489
121
1
131
10
Cat. No. | Product Name | ||
---|---|---|---|
L5400 | 抗心血管疾病化合物库 | 1408 compounds | |
1408 种心血管疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1667 |
Platelet Factor 4 (58-70), human
|
||
Platelet Factor 4 (58-70), human is a polypeptide based on the 58-70 amino acid sequence of Platelet Factor 4 (pf-4) residues. | |||
TP2466 |
Platelet factor 4 (59-70)
PF4 (59-70) |
||
Platelet factor 4 (59-70) elicits human neutrophil & monocyte chemotaxis. | |||
TP2198 |
Platelet Membrane Glycoprotein IIB Peptide (296-306)
|
Others | Others |
GPllb is composed of a 125 Kd heavy chain that is disulfide-linked to a 23 Kd light chain. Hydropathicity analysis of the cDNA sequence indicates that GPllb is anchored to the platelet through a single transmembrane domain located within 20 amino acids of | |||
T9030 |
SU4984
|
FGFR; IGF-1R; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SU4984 是蛋白质酪氨酸激酶抑制剂,能够抑制成纤维细胞生长因子受体 1 (FGFR1) (IC50:10-20 μM),还能够抑制血小板衍生的生长因子受体和胰岛素受体的活性。它可用于研究癌症。 | |||
T5036 |
cangrelor tetrasodium
|
GPR; P2Y Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Cangrelor tetrasodium 是三磷酸腺苷类似物,是可逆的选择性血小板P2Y12拮抗剂,也是非特异性的GPR17拮抗剂。它直接阻断腺苷二磷酸诱导的血小板活化和聚集,具有迅速有效的抗血小板作用。 | |||
T6091 |
CP-673451
|
VEGFR; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
CP673451 是选择性的血小板源生长因子受体 (PDGFR) 抑制剂,能够抑制 PDGFRα (IC50:10 nM) 和 PDGFRβ (IC50:1 nM) 的活性。 | |||
T14137 |
AG 1295
|
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
AG 1295 是选择性血小板衍生生长因子受体酪氨酸激酶抑制剂。它能抑制 PDGFR 的自磷酸化,对 EGF 受体的自磷酸化无影响。 | |||
T5460 |
Mofezolac
莫苯唑酸,莫非佐酸 |
COX | Immunology/Inflammation; Neuroscience |
Mofezolac 是一种非甾体类抗炎药,可缓解疼痛并具有抗炎活性,抑制 COX-1和COX-2的IC50为 1.44 和 447 nM。 | |||
T11339 |
Furegrelate sodium
U-63557A |
PPAR | DNA Damage/DNA Repair; Metabolism |
Furegrelate sodium (U-63557A) 是口服有效的、血栓素合酶选择性抑制剂,抑制人血小板微粒体血栓素 A2 (TxA2) 合酶的 IC50为 15 nM。它正在开发作为抗血小板药物。 | |||
T6594 |
MNS
|
Syk; Src; p97 | Angiogenesis; Tyrosine Kinase/Adaptors; Ubiquitination |
MNS 是一种酪氨酸激酶抑制剂和广谱抗血小板药物,是一种 β-硝基苯乙烯衍生物。它完全抑制 U46619 (IC50:2.1 μM)、ADP (IC50:4.1 μM)、花生四烯酸 (IC50:5.8 μM)、胶原 (IC50:7.0 μM)和凝血酶 (IC50:12.7 μM)诱导的血小板聚集,并抑制 Src (IC50:27.3 μM)、Syk (IC50:2.8 μM) 和 FAK (IC50:97.6 μM)。 | |||
T2629 |
UNC2881
|
TAM Receptor | Tyrosine Kinase/Adaptors |
UNC2881 是一种特异性Mer 激酶抑制剂,可抑制稳态的Mer 激酶磷酸化,其IC50=22 nM。 | |||
T1265 |
Amrinone
Inamrinone,Inocor,氨力农,Wincoram |
TNF; PDE | Apoptosis; Metabolism |
Amrinone (Inocor) 是一种正性肌力血管扩张剂,是一种具有口服活性的,非糖苷和非儿茶酚胺的强心剂,也是一种选择性磷酸二酯酶 III (phosphodiesterase III) 抑制剂,能够防止环磷酸腺苷分解,从而增加环磷酸腺苷水平。 | |||
T16975 |
TAK-593
|
VEGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
TAK-593 是一种 VEGFR2 和 PDGFR 抑制剂,能够作用于VEGFR1 (IC50:3.2 nM)、VEGFR2 (IC50:0.95 nM)、VEGFR3 (IC50:1.1 nM)、PDFGRα (IC50:4.3 nM)、PDFGRβ (IC50:13 nM)。 | |||
T5109 |
Avapritinib
BLU-285 |
PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Avapritinib (BLU-285) 是选择性的、高效的、具有口服活性的 KIT 和 PDGFRA 激活环突变激酶抑制剂,能够作用于 KIT D816V (IC50:0.27 nM) 和 PDGFRA D842V (IC50:0.24 nM)。它减弱 ABCB1 和 ABCG2 的传输功能。它与激酶的活性构象结合,并显示抗肿瘤活性。 | |||
T4320 |
Flumatinib
HHGV678 |
Bcr-Abl; PDGFR; c-Kit | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Flumatinib (HHGV678) 是一种具有口服活性的选择性 Bcr-Abl 抑制剂,能够作用于 c-Abl (IC50:1.2 nM),PDGFRβ (IC50:307.6 nM) 和 c-Kit (IC50:665.5 nM)。 | |||
T15031 |
CYM50260
|
Others; LPL Receptor | GPCR/G Protein; Others |
CYM50260 是有效的、强选择性的鞘氨醇-1-磷酸 4 受体 (S1P4-R) 激动剂 (EC50= 45 nM),对 S1P1-R,S1P2-R,S1P3-R 和 S1P5-R 无活性。 | |||
T7945 |
SU14813
|
VEGFR; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
SU14813 是一种多靶点受体酪氨酸激酶抑制剂,能够抑制 VEGFR2 (IC50:50 nM),VEGFR1 (IC50:2 nM),PDGFRβ (IC50:4 nM),KIT (IC50:15 nM)。 | |||
T26019 |
R59949
R-59949,R 59949 |
Others; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Others |
R59949 是一种泛二酰甘油激酶(DGK)抑制剂,IC50为 300 nM。它通过提高内源性配体二酰甘油水平来激活蛋白激酶 C(PKC)。它强烈抑制 Ⅰ 型 DGKα 和 γ 的活性,中度减弱 Ⅱ 型 DGKθ 和 κ 的活性。 | |||
T6711 |
Tyrphostin AG1296
Tyrphostin AG 1296,AG 1296 |
Apoptosis; FGFR; FLT; PDGFR; c-Kit | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Tyrphostin AG1296 (Tyrphostin AG 1296) 抑制人PDGF α和β受体以及相关干细胞因子受体的信号传导,是一种选择性血小板衍生生长因子受体抑制剂,IC50值为 0.8 μM。 | |||
T0160 |
Anagrelide
Anagrelida,Xagrid,Anagrelidum,阿那格雷 |
PDE | Metabolism |
Anagrelide (Xagrid) 是III 型磷酸二酯酶(PDEIII)抑制剂 (IC50=36 nM),是咪唑喹唑啉衍生物。它能够抑制血小板生成,以及抗血栓形成作用,可用作血小板聚集抑制剂。 | |||
T6996 |
SU 5402
SU5402 |
VEGFR; FGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SU 5402 是多靶点受体酪氨酸激酶抑制剂,能够抑制VEGFR2 (IC50:20 nM),FGFR1 (IC50:30 nM),PDGFRβ (IC50:510 nM)。 | |||
T5466 |
Tyrosine kinase-IN-1
|
VEGFR; FGFR; FLT; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Tyrosine kinase-IN-1是一种多靶点酪氨酸激酶抑制剂,能够抑制KDR (IC50:4 nM),Flt-1 (IC50:20 nM),FGFR1 (IC50:4 nM) 和 PDGFRα (IC50:2 nM)。 | |||
T8900 |
Seralutinib
GB002 |
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Seralutinib (GB002) 是可吸入的PDGFRα 和 PDGFRβ激酶抑制剂,可用于研究肺动脉高压。 | |||
T6236 |
Ozagrel
奥扎格雷,OKY-046,Domenan |
