets Recommended: Antiviral DNA/RNA Synthesis

348

抑制剂 & 化合物

49

天然产物

3

化合物库

3

TargetMol 试剂盒

119

重组蛋白

11

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求,可以联系我们专业顾问为您提供针对性的合理建议。     QQ咨询       网站留言咨询

提交您的定制咨询

点击图片重新获取验证码
Cat. No. Product Name
L6120 黄酮类天然产物库

514 compounds
514 种黄酮类天然产物的独特集合,可用于高通量筛选和高内涵筛选;
L3800 NF-κB 通路分子库

729 compounds
729 个 NF-κB 信号通路相关的小分子化合物的特有集合,用于高通量、高内涵筛选;
L1710 抗COVID-19化合物库

1133 compounds
1133 种对SARS-CoV-2有抑制作用或潜在抑制作用的化合物集合,可用于高通量和高内涵筛选;

化合物库

黄酮类天然产物库
Cat.No: L6120
Compounds: 514
NF-κB 通路分子库
Cat.No: L3800
Compounds: 729
抗COVID-19化合物库
Cat.No: L1710
Compounds: 1133
Cat. No. Product Name Form Specificity Of Inhibition
C0008 SYBR Green qPCR Master Mix (Low ROX)

SYBR Green qPCR Master Mix (Low ROX)

Solution in bottle
C0006 SYBR Green qPCR Master Mix (No ROX)

SYBR Green qPCR Master Mix (No ROX)

Solution in bottle
C0007 SYBR Green qPCR Master Mix (High ROX)

SYBR Green qPCR Master Mix (High ROX)

Solution in bottle

TargetMol 试剂盒

SYBR Green qPCR Master Mix (Low ROX)
Cat.No: C0008
SYBR Green qPCR Master Mix (No ROX)
Cat.No: C0006
SYBR Green qPCR Master Mix (High ROX)
Cat.No: C0007
Cat. No. Product Name Target Signaling Pathways
T80644 DNA polymerase-IN-1

Antiviral; DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation
DNA polymerase-IN-1 作为DNA聚合酶抑制剂,展现出对肿瘤细胞的抗增殖活性,其半抑制浓度(IC50)为20.7 μM。DNA polymerase-IN-1 抑制 Taq DNA 聚合酶,IC 值低于 250μM。DNA polymerase-IN-1 通过RT-PCR检测在体外显示出抗逆转录病毒活性,可用于研究氧化损伤和结直肠癌。
T79922 Taq DNA polymerase

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Taq DNA 聚合酶是一种在PCR过程中广泛使用的耐热性酶,由Thermus aquaticus细菌产生,其功能是在高温下合成DNA链。
T79926 Poly(A) polymerase

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Poly(A) polymerase 通过使用 ATP 作为单元,催化在 RNA 的 3'末端顺序掺入 AMP,形成多聚腺苷尾,从而增强 RNA 稳定性并提升真核细胞 mRNA 的翻译效能。该酶具备高效的聚腺苷酸化活性,能在 RNA 3'端添加 20-200 个腺苷酸(A)单元。
T79308 DNA polymerase-IN-3

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
DNA polymerase-IN-3 (Compd 5b) 为香豆素衍生物,对 Taq DNA聚合酶具有抑制活性,适用于增值性疾病研究。
T82536 DNA polymerase-IN-4

Others Others
DNA polymerase-IN-4 (Compd 5c),香豆素衍生物,显示出抗逆转录病毒活性,IC50为134.22 μM。
T79307 DNA polymerase-IN-2

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
DNA polymerase-IN-2 (Compd 3c)为香豆素衍生物,对Taq DNA聚合酶具有抑制作用,IC50为48.25 μM,适用于增殖性疾病研究。
T74630 RNA polymerase II-IN-1

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
RNA polymerase II-IN-1(compound 19iv)是一款鹅膏毒素类化合物,能够抑制RNA聚合酶II(Pol II),其半抑制浓度IC50为36.66 nM。该化合物相较于α-Amanitin,对癌细胞展现出更高的细胞毒性,而对正常细胞的毒性较低。
T74765 Viral polymerase-IN-1 hydrochloride

Others Others
Viral polymerase-IN-1 hydrochloride 是一种 Gemcitabine 衍生物,有效抑制甲型和乙型流感病毒 (influenza) 感染,IC90值为 11.4-15.9 μM。Viral polymerase-IN-1 hydrochloride 对 SARS-CoV-2感染具有活性。Viral polymerase-IN-1 hydrochloride 通过影响细胞中的病毒 RNA 复制/转录来抑制流感病毒感染。
T79923 T7 RNA polymerase

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
T7 RNA polymerase是一种由大肠杆菌表达的聚合酶,由T7噬菌体的RNA聚合酶基因编码。它在合成mRNA体外转录(IVT)过程中显示出高度专一性。T7 RNA polymerase能在Mg2+的作用下,针对含有T7启动子序列的单链或双链DNA模板,使用NTP作为底物进行RNA合成,产生的RNA与DNA模板的启动子下游区域互补。
T74631 RNA polymerase II-IN-2

Others Others
RNA polymerase II-IN-2 (compound 20iii)是高效的RNA polymerase II (Pol II)抑制剂,其Ki值为74.1 nM。该化合物对癌细胞展现出细胞毒性,其对CHO和HEK293细胞的毒性分别为α-amanitin的2倍和5倍。
T22749 DR2313

DR 2313

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
DR2313 是一种选择性,竞争性的和可透过血脑屏障的PARP 抑制剂,对PARP-1和PARP-2的IC50值分别为 0.20 和 0.24 μM。它在体内外均有对缺血性损伤的神经保护作用。
T16761 RK-287107

Others; PARP Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
RK-287107 是一种有效且特异性的 tankyrase 抑制剂,可阻断结直肠癌细胞生长,对 tankyrase-1和 tankyrase-2的 IC50分别为 14.3 和 10.6 nM。
T6181 UPF 1069

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
UPF 1069 是一种特异性PARP 抑制剂,对 PARP-1 和 PARP-2 的IC50值分别为 8 和 0.3 μM。
T6197 PJ34

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
PJ34 是一种PARP1/2的特异性有效抑制剂,IC50分别为 110 nM 和 86 nM。
T6578 ME0328

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
ME0328 是一种有效的选择性 PARP 抑制剂,对 PARP3 的 IC50 为 0.89 μM。
T6768 AZ6102

PARP; Wnt/beta-catenin Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
AZ6102 是TNKS1和TNKS2双重抑制剂,IC50值分别为 3 和 1 nM,选择性是对 PARP 家族其他蛋白的 100 多倍,对 PARP1、PARP2 和 PARP6 的IC50值分别为 2.0、0.5 和大于 3 μM。
T3168 MN-64

MN64

Others; PARP; Wnt/beta-catenin Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Others; Stem Cells
MN-64 是一种有效的tankyrase 1抑制剂,对TNKS1、TNKS2、ARTD1 和 ARTD2 的IC50值分别为 6、72、19.1 和 39.4 μM。
T2484 AZD-2461

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
AZD-2461 是一种 PARP 抑制剂,可抑制 PARP1、PARP2 和 PARP3 的活性,IC50值分别为 5、2 和 200 nM。
T15639 K-756

PARP; Wnt/beta-catenin Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
K-756 是一种直接的 tankyrase(TNKS) 选择性抑制剂,对 TNKS1和 TNKS2的 ADP-核糖基化活性有抑制作用,IC50分别为 31 和 36 nM。
T6842 G007-LK

PARP; Wnt/beta-catenin Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
G007-LK 是 TNKS1 和 TNKS2 的选择性抑制剂,IC50 分别为 46 nM 和 25 nM。
T8964 G244-LM

Others; PARP Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
G244-LM 是一种特异性有效的tankyrase 1/2抑制剂,可抑制Wnt 信号传导。
T21524 4-amino-1,8-Naphthalimide

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
4-amino-1,8-Naphthalimide 是PARP 抑制剂,可增强癌细胞对 γ 辐射诱导的细胞毒性的敏感度。
T1807 JW 55

