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抑制剂 & 化合物

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TargetMol 试剂盒

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重组蛋白

1

同位素标记化合物

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Cat. No. Product Name
L1500 GPCR靶点分子库

1940 compounds
1940 种与 G 蛋白及其耦联受体相关的生物活性小分子化合物,所有小分子都具有良好的生物和药理活性,部分是 FDA 批准的上市药物;
L7200 钙通道分子库

140 compounds
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选;
L5100 含氟化合物库

574 compounds
574 个含氟化合物的独特集合,可用于高通量筛选和高内涵筛选;
L9300 大环化合物库

210 compounds
210 种活性已知的大环化合物,用于高通量、高内涵筛选;

化合物库

GPCR靶点分子库
Cat.No: L1500
Compounds: 1940
钙通道分子库
Cat.No: L7200
Compounds: 140
含氟化合物库
Cat.No: L5100
Compounds: 574
大环化合物库
Cat.No: L9300
Compounds: 210
Cat. No. Product Name Form Specificity Of Inhibition
C0052 Penicillin-Streptomycin-Amphotericin B Solution (100×), Sterile

青霉素-链霉素-两性霉素B三抗溶液(100×),灭菌

Solution in bottle

TargetMol 试剂盒

青霉素-链霉素-两性霉素B三抗溶液(100×),灭菌
Cat.No: C0052
Cat. No. Product Name Target Signaling Pathways
T4701 Diclofop-methyl

Others Others
Diclofop-methyl 是常见的生后除草剂,普遍用于农业生产。它能够增强离体燕麦根液泡膜的质子通透性。
T8844 Diflapolin

Others; FLAP; Epoxide Hydrolase Immunology/Inflammation; Metabolism; Others
Diflapolin 是高活性的双 5-脂氧合酶激活蛋白(FLAP)/可溶性环氧化物水解酶抑制剂,具有显著的抗炎作用和较高的靶向选择性。它抑制分离的 sEH 的活性,IC50为20 nM。它还抑制完整人单核细胞和中性粒细胞中 5-LOX 产物的形成,IC50分别为 30 和 170 nM。
T11014 DFP00173

Aquaporin Membrane transporter/Ion channel
DFP00173 是一种aquaporin-3 (AQP3)的选择性抑制剂。它对 AQP3 的选择性高于同源 AQP 亚型 AQP7 和 AQP9。它能够抑制小鼠和人 AQP3,IC50值为 ~0.1-0.4 μM。
T2009 SB-3CT

MMP Proteases/Proteasome
SB-3CT 是一种可透过血脑屏障的、竞争性的金属蛋白酶MMP-2和MMP-9抑制剂,Ki 分别为 13.9 nM、600 nM。他对明胶酶具有高选择性。它具有神经保护和抗癌作用。
T10760 Ceramides Mixture

神经酰胺混合物,神经酰胺

Telomerase DNA Damage/DNA Repair
Ceramides Mixture 是表皮渗透屏障的主要脂质成分,参与生长抑制,细胞周期停滞和端粒酶活性的调节。它是一种内源性神经酰胺,由含羟基和非羟基脂肪酸的神经酰胺组成。
T5194 SPHINX31

Serine/threonin kinase Cell Cycle/Checkpoint; Metabolism
SPHINX31 是丝氨酸/富含精氨酸的蛋白激酶1的选择性抑制剂,其IC50值为 5.9 nM。它有效抑制丝氨酸/丰富精氨酸的剪接因子1 磷酸化,有用于局部新生血管性眼病的研究潜力。
T2670 ML167

NCGC00188654,CID44968231

DYRK; CDK Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
ML167 (CID44968231) 是一种高选择性的 Cdc2 样激酶 4 抑制剂,IC50为 136 nM。
T2456 Tivozanib

替沃扎尼,AV-951,KRN951

VEGFR; PDGFR; Ephrin Receptor Angiogenesis; Tyrosine Kinase/Adaptors
Tivozanib (KRN951) 是一种选择性的 VEGFR 1/2/3抑制剂,它们的 IC50值分别为0.21 nM、0.16 nM、0.24 nM。
T23426 TC-A 2317 hydrochloride

Others; Aurora Kinase Cell Cycle/Checkpoint; Chromatin/Epigenetic; Others
TC-A 2317 hydrochloride 是 Aurora 激酶 A 的抑制剂,Ki 为 1.2 nM,而 Aurora 激酶 B 的 Ki 为 101 nM。 TC-A 2317 hydrochloride 显示出抗肿瘤活性。
T8490 Butoconazole

1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole,布康唑

Antifungal Microbiology/Virology
Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) 是一种咪唑类抗真菌药物,可治疗白色念珠菌引起的阴道感染。它可通过抑制类固醇起抗菌作用。
T37890L GLP-1(28-36)amide acetate

GLP-1(28-36)amide acetate(1225021-13-5 Free base)