Thrombin; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Ozagrel (Domenan) 是血栓烷 A2(TXA2) 合酶抑制剂,可抑制哮喘。它也是一种抗血小板剂,可选择性抑制人血小板聚集,IC50为 53.12 μM。 | |||
T6166 |
Telatinib
Bay 57-9352,替拉替尼 |
VEGFR; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Telatinib (Bay 57-9352) 是一种口服具有活力的,小分子的 VEGFR2,VEGFR3,PDGFα 和 c-Kit 抑制剂,它们的 IC50 值分别为6,4,15,1 nM。 | |||
T15047 |
Dacisteine
N,S-Diacetyl-L-cysteine,达西司坦 |
Others | Others |
Dacisteine (N,S-Diacetyl-L-cysteine) 是 New Delhi metallo-beta-lactamase-1 (NDM-1) 的抑制剂 (IC50 = 1000 μM)。 | |||
TQ0235 |
AC710
|
FLT; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
AC710是一种 PDGFR 抑制剂,能够作用于 FLT3 (Kd:0.6),CSF1R (Kd:1.57),KIT (Kd:1),PDGFRα (Kd:1.3) 和 PDGFRβ (Kd:1.0)。 | |||
T6350 |
CHIR-124
CHIR124,CHIR 124 |
Apoptosis; GSK-3; FLT; Chk; PDGFR; Src | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
CHIR-124 是一种选择性 Chk1抑制剂,IC50值为 0.3 nM,可有效抑制 PDGFR 和 FLT3,IC50值分别为 6.6 nM 和 5.8 nM。 | |||
T3570 |
SU4312
SU 4312,NSC 86429 |
VEGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
NSC-86429 是一种 (Z)-SU4312 (SU 4312) 和 (E)-SU4312 的外消旋体。其中(Z)-SU4312 能够抑制 PDGFR 和 FLK-1。(E)-SU4312 能够抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R。 | |||
T10157 |
Regorafénib N-oxyde (M2)
瑞戈非尼杂质 13 |
Raf; VEGFR; c-RET; PDGFR; c-Kit; Drug Metabolite | Angiogenesis; Apoptosis; MAPK; Metabolism; Tyrosine Kinase/Adaptors |
Regorafénib N-oxyde M2 是 Regorafenib 的活性代谢物。Regorafenib 是多靶点抑制剂,包括VEGFR1/2/3,PDGFRβ,Kit,RET 和 Raf-1 , IC50分别是 13/4.2/46,22,7,1.5 和 2.5 nM。 | |||
T3476 |
JI-101
CGI-1842,JI 101 |
VEGFR; PDGFR; Ephrin Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
JI-101 (CGI-1842) 是一种有口服活性的多靶点激酶抑制剂,能够抑制VEGFR2,PDGFRβ和EphB4,具有抗癌作用。 | |||
T8719 |
SC99
|
Apoptosis; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
SC99 是一种口服有效选择性STAT3抑制剂,靶向 JAK2-STAT3 途径,抑制血小板活化和聚集,有抗骨髓瘤和抗血栓活性。它结合在 JAK2 的 ATP 结合袋中,抑制 JAK2 和 STAT3 的磷酸化。 | |||
T1452 |
Axitinib
AG-013736,阿昔替尼,阿西替尼 |
VEGFR; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Axitinib (AG-013736) 是一种多靶点酪氨酸激酶抑制剂,能够抑制 VEGFR1 (IC50:4 nM),VEGFR2 (IC50:20 nM),VEGFR3 (IC50:0.4 nM),PDGFRβ (IC50:2 nM)。 | |||
T0435 |
Sulfinpyrazone
(+/-)-Sulfinpyrazone,G-28315,苯磺保泰松,NSC 75925 |
COX | Immunology/Inflammation; Neuroscience |
Sulfinpyrazone (NSC-75925) 是一种口服有效的尿酸剂,具有抗血栓和血小板抑制作用。它可作用于慢性和间歇性痛风性关节炎。 | |||
T1893 |
Parmodulin 2
ML 161 |
Protease-activated Receptor | GPCR/G Protein |
Parmodulin 2 (ML 161) 是一种蛋白酶激活受体 1(PAR1) 变构抑制剂,IC50为 0.26 μM。它是蛋白酶激活受体 1 (PAR1) 介导的血小板活化的抑制剂,可以抑制体外血小板聚集和体内血小板血栓形成。 | |||
T2500 |
Cediranib
AZD2171,NSC-732208,西地尼布 |
VEGFR; FLT; PDGFR; c-Kit; Autophagy | Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors |
Cediranib (AZD2171) 是一种可口服的高选择性VEGFR2抑制剂,对Flt1、KDR、Flt4、PDGFRα、PDGFRβ和c-Kit 的IC50值分别为小于1、小于3、5、5、36和 2nM。 | |||
T6625 |
Ozagrel hydrochloride
Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl |
Thrombin; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Ozagrel hydrochloride (OKY-046 HCl) 是一种选择性血栓素 A(2) 合成酶抑制剂,用于改善术后脑血管收缩和伴随的脑缺血。它是一种抗血小板剂,可选择性抑制人血小板聚集,IC50为 53.12 μM。 | |||
T0097L |
Pazopanib
帕唑帕尼,GW786034 |
VEGFR; FGFR; PDGFR; c-Kit; Autophagy | Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors |
Pazopanib (GW786034) 是一种小分子抑制剂,可抑制多种具有潜在抗肿瘤活性的蛋白酪氨酸激酶。它抑制VEGFR1、VEGFR2、VEGFR3、PDGFRβ、c-Kit、FGFR1和c-Fms 的IC50分别为10、30、47、84、74、140和146 nM。 | |||
T4191 |
Multi-kinase inhibitor 1
Multi-kinase inhibitor I |
Others; Bcr-Abl; PDGFR; c-Kit | Angiogenesis; Cytoskeletal Signaling; Others; Tyrosine Kinase/Adaptors |
Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) 是多激酶抑制剂。它有用于导致与酪氨酸激酶活性异常或失控有关的疾病或失调的潜力,特别是与c-Kit,PDGF-R,Bcr-abl 活性相关的疾病。 | |||
T1777 |
Nintedanib
BIBF 1120,Intedanib,尼达尼布 |
VEGFR; FGFR; FLT; PDGFR; Src | Angiogenesis; Tyrosine Kinase/Adaptors |
Nintedanib (Intedanib) 是一种三重血管激酶抑制剂,抑制 VEGFR1、VEGFR2、VEGFR3 (IC50=34/13/13 nM),FGFR1、FGFR2、FGFR3 (IC50=69/37/108 nM),PDGFRα、PDGFRβ (IC50=59/65 nM)。Nintedanib 具有抗肿瘤活性,通过抑制血管生成来抑制肿瘤生长。 | |||
T4190 |
Ticlopidine
PCR 5332,Ticlid,噻氯匹定 |
ATPase; Adiponectin receptor | GPCR/G Protein; Membrane transporter/Ion channel |
Ticlopidine (PCR 5332) 是抗血栓前药。它是CYP2C19人肝细胞色素的抑制剂,抑制 CYP2C9 及 CYP3A4。他是变构CD39的非竞争性抑制剂,能够阻断 NTPDase 同工酶,对NTPDase2和NTPDase3的IC50分别为 170 µM 和 149 µM。 | |||
T1836 |
AZD2932
|
VEGFR; FLT; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
AZD2932是一种多靶点激酶抑制剂,细胞试验中能够抑制 VEGFR2 (IC50:8 nM),PDGFβ (IC50:4 nM),PDGFβ (IC50:7 nM) 和 PDGFβ (IC50:9 nM)。 | |||
T13178 |
Toceranib
托西尼布,PHA 291639E,SU11654 |
VEGFR; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Toceranib (PHA 291639E) 是口服具有活力的受体酪氨酸激酶 (RTK) 抑制剂,能有效抑制PDGFR,VEGFR,Kit,抑制 PDGFRβ 和 Flk-1/KDR 的Ki 分别为 5 nM 和 6 nM。它具有抗肿瘤和抗血管生成作用,用于研究犬肥大细胞肿瘤。 | |||
T0080 |
Trapidil
唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008 |
PDGFR; PDE | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
Trapidil (Avantrin) 是一种抗血小板药物,是一种血管扩张剂,有特异性血小板衍生生长因子。 | |||
T1792L |
Regorafenib monohydrate
|
Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Regorafenib monohydrate 是一种新型口服多激酶抑制剂,对VEGFR1/2/3、PDGFRβ、Kit、RET 和Raf-1的IC50分别为 13、4.2、46、22、7、1.5 和 2.5 nM。 | |||
T0230 |
Prasugrel
LY640315,CS-747,普拉格雷,PCR 4099 |
P2Y Receptor | GPCR/G Protein; Neuroscience |
Prasugrel (CS-747) 是一种噻吩吡啶和前药,是一种可口服的 P2Y12受体拮抗剂,抑制 ADP 诱导的血小板聚集,用于预防急性冠状动脉综合征患者的血栓形成、不稳定型心绞痛和心肌梗塞,以及接受经皮冠状动脉介入治疗的患者。 | |||
T4478 |
CID 16020046
C390-0219 |
Cannabinoid Receptor | GPCR/G Protein |
CID 16020046 (C390-0219) 是一种选择性 GPR55 拮抗剂,在酵母中抑制 GPR55 组成型活性,IC50 为 0.15 μM。它抑制 GPR55 介导的 Ca2+信号传导和 GPR55 介导的 ERK1/2 磷酸化,可降低内皮细胞的伤口愈合,参与血小板功能的调节。 | |||
T6920 |
ON123300
|
FGFR; c-RET; JAK; CDK; PDGFR; Src; AMPK | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
ON123300 是一种可透过血脑屏障的多激酶抑制剂,作用于 CDK4、CDK6、Ark5、PDGFRβ、FGFR1、RET 和 Fyn,IC50值为3.9、9.82、5、26、26、9.2和11 nM。它在脑肿瘤中抑制 Akt 磷酸化及激活 Erk。 | |||
TQ0059 |
Ilorasertib
ABT-348 |
VEGFR; FLT; c-RET; PDGFR; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
Ilorasertib (ABT-348) 是一种 ATP 竞争性多靶点激酶抑制剂,可抑制 Aurora A、Aurora B 和Aurora C,IC50值为120 nM、7 nM 和1 nM。它还抑制 RET 酪氨酸激酶、PDGFRβ 和 Flt1,IC50为7 nM、3 nM 和 32 nM。 | |||
T16164 |
MY-5445
N-(3-chlorophenyl)-4-phenylphthalazin-1-amine |
PDE | Metabolism |
MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) 是特异性的 cGMP 磷酸二酯酶 PDE5抑制剂,其 Ki=1.3 μM。它是一种 ABCG2转运蛋白调节剂,具有抗增殖活性。它能抑制人血小板凝集。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2085 |
Piperlonguminine
|
Anti-infection; Antibacterial; Antifungal | Microbiology/Virology |
Piperlonguminine 是一种从 Piper 中分离出的生物碱酰胺。它具有多种生物活性,如神经保护、抗炎、抗肿瘤、抗血小板、抗黑素生成、抗真菌和抗菌活性。 | |||
T2734 |
Sennoside B
番泻苷 B,番泻苷B |
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Sennoside B 是在番泻叶的叶子和豆荚中大量发现的蒽醌苷。它可通过与 PDGF-BB 及其受体结合并下调 PDGFR-β 信号传导途径来抑制 PDGF 刺激的细胞增殖。 | |||
T6S0139 |
Neobavaisoflavone
|
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎,抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶,也可抑制血小板聚集。 | |||
T3781 |
Jujuboside B
酸枣仁皂苷 B,酸枣仁皂苷B |
Others | Others |
Jujuboside B 是一种提取自Zizyphus jujuba 中的活性成分,对血小板聚集具有抑制作用。 | |||
T3S1591 |
Notoginsenoside Fc
三七皂苷 FC,三七皂苷Fc |
Others; Autophagy | Autophagy; Others |
Notoginsenoside Fc 是从三七叶中分离得到的原卟啉二醇型皂苷,可通过促进自噬促进糖尿病大鼠血管损伤后的内皮细胞再生,具有抗血小板聚集的作用。 | |||
TN1969 |
N-(p-Coumaroyl) serotonin
|
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
N-(p-Coumaroyl) Serotonin 是从红花种子中分离出来的多酚,具有抗氧化、抗动脉粥样硬化和抗炎作用,常用于动脉粥样硬化的研究。它可改善动脉粥样硬化和主动脉壁膨大。它可降低肌浆网中 PDGF 诱导的对中PDGFR 酪氨酸磷酸化和 Ca2+释放的作用。 | |||
T0853 |
Adenosine
腺苷,D-Adenosine,Adenine riboside |
Apoptosis; Nucleoside Antimetabolite/Analog; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Adenosine (D-Adenosine) 是一种核糖核苷,由与核糖结合的腺嘌呤组成,具有血管扩张、抗心律失常和镇痛作用。 | |||
TN2244 |
Sulfuretin
硫黄菊素 |
NF-κB; Autophagy | Autophagy; NF-κB |
Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂,IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。 它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。 | |||
TN1926 |
Methyl caffeate
Methyl caffeate acid,金银花,咖啡酸甲酯 |
Others; Antibacterial | Microbiology/Virology; Others |
Methyl caffeate (Methyl caffeate acid) acid 是一种抗微生物剂,有抗菌和抗分枝杆菌活性。它还抑制 α-葡萄糖苷酶,有氧化应激抑制活性,抗血小板活性,子宫颈癌的抗增殖活性以及肺和白细胞的抗癌活性。 | |||
T8288 |
14-Deoxyandrographolide
去氧穿心莲内酯,14-去氧穿心莲内酯 |
Apoptosis; Others | Apoptosis; Others |
14-Deoxyandrographolide 是穿心莲中的一种天然产物,是一种钙通道阻断剂,具有保肝功效。它通过诱导 TNFRSF1A 的释放,使肝细胞对 TNF-α 介导的凋亡脱敏。 | |||
T1626 |
Prostaglandin E1
前列地尔,PGE1,列腺素E1,Alprostadil |
Endogenous Metabolite; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism |
Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体,对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集,可作为血管扩张剂用于外周血管疾病的研究。 | |||
TN2354 |
Methylnissolin
3-Hydroxy-9,10-dimethoxyptercarpan,黄芪紫檀烷,黄芪紫檀烷苷,3-羟基-9,10-二甲氧基紫檀烷 |
ERK; PDGFR | Angiogenesis; MAPK; Tyrosine Kinase/Adaptors |
Methylnissolin 是从黄芪中分离的一种天然产物,可抑制血小板衍生生长因子 (PDGF)-BB 诱导的细胞增殖,IC50为 10 μM。。它通过抑制ERK1/2MAP 激酶级联反应抑制 PDGF-BB 诱导的血管平滑肌细胞增殖。它还抑制 PDGF-BB 诱导的细胞外信号调节激酶 1/2 (ERIC1/2) 丝裂原活化蛋白 (MAP) 激酶的磷酸化,具有抗菌和抗癌作用。 | |||
TN4222 |
Homoeriodictyol 7-O-β-D-glucoside
高圣草素-7-O-Β-D-葡萄糖苷,Homoeriodictyol 7-O-glucoside |
Others; Platelet aggregation | Others |
Homoeriodictyol 7-O-β-D-glucoside (Homoeriodictyol 7-O-glucoside) 是 Viscum coloratum(Kom.)Nakai 的天然产物。Homoeriodictyol 7-O-β-D-glucoside 是血小板活化因子 (PAF) 的拮抗剂。 | |||
TN6924 |
Anhydrosafflor yellow B
(2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,脱水红花黄色素B,AHSYB |
Others | Others |
Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1) 是从红花中分离出来的,可抑制 ADP 诱导的血小板聚集,在体外表现出显着的抗氧化作用,并对 H2O2 诱导的细胞毒性具有一定的活性。 | |||
T5S2358 |
Dehydrocorydaline
Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine |
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome |
Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax,Bcl-2蛋白表达,激活caspase-7,caspase-8,并使PARP 失活。它能增强p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。 | |||
T3817 |
Darutigenol
|
Others | Others |
Darutigenol 是一种戊二萜,从Siegesbecikia orientalis L.中分离得到。 | |||
TMA0536 |
2-Acetylbenzoic acid