JW55

PARP; Wnt/beta-catenin Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
JW 55 (JW55) 是一种有效且选择性的 β-catenin 信号通路抑制剂,通过抑制 tankyrase 1 和 tankyrase 2 (TNKS1/2) 的 PARP 结构域起作用。
T9165 AZD5305

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
AZD5305 是一种强效、选择性和口服活性 PARP 抑制剂,可用于肿瘤异体移植模型研究。
T22264 AZ9482

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
AZ9482 是一种选择性 PARP1/2/6的三重抑制剂,IC50值分别为 1 、1 和640 nM。
T7042 1,5-Isoquinolinediol

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
1,5-Isoquinolinediol 是一种多聚(ADP-核糖)合成酶抑制剂,对PARP1的IC50值为 0.39 µM。它用于研究 PARP1 在 DNA 修复和氧化应激诱导的细胞死亡中的作用。
T3062 WIKI4

PARP; Wnt/beta-catenin Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
WIKI4 是tankyrase 有效抑制剂,其对TNKS2的IC50值为 26 nM。它有效抑制Wnt/β-catenin 信号传导,其EC50值为 75 nM。它通过抑制TNKS2的酶活性来介导其对Wnt/β-catenin 信号传导的影响。它对 SCLC 细胞具有细胞毒性,其IC50值为 0.02 μM。
T1767 BMH-21

BMH21

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
BMH-21 是一种小分子 DNA 嵌入剂,可结合核糖体 DNA 并抑制 RNA 聚合酶 I (Pol I) 转录,具有抗癌活性。
T4471 E7449

Stenoparib,UNII-9X5A2QIA7C

Others; PARP Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
E7449 (UNII-9X5A2QIA7C) 是一种有效的 PARP1 和 PARP2 抑制剂,也抑制 TNKS1 和 TNKS2,使用 32P-NAD+ 作为底物,对 PARP1、PARP2、TNKS1 和 TNKS2 的 IC50 分别为 2.0、1.0、约 50 和约 50 nM。
T50098 TIQ-A

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
TIQ-A 是一种 PARP1 抑制剂,通过碱基切除修复途径参与 DNA 单链断裂修复。 PARP1 由 DNA 损伤触发,其过度激活已被认为是许多病理状况的致病因素,包括缺血和再灌注损伤、哮喘相关炎症和动脉粥样硬化形成。
T5058 Pamiparib

BGB-290

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
Pamiparib (BGB-290) 是一种具有口服活性、强效、高选择性的 PARP 抑制剂,对PARP1和PARP2的IC50值分别为 0.9 nM 和 0.5 nM。它具有强大的 PARP 捕获能力,具有穿透大脑的能力,可用于研究癌症。
T6339 AG14361

AG 14361,AG-14361

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
AG14361 是一种 PARP-1抑制剂,Ki 值小于 5 nM,在通透的 SW620 细胞和完整的 SW620 细胞中,抑制 PARP-1的活性,IC50值分别为 29 和 14 nM。
T4472 NMS-P118

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
NMS-P118是可口服的高选择性PARP-1抑制剂,用于癌症治疗,在HeLa 细胞中的IC50值为0.04 μM。
T9593 Senaparib

IMP4297

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
Senaparib (IMP4297) 是一种选择性和口服有效的PARP1/2抑制剂,具有强效的抗肿瘤活性。
T22414 RBN012759

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
RBN012759 是选择性和具有口服活性的 PARP14抑制剂,IC50值小于3 nM,可降低促肿瘤巨噬细胞功能并在肿瘤外植体中引发炎症反应,比对 monoPARPs 的选择性高 300 倍,比对 polyPARPs 的选择性高 1000 倍。
T5399 GeA-69

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
GeA-69 是一种选择性变构 PARP14 大结构域 2 (MD2) 抑制剂,Kd 值为 2.1 µM。
T7896 BYK204165

RT-017290

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
BYK204165 (RT-017290) 是一种选择性PARP1抑制剂,对重组人 PARP1的pIC50值为 7.35,pKi 值为7.05。它对鼠 PARP-2的pIC50值为 5.38 ,其对 PARP1 的选择性比对 PARP2 高 100 倍。
T3649 BGP-15

BGP15,BGP-15 2HCl

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
BGP-15 (BGP-15 2HCl) 是一种PARP 抑制剂,IC50和Ki 值分别为 120 和 57 μM,在缺血再灌注损伤后具有保护作用。
T9430 Venadaparib

NOV140101,IDX-1197

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
Venadaparib (NOV140101) 是一种选择性和具有口服活性的 PARP 抑制剂,对 PARP1和 PARP2的 IC50分别为 1.4 和 1.0 nM。它可防止 DNA 单链断裂 (SSB) 的修复,可研究实体瘤。
T12695 RBN-2397

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
RBN-2397 是一种有效的、选择性的、具有口服活性的跨物种 NAD+ 竞争性 PARP7 抑制剂,IC50 小于 3 nM。它选择性结合 PARP7 ,Kd 为0.001 μM,可恢复干扰素 I 型信号转导,有用于晚期或转移性实体肿瘤的研究潜力。
T9497 Niraparib tosylate monohyrate

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
Niraparib tosylate monohyrate 也称为 MK-4827,是一种聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂,具有潜在的抗肿瘤活性。 MK4827 抑制 PARP 活性,增强 DNA 链断裂的积累,促进基因组不稳定性和细胞凋亡。 PARP 蛋白家族通过碱基切除修复 (BER) 途径检测和修复单链 DNA 断裂。
T0220 Foscarnet sodium

Phosphonoformate,膦甲酸钠

Virus Protease; Reverse Transcriptase; DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
Foscarnet sodium (Phosphonoformate) 是一种病毒 DNA 聚合酶活性抑制剂,可逆地抑制病毒复制。它是一种用于治疗巨细胞病毒性视网膜炎的抗病毒剂。
T1454 Acyclovir

Aciclovir,Acycloguanosine,阿昔洛韦

Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; HSV Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
Acyclovir (Aciclovir) 是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM),HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。
T6446 Clevudine

L-FMAU,克拉夫定,Levovir

HBV; DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
Clevudine (Levovir) 是一种非自然 L-构型的核苷类似物,是一种与聚合酶结合的非竞争性抑制剂,具有较强的抗 HBV 活性,半衰期长,毒性低的特点。
T1878 XAV-939

XAV939,NVP-XAV939

PARP; Wnt/beta-catenin Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
XAV-939 (NVP-XAV939) 是一种 Tankyrase (TNKS) 抑制剂,抑制 TNKS1 和 TNKS2 (IC50=11/4 nM)。XAV-939 可以选择性抑制 Wnt/β-catenin 介导的转录。
T2591 Veliparib

ABT-888,NSC 737664,维利帕尼

PARP; Autophagy Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
Veliparib (ABT-888) 是一种可口服的 PARP 抑制剂,抑制PARP1和PARP2的Ki 分别为 5.2 和 2.9 nM。它增强细胞凋亡和自噬。
T2124 PJ34 hydrochloride

PJ34 HCl

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
PJ34 hydrochloride (PJ34 HCl) 是一种 PARP1/2的特异性有效抑制剂,IC50值分别为 110 nM 和 86 nM。
T3231 Niraparib

尼拉帕尼,MK-4827

Apoptosis; Others; PARP Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
Niraparib (MK-4827) 是一种 PARP 抑制剂,可以抑制 PARP1 和 PARP2 (IC50=3.8/2.1 nM),具有选择性。Niraparib 具有抗肿瘤活性,可以抑制 DNA 损伤修复、诱导细胞凋亡。
T6912 NU1025

NSC 696807

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
NU1025 (NSC-696807) 是一种PARP 的有效抑制剂,IC50为 400 nM,Ki 为 48 nM。它可增强电离辐射和抗癌药物的细胞毒性,有抗癌和神经保护的作用。
T7439 3-Methoxybenzamide

3-MBA,3-甲氧基苯甲酰胺

PARP; Antibacterial; Transferase Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
3-Methoxybenzamide (3-MBA) 是一种多聚 ADP-核糖合成酶的竞争性抑制剂,可抑制枯草芽孢杆菌的细胞分裂,诱导细胞凋亡。它可促进蓝薯植株的生长、微瘤化和转化效率。