Antioxidant; Glucagon Receptor GPCR/G Protein; oxidation-reduction
GLP-1(28-36)amide acetate 抑制线粒体通透性转变,具有抗氧化、抗糖尿病和心脏保护活性。
T19562 Polyethylene glycol 12-hydroxystearate

Solutol HS-15

Others Others
Polyethylene glycol 12-hydroxystearate (Solutol HS-15) 是一种通透性增强剂,是一种 Macrogol 15 羟基硬脂酸酯。
T18988L FITC-Dextran (MW 4000)

荧光素异硫氰酸酯-葡聚糖,FITC-Dextran (60842-46-8 MW 4000)

Others Others
FITC-Dextran (MW 4000) 是一种标记物,由与 4 kDa 葡聚糖偶联的异硫氰酸荧光素组成,广泛用于微循环和细胞通透性研究。
T15241 ER-000444793

Others; Mitochondrial Metabolism Metabolism; Others
ER-000444793 是一种线粒体通透性转换孔开放抑制剂。它能够抑制 mPTP,IC50=2.8 μM。
T7486 Imeglimin hydrochloride

EMD 387008 hydrochloride,(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐

Reactive Oxygen Species; Mitochondrial Metabolism Immunology/Inflammation; Metabolism; NF-κB
Imeglimin hydrochloride (EMD 387008 hydrochloride) 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性,能够抑制活性氧的产生、增加线粒体 DNA、改善线粒体功能。
T41308L Gly-Phe β-naphthylamide acetate

Gly-Phe β-naphthylamide acetate(21438-66-4 Free base)

Others Others
Gly-Phe β-naphthylamide acetate 是 Cathepsin C 的底物,可用于研究组织蛋白酶 C 的功能、溶酶体内水解和溶酶体膜通透性。
T68030 Acitemate

Chinoin 123

Others Others
Acitemate(Chinoin 123) 对动脉硬化有抑制作用,可降低高脂血症饮食喂养的家兔主动脉的通透性,可用于研究动脉粥样硬化。
T77576 17β-HSD10-IN-1

Dehydrogenase; Endogenous Metabolite Metabolism
17β-HSD10-IN-1 是一种可口服且具有血脑通透性和有效性的 17β-羟基类固醇脱氢酶 10 型 (17β-HSD10) 抑制剂,可用于研究阿尔茨海默症。
T15458 H2DCFDA

2',7'-二氯荧光素二乙酸酯,2',7'-Dichlorodihydrofluorescein diacetate,DCFH-DA

Reactive Oxygen Species Immunology/Inflammation; Metabolism; NF-κB
H2DCFDA (DCFH-DA) 属于绿色荧光染料,是一种检测细胞内活性氧 (ROS) 的探针 (Ex/Em=488/525 nm),具有细胞膜渗透性。
T10404 ATP synthase inhibitor 1

ATPase Membrane transporter/Ion channel
ATP synthase inhibitor 1 是 F1/FO-ATP 合酶复合物 c 亚基的有效抑制剂,抑制线粒体通透性转换孔的开放。
T77758 AChE/BuChE-IN-4

AChE Neuroscience
AChE/BuChE-IN-4是一种具有口服活性和血脑屏障通透性的多靶点AChE/BuChE抑制剂,对AChE和BuChE的IC50值分别为2.08和7.41 μM。
T16684 Puromycin aminonucleoside

维生素E醋酸酯,NSC 3056

Apoptosis; Proteasome; Aminopeptidase; Antibacterial; Antibiotic Apoptosis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination
Puromycin aminonucleoside (NSC-3056) 是一种氨基核苷类抗生素,是嘌呤霉素类似物。它可逆抑制二肽基肽酶和胞浆丙氨酸氨基肽酶。它通过以氧化应激依赖性方式调节 ZO-1 来增加足细胞通透性。它诱导细胞凋亡 。
T77042 Aducanumab

BIIB037

Beta Amyloid Neuroscience
Aducanumab (BIIB037),一种选择性人免疫球蛋白γ-1(IgG1)单克隆抗体,靶向β淀粉样蛋白 (Aβ) 的聚集形式。Aducanumab 显示出脑渗透性,可用于治疗阿尔茨海默病 (AD) 。
T2213 Terconazole

Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,特康唑,曲康唑,R42470

Antifection; Antifungal Microbiology/Virology
Terconazole (Terazol 7) 是一种广谱抗真菌药物,用于研究阴道酵母菌感染。
T0796 Prilocaine hydrochloride

Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因

ATPase; Sodium Channel Membrane transporter/Ion channel
Prilocaine hydrochloride (Prilocaine HCl) 是一种氨基酰胺类局部麻醉剂,作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂,具有神经毒性作用。
T2274 SC79

SC 79,2-氨基-6-氯-alpha-氰基-3-(乙氧羰基)-4H-1-苯并吡喃-4-乙酸乙酯

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
SC79 是一个 AKT 激动剂,具有特异性和血脑屏障渗透性。SC79 可以特异性结合 AKT 的 PH 结构域,激活胞质中 AKT,并抑制 AKT 膜转位。SC79 具有神经保护活性。
T8526 Metformin