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
2-Acetylbenzoic acid 在抑制血小板功能和血小板前列腺素 (PG) 合成方面比 2-丙酰氧基苯甲酸更有效,尽管这些药物在抑制前列环素 (PGI2) 合成方面的效力相当。 | |||
T1723 |
Adenosine 5'-diphosphate
腺苷5'-二磷酸,Adenosine diphosphate,adenosine pyrophosphate,ADP |
Endogenous Metabolite | Metabolism |
Adenosine 5'-diphosphate (ADP) 是一种嘌呤核糖核苷5'-二磷酸,是 ATP 在 ATP 酶作用下去磷酸化的产物。Adenosine 5'-diphosphate (adenosine pyrophosphate) 可诱导人血小板聚集并通过作用于P2T-嘌呤受体抑制受刺激的腺苷酸环化酶。 | |||
TN2343 |
Pseudojervine
Jervin-3-glucoside,O-beta-D-Glucopyranosyljervine,假白藜芦碱 |
Platelet aggregation | Others |
Pseudojervine (O-beta-D-Glucopyranosyljervine) 来源于 Veratrum nigrum L. Pseudojervine 对血小板聚集表现出微弱的抑制活性。 | |||
T12164 |
N6-(4-Hydroxybenzyl)adenosine
Para-topolin riboside,N6-羟苄腺苷 |
P2Y Receptor | GPCR/G Protein; Neuroscience |
N6-(4-Hydroxybenzyl)adenosine (Para-topolin riboside) 是一种血小板聚集抑制剂。 | |||
TQ0036 |
Anemarrhenasaponin I
|
Others | Others |
Anemarrhenasaponin I 是一种对血小板聚集有显著的抑制作用的传统中药。 | |||
TN1643 |
Ferulamide
4-Hydroxy-3-methoxycinnamide,阿魏酸酰胺 |
PAFR; AChR | GPCR/G Protein; Neuroscience |
Ferulamide (4-Hydroxy-3-methoxycinnamide) 是从巴豆中分离的阿魏酸衍生物,具有抗胆碱酯酶活性。 | |||
TN1057 |
Veratrosine
藜芦托素,Veratramine 3-glycoside,Veratramine-beta-D-glucoside |
Platelet aggregation | Others |
Veratrosine (Veratramine-beta-D-glucoside) 是一种从藜芦草本植物中分离出来的生物碱。 Veratrosine 对血小板聚集表现出微弱的抑制活性。 | |||
T3429 |
Protopine
原阿片碱,Macleyine,Hypercorine,Corydinine,Biflorine,Fumarine |
Reactive Oxygen Species; Platelet aggregation; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB; Others |
Protopine (Fumarine) 是一种常存在于亚洲东北部的一些植物中的异喹啉类生物碱,常用于抗肿瘤、抗炎活性的研究。 | |||
T7053 |
p-Hydroxycinnamic acid
p-Coumaric acid,p-Cumaric acid,p-Hydroxy-cinnamic acid,对羟基肉桂酸,NSC 59260 |
Thrombin; Endogenous Metabolite; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Proteases/Proteasome |
p-Hydroxycinnamic acid (NSC-59260) 是常见的食用酚,可抑制血小板活性,对血栓素 B2 和前列腺素 E2 的 IC50值分别为 371 和 126 μM。 | |||
T2898 |
Andrographolide
Andrographis,穿心莲内酯 |
SARS-CoV; Influenza Virus; NF-κB; Autophagy | Autophagy; Microbiology/Virology; NF-κB |
Andrographolide (Andrographis) 是 NF-κB 的不可逆拮抗剂,具有抗病毒、抗炎和抗血小板聚集活性和潜在的抗肿瘤作用。 | |||
T3734 |
3',4'-Dihydroxyacetophenone
二羟基苯乙酮,Qingxintong,4-Acetylpyrocatechol |
Tyrosinase; Platelet aggregation | Others; Proteases/Proteasome |
3',4'-Dihydroxyacetophenone (Qingxintong) 是一种血管活性物质和抗氧化剂,可从Picea Schrenkiana 中分离得到,能抑制酪氨酸酶,其IC50=10 μM。 | |||
T2839 |
Orsellinic acid
|
Apoptosis; Others | Apoptosis; Others |
Orsellinic acid是一种利用Lecanoric acidy 用醇处理后得到的化合物,,抑制血小板活化因子 (PAF) 介导的神经元凋亡。 | |||
T5079 |
Adenosine 5'-diphosphate sodium salt
腺苷-5‘-二磷酸钠盐,Adenosine-5'-diphosphate trisodium salt,ADP sodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Adenosine 5'-diphosphate sodium salt (ADP sodium salt) 是一种核苷二磷酸,是一种 ATP 酶对 ATP 去磷酸化的产物。它通过在 P2T-嘌呤受体上的作用诱导人血小板聚集并抑制刺激的腺苷酸环化酶。 | |||
T5S0896 |
Loureirin A
龙血素 A,龙血素A |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Loureirin A 是一种黄酮类物质,从龙血树中分离得到,能够降低Akt 的磷酸化,具有抗血小板聚集作用。 | |||
T11012 |
Dextran
Dextran 40,葡聚糖 |
Platelet aggregation | Others |
Dextran 对血小板聚集和凝血因子有抑制作用,用作增加血浆容量的药剂。 | |||
T4S1658 |
Benzoyloxypaeoniflorin
苯甲酰氧化芍药苷,Benzoyloxypeoniflorin,苯甲酰氧芍药苷 |
NF-κB; Tyrosinase | NF-κB; Proteases/Proteasome |
Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) 是一种酪氨酸酶抑制剂,分离于Paeonia suffruticosa 的根,对mushroom tyrosinase 的 IC50为 0.453 mM。它是一种NF-κB 抑制剂,它通过对血小板聚集和凝血的抑制作用,有助于改善血液循环。 | |||
T28551 |
Ro 09-0680
Ro-09-0680,Ro 09 0680 |
||
Ro 09-0680 是从丹参中提取的化合物,是一种由胶原蛋白诱导的兔血小板聚集的有效抑制剂,具有潜在的抗炎活性,可用于研究心血管疾病。 | |||
TN2315 |
Xanthopurpurin
茜草红素,1,3-二羥蒽醌,异茜草素 |
Platelet aggregation; Antifection | Microbiology/Virology; Others |
Xanthopurpurin 是分离自Rubia akane 根茎的蒽醌苷。Xanthopurpurin 主要对胶原诱导的血小板聚集有较强的抑制作用。 | |||
TN6710 |
Methyl acetylsalicylate
ACETYLSALICYLIC ACID METHYL ESTER,乙酰水杨酸甲酯 |
Others | Others |
Methyl acetylsalicylate (ACETYLSALICYLIC ACID METHYL ESTER) 是一种从豌豆中分离出来的天然产物。抑制胶原蛋白诱导的人富含血小板的血浆聚集。 | |||
TN1564 |
Delphinidin 3-glucoside chloride
Delphinidin-3-O-glucoside chloride |
Apoptosis; EGFR | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Delphinidin 3-glucoside chloride (Delphinidin-3-O-glucoside chloride) 是从 Hibiscus sabdariffa 提取物中发现的膳食酚类物质。Delphinidin 3-glucoside chloride 具有抗氧化活性,可诱导 B 细胞慢性淋巴细胞性白血病 (B CLL) 的促凋亡作用,抑制 EGFR,抑制血小板聚集。Delphinidin 3-glucoside chloride 具有抗肿瘤活性,通过调节 pAKT/IRF1/HOTAIR 通路发挥作用。 | |||
TN3460 |
Asebogenin
|
Antifungal | Microbiology/Virology |
Asebogenin 是从丹参中分离出来的化合物,具有抗真菌活性,对GPVI 诱导的血小板反应有抑制作用,抑制促炎刺激诱导的 NET 形成。 | |||
T3408 |
Syringin
Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine,紫丁香苷 |
NOS; Autophagy | Autophagy; Immunology/Inflammation |
Syringin (eleutheroside-b) 是欧丁香中的一种苯丙素类天然产物,通过抑制自噬来防止压力超载引起的心肌肥厚,具有抗肿瘤、抗增殖、抗骨质疏松、免疫调节和血小板聚集抑制作用。 | |||
TN1383 |
Timosaponin B III
Anemarsaponin BIII,知母皂苷B3,知母皂苷BIII |
Others; Platelet aggregation | Others |
Timosaponin B III (Anemarsaponin BIII) 是一种具有生物活性的甾体皂苷,从知母中分离出来。Timosaponin B III 具有抗炎、抗血小板聚集和抗抑郁作用。 | |||