化合物

DNA polymerase-IN-1
Cat.No: T80644
Synonym:
Target: Antiviral, DNA/RNA Synthesis
Taq DNA polymerase
Cat.No: T79922
Synonym:
Target: DNA/RNA Synthesis
Poly(A) polymerase
Cat.No: T79926
Synonym:
Target: DNA/RNA Synthesis
DNA polymerase-IN-3
Cat.No: T79308
Synonym:
Target: DNA/RNA Synthesis
DNA polymerase-IN-4
Cat.No: T82536
Synonym:
Target: Others
DNA polymerase-IN-2
Cat.No: T79307
Synonym:
Target: DNA/RNA Synthesis
RNA polymerase II-IN-1
Cat.No: T74630
Synonym:
Target: DNA/RNA Synthesis
Viral polymerase-IN-1 hydrochloride
Cat.No: T74765
Synonym:
Target: Others
T7 RNA polymerase
Cat.No: T79923
Synonym:
Target: DNA/RNA Synthesis
RNA polymerase II-IN-2
Cat.No: T74631
Synonym:
Target: Others
DR2313
Cat.No: T22749
Synonym: DR 2313
Target: PARP
RK-287107
Cat.No: T16761
Synonym:
Target: Others, PARP
UPF 1069
Cat.No: T6181
Synonym:
Target: PARP
PJ34
Cat.No: T6197
Synonym:
Target: PARP
ME0328
Cat.No: T6578
Synonym:
Target: PARP
AZ6102
Cat.No: T6768
Synonym:
Target: PARP, Wnt/beta-catenin
MN-64
Cat.No: T3168
Synonym: MN64
Target: Others, PARP, Wnt/beta-catenin
AZD-2461
Cat.No: T2484
Synonym:
Target: PARP
K-756
Cat.No: T15639
Synonym:
Target: PARP, Wnt/beta-catenin
G007-LK
Cat.No: T6842
Synonym:
Target: PARP, Wnt/beta-catenin
G244-LM
Cat.No: T8964
Synonym:
Target: Others, PARP
4-amino-1,8-Naphthalimide
Cat.No: T21524
Synonym:
Target: PARP
JW 55
Cat.No: T1807
Synonym: JW55
Target: PARP, Wnt/beta-catenin
AZD5305
Cat.No: T9165
Synonym:
Target: PARP
AZ9482
Cat.No: T22264
Synonym:
Target: PARP
1,5-Isoquinolinediol
Cat.No: T7042
Synonym:
Target: PARP
WIKI4
Cat.No: T3062
Synonym:
Target: PARP, Wnt/beta-catenin
BMH-21
Cat.No: T1767
Synonym: BMH21
Target: DNA/RNA Synthesis
E7449
Cat.No: T4471
Synonym: Stenoparib,UNII-9X5A2QIA7C
Target: Others, PARP
TIQ-A
Cat.No: T50098
Synonym:
Target: PARP
Pamiparib
Cat.No: T5058
Synonym: BGB-290
Target: PARP
AG14361
Cat.No: T6339
Synonym: AG 14361,AG-14361
Target: PARP
NMS-P118
Cat.No: T4472
Synonym:
Target: PARP
Senaparib
Cat.No: T9593
Synonym: IMP4297
Target: PARP
RBN012759
Cat.No: T22414
Synonym:
Target: PARP
GeA-69
Cat.No: T5399
Synonym:
Target: PARP
BYK204165
Cat.No: T7896
Synonym: RT-017290
Target: PARP
BGP-15
Cat.No: T3649
Synonym: BGP15,BGP-15 2HCl
Target: PARP
Venadaparib
Cat.No: T9430
Synonym: NOV140101,IDX-1197
Target: PARP
RBN-2397
Cat.No: T12695
Synonym:
Target: PARP
Niraparib tosylate monohyrate
Cat.No: T9497
Synonym:
Target: PARP
Foscarnet sodium
Cat.No: T0220
Synonym: Phosphonoformate,膦甲酸钠
Target: Virus Protease, Reverse Transcriptase, DNA/RNA Synthesis
Acyclovir
Cat.No: T1454
Synonym: Aciclovir,Acycloguanosine,阿昔洛韦
Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic, HSV
Clevudine
Cat.No: T6446
Synonym: L-FMAU,克拉夫定,Levovir
Target: HBV, DNA/RNA Synthesis
XAV-939
Cat.No: T1878
Synonym: XAV939,NVP-XAV939
Target: PARP, Wnt/beta-catenin
Veliparib
Cat.No: T2591
Synonym: ABT-888,NSC 737664,维利帕尼
Target: PARP, Autophagy
PJ34 hydrochloride
Cat.No: T2124
Synonym: PJ34 HCl
Target: PARP
Niraparib
Cat.No: T3231
Synonym: 尼拉帕尼,MK-4827
Target: Apoptosis, Others, PARP
NU1025
Cat.No: T6912
Synonym: NSC 696807
Target: PARP
3-Methoxybenzamide
Cat.No: T7439
Synonym: 3-MBA,3-甲氧基苯甲酰胺
Target: PARP, Antibacterial, Transferase
Cat. No. Product Name Target Signaling Pathways
T8184 Fucosterol

岩皂甾醇,岩藻甾醇

PARP; Endogenous Metabolite; PPAR Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
Fucosterol 是从藻类、海藻或硅藻中分离的一种甾醇,具有抗氧化、抗脂肪、降低血液胆固醇、抗糖尿病和抗癌活性。它通过抑制 PPARα和C/EBPα的表达调控脂肪生成,可用于抗肥胖试剂开发研究。
T6S0139 Neobavaisoflavone

Apoptosis; DNA/RNA Synthesis Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎,抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶,也可抑制血小板聚集。
T3332 Isosteviol

异甜菊醇,(-)-Isosteviol

IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂,属于四环二萜糖苷,是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶,具有抗菌、抗癌和抗结核作用。
T7443 4'-Methoxychalcone

4'-甲氧基查耳酮,4'-甲氧基查尔酮

PARP; PPAR Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
4'-Methoxychalcone 通过PPARγ活化调节脂肪细胞分化,并调节参与胰岛素敏感性的脂肪组织中各种脂肪因子的表达和分泌,具抗肿瘤和抗炎活性。
T8150 Nudifloramide

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide,1-甲基-6-氧代吡啶-3-甲酰胺

PARP; Endogenous Metabolite Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
Nudifloramide 是烟酰胺-腺嘌呤二核苷酸 (NAD) 降解的一种最终产物,可显著抑制PARP-1活性。
T5S2358 Dehydrocorydaline

Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine

BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax,Bcl-2蛋白表达,激活caspase-7,caspase-8,并使PARP 失活。它能增强p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。
T6780 Benzamide

Amid kyseliny benzoove,苯甲酰胺,Phenylcarboxyamide,Benzoylamide

PARP; Endogenous Metabolite Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
Benzamide (Amid kyseliny benzoove) 是聚(ADP-核糖)聚合酶的抑制剂,是苯甲酸的衍生物。
T2S2362 Dehydrocorydaline nitrate

去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达,激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌、抗疟疾等功效。
T10990 Dehydrocorydaline chloride

盐酸脱氢紫堇碱,13-Methylpalmatine chloride

BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
Dehydrocorydaline chloride (13-Methylpalmatine chloride) 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达;激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。
TN2883 3',4'-Dimethoxyflavone

Others; PARP Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准,类黄酮化合物具有多种药用活性。
T5S1805 5,7-Dihydroxychromone

5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮

Others; Virus Protease; PARP; Caspase; Nrf2 Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome
5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物,通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3,caspase-9以及切割的PARP 表达。
T8296 5,​7,​4'-​Trimethoxyflavone

5,7,4'-三甲氧基黄酮,芹菜素三甲醚,4',5,7-三甲氧基黄酮,4',5,7-Trimethoxyflavone

Apoptosis; PARP; Caspase Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
5,​7,​4'-​Trimethoxyflavone (4',5,7-Trimethoxyflavone) 是从泰国著名的药用植物 Kaempferia parviflora 中分离出来的一种天然产物。它以浓度依赖性方式显著有效抑制 SNU-16 人胃癌细胞的增殖,诱导细胞凋亡。
T6194 Fidaxomicin