甲福明,二甲双胍,1,1-Dimethylbiguanide

Mitophagy; AMPK; Autophagy Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Metformin (1,1-Dimethylbiguanide) 是一种 AMPK 激活剂,具有血脑屏障渗透性。Metformin 可通过提高胰岛素敏感性和减少肠道对葡萄糖的吸收来改善血糖控制,常用于 2 型糖尿病的研究。
T9646 Stafib-2

STAT JAK/STAT signaling; Stem Cells
Stafib-2 是一种转录因子 STAT5b 抑制剂,具有有效性和选择性。Stafib-2 对STAT5b 和 STAT5a 有抑制作用 , IC50 值分别为 82 nM 和 1.7 μM。Stafib-2 的细胞通透性较差。
T19649 PF-06273340

PF 6273340,PF 06273340,PF6273340,PF-6273340

Trk receptor Tyrosine Kinase/Adaptors
PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。
T41008 BODIPY-Cholesterol

BCh2

BODIPY-Cholesterol (TF-Chol)是一种带有荧光 BODIPY 基团和细胞通透性的胆固醇类似物,是一种新型 BODIPY 胆固醇探针。BODIPY-Cholesterol 可用于研究细胞内固醇摄取和细胞器间固醇通量。
T61969 AChE/BChE-IN-10

AChR; AChE Neuroscience
AChE/BChE-IN-10 (Compound 7b) 是有效的、血脑屏障渗透性的 AChE 和 BChE 双重抑制剂,IC50 值分别为 0.176 和 0.47 μM。AChE/BChE-IN-10 可以抑制 Aβ 的聚集。
T10585 Bozitinib

CBT-101,PLB-1001

c-Met/HGFR Tyrosine Kinase/Adaptors
Bozitinib (PLB-1001) 是一种可透过血脑屏障的、高效的、选择性的的、 ATP 竞争性的小分子 c-MET 激酶抑制剂,能够与酪氨酸激酶超家族的常规 ATP 结合口袋结合。
T4081 MPTP hydrochloride

MPTP-hydrochloride

Apoptosis; Dopamine Receptor Apoptosis; GPCR/G Protein; Neuroscience
MPTP hydrochloride 是 MPP+ 的前体,是一种多巴胺神经毒素,具有血脑屏障渗透性。MPTP hydrochloride 对多巴胺能神经元有毒,可以导致帕金森症,被广泛应用于帕金森动物模型的构建。
T61564 PF-03463275

PF-3463275

GlyT Neuroscience
PF-03463275 是一种具有口服活性和选择性的竞争性甘氨酸转运蛋白-1 (GlyT1) 可逆抑制剂,Ki 为 11.6 nM。PF-03463275 具有中枢神经系统渗透性,可用于改善与精神分裂症相关的认知障碍。
T1497 Liranaftate

Piritetrate,利拉萘酯,M-732

Antifungal Microbiology/Virology
Liranaftate (Piritetrate) 是一种具有抗真菌活性的硫代氨基甲酸酯和角鲨烯环氧酶抑制剂,可研究皮肤癣菌。
T6961 PX-478

PX-478 2HCl

HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism
PX-478 是一种 HIF-1α 抑制剂,具有选择性、口服活性和血脑屏障渗透性。PX-478 具有抗肿瘤活性,还可以保护糖尿病中的胰腺 β 细胞功能,用于 2 型糖尿病的研究。
T8832 Eledoisin trifluoroacetate (69-25-0 free base)

Eledoisin trifluoroacetate

Others Others
Eledoisin trifluoroacetate (69-25-0 free base) 是从某些小章鱼(Eledone spp.,Mollusca)的后唾液腺中提取或合成获得的肽。它的作用类似于 P 物质的作用;它是一种有效的血管扩张剂,可增加毛细血管的通透性。
TP1095 Elamipretide

MTP-131,RX-31,SS-31

Others Others
Elamipretide (MTP-131) 是一种线粒体靶向抗氧化四肽 (D-Arg-dimethylTyr-Lys-Phe-NH2),可以减少有毒活性氧的产生并稳定心磷脂,具有血脑屏障渗透性。Elamipretide 是罕见病巴氏综合征的潜在治疗剂。
T8851 I3MT-3

HMPSNE

Hippo pathway Stem Cells
I3MT-3 (HMPSNE) 是一种有效的、具有细胞膜渗透性的、选择性的 3-巯基丙酮酸硫转移酶 (3MST)的抑制剂,IC50值为2.7 μM,对其他硫化氢/磺胺制硫酶没有活性。它靶向位于 3MST 活性位点的过硫半胱氨酸残基。
T0030 Bupivacaine hydrochloride