T0131 |
Cepharanthine
NSC-623442,千金藤碱,千金藤素 |
Apoptosis; TNF; HIV Protease; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome |
Cepharanthine (NSC-623442) 是从Stephania cepharanthaHayata 中提取的一种生物碱,具有抗炎、抗氧化作用。它可抑制肿瘤坏死因子 (TNF)-α 介导的 NFκB 刺激、质膜脂质过氧化和血小板聚集,并抑制细胞因子的产生。 | |||
TJS0314 |
5,7-Dihydroxy-4-methylcoumarin
Methyl-2H-Chromen-2-One,5,7-二羟基-4-甲基香豆素,4-Methyllimetol,4-Methyl-5,7-Dihydroxycoumarin |
Others; Antibacterial; Antifungal | Microbiology/Virology; Others |
5,7-Dihydroxy-4-methylcoumarin (Methyl-2H-Chromen-2-One) 是墨西哥龙蒿中的一种香豆素衍生物。它抑制人类中性粒细胞氧化代谢和弹性蛋白酶活性,有抗真菌和抗细菌活性。 | |||
TL0001 |
dencichine
L-Dencichin,ODAP,Dencichin,三七素 |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Dencichine (ODAP) 是抑制从三七中分到的非蛋白氨基酸,可抑制 HIF-prolyl hydroxylase-2 的活性。 | |||
T6943 |
Picropodophyllin
AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素 |
Apoptosis; IGF-1R | Apoptosis; Tyrosine Kinase/Adaptors |
Picropodophyllin (Picropodophyllin (PPP)) 是一种选择性的胰岛素样生长因子-1受体抑制剂,IC50为1 nM。 | |||
T2939 |
Forskolin
毛喉素,Coleonol,Colforsin |
FXR; Adenylyl cyclase; AChR; Autophagy | Autophagy; Metabolism; Neuroscience |
Forskolin (Coleonol) 属于天然产物,是一种腺苷酸环化酶激活剂 (EC50=0.5 μM)。Forskolin 可以增加 cAMP 水平,可以激活 PXR 和 FXR,也可以诱导细胞自噬。Forskolin 对心脏产生正性肌力作用,具有血小板抗凝集和降压作用。 | |||
T0070 |
Pentoxifylline
Oxpentifylline,PTX,己酮可可碱,BL-191 |
HIV Protease; PDE; Adenosine Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Pentoxifylline (PTX) 是一种具有口服活性的磷酸二酯酶非选择性抑制剂,具有免疫调节、抗炎、抗纤溶、抗增殖和血液流变学改善作用。它可研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。 | |||
T3S0645 |
N-trans-Feruloyltyramine
Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺 |
Others; COX | Immunology/Inflammation; Neuroscience; Others |
N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱,是COX1和COX2的抑制剂,具有抗氧化和抗炎活性。 | |||
TN2322 |
Yangambin
|
Calcium Channel; PAFR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素,是选择性PAF 受体拮抗剂,通过调控Ca2+通道抑制 Ca2+流入,导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少,具有降压作用。 | |||
TN1170 |
1-Cinnamoylpyrrolidine
|
Platelet aggregation | Others |
1-Cinnamoylpyrrolidine 是从 Piper caninum 制备的天然产物,可作为一种 DNA 链断裂剂,在Cu2+ 存在下诱导质粒 pBR322 DNA 超螺旋的松弛。1-Cinnamoylpyrrolidine 对 PAF 诱导的血小板聚集有抑制作用,IC50 值为 37.3 μM。 | |||
T7030 |
anemarsaponin B
知母皂苷B,知母皂苷 B |
p38 MAPK; NF-κB; MEK; COX; NO Synthase | Immunology/Inflammation; MAPK; Neuroscience; NF-κB |
Anemarsaponin B 是一种甾体皂苷,可降低iNOS 和COX-2的蛋白和 mRNA 水平,减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位,还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。 | |||
TN6975 |
Cirsiumaldehyde
5,5’-oxydimethylenebis(2-furfural) |
Platelet aggregation | Others |
Cirsiumaldehyde 是一种从Lobelia chinensis、Cornus officinalis 成熟果实和 Hippophae rhamnoides 果实中分分离出的化合物。Cirsiumaldehyde 在胶原蛋白存在下对 U46619 诱导(1~5 uM)的大鼠血小板聚集的抑制浓度为 0.8~1.0 ug/mL。 | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01139 |
PDGFRA Protein, Human, Recombinant (His)
PDGFR-2,CD140A,RHEPDGFRA,platelet-derived growth fa... |
Human | HEK293 Cells |
PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number is P16234-1. | |||
TMPY-04644 |
PDGFB Protein, Human, Recombinant (His)
platelet-derived growth factor beta polypeptide,SSV... |
Human | P. pastoris (Yeast) |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted... | |||
TMPY-05034 |
CD42b/GP1BA Protein, Human, Recombinant (His)
DBPLT3,CD42B,glycoprotein Ib (platelet), α polypept... |
Human | HEK293 Cells |
CD42b/GP1BA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is A5CKE2. | |||
TMPY-04976 |
PDGFC Protein, Mouse, Recombinant (His)
platelet derived growth factor C,血小板源生长因子,AI647969,... |
Mouse | P. pastoris (Yeast) |
PDGFC Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 14.4 kDa and the accession number is Q8CI19. | |||
TMPY-00970 |
CD31/PECAM-1 Protein, Human, Recombinant (His)
platelet/endothelial cell adhesion molecule 1,GPIIA... |
Human | HEK293 Cells |
CD31/PECAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66 kDa and the accession number is EAW94208.1. | |||
TMPY-03234 |
CD42c Protein, Rat, Recombinant (hFc)
glycoprotein Ib (platelet), β polypeptide,glycoprot... |
Rat | HEK293 Cells |
CD42c Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.1 kDa and the accession number is Q9JJM7. | |||
TMPY-00624 |
PEAR1 Protein, Rat, Recombinant (His)
platelet endothelial aggregation receptor 1 |
Rat | Baculovirus Insect Cells |
Platelet endothelial aggregation receptor-1 (PEAR1), an epidermal growth factor repeat-containing transmembrane receptor, is known to participate in platelet contact-induced activation. Platelet endothelial aggregation receptor 1 (PEAR1) triggers platelet aggregation and is expressed in platelets and endothelial cells.PEAR1 encodes the Platelet-Endothelial Aggregation Receptor 1, a contact receptor involved in platelet function and megakaryocyte and endothelial cell proliferation. PEAR1 expressi... | |||
TMPY-00385 |
PDGFRB Protein, Rhesus, Recombinant (hFc)