非达米星,Tiacumicin B,OPT-80,Clostomicin B1,PAR-101

Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
Fidaxomicin (Tiacumicin B) 是一种大环RNA 聚合酶抑制剂,具有窄谱活性。它选择性地根除致病性艰难梭菌,对构成正常健康肠道菌群的多种细菌影响很小。
T2851 Daphnetin

7,8-Dihydroxycoumarin,Daphnetol,瑞香素

EGFR; PKA; PKC; Parasite; Autophagy Angiogenesis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
Daphnetin (7,8-Dihydroxycoumarin) 是从 Genus Daphne 中分离得到的香豆素衍生物,有抗氧化、抗炎、抗疟疾和解热作用,可用于凝血功能障碍、类风湿性关节炎等疾病的相关研究。
T4085 Paris saponin VII

重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome
Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位,增加凋亡相关蛋白的表达,并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬,可研究白血病。
T3376 Cynaroside

朝蓟糖甙,Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,木犀草苷,Luteolin 7-glucoside

Others; Influenza Virus; DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
Cynaroside (Luteolin 7-O-Glucoside) 是一个抗氧化类黄酮。它还是一种流感依赖 RNA 的RNA 聚合酶抑制剂,IC50为 32 nM。
T14304 Aphidicolin

Others Others
Aphidicolin is a potent inhibitor of cellular deoxyribonucleic acid synthesis and inhibits the growth of herpes simplex virus[2]. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering with the activity of DNA
T3772 Maslinic acid

2α-Hydroxyoleanoic Acid,山楂酸,2α-Hydroxyoleanolic acid,Crategolic acid

NF-κB; HIV Protease; DNA/RNA Synthesis; Antibacterial Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; NF-κB; Proteases/Proteasome
Maslinic acid (Crategolic acid) 是一种 DNA 聚合酶 B 抑制剂,抑制 NF-κB p65的 DNA 结合活性并消除 IκB-α磷酸化。
T37635 2'-Deoxyadenosine-5'-triphosphate trisodium

dATP trisodium

DNA/RNA Synthesis; Endogenous Metabolite Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) 是一种核苷酸,是 DNA 聚合酶的底物,在细胞中用于 DNA 合成或复制。
T7607 PSI-6130

R 1656,2'-去氧-2'-氟-2'-C-甲基胞苷

HCV Protease Microbiology/Virology; Proteases/Proteasome
PSI-6130 (R 1656) 是高效选择性 HCV NS5B 聚合酶抑制剂,抑制 HCV 复制,IC50值为 0.6 μM。
T5003 Rifamycin sodium

Rifamycin sodium salt,利福霉素钠

Antibacterial; Antibiotic Microbiology/Virology
Rifamycin sodium (Rifamycin sodium salt) salt 是从地中海曲霉或其突变体的发酵中分离出来的一种安沙霉素抗生素家族。它对革兰氏阳性菌和某些革兰氏阴性菌有抗生素活性。
T1272 Cytarabine

阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine

Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; HSV Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
Cytarabine (Ara-C) 是一种核苷类似物,一种 DNA 合成抑制剂 (IC50=16 nM)。Cytarabine 可以抑制 DNA 聚合酶,诱导细胞周期阻滞、细胞自噬和凋亡。Cytarabine 具有抗肿瘤活性。
T9086 Deoxythymidine-5'-triphosphate trisodium

dTTP trisodium salt,thymidine 5'-(trisodium hydrogen triphosphate),胸苷-5'-三磷酸三钠盐,脱氧胸苷三磷酸三钠盐,Deoxythymidine-5'-triphosphate (dTTP) trisodium salt

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Deoxythymidine-5'-triphosphate trisodium (Deoxythymidine-5'-triphosphate(dTTP) trisodium salt) 是四种天然脱氧核苷酸之一,用于通过 DNA 聚合酶和逆转录酶生物合成脱氧核糖核酸。
T1086 Vitamin D2

Calciferol,Ergocalciferol,Ercalciol,维生素D2

DNA/RNA Synthesis; Endogenous Metabolite Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
Vitamin D2 (Calciferol) 来源于植物或膳食补充剂,能够用作维生素 D 的补充剂。
T8347 Rifamycin S

Reactive Oxygen Species; ROS; Antibacterial; Antibiotic Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
Rifamycin S 是一种 DNA 依赖性 RNA 聚合酶抑制剂,是一种醌和一种针对革兰氏阳性细菌的抗生素试剂。它是涉及两个电子的可逆氧化还原系统的氧化形式。它能产生活性氧并抑制微粒体脂质过氧化,可研究肺结核和麻风病。
T7961 N4-Benzoyl-2′-deoxycytidine

N-苯甲酰-2'-脱氧胞苷

Others Others
N4-Benzoyl-2′-deoxycytidine 是天然核苷脱氧胞苷(dC)的合成核苷类似物,是一种DNA 聚合酶的竞争性抑制剂。体外研究表明,它可以抑制病毒、细菌和真核细胞的复制。在动物模型中,它也被证明可以抑制肿瘤细胞的生长。
T16223 N-Dodecyl-β-D-maltoside

十二烷基-β-D-麦芽糖苷,Lauryl Maltoside

Others Others
N-Dodecyl-β-D-maltoside (Lauryl Maltoside) 是一种芘 (Py) 的衍生物。它可用作烷基吡喃麦芽糖苷清洁剂,尤其是在转运蛋白和呼吸复合物中。它已用于诸如 RNA 聚合酶的纯化和稳定化,以及蛋白质-脂质相互作用的检测的应用中。
TN1134 Euscaphic acid

Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling
Euscaphic acid 是来源于枣的一种三萜,是DNA 聚合酶抑制剂,可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。
T2860 Vanillyl Alcohol

4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol

Apoptosis; Others Apoptosis; Others
Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) 是一种酚类醇,具有抗血管生成、抗惊厥、抗炎、抗氧化、神经保护和抗伤害活性。它由香兰素衍生而来,在食品和饮料中用作调味剂。
T40834 5-Hydroxymethyl-2'-deoxycytidine

5hmdC,2'-脱氧-5-(羟甲基)胞啶

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
5-Hydroxymethyl-2'-deoxycytidine 是 DNA 中 5-methyl-2'-deoxycytidine (5-mdC) 的氧化衍生物,引起DNA损伤反应,染色体畸变,复制叉损伤和细胞活力丧失。5-Hydroxymethyl-2’-deoxycytidine 复制叉不稳定性与染色质上聚(ADP-核糖)聚合酶1(PARP1)的存在有关。
T6S2391 L-Chicoric Acid

(-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸

Others; HIV Protease Microbiology/Virology; Others; Proteases/Proteasome
L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸,是一种选择性可逆的 HIV-1 整合酶抑制剂,IC50约为 100 nM。它还可抑制 HIV-1 复制。
T1591 Ancitabine hydrochloride

NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C

Others; DNA/RNA Synthesis; Autophagy Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
Ancitabine hydrochloride (NSC 145668 HCl) 是一种天然的抗白血病药物。
TN1163 2'-Hydroxychalcone

Others Others
2'-Hydroxychalcone 是一种药物合成中间体,可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1,VCAM-1和E-选择素的稳态转录水平,因此可能会干扰其基因的转录。
T1558 Resveratrol

白藜芦醇,trans-Resveratrol,SRT 501

Apoptosis; Mitophagy; IκB/IKK; Lipoxygenase; Sirtuin; COX; NADPH; DNA/RNA Synthesis; Nrf2; Antibacterial; Antibiotic; Autophagy; Antifungal Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
Resveratrol (SRT 501) 属于多酚类天然产物,是一种植物抗毒素,具有抗氧化和化学预防活性。Resveratrol 的靶点广泛,包括 COX、SIRT、LOC 等。Resveratrol 可以诱导细胞自噬和凋亡。
T15094 Dehydroaltenusin

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits mammalian pol α activity.
TN5879 Edgeworin

Edgeworin is a DNA polymerase beta (pol beta) inhibitor, it inhibits both the lyase and polymerase activities of DNA polymerase beta; it can potentiate the inhibitory action of the anticancer drug bleomycin in cultured A549 cells via an inhibition of DNA
T16673 Pseudouridimycin

