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Fmoc-L-Asn(EDA-N3)-OH 是一种点化学试剂,其结构中包含了叠氮基团.据文献报道,此构建块能经由点击化学方法对羊草素进行修饰.羊草素属于酪毒素肽家族,由死亡帽蘑菇生成,是一种致命性极高的口服刚性双环八肽,其致死剂量(LD50=50-100 μg/kg)表明它是最危险的天然产物之一,并且作为 RNA 聚合酶 II 的高度选择性变构抑制剂.
Fmoc-L-Asn(EDA-N3)-OH 是一种点化学试剂,其结构中包含了叠氮基团.据文献报道,此构建块能经由点击化学方法对羊草素进行修饰.羊草素属于酪毒素肽家族,由死亡帽蘑菇生成,是一种致命性极高的口服刚性双环八肽,其致死剂量(LD50=50-100 μg/kg)表明它是最危险的天然产物之一,并且作为 RNA 聚合酶 II 的高度选择性变构抑制剂.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | Fmoc-L-Asn(EDA-N3)-OH is a chemical compound equipped with an azide group used in click chemistry. Reports in the literature have demonstrated its application in the modification of α-amanitin, the deadliest member of the amatoxin peptide family produced by the death cap mushroom. α-Amanitin is a highly lethal natural compound (LD50=50-100 µg/kg), an orally ingested rigid bicyclic octapeptide, acting as a highly selective conformational inhibitor of RNA polymerase II. |
分子量 | 423.42 |
分子式 | C21H21N5O5 |
CAS No. | 2616562-74-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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