platelet-derived growth factor receptor, β polypept... |
Rhesus | HEK293 Cells |
PDGFRB Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.3 kDa and the accession number is F7BTH1. | |||
TMPY-01218 |
CD42c Protein, Human, Recombinant (His)
glycoprotein Ib (platelet), β polypeptide,BS,BDPLT1... |
Human | HEK293 Cells |
CD42c Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.3 kDa and the accession number is P13224-1. | |||
TMPY-06921 |
PDGFRA Protein, Cynomolgus, Recombinant (His)
platelet-derived growth factor receptor, alpha poly... |
Cynomolgus | HEK293 Cells |
PDGFRA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.68 kDa and the accession number is Q0PW86. | |||
TMPY-03825 |
PDGFRA Protein, Rat, Recombinant (His)
platelet-derived growth factor receptor, α polypept... |
Rat | HEK293 Cells |
PDGFRA Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is A6JD04. | |||
TMPY-04838 |
PDGFA Protein, Mouse, Recombinant (His)
platelet-derived growth factor α polypeptide,血小板源生长... |
Mouse | P. pastoris (Yeast) |
Platelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis. The human platelet-derived growth factor A chain gene (PDGFA) on chromosome 7p22 encodes an important mitogen. Within PDGFA lies a complex minisatellite structure that results in partial duplications of exon 4 and the IVS4 splice donor site. PDG... | |||
TMPY-05077 |
PDGFB Protein, Rhesus, Recombinant (His)
platelet-derived growth factor β polypeptide,pl... |
Rhesus | P. pastoris (Yeast) |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Rhesus, Recombinant (His) is expressed in yeast with His tag. The predicte... | |||
TMPY-03590 |
PDGFRB Protein, Rhesus, Recombinant (His)
platelet-derived growth factor receptor, β polypept... |
Rhesus | HEK293 Cells |
PDGFRB Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number is F7BTH1. | |||
TMPY-03474 |
PDGFRB Protein, Rat, Recombinant (hFc)
platelet-derived growth factor receptor, β polypept... |
Rat | HEK293 Cells |
PDGFRB Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.2 kDa and the accession number is Q05030. | |||
TMPY-03919 |
PDGFRA Protein, Rat, Recombinant (hFc)
platelet-derived growth factor receptor, alpha poly... |
Rat | HEK293 Cells |
PDGFRA Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.2 kDa and the accession number is G3V6A0. | |||
TMPY-03140 |
PDGFRB Protein, Rat, Recombinant (His)
platelet-derived growth factor receptor, beta polyp... |
Rat | HEK293 Cells |
PDGFRB Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is Q05030. | |||
TMPJ-00605 |
GPVI Protein, Mouse, Recombinant (His)
Glycoprotein 6,GP6,glycoprotein VI (platelet),GPVI,... |
Mouse | HEK293 Cells |
Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregation and thrombin generation. GPVI is also a secondary receptor required for platelet spreading on laminin. GPVI associates with the Fc receptor gamma -chain via charged aa in the TM domains of GPVI (arginine) and the FcR gamma (aspartic acid). Collagen binding by the GPVI Ig-like... | |||
TMPY-05068 |
PDGFA Protein, Rat, Recombinant (His)
血小板源生长因子,platelet-derived growth factor alpha polyp... |
Rat | P. pastoris (Yeast) |
Platelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis. The human platelet-derived growth factor A chain gene (PDGFA) on chromosome 7p22 encodes an important mitogen. Within PDGFA lies a complex minisatellite structure that results in partial duplications of exon 4 and the IVS4 splice donor site. PDG... | |||
TMPY-05075 |
PDGFA Protein, Canine, Recombinant (His)
platelet-derived growth factor α polypeptide,血小板源生长... |
Canine | P. pastoris (Yeast) |
Platelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis. The human platelet-derived growth factor A chain gene (PDGFA) on chromosome 7p22 encodes an important mitogen. Within PDGFA lies a complex minisatellite structure that results in partial duplications of exon 4 and the IVS4 splice donor site. PDG... | |||
TMPY-05076 |
PDGFB Protein, Canine, Recombinant (His)
platelet-derived growth factor beta polypeptide, |
Canine | P. pastoris (Yeast) |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Canine, Recombinant (His) is expressed in yeast with His tag. The predicte... | |||
TMPY-02395 |
PDGFB Protein, Cynomolgus, Recombinant (mFc)
血小板源生长因子,platelet-derived growth factor beta polype... |
Cynomolgus | HEK293 Cells |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with ... | |||
TMPY-00455 |
PDGFA Protein, Canine, Recombinant (hFc)
血小板源生长因子,platelet-derived growth factor α polypepti... |
Canine | HEK293 Cells |
Platelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis. The human platelet-derived growth factor A chain gene (PDGFA) on chromosome 7p22 encodes an important mitogen. Within PDGFA lies a complex minisatellite structure that results in partial duplications of exon 4 and the IVS4 splice donor site. PDG... | |||
TMPY-00741 |
CXCL4 Protein, Human, Recombinant