PUM

Others Others
Pseudouridimycin is a C-nucleoside analogue. Pseudouridimycin is an antibiotic and is a selective bacterial RNA polymerase (RNAP) inhibitor. It is effective against both Gram-negative and Gram-positive bacteria.
TN6148 3-O-trans-p-Coumaroylmaslinic acid

3-beta-O-(trans-p-Coumaroyl)maslinic acid is a DNA polymerase B" inhibitor. It shows antimicrobial activity on Gram-positive bacteria and yeasts.
T39649 ε-Amanitin

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
ε-Amanitin is a cyclic peptide obtained from various mushroom species. It exhibits a strong affinity for RNA polymerase II and effectively inhibits its activity.
T19463 N4-Acetylcytidine triphosphate

ac4CTP

Others Others
N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription .
T19462 N4-Acetylcytidine triphosphate sodium

ac4CTP sodium

Others Others
N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription.
T39562 γ-Amanitin

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin.
TN2222 Sotetsuflavone

Others Others
Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 μM, is the most active compound of this series.
TMA0984 Cerevisterol

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Cerevisterol 是一种细胞毒性类固醇,提取于Agaricus blazei 子实体,对 DNA 聚合酶 α 的活性具有抑制作用。
T74516 CI-39

Others Others
CI-39 是一种抗病毒天然产物。CI-39 是一种 NNRTI (非核苷类逆转录酶抑制) 抗病毒剂,对野生型HIV 的EC50为 3.40 µM,CC50>30 µM。CI-39 抑制HIV-1RT DNA 聚合酶和核糖核酸酶 H 活性。
TN4046 Excisanin A

MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ...
T36667 2'-Deoxyadenosine-5'-triphosphate

dATP,Deoxyadenosine 5-triphosphate

DNA/RNA Synthesis; Endogenous Metabolite Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) 是一种天然存在的小分子核苷酸,在细胞中用于DNA合成或复制。2'-Deoxyadenosine-5'-triphosphate (dATP) 是 DNA 聚合酶的底物。2'-Deoxyadenosine-5'-triphosphate 通过无活性的 α4beta4 四级结构抑制RNA。2'-Deoxyadenosine-5'-triphosphate 与心肌细胞生长有关。
T73403 Aviculin

Others Others
Aviculin 是一种木聚糖苷,是一种有效的抗癌剂 (anticanceragent)。Aviculin 可降低 MCF-7 细胞代谢活性到 50% 以下,IC50为 75.47 μM。Aviculin 通过内在凋亡途径诱导乳腺癌细胞凋亡 (apoptosis)。Aviculin 增加了 caspase-9、caspase-7和 PARP 的表达。Aviculin 使 Bax/Bcl-2 的比值升高。
T35779 Oosporein

Others Others
Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Fucosterol
Cat.No: T8184
Synonym: 岩皂甾醇,岩藻甾醇
Target: PARP, Endogenous Metabolite, PPAR
Neobavaisoflavone
Cat.No: T6S0139
Synonym:
Target: Apoptosis, DNA/RNA Synthesis
Isosteviol
Cat.No: T3332
Synonym: 异甜菊醇,(-)-Isosteviol
Target: IL Receptor, Potassium Channel, TNF, NF-κB, Reactive Oxygen Species, COX, Topoisomerase
4'-Methoxychalcone
Cat.No: T7443
Synonym: 4'-甲氧基查耳酮,4'-甲氧基查尔酮
Target: PARP, PPAR
Nudifloramide
Cat.No: T8150
Synonym: 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide,1-甲基-6-氧代吡啶-3-甲酰胺
Target: PARP, Endogenous Metabolite
Dehydrocorydaline
Cat.No: T5S2358
Synonym: Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine
Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy
Benzamide
Cat.No: T6780
Synonym: Amid kyseliny benzoove,苯甲酰胺,Phenylcarboxyamide,Benzoylamide
Target: PARP, Endogenous Metabolite
Dehydrocorydaline nitrate
Cat.No: T2S2362
Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱
Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy
Dehydrocorydaline chloride
Cat.No: T10990
Synonym: 盐酸脱氢紫堇碱,13-Methylpalmatine chloride
Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy
3',4'-Dimethoxyflavone
Cat.No: TN2883
Synonym:
Target: Others, PARP
5,7-Dihydroxychromone
Cat.No: T5S1805
Synonym: 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮
Target: Others, Virus Protease, PARP, Caspase, Nrf2
5,​7,​4'-​Trimethoxyflavone
Cat.No: T8296
Synonym: 5,7,4'-三甲氧基黄酮,芹菜素三甲醚,4',5,7-三甲氧基黄酮,4',5,7-Trimethoxyflavone
Target: Apoptosis, PARP, Caspase
Fidaxomicin
Cat.No: T6194
Synonym: 非达米星,Tiacumicin B,OPT-80,Clostomicin B1,PAR-101
Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic
Daphnetin
Cat.No: T2851
Synonym: 7,8-Dihydroxycoumarin,Daphnetol,瑞香素
Target: EGFR, PKA, PKC, Parasite, Autophagy
Paris saponin VII
Cat.No: T4085
Synonym: 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII
Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy
Cynaroside
Cat.No: T3376
Synonym: 朝蓟糖甙,Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,木犀草苷,Luteolin 7-glucoside
Target: Others, Influenza Virus, DNA/RNA Synthesis
Aphidicolin
Cat.No: T14304
Synonym:
Target: Others
Maslinic acid
Cat.No: T3772
Synonym: 2α-Hydroxyoleanoic Acid,山楂酸,2α-Hydroxyoleanolic acid,Crategolic acid
Target: NF-κB, HIV Protease, DNA/RNA Synthesis, Antibacterial
2'-Deoxyadenosine-5'-triphosphate trisodium
Cat.No: T37635
Synonym: dATP trisodium
Target: DNA/RNA Synthesis, Endogenous Metabolite
PSI-6130
Cat.No: T7607
Synonym: R 1656,2'-去氧-2'-氟-2'-C-甲基胞苷
Target: HCV Protease
Rifamycin sodium
Cat.No: T5003
Synonym: Rifamycin sodium salt,利福霉素钠
Target: Antibacterial, Antibiotic
Cytarabine
Cat.No: T1272
Synonym: 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine
Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV
Deoxythymidine-5'-triphosphate trisodium
Cat.No: T9086
Synonym: dTTP trisodium salt,thymidine 5'-(trisodium hydrogen triphosphate),胸苷-5'-三磷酸三钠盐,脱氧胸苷三磷酸三钠盐,Deoxythymidine-5'-triphosphate (dTTP) trisodium salt
Target: DNA/RNA Synthesis
Vitamin D2
Cat.No: T1086
Synonym: Calciferol,Ergocalciferol,Ercalciol,维生素D2
Target: DNA/RNA Synthesis, Endogenous Metabolite
Rifamycin S
Cat.No: T8347
Synonym:
Target: Reactive Oxygen Species, ROS, Antibacterial, Antibiotic
N4-Benzoyl-2′-deoxycytidine
Cat.No: T7961
Synonym: N-苯甲酰-2'-脱氧胞苷
Target: Others
N-Dodecyl-β-D-maltoside
Cat.No: T16223
Synonym: 十二烷基-β-D-麦芽糖苷,Lauryl Maltoside
Target: Others
Euscaphic acid
Cat.No: TN1134
Synonym:
Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor
Vanillyl Alcohol
Cat.No: T2860
Synonym: 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol
Target: Apoptosis, Others
5-Hydroxymethyl-2'-deoxycytidine
Cat.No: T40834
Synonym: 5hmdC,2'-脱氧-5-(羟甲基)胞啶
Target: PARP
L-Chicoric Acid
Cat.No: T6S2391
Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸
Target: Others, HIV Protease
Ancitabine hydrochloride
Cat.No: T1591
Synonym: NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C
Target: Others, DNA/RNA Synthesis, Autophagy
2'-Hydroxychalcone
Cat.No: TN1163
Synonym:
Target: Others
Resveratrol
Cat.No: T1558
Synonym: 白藜芦醇,trans-Resveratrol,SRT 501
Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal
Dehydroaltenusin
Cat.No: T15094
Synonym:
Target: DNA/RNA Synthesis
Edgeworin
Cat.No: TN5879
Synonym:
Target:
Pseudouridimycin
Cat.No: T16673
Synonym: PUM
Target: Others
3-O-trans-p-Coumaroylmaslinic acid
Cat.No: TN6148
Synonym:
Target:
ε-Amanitin
Cat.No: T39649
Synonym:
Target: Others, ADC Cytotoxin
N4-Acetylcytidine triphosphate
Cat.No: T19463
Synonym: ac4CTP
Target: Others
N4-Acetylcytidine triphosphate sodium
Cat.No: T19462
Synonym: ac4CTP sodium
Target: Others
γ-Amanitin
Cat.No: T39562
Synonym:
Target: Others, ADC Cytotoxin
Sotetsuflavone
Cat.No: TN2222
Synonym:
Target: Others
Cerevisterol
Cat.No: TMA0984
Synonym:
Target: DNA/RNA Synthesis
CI-39
Cat.No: T74516
Synonym:
Target: Others
Excisanin A
Cat.No: TN4046
Synonym:
Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK
2'-Deoxyadenosine-5'-triphosphate
Cat.No: T36667
Synonym: dATP,Deoxyadenosine 5-triphosphate
Target: DNA/RNA Synthesis, Endogenous Metabolite
Aviculin
Cat.No: T73403
Synonym:
Target: Others
Oosporein
Cat.No: T35779
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPH-00533 T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc)