Vivacaine,Bupivacaine HCl,盐酸布比卡因

Sodium Channel Membrane transporter/Ion channel
Bupivacaine hydrochloride (Vivacaine) 是NMDA 受体抑制剂,可用于慢性疼痛的研究。它可阻断钠、L-钙和钾通道,还阻断SCN5A 通道,IC50为 69.5 μM。
T10593 BPR1M97

Opioid Receptor Endocrinology/Hormones; GPCR/G Protein; Neuroscience
BPR1M97 是一种具有血脑屏障渗透性和有效性的 mu 阿片受体(MOP)和神经肽-啡肽 FQ(NOP)受体激动剂,对 MOP 的 Kis 值为1.8 nM,对 NOP 的Kis 值为 4.2 nM。BPR1M97 具有抗伤害作用和抗痛觉作用。
T1178 Temozolomide

NSC 362856,替莫唑胺,TZM,CCRG 81045,TMZ

Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Autophagy Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Temozolomide (TMZ) 是一种 DNA 烷基化剂,具有血脑屏障渗透性和口服活性。Temozolomide 具有抗肿瘤活性和抗血管生成活性,还可以诱导细胞凋亡和自噬。 Temozolomide 在酸性条件下稳定,在中性或微碱性条件下会发生水解。
T18988 FITC-Dextran (MW 10000)

FITC-Dextran,荧光素异硫氰酸酯-葡聚糖(MW 10000),荧光素异硫氰酸酯-葡聚糖

Others Others
FITC-Dextran (MW 10000) (FITC-Dextran) 是由 FITC 偶联葡聚糖形成的标记物 (10 kDa)。它是由不同长度的支链葡萄糖分子组成的被标记的多糖,能够依照所使用的葡聚糖的大小,测定血脑屏障的溶质、离子和蛋白质渗透性。
T6802 CFSE

5(6)-CFDA N-succinmidyl ester,Carboxyfluorescein succinimidyl ester,CFDA-SE,5(6)-羧基二乙酸荧光素琥珀酰亚胺酯,5(6)-Carboxyfluorescein diacetate succinimidyl ester

Others Others
CFSE (CFDA-SE) 属于荧光染料,具有细胞膜渗透性。CFSE 可在活细胞内与胞内蛋白进行不可逆的结合,用于检测细胞增殖,标记的细胞呈绿色荧光,激发波长为 488 nm,发射波长为 518 nm。
T28165 NF-1819

NF 1819,NF1819

Lipase Metabolism
NF-1819 是一种高效、选择性的不可逆 MGL (β-内酰胺基单酰甘油脂肪酶)抑制剂。NF-1819 在体内多发性硬化症模型中缓解疾病症状,在体内急性炎性疼痛模型中表现出镇痛作用。NF-1819 具有较高的膜通透性和血脑屏障通透性。
T1438 Butoconazole nitrate

RS 35887,硝酸布康唑

Estrogen/progestogen Receptor; Antifungal Endocrinology/Hormones; Microbiology/Virology
Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物,可治疗由白色念珠菌引起的阴道感染。它可通过抑制类固醇合成起到抗菌作用。
T1435 Praziquantel

吡喹酮,Pyquiton,Droncit,Biltricide

Calcium Channel; Antibiotic; Parasite Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
Praziquantel (Droncit) 是一种外消旋混合物,由 (R)-Praziquantel 和 (S)-Praziquantel 组成。它可研究血吸虫病。
T12992 SPR741 acetate

SPR741 acetate,NAB741 acetate,SPR741 acetate (1179330-52-9 free base)

Antibacterial Microbiology/Virology
SPR741 acetate 是衍生自多粘菌素 B 的阳离子肽,通过增加革兰氏阴性细菌外膜的通透性来抑制严重的革兰氏阴性细菌感从而展现出对革兰氏阴性菌的抗菌活性。SPR741 acetate 常与抗生素联合使用来治疗一些疾病。
T6686 Sulconazole mononitrate

Exelderm,Sulconazole Nitrate,RS 44872,硝酸硫康唑

Antibacterial; Antibiotic; Antifungal Microbiology/Virology
Sulconazole mononitrate (Exelderm) 是一种咪唑类广谱杀菌剂。它可研究皮肤真菌病,花斑糠疹病,皮肤念珠菌病。
T1290 Oxiconazole nitrate

硝酸奥昔康唑,Ro 13-8996

Others; Antibiotic; Antifection; Antifungal Microbiology/Virology; Others
Oxiconazole nitrate (Ro 13-8996) 是广谱抗真菌药物,抑制T. tonsurans 和T.rubrum 的生长,MIC90值分别为 0.25 和 0.5 μg/mL。