PF-4,platelet factor 4,SCYB4,CXCL4 |
Human | E. coli |
Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils a... | |||
TMPY-04877 |
PDGFB Protein, Mouse, Recombinant (His)
platelet-derived growth factor β polypeptide,血小板源生长... |
Mouse | P. pastoris (Yeast) |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted... | |||
TMPY-05160 |
PFKP Protein, Human, Recombinant (His & GST)
PFK-P,PFKF,ATP-PFK,phosphofructokinase, platelet,PF... |
Human | Baculovirus Insect Cells |
PFKP plays a critical role in cell proliferation in breast cancer cells. PFKP is necessary for starvation-mediated autophagy, glycolysis, and EMT, thereby promoting the malignant progression of OSCC. The Snail-PFKP axis plays an important role in cancer cell survival via regulation of glucose flux between glycolysis and PPP. | |||
TMPY-05056 |
PDGFA Protein, Human, Recombinant (His)
PDGF1,PDGF-A,血小板源生长因子,platelet-derived growth facto... |
Human | P. pastoris (Yeast) |
Platelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis. The human platelet-derived growth factor A chain gene (PDGFA) on chromosome 7p22 encodes an important mitogen. Within PDGFA lies a complex minisatellite structure that results in partial duplications of exon 4 and the IVS4 splice donor site. PDG... | |||
TMPY-05789 |
PDGFRA Protein, Mouse, Recombinant (hFc)
AI115593,platelet-derived growth factor receptor, a... |
Mouse | HEK293 Cells |
PDGFRA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.15 kDa and the accession number is P26618-2. | |||
TMPY-05787 |
PDGFRA Protein, Mouse, Recombinant (His)
CD140a,platelet-derived growth factor receptor, alp... |
Mouse | HEK293 Cells |
PDGFRA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.87 kDa and the accession number is P26618-2. | |||
TMPH-00213 |
Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc)
Platelet aggregation activation inhibitor,Disintegr... |
Bothrops atrox | E. coli |
Inhibits fibrinogen interaction with platelets. Acts by binding to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Also inhibits T24 and SK-Mel-28 cell adhesion to fibronectin with IC(50) of 4.4 uM and 33 nM, respectively. Disintegrin batroxostatin Protein, Bothrops atrox, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted... | |||
TMPY-00269 |
PDGFC Protein, Cynomolgus, Recombinant (hFc)
platelet derived growth factor C,血小板源生长因子 |
Cynomolgus | HEK293 Cells |
PDGFC Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.9 kDa and the accession number is G7P6G9. | |||
TMPY-05608 |
PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
platelet-derived growth factor receptor, α polypept... |
Human | HEK293 Cells |
PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 59.4 kDa and the accession number is P16234-1. | |||
TMPY-00900 |
PDGFRA Protein, Human, Recombinant (hFc)
PDGFR-2,platelet-derived growth factor receptor, al... |
Human | HEK293 Cells |
PDGFRA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.9 kDa and the accession number is P16234-1. | |||
TMPY-04622 |
PF4V1 Protein, Human, Recombinant (mFc)
PF4A,CXCL4V1,platelet factor 4 variant 1,PF4-ALT,SC... |
Human | HEK293 Cells |
PF4V1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34.6 kDa and the accession number is P10720. | |||
TMPY-02681 |
CXCL7 Protein, Rat, Recombinant (hFc)
pro-platelet basic protein (chemokine (C-X-C motif)... |
Rat | HEK293 Cells |
CXCL7 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.3 kDa and the accession number is A6KKE5. | |||
TMPY-04724 |
CXCL7 Protein, Rat, Recombinant (His)
pro-platelet basic protein (chemokine (C-X-C motif)... |
Rat | P. pastoris (Yeast) |
CXCL7 Protein, Rat, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.6 kDa and the accession number is A6KKE5. | |||
TMPY-03043 |
CXCL7 Protein, Cynomolgus, Recombinant (mFc)
pro-platelet basic protein (chemokine (C-X-C motif)... |
Cynomolgus | HEK293 Cells |
CXCL7 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34.3 kDa and the accession number is F6SCP6. | |||
TMPY-04725 |
CXCL7 Protein, Cynomolgus, Rhesus, Recombinant (His)
pro-platelet basic protein (chemokine (C-X-C motif)... |
Cynomolgus,Rhesus | P. pastoris (Yeast) |
CXCL7 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 11.7 kDa and the accession number is A0A2K5UVV0. | |||
TMPY-02815 |
PDGFC Protein, Human, Recombinant (His)
platelet derived growth factor C,FALLOTEIN,血小板源生长因子... |
Human | Baculovirus Insect Cells |
PDGFC Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 13.89 kDa and the accession number is Q9NRA1-1. | |||
TMPY-00898 |
PDGFC Protein, Human, Recombinant (hFc)
血小板源生长因子,FALLOTEIN,SCDGF,platelet derived growth fa... |
Human | HEK293 Cells |
PDGFC Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39 kDa and the accession number is Q9NRA1-1. | |||
TMPY-01619 |
CD31/PECAM-1 Protein, Mouse, Recombinant (His)
Pecam,C85791,PECAM-1,Cd31,platelet/endothelial cell... |