T7 RNA polymerase,DNA-directed RNA polymerase

Escherichia phage T7 E. coli
Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short transcripts are synthesized and released before proceeding to the processive transcription of long RNA chains. Unwinds the double-stranded DNA to expose the coding strand for templating. Participates in the initiation of viral DNA replication presumably by making primers accessible...
TMPH-00426 DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His)

dinB,DNA polymerase IV,Pol IV

Colwellia psychrerythraea E. coli
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His) is expressed in E. coli expression...
TMPH-00427 DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant

DNA polymerase IV,dinB,Pol IV

Colwellia psychrerythraea E. coli
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant is expressed in E. coli expression syste...
TMPH-02357 Influenza A H3N2 (strain A/X-31) Polymerase acidic Protein (His)

Polymerase acidic protein,PA,RNA-directed RNA p...

H3N2 E. coli
Influenza A H3N2 (strain A/X-31) Polymerase acidic Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.6 kDa and the accession number is Q9IQ47.
TMPH-02356 Influenza A H1N1 (strain A/USA:Huston/AA/1945) Polymerase acidic Protein (His)

PA,RNA-directed RNA polymerase subunit P2,Polym...

H1N1 P. pastoris (Yeast)
Influenza A H1N1 (strain A/USA:Huston/AA/1945) Polymerase acidic Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.6 kDa and the accession number is A4U6V9.
TMPH-00523 DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc)

Gp43,DNA-directed DNA polymerase

Escherichia phage RB69 E. coli
Replicates the viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction for proofreading purpose. DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 35.4 kDa and the accession number is Q38087.
TMPH-00613 DNA polymerase II Protein, E. coli, Recombinant (His & Myc)

DNA polymerase II,polB,dinA,Pol II

E. coli E. coli
Thought to be involved in DNA repair and/or mutagenesis. Its processivity is enhanced by the beta sliding clamp (dnaN) and clamp loader.
TMPH-01450 Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) DNA polymerase processivity factor (His)

Phosphoprotein P41,U27,DNA polymerase processivity ...

HHV-6A P. pastoris (Yeast)
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) DNA polymerase processivity factor (His) is expressed in Yeast.
TMPH-00360 DNA polymerase II large subunit Protein, Cenarchaeum symbiosum, Recombinant

Exodeoxyribonuclease large subunit,DNA polymerase I...

Cenarchaeum symbiosum E. coli
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. DNA polymerase II large subunit Protein, Cenarchaeum symbiosum, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 59.0 kDa and the accession number is A0RYM0.
TMPY-06071 SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His)

SARS-CoV-2 Baculovirus Insect Cells
SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 108.3 kDa and the accession number is YP_009725307.1.
TMPY-01188 PARP Protein, Human, Recombinant (His)

ADPRT1,ADPRT,pADPRT-1,PPOL,ARTD1,PARP-1,poly (ADP-ribose)

Human Baculovirus Insect Cells
PARP Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 114.5 kDa and the accession number is A0A024R3T8.
TMPH-01238 POLQ Protein, Human, Recombinant (His)

DNA polymerase eta,POLQ,DNA polymerase the...

Human Baculovirus Insect Cells
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...
TMPH-03622 PolA Protein, Thermus aquaticus, Recombinant (M747K, His)

DNA polymerase I, thermostable,Taq polymerase

Thermus aquaticus E. coli
N/A. PolA Protein, Thermus aquaticus, Recombinant (M747K, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 64.9 kDa and the accession number is P19821.
TMPH-01237 POLQ Protein, Human, Recombinant (E. coli, His)

DNA polymerase eta,POLQ,DNA polymerase the...

Human E. coli
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...
TMPJ-00792 DNA PolymeraseBeta Protein, Human, Recombinant (His)

DNA Polymeraseβ,POLB,DNA Polymerase Beta,D...

Human E. coli
Human DNA polymerase β is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. It conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a proce...
TMPH-01247 POLR3K Protein, Human, Recombinant (His)

RNA polymerase III subunit C11,POLR3K,RNA polym...

Human Baculovirus Insect Cells
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase I...
TMPH-01246 POLR3A Protein, Human, Recombinant (His)

RNA polymerase III subunit C160,RNA polymerase<...

Human E. coli
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft ...
TMPH-00505 RPB1 Protein, Drosophila melanogaster, Recombinant (His)

RNA polymerase II subunit A,DNA-directed RNA po...

Fruit fly P. pastoris (Yeast)
RPB1 Protein, Drosophila melanogaster, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 33.6 kDa and the accession number is P04052.
TMPH-00729 RpoH Protein, E. coli, Recombinant (His & Myc)

RNA polymerase sigma-32 factor,Heat shock regulator...

E. coli E. coli
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. Intracellular concentration of free RpoH protein increases in response to heat shock, which causes association with RNA polymerase (RNAP) and initiation of transcription of heat shock genes, including numerous global transcriptional regulators and genes involved in maintaining membrane...
TMPH-03732 Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)

Polymerase cofactor VP35,Ebola VP35,VP35

ZEBOV E. coli
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen...
TMPH-03733 Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)

Polymerase cofactor VP35,VP35,Ebola VP35

ZEBOV HEK293 Cells
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen...
TMPH-02383 Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His)

Polymerase cofactor VP35,VP35,Marburg VP35

MARV E. coli
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.
TMPH-00728 FliA Protein, E. coli, Recombinant

fliA,Sigma-27,Sigma F,Sigma-28,RNA polymerase sigma...

E. coli E. coli
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes. FliA Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 27.7 kDa and the accession number is P0AEM6.
TMPH-03184 P2 Protein, Pseudomonas phage phi6, Recombinant (His & Myc)

P2,Protein P2,RNA-directed RNA polymerase

Pseudomonas phage phi6 E. coli
Rna-dependent RNA polymerase part of the packaging complex that packages the viral RNA segments, replicate them into a double-stranded form and transcribe them. P2 Protein, Pseudomonas phage phi6, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.2 kDa and the accession number is P11124.
TMPH-00727 FliA Protein, E. coli, Recombinant (His)

RNA polymerase sigma factor for flagellar operon,Si...

E. coli E. coli
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.
TMPH-00701 PBP1b Protein, E. coli, Recombinant (His & Myc)

Penicillin-binding protein 1B,Murein polymerase,mrc...

E. coli E. coli
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits). PBP1b Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 38.6 kDa and the accession number is P02919...
TMPH-01945 TIPARP Protein, Human, Recombinant (His)

ADP-ribosyltransferase diphtheria toxin-like 14,Poly [ADP-ri...

Human Baculovirus Insect Cells
TIPARP Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPH-01245 POLM Protein, Human, Recombinant (His & Myc)

DNA-directed DNA/RNA polymerase mu,POLM,Terminal tr...