化合物

Diclofop-methyl
Cat.No: T4701
Synonym:
Target: Others
Diflapolin
Cat.No: T8844
Synonym:
Target: Others, FLAP, Epoxide Hydrolase
DFP00173
Cat.No: T11014
Synonym:
Target: Aquaporin
SB-3CT
Cat.No: T2009
Synonym:
Target: MMP
Ceramides Mixture
Cat.No: T10760
Synonym: 神经酰胺混合物,神经酰胺
Target: Telomerase
SPHINX31
Cat.No: T5194
Synonym:
Target: Serine/threonin kinase
ML167
Cat.No: T2670
Synonym: NCGC00188654,CID44968231
Target: DYRK, CDK
Tivozanib
Cat.No: T2456
Synonym: 替沃扎尼,AV-951,KRN951
Target: VEGFR, PDGFR, Ephrin Receptor
TC-A 2317 hydrochloride
Cat.No: T23426
Synonym:
Target: Others, Aurora Kinase
Butoconazole
Cat.No: T8490
Synonym: 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole,布康唑
Target: Antifungal
GLP-1(28-36)amide acetate
Cat.No: T37890L
Synonym: GLP-1(28-36)amide acetate(1225021-13-5 Free base)
Target: Antioxidant, Glucagon Receptor
Polyethylene glycol 12-hydroxystearate
Cat.No: T19562
Synonym: Solutol HS-15
Target: Others
FITC-Dextran (MW 4000)
Cat.No: T18988L
Synonym: 荧光素异硫氰酸酯-葡聚糖,FITC-Dextran (60842-46-8 MW 4000)
Target: Others
ER-000444793
Cat.No: T15241
Synonym:
Target: Others, Mitochondrial Metabolism
Imeglimin hydrochloride
Cat.No: T7486
Synonym: EMD 387008 hydrochloride,(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐
Target: Reactive Oxygen Species, Mitochondrial Metabolism
Gly-Phe β-naphthylamide acetate
Cat.No: T41308L
Synonym: Gly-Phe β-naphthylamide acetate(21438-66-4 Free base)
Target: Others
Acitemate
Cat.No: T68030
Synonym: Chinoin 123
Target: Others
17β-HSD10-IN-1
Cat.No: T77576
Synonym:
Target: Dehydrogenase, Endogenous Metabolite
H2DCFDA
Cat.No: T15458
Synonym: 2',7'-二氯荧光素二乙酸酯,2',7'-Dichlorodihydrofluorescein diacetate,DCFH-DA
Target: Reactive Oxygen Species
ATP synthase inhibitor 1
Cat.No: T10404
Synonym:
Target: ATPase
AChE/BuChE-IN-4
Cat.No: T77758
Synonym:
Target: AChE
Puromycin aminonucleoside
Cat.No: T16684
Synonym: 维生素E醋酸酯,NSC 3056
Target: Apoptosis, Proteasome, Aminopeptidase, Antibacterial, Antibiotic
Aducanumab
Cat.No: T77042
Synonym: BIIB037
Target: Beta Amyloid
Terconazole
Cat.No: T2213
Synonym: Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,特康唑,曲康唑,R42470
Target: Antifection, Antifungal
Prilocaine hydrochloride
Cat.No: T0796
Synonym: Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因
Target: ATPase, Sodium Channel
SC79
Cat.No: T2274
Synonym: SC 79,2-氨基-6-氯-alpha-氰基-3-(乙氧羰基)-4H-1-苯并吡喃-4-乙酸乙酯
Target: Akt
Metformin
Cat.No: T8526
Synonym: 甲福明,二甲双胍,1,1-Dimethylbiguanide
Target: Mitophagy, AMPK, Autophagy
Stafib-2
Cat.No: T9646
Synonym:
Target: STAT
PF-06273340
Cat.No: T19649
Synonym: PF 6273340,PF 06273340,PF6273340,PF-6273340
Target: Trk receptor
BODIPY-Cholesterol
Cat.No: T41008
Synonym: BCh2
Target:
AChE/BChE-IN-10
Cat.No: T61969
Synonym:
Target: AChR, AChE
Bozitinib
Cat.No: T10585
Synonym: CBT-101,PLB-1001
Target: c-Met/HGFR
MPTP hydrochloride
Cat.No: T4081
Synonym: MPTP-hydrochloride
Target: Apoptosis, Dopamine Receptor
PF-03463275
Cat.No: T61564
Synonym: PF-3463275
Target: GlyT
Liranaftate
Cat.No: T1497
Synonym: Piritetrate,利拉萘酯,M-732
Target: Antifungal
PX-478
Cat.No: T6961
Synonym: PX-478 2HCl
Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy
Eledoisin trifluoroacetate (69-25-0 free base)
Cat.No: T8832
Synonym: Eledoisin trifluoroacetate
Target: Others
Elamipretide
Cat.No: TP1095
Synonym: MTP-131,RX-31,SS-31
Target: Others
I3MT-3
Cat.No: T8851
Synonym: HMPSNE
Target: Hippo pathway
Bupivacaine hydrochloride
Cat.No: T0030
Synonym: Vivacaine,Bupivacaine HCl,盐酸布比卡因
Target: Sodium Channel
BPR1M97
Cat.No: T10593
Synonym:
Target: Opioid Receptor
Temozolomide
Cat.No: T1178
Synonym: NSC 362856,替莫唑胺,TZM,CCRG 81045,TMZ
Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy
FITC-Dextran (MW 10000)
Cat.No: T18988
Synonym: FITC-Dextran,荧光素异硫氰酸酯-葡聚糖(MW 10000),荧光素异硫氰酸酯-葡聚糖
Target: Others
CFSE
Cat.No: T6802
Synonym: 5(6)-CFDA N-succinmidyl ester,Carboxyfluorescein succinimidyl ester,CFDA-SE,5(6)-羧基二乙酸荧光素琥珀酰亚胺酯,5(6)-Carboxyfluorescein diacetate succinimidyl ester
Target: Others
NF-1819
Cat.No: T28165
Synonym: NF 1819,NF1819
Target: Lipase
Butoconazole nitrate
Cat.No: T1438
Synonym: RS 35887,硝酸布康唑
Target: Estrogen/progestogen Receptor, Antifungal
Praziquantel
Cat.No: T1435
Synonym: 吡喹酮,Pyquiton,Droncit,Biltricide
Target: Calcium Channel, Antibiotic, Parasite
SPR741 acetate
Cat.No: T12992
Synonym: SPR741 acetate,NAB741 acetate,SPR741 acetate (1179330-52-9 free base)
Target: Antibacterial
Sulconazole mononitrate
Cat.No: T6686
Synonym: Exelderm,Sulconazole Nitrate,RS 44872,硝酸硫康唑
Target: Antibacterial, Antibiotic, Antifungal
Oxiconazole nitrate
Cat.No: T1290
Synonym: 硝酸奥昔康唑,Ro 13-8996
Target: Others, Antibiotic, Antifection, Antifungal
Cat. No. Product Name Target Signaling Pathways
T2721 Digitonin