Mouse | HEK293 Cells |
CD31/PECAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66 kDa and the accession number is Q03311. | |||
TMPJ-00433 |
VSIR Protein, Cynomolgus, Recombinant (His)
Stress-induced secreted protein-1,Platelet receptor... |
Cynomolgus | HEK293 Cells |
platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling pathway. It also regulates the CD4-pasitive, alpha-beta T cell proliferation, and T cell cytokine production negatively. However, the protein can regulate stem cell differentiation positively. | |||
TMPJ-00294 |
CD36 Protein, Mouse, Recombinant (hFc)
GPIV,PAS-4,CD36,PAS IV,GPIIIB,Platelet glycoprotein... |
Mouse | HEK293 Cells |
CD36 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 100-130 KDa and the accession number is Q08857. | |||
TMPJ-00293 |
CD36 Protein, Mouse, Recombinant (Avi & His), Biotinylated
Platelet glycoprotein IV,Glycoprotein IIIb,CD36,GPI... |
Mouse | HEK293 Cells |
CD36 Protein, Mouse, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 85-120 KDa and the accession number is Q08857. | |||
TMPY-05358 |
PDGFRB Protein, Human, Recombinant
PENTT,platelet-derived growth factor receptor, beta... |
Human | HEK293 Cells |
PDGFRB Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 56.2 kDa and the accession number is P09619-1. | |||
TMPH-02835 |
PDGFD Protein, Mouse, Recombinant (His & SUMO)
Platelet-derived growth factor D,Pdgfd,Spinal cord-... |
Mouse | E. coli |
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including inf... | |||
TMPY-02251 |
PDGFC Protein, Mouse, Recombinant (hFc)
1110064L01Rik,PDGF-C,AI647969,血小板源生长因子,platelet der... |
Mouse | HEK293 Cells |
PDGFC Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.9 kDa and the accession number is Q8CI19. | |||
TMPY-01207 |
PDGFRB Protein, Human, Recombinant (His)
CD140B,IMF1,KOGS,PDGFR,PDGFR-1,platelet-derived gro... |
Human | HEK293 Cells |
PDGFRB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is P09619-1. | |||
TMPY-04937 |
PDGFRB Protein, Human, Recombinant (His), Biotinylated
platelet-derived growth factor receptor, beta polyp... |
Human | HEK293 Cells |
PDGFRB Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is P09619-1. | |||
TMPY-05497 |
PDGFRB Protein, Human, Recombinant (hFc)
PDGFR,CD140B,PENTT,JTK12,KOGS,platelet-derived grow... |
Human | HEK293 Cells |
PDGFRB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.8 kDa and the accession number is P09619-1. | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0220 |
Dipyridamole-d16
|
||
Dipyridamole-d16 是 Dipyridamole 的氘代化合物。Dipyridamole 的 CAS 号为 58-32-2。Dipyridamole 是一种磷酸二酯酶抑制剂,能阻断红细胞和血管内皮细胞对腺苷的吸收和代谢。 | |||
TMIH-0281 |
Indobufen-d5
|
||
Indobufen-d5 是 Indobufen 的氘代化合物。Indobufen 的 CAS 号为 63610-08-2。Indobufen 是一种血小板聚集抑制剂,是下调单核细胞中的组织因子,可逆抑制血小板环氧合酶 (Cox) 的活性和血栓素 A2 (TxA2) 的合成。 | |||
T38638 |
4-Trifluoromethylsalicylic acid-13C6
4-Trifluoromethylsalicylic acid-13C6,Desacetyl triflusal-13C6 |
||
4-Trifluoromethylsalicylic acid-13C6 是 13C 标记的 4-Trifluoromethylsalicylic acid,主要用于药物开发过程中的定量示踪剂。4-Trifluoromethylsalicylic acid 也是一种血小板聚集抑制剂。 | |||
TMIH-0102 |
Avatrombopag-d8
|
||
Avatrombopag-d8 是 Avatrombopag 的氘代化合物。Avatrombopag 的 CAS 号为 570406-98-3。Avatrombopag 是一种新型口服血小板生成素 (TPO) 受体激动剂,可激活 TPO 受体并增加巨核细胞增殖/分化和血小板生成。 | |||
TMID-0200 |
rac-Clopidogrel-d4 Carboxylic Acid
|
||
rac-Clopidogrel-d4 Carboxylic Acid 是 rac-Clopidogrel Carboxylic Acid 的氘代化合物。rac-Clopidogrel Carboxylic Acid 的 CAS 号为 113665-84-2。Clopidogrel 是一种 P2Y12 受体拮抗剂,可降低血小板聚集,用于抑制冠状动脉疾病、周围血管疾病和脑血管疾病中的血凝块。 | |||
T71300 |
Pentoxifylline-d6
|
||
Pentoxifylline-d6 is intended for use as an internal standard for the quantification of pentoxifylline by GC- or LC-MS. Pentoxifylline is a hemorrheologic agent. It increases the deformability of washed isolated human erythrocytes when used at a concentration of 100 µM. Pentoxifylline (1, 2, and 3 mM) inhibits ADP-induced platelet aggregation in isolated human whole blood. It inhibits thrombus formation induced by ADP in a hamster cheek pouch model when administered at doses of 5, 10, and 20 mg/... | |||
TMIJ-0139 |
Ticagrelor-d7
|
||
Ticagrelor-d7 是 Ticagrelor 的氘代化合物。Ticagrelor 的 CAS 号为 274693-27-5。Ticagrelor (AZD6140) 是可逆的,可口服的P2Y12受体拮抗剂,可抑制血小板聚集。 | |||
T35695 |
Oleic Acid-13C
|
||
Oleic acid-13C is intended for use as an internal standard for the quantification of oleic acid by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.1,2 It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1 Oleic acid inhibits collagen-stimulated platelet aggregation by approximate... | |||
T70882 |
Orlistat-d3
|
||
Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit... | |||
TMIJ-0272 |
Sarpogrelate-d3 HCl
|
||
Sarpogrelate-d3 HCl 是 Sarpogrelate HCl 的氘代化合物。Sarpogrelate HCl 的 CAS 号为 135159-51-2。Sarpogrelate hydrochloride 是一种选择性5-HT2R拮抗剂,可用于研究与血栓形成有关的血管疾病,对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi值分别为 8.52、6.57 和 7.43。 |