Human Baculovirus Insect Cells
Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 58.8 kDa and the accession number is Q9NP87.
TMPH-01244 POLM Protein, Human, Recombinant (His)

DNA-directed DNA/RNA polymerase mu,Terminal transfe...

Human E. coli
Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.8 kDa and the accession number is Q9NP87.
TMPH-00730 RpoS Protein, E. coli, Recombinant (His)

Sigma S,rpoS,RNA polymerase sigma factor RpoS,Sigma...

E. coli E. coli
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.; Protects stationary phase cells from killing induced by endoribonuclease MazF.
TMPH-02384 Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc)

L,Replicase,RNA-directed RNA polymerase L,Transcrip...

MARV E. coli
Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.7 kDa and the accession number is P35262.
TMPH-03734 Zaire ebolavirus (strain Mayinga-76) L Protein (His)

Transcriptase,L,RNA-directed RNA polymerase L,Large...

ZEBOV E. coli
Zaire ebolavirus (strain Mayinga-76) L Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.9 kDa and the accession number is Q05318.
TMPH-00731 RpoS Protein, E. coli, Recombinant

RNA polymerase sigma factor RpoS,rpoS,Sigma S,Sigma...

E. coli E. coli
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.; Protects stationary phase cells from killing induced by endoribonuclease MazF.
TMPH-03699 VSIV (strain 94GUB Central America) L Protein (His)

RNA-directed RNA polymerase L,Replicase,Transcripta...

VSIV E. coli
VSIV (strain 94GUB Central America) L Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.4 kDa and the accession number is Q8B0H0.
TMPH-03735 Zaire ebolavirus (strain Kikwit-95) L Protein (His & Myc)

RNA-directed RNA polymerase L,L,Large structural pr...

ZEBOV E. coli
Zaire ebolavirus (strain Kikwit-95) L Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.9 kDa and the accession number is Q6V1Q2.
TMPH-01943 PARP4 Protein, Human, Recombinant (His)

Poly [ADP-ribose] polymerase 4,ADP-ribosyltransfera...

Human E. coli
PARP4 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02884 CTDP1 Protein, Mouse, Recombinant (His & Myc)

Fcp1,Ctdp1,RNA polymerase II subunit A C-terminal d...

Mouse E. coli
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. CTDP1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The p...
TMPY-02421 PARP3 Protein, Human, Recombinant (His & GST)

ARTD3,IRT1,ADPRTL2,ADPRTL3,poly (ADP-ribose) polymerase<...

Human Baculovirus Insect Cells
Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular response to DNA double-strand breaks (DSBs), plays an essential role in the maintenance of genome integrity. The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation...
TMPY-02465 PARP Protein, Mouse, Recombinant (His)

AI893648,Adprp,5830444G22Rik,C80510,sPARP-1,poly (ADP-ribose...

Mouse Baculovirus Insect Cells
PARP Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 115 kDa and the accession number is Q921K2.
TMPH-01879 PARP11 Protein, Human, Recombinant (His)

PARP11,Poly [ADP-ribose] polymerase 11,Protein mono...

Human E. coli
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis. PARP11 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.0 kDa and the accession number is Q9NR21.
TMPH-01944 PARP9 Protein, Human, Recombinant (His & Myc)

Poly [ADP-ribose] polymerase 9,ADP-ribosyltransfera...

Human HEK293 Cells
PARP9 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPH-02175 TAF5L Protein, Human, Recombinant (GST)

TAF5L,TAF5-like RNA polymerase II p300/CBP-associat...

Human E. coli
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state.
TMPH-01942 PARP14 Protein, Human, Recombinant (His & Myc)

Protein mono-ADP-ribosyltransferase PARP14,B aggressive lymp...

Human HEK293 Cells
PARP14 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPH-01882 PARP9 Protein, Human, Recombinant (His)

PARP9,Poly [ADP-ribose] polymerase 9,ADP-ribosyltra...

Human E. coli
PARP9 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 30.0 kDa and the accession number is Q8IXQ6.
TMPH-02580 CHRAC1 Protein, Mouse, Recombinant (His & Myc)

CHRAC-1,NF-YC-like protein,Chrac1,YCL1,Chromatin accessibili...

Mouse E. coli
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex. CHRAC1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 21.4 kDa and the accession number is Q9JKP8.
TMPH-01941 PARP12 Protein, Human, Recombinant (His & Myc)

Protein mono-ADP-ribosyltransferase PARP12,PARP12,ADP-ribosy...

Human E. coli
PARP12 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-02189 TENT4B Protein, Human, Recombinant (His)

Topoisomerase-related function protein 4-2,Terminal guanylyl...

Human E. coli
TENT4B Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 67.3 kDa and the accession number is Q8NDF8.
TMPH-01881 PARP2 Protein, Human, Recombinant (GST & His)

Protein poly-ADP-ribosyltransferase PARP2,NAD(+) ADP-ribosyl...

Human Baculovirus Insect Cells
PARP2 Protein, Human, Recombinant (GST & His) is expressed in Baculovirus insect cells with N-GST and C-6xHis tag. The predicted molecular weight is 92.8 kDa and the accession number is Q9UGN5.
TMPH-01880 PARP2 Protein, Human, Recombinant (His)

Protein poly-ADP-ribosyltransferase PARP2,Poly [ADP-ribose] ...

Human E. coli
PARP2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 72.2 kDa and the accession number is Q9UGN5.
TMPH-01648 MED1 Protein, Human, Recombinant (His & SUMO)

Activator-recruited cofactor 205 kDa component,Mediator comp...

Human E. coli
MED1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.2 kDa and the accession number is Q15648.
------------------------ 更多 ------------------------