Others Others
Digitonin 属于糖苷类天然产物,是一种去垢剂。Digitonin 具有抗肿瘤活性,可以与胆固醇分子结合从而增加细胞膜的通透性,对多种细胞的细胞膜具有裂解活性。
T15157 Dodecanoylcarnitine

Lauroylcarnitine

Endogenous Metabolite Metabolism
Dodecanoylcarnitine((-)-Lauroylcarnitine) 和脂肪酸氧化紊乱有关,使用 Dodecanoylcarnitine 可使鲑鱼降钙素的通透性增加。
T8102 8-Aminooctanoic acid

Others Others
8-Aminooctanoic acid 是 ω-氨基脂肪酸,是在第 8 位带有一个氨基的辛酸,具有代谢活性。
TF0083 POPE

POPE 是从大肠杆菌中发现的化合物,是细胞膜的一部分,可用来研究改变细胞膜通透性。
TN1048 Cnidilin

Knidilin

Cnidilin (Knidilin) 存在与Angelica dahurica 根中,具有高BBB 通透性,在治疗中枢神经系统疾病方面具有药代动力学潜力。
TN1990 Norathyriol

芒果苷元

Akt; DNA/RNA Synthesis; AMPK; PPAR Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
Norathyriol 是来自芒果的芒果苷代谢物,具有抗氧化、抗癌、抗菌和抗炎活性。它以非竞争性方式抑制 α-葡萄糖苷酶,IC50为 3.12 μM。它还抑制PPARα、PPARβ和PPARγ,IC50分别为 92.8、102.4 和 153.5 µM。
T0146 Tioconazole

UK-20349,Vagistat,噻康唑

Antibiotic; Antifection; Antifungal Microbiology/Virology
Tioconazole (Vagistat) 是一种广谱性的抗真菌咪唑衍生物。它抑制几种皮肤真菌和几种酵母菌的 MIC50分别小于 3.12 mg/L 和 9 mg/L。
T8641 Vancomycin

Antibacterial; Antibiotic; Autophagy Autophagy; Microbiology/Virology
Vancomycin 是一种糖肽类抗生素,可以通过改变细胞膜的渗透性并选择性地抑制核糖核酸的合成以发挥抗菌活性。Vancomycin 可以用于治疗所有抗生素均无效的严重感染。
T13708 Glycol chitosan

羟乙基脱乙酰壳多糖,乙二醇壳聚糖

Antibacterial Microbiology/Virology
Glycol chitosan 是具有亲水性乙二醇支链的壳聚糖衍生物。它抑制大肠杆菌,金黄色葡萄球菌和肠炎链球菌的生长,MIC 值分别为 4 μg/mL,32 μg/m L 和 <0.5 μg/mL。它可增强 Glycine max Harosoy 63W 细胞的膜通透性和渗漏。
TN2160 Roemerine

(-)-Roemerine

Antibiotic Microbiology/Virology
Roemerine ((-)-Roemerine) 是一种来自塞内加尔番荔枝的卟啉生物碱,具有抗真菌和抗癌活性,通过抑制 Bmr 来防止小檗碱外排。Roemerine 以浓度依赖性方式增加细胞膜通透性,可用于研究真菌感染和前列腺癌。
T14140 Agaric acid

落叶松蕈酸,Agaricinic Acid

Mitochondrial Metabolism; AChR Metabolism; Neuroscience
Agaric acid (Agaricinic Acid) 来一种自真菌部落的Polyporus officinalis 和Polyporus igniarius。它可促进积累的 Ca2+流出,跨膜电位的破坏和线粒体肿胀。它通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。它用于调节脂类代谢。
T5S1889 Yunaconitine

Guayewuanine B,滇乌头碱

Others Others
Yunaconitine (Guayewuanine B) 是一种乌头类生物碱,具有剧毒。
T3926 Echinatin

刺甘草查尔酮,Retrochalcone

Free radical scavengers oxidation-reduction
Echinatin (Retrochalcone) 是分离自中草药甘草中,具有保肝和抗炎活性。在大鼠中,它可以被快速吸收和消除,并广泛分布,绝对生物利用度约为 6.81%。
T2520 Desloratadine

Sch34117,地氯雷他定,NSC 675447

Endogenous Metabolite; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
Desloratadine (Sch34117) 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。
T0795 Rutin

Quercetin 3-O-rutinoside,芦丁,Rutoside

Beta Amyloid; Prostaglandin Receptor; Autophagy Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
Rutin (Quercetin 3-O-rutinoside) 属于黄酮类天然产物,具有血脑屏障渗透性。Rutin 具有广泛的生物活性,包括抗氧化、抗炎、抗肿瘤、降血糖、神经保护、抗菌、抗衰老等等。
T29888 Aloe-emodin-glucoside

Aloe-emodin-glucoside is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.
TN5575 Coronarin D methyl ether

Coronarin D methyl ether has inhibitory effects on the increase in vascular permeability, nitric oxide production, and inducible nitric oxide synthase induction.
TN6198 Mahanine

Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can reverse an epigenetically silenced g
T40910 Cognac oil

Others Others
Cognac oil, predominantly derived from wine lees, exhibits distinctive fatty acid compositions, characterized by high proportions of Palmitic acid (59.26%), Linoleic acid (11.92%), Myristic acid (8.97%), and Oleic acid (8.3%) among other fatty acids. Notably, the application of Cognac oil enhances the permeability of Rhodamine 6G (R6G) across various membranes, resulting in a generalized increase in permeation.
TN4475 Macrocarpal C

ROS; Antifection Immunology/Inflammation; Microbiology/Virology
Macrocarpal C, isolated from the fresh leaves of Eucalyptus globulus Labill. (Lan An) and identified as its major antifungal component by bioassay-guided purification, the antifungal action of macrocarpal C was associated with increases of membrane permea
T75967 Bactenecin TFA

Others Others
Bactenecin TFA (Bactenecin, bovine TFA) 是一种从牛嗜中性粒细胞中分离出来的有效的含 12 个氨基酸的环状抗菌肽。Bactenecin TFA 抑制细菌和酵母菌 (bacteria 和 yeast) 的生长,并能杀死真菌红毛癣菌 (fungusTrichophyton rubrum)。Bactenecin TFA 增加了膜的通透性,抑制了假苹果芽孢杆菌 (B. pseudomallei) 的生长和生物膜的形成。
TN2945 3-Hydroxybakuchiol

ATPase; Caspase Apoptosis; Membrane transporter/Ion channel; Proteases/Proteasome
3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial perm
TN3914 Echinatine

ATPase; IL Receptor; TNF Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity whil
T37810 6',7'-Epoxybergamottin

Others Others
6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transpo...

天然产物

Digitonin
Cat.No: T2721
Synonym:
Target: Others
Dodecanoylcarnitine
Cat.No: T15157
Synonym: Lauroylcarnitine
Target: Endogenous Metabolite
8-Aminooctanoic acid
Cat.No: T8102
Synonym:
Target: Others
POPE
Cat.No: TF0083
Synonym:
Target:
Cnidilin
Cat.No: TN1048
Synonym: Knidilin
Target:
Norathyriol
Cat.No: TN1990
Synonym: 芒果苷元
Target: Akt, DNA/RNA Synthesis, AMPK, PPAR
Tioconazole
Cat.No: T0146
Synonym: UK-20349,Vagistat,噻康唑
Target: Antibiotic, Antifection, Antifungal
Vancomycin
Cat.No: T8641
Synonym:
Target: Antibacterial, Antibiotic, Autophagy
Glycol chitosan
Cat.No: T13708
Synonym: 羟乙基脱乙酰壳多糖,乙二醇壳聚糖
Target: Antibacterial
Roemerine
Cat.No: TN2160
Synonym: (-)-Roemerine
Target: Antibiotic
Agaric acid
Cat.No: T14140
Synonym: 落叶松蕈酸,Agaricinic Acid
Target: Mitochondrial Metabolism, AChR
Yunaconitine
Cat.No: T5S1889
Synonym: Guayewuanine B,滇乌头碱
Target: Others
Echinatin
Cat.No: T3926
Synonym: 刺甘草查尔酮,Retrochalcone
Target: Free radical scavengers
Desloratadine
Cat.No: T2520
Synonym: Sch34117,地氯雷他定,NSC 675447
Target: Endogenous Metabolite, Histamine Receptor
Rutin
Cat.No: T0795
Synonym: Quercetin 3-O-rutinoside,芦丁,Rutoside
Target: Beta Amyloid, Prostaglandin Receptor, Autophagy
Aloe-emodin-glucoside
Cat.No: T29888
Synonym:
Target:
Coronarin D methyl ether
Cat.No: TN5575
Synonym:
Target:
Mahanine
Cat.No: TN6198
Synonym:
Target:
Cognac oil
Cat.No: T40910
Synonym:
Target: Others
Macrocarpal C
Cat.No: TN4475
Synonym:
Target: ROS, Antifection
Bactenecin TFA
Cat.No: T75967
Synonym:
Target: Others
3-Hydroxybakuchiol
Cat.No: TN2945
Synonym:
Target: ATPase, Caspase
Echinatine
Cat.No: TN3914
Synonym:
Target: ATPase, IL Receptor, TNF
6',7'-Epoxybergamottin
Cat.No: T37810
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPJ-00865 VEGF121 Protein, Human, Recombinant (His)

VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生...

Human HEK293 Cells
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPJ-00412 VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)

Vascular endothelial growth factor receptor 1,Vascular p...

Human HEK293 Cells
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas...
TMPY-02908 BPI Protein, Human, Recombinant (His)

BPIFD1,bactericidal/permeability-increasing protein...

Human HEK293 Cells
Bactericidal/permeability-increasing protein is a member of the BPI/LBP/Plunc superfamily and BPI/LBP family. It is a cationic protein which can be detected in the azurophilic granule and on the surface of polymorphonuclear leukocytes. Bactericidal/permeability-increasing protein also is a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms. Bactericidal/permeability-increasing protein contains two domains t...
TMPH-03131 VEGFA Protein, Pig, Recombinant (His)

Vascular endothelial growth factor A,VEGFA,Vascular perm...

Sus scrofa (Pig) E. coli
VEGFA Protein, Pig, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.2 kDa and the accession number is P49151.
TMPK-00823 VEGF165 Protein, Human, Recombinant (His & Avi)

血管内皮生长因子,RP1-261G23.1,MVCD1,MGC70609,VEGFA,VEGFMGC70609,VPF,...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4.
TMPJ-00864 VEGF165 Protein, Human, Recombinant

Vascular Endothelial Growth Factor Isoform 165,血管内皮生长因子,VEGF...

Human HEK293 Cells
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul...
TMPY-02700 BCL2 Protein, Human, Recombinant (His)

Bcl-2,PPP1R50,B-cell CLL/lymphoma 2

Human E. coli
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins...
TMPH-03703 Zot Protein, Vibrio cholerae serotype O1, Recombinant (His)

Zona occludens toxin,Zonular occludens toxin,zot

Vibrio cholerae E. coli
Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens). Zot Protein, Vibrio cholerae serotype O1, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 48.4 kDa and the accession number is P38442.
TMPH-00949 APOLD1 Protein, Human, Recombinant (His)

Vascular early response gene protein,APOLD1,VERGE,Apolipopro...

Human E. coli
May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability. APOLD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 33.4 kDa and the accession number is Q96LR9.
TMPH-03701 Vespakinin-M Protein, Vespa mandarinia, Recombinant (His & KSI)

Vespakinin-M,Bradykinin-related peptide

Vespa mandarinia E. coli
Bradykinins are a potent but short-lived agent of arteriolar dilation and increased capillary permeability. May target bradykinin receptors (BDKRB). May cause hypotension. Vespakinin-M Protein, Vespa mandarinia, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 16.7 kDa and the accession number is Q7M3T3.
TMPH-00031 Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc)

Hemolysin

Aeromonas sobria E. coli
Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and cell death. The pores are formed by transmembrane beta-strands and are approximately 3 nm in diameter.
TMPH-00782 OMP P5 Protein, Haemophilus influenzae, Recombinant (His & Myc & SUMO)

Outer membrane porin A,Outer membrane protein P5,Outer membr...

Haemophilus influenzae E. coli
Acts as a fimbriae subunit, allowing adhesion to host cells.; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.
TMPH-02377 OmpA Protein, Klebsiella pneumoniae, Recombinant (His & Myc)

Outer membrane protein 3A,Outer membrane protein A,ompA,Oute...

Klebsiella pneumoniae E. coli
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.; Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells.
TMPK-00562 CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His)

FLJ58394,PECAM-1,GPIIA',FLