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Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(R)-Iloprost inhibits platelet aggregation with an IC50 value of 65 nM.
Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(R)-Iloprost inhibits platelet aggregation with an IC50 value of 65 nM.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 μg | 待估 | 35日内发货 | |
1 mg | 待估 | 35日内发货 | |
5 mg | 待估 | 35日内发货 |
产品描述 | Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(R)-Iloprost inhibits platelet aggregation with an IC50 value of 65 nM. |
分子量 | 360.49 |
分子式 | C22H32O4 |
CAS No. | 74843-13-3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMF: 30 mg/mL (83.22 mM), Sonication is recommended. DMSO: 25 mg/mL (69.35 mM), Sonication is recommended. Ethanol: 30 mg/mL (83.22 mM), Sonication is recommended. PBS (pH 7.2): 1 mg/mL (2.77 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
PBS (pH 7.2)/DMSO/DMF/Ethanol
DMSO/DMF/Ethanol
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