重组蛋白

T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc)
Cat.No: TMPH-00533
Species: Escherichia phage T7
Expression System: E. coli
DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His)
Cat.No: TMPH-00426
Species: Colwellia psychrerythraea
Expression System: E. coli
DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant
Cat.No: TMPH-00427
Species: Colwellia psychrerythraea
Expression System: E. coli
Influenza A H3N2 (strain A/X-31) Polymerase acidic Protein (His)
Cat.No: TMPH-02357
Species: H3N2
Expression System: E. coli
Influenza A H1N1 (strain A/USA:Huston/AA/1945) Polymerase acidic Protein (His)
Cat.No: TMPH-02356
Species: H1N1
Expression System: P. pastoris (Yeast)
DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc)
Cat.No: TMPH-00523
Species: Escherichia phage RB69
Expression System: E. coli
DNA polymerase II Protein, E. coli, Recombinant (His & Myc)
Cat.No: TMPH-00613
Species: E. coli
Expression System: E. coli
Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) DNA polymerase processivity factor (His)
Cat.No: TMPH-01450
Species: HHV-6A
Expression System: P. pastoris (Yeast)
DNA polymerase II large subunit Protein, Cenarchaeum symbiosum, Recombinant
Cat.No: TMPH-00360
Species: Cenarchaeum symbiosum
Expression System: E. coli
SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His)
Cat.No: TMPY-06071
Species: SARS-CoV-2
Expression System: Baculovirus Insect Cells
PARP Protein, Human, Recombinant (His)
Cat.No: TMPY-01188
Species: Human
Expression System: Baculovirus Insect Cells
POLQ Protein, Human, Recombinant (His)
Cat.No: TMPH-01238
Species: Human
Expression System: Baculovirus Insect Cells
PolA Protein, Thermus aquaticus, Recombinant (M747K, His)
Cat.No: TMPH-03622
Species: Thermus aquaticus
Expression System: E. coli
POLQ Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPH-01237
Species: Human
Expression System: E. coli
DNA PolymeraseBeta Protein, Human, Recombinant (His)
Cat.No: TMPJ-00792
Species: Human
Expression System: E. coli
POLR3K Protein, Human, Recombinant (His)
Cat.No: TMPH-01247
Species: Human
Expression System: Baculovirus Insect Cells
POLR3A Protein, Human, Recombinant (His)
Cat.No: TMPH-01246
Species: Human
Expression System: E. coli
RPB1 Protein, Drosophila melanogaster, Recombinant (His)
Cat.No: TMPH-00505
Species: Fruit fly
Expression System: P. pastoris (Yeast)
RpoH Protein, E. coli, Recombinant (His & Myc)
Cat.No: TMPH-00729
Species: E. coli
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)
Cat.No: TMPH-03732
Species: ZEBOV
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)
Cat.No: TMPH-03733
Species: ZEBOV
Expression System: HEK293 Cells
Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His)
Cat.No: TMPH-02383
Species: MARV
Expression System: E. coli
FliA Protein, E. coli, Recombinant
Cat.No: TMPH-00728
Species: E. coli
Expression System: E. coli
P2 Protein, Pseudomonas phage phi6, Recombinant (His & Myc)
Cat.No: TMPH-03184
Species: Pseudomonas phage phi6
Expression System: E. coli
FliA Protein, E. coli, Recombinant (His)
Cat.No: TMPH-00727
Species: E. coli
Expression System: E. coli
PBP1b Protein, E. coli, Recombinant (His & Myc)
Cat.No: TMPH-00701
Species: E. coli
Expression System: E. coli
TIPARP Protein, Human, Recombinant (His)
Cat.No: TMPH-01945
Species: Human
Expression System: Baculovirus Insect Cells
POLM Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01245
Species: Human
Expression System: Baculovirus Insect Cells
POLM Protein, Human, Recombinant (His)
Cat.No: TMPH-01244
Species: Human
Expression System: E. coli
RpoS Protein, E. coli, Recombinant (His)
Cat.No: TMPH-00730
Species: E. coli
Expression System: E. coli
Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc)
Cat.No: TMPH-02384
Species: MARV
Expression System: E. coli
Zaire ebolavirus (strain Mayinga-76) L Protein (His)
Cat.No: TMPH-03734
Species: ZEBOV
Expression System: E. coli
RpoS Protein, E. coli, Recombinant
Cat.No: TMPH-00731
Species: E. coli
Expression System: E. coli
VSIV (strain 94GUB Central America) L Protein (His)
Cat.No: TMPH-03699
Species: VSIV
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) L Protein (His & Myc)
Cat.No: TMPH-03735
Species: ZEBOV
Expression System: E. coli
PARP4 Protein, Human, Recombinant (His)
Cat.No: TMPH-01943
Species: Human
Expression System: E. coli
CTDP1 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02884
Species: Mouse
Expression System: E. coli
PARP3 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-02421
Species: Human
Expression System: Baculovirus Insect Cells
PARP Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02465
Species: Mouse
Expression System: Baculovirus Insect Cells
PARP11 Protein, Human, Recombinant (His)
Cat.No: TMPH-01879
Species: Human
Expression System: E. coli
PARP9 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01944
Species: Human
Expression System: HEK293 Cells
TAF5L Protein, Human, Recombinant (GST)
Cat.No: TMPH-02175
Species: Human
Expression System: E. coli
PARP14 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01942
Species: Human
Expression System: HEK293 Cells
PARP9 Protein, Human, Recombinant (His)
Cat.No: TMPH-01882
Species: Human
Expression System: E. coli
CHRAC1 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02580
Species: Mouse
Expression System: E. coli
PARP12 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01941
Species: Human
Expression System: E. coli
TENT4B Protein, Human, Recombinant (His)
Cat.No: TMPH-02189
Species: Human
Expression System: E. coli
PARP2 Protein, Human, Recombinant (GST & His)
Cat.No: TMPH-01881
Species: Human
Expression System: Baculovirus Insect Cells
PARP2 Protein, Human, Recombinant (His)
Cat.No: TMPH-01880
Species: Human
Expression System: E. coli
MED1 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01648
Species: Human
Expression System: E. coli
--------- 更多 ---------
Cat. No. Product Name Target Signaling Pathways
T26871 BMT-052

BMT052

BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM).
T40394 Benzamide-15N

Phenylamide-15N,Benzenecarboxamide-15N,NSC-3114-15N,Benzamide-15N

Benzamide-15N (NSC-3114-15N) is a 15N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP).
T12571 PSI-6206 13C,d3

Sofosbuvir metabolite GS-331007 13CD3,RO-2433 13CD3,PSI-6206 13CD3,GS-331007 13CD3

Others Others
PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is a potent and selective HCV NS5B polymerase inhibitor.
TMIH-0105 Baloxavir-d4

Baloxavir-d4 是 Baloxavir 的氘代化合物。Baloxavir 的 CAS 号为 1985605-59-1。Baloxavir 是衍生自前药 Baloxavir marboxil,是流感病毒聚合酶 PA 亚基的一流帽依赖性核酸内切酶抑制剂。它抑制病毒 RNA 的转录和复制,具有强大的抗病毒活性。
TMID-0227 Rifabutin-d7

Rifabutin-d7 是 Rifabutin 的氘代化合物。Rifabutin 的 CAS 号为 72559-06-9。Rifabutin是半合成的安莎霉素抗生素,抑制 DNA 依赖性 RNA 聚合酶,有抗分枝杆菌作用。
T12135 Mycophenolic acid-d3

Mycophenolate-d3,Mycophenolate D3

Others; Antibacterial Microbiology/Virology; Others
Mycophenolic acid-d3 (Mycophenolate-d3) 是 Mycophenolic acid 的衍生物。Mycophenolic acid 是一种降低GTP 水平和损害RNA 聚合酶II (RNAP II)转录延伸的化合物,促进了近端位点的使用,能够逆转虫草素对选择性聚腺苷化的作用。
TMIH-0524 Sofosbuvir-13C-d3

Sofosbuvir-13C-d3 是 Sofosbuvir 的 13C 和氘代化合物。Sofosbuvir 的 CAS 号为 1190307-88-0。Sofosbuvir 是一种丙型肝炎病毒聚合酶 NS5B 的尿苷单磷酸类似物抑制剂,用作治疗慢性丙型肝炎的抗病毒剂。
TMIH-0091 AOH-d3

AOH-d3 是 AOH 的氘代化合物。AOH 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体,靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用,导致 DNA 复制应激,诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用,可抑制肿瘤细胞生长。
TMIH-0025 13C-d3-AOH1996

13C-d3-AOH1996 是 AOH1996 的 13C 和氘代化合物。AOH1996 的 CAS 号为 2089314-64-5。AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体,靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用,导致 DNA 复制应激,诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用,可抑制肿瘤细胞生长。
TMID-0286 Rifaximin-d6

Rifaximin-d6 是 Rifaximin 的氘代化合物。Rifaximin 的 CAS 号为 80621-81-4。Rifaximin是一种胃肠道选择性抗生素,与细菌 DNA 依赖性 RNA 聚合酶的 β 亚基结合,抑制细菌 RNA 合成。与革兰氏阴性菌(MIC:8-50 毫克/毫升)相比,它对革兰氏阳性菌株(MIC:0.03-5 毫克/毫升)的敏感性更高。
T38297 Ribavirin-13C5

Ribavirin-13C5

Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...

同位素标记化合物

BMT-052
Cat.No: T26871
Synonym: BMT052
Target:
Benzamide-15N
Cat.No: T40394
Synonym: Phenylamide-15N,Benzenecarboxamide-15N,NSC-3114-15N,Benzamide-15N
Target:
PSI-6206 13C,d3
Cat.No: T12571
Synonym: Sofosbuvir metabolite GS-331007 13CD3,RO-2433 13CD3,PSI-6206 13CD3,GS-331007 13CD3
Target: Others
Baloxavir-d4
Cat.No: TMIH-0105
Synonym:
Target:
Rifabutin-d7
Cat.No: TMID-0227
Synonym:
Target:
Mycophenolic acid-d3
Cat.No: T12135
Synonym: Mycophenolate-d3,Mycophenolate D3
Target: Others, Antibacterial
Sofosbuvir-13C-d3
Cat.No: TMIH-0524
Synonym:
Target:
AOH-d3
Cat.No: TMIH-0091
Synonym:
Target:
13C-d3-AOH1996
Cat.No: TMIH-0025
Synonym:
Target:
Rifaximin-d6
Cat.No: TMID-0286
Synonym:
Target:
Ribavirin-13C5
Cat.No: T38297
Synonym: Ribavirin-13C5
Target:
共348条,每页50条 1 2 3 4 5 6 7
TargetMol Loading
联系我们
400-820-0310

上海市静安区江场三路238号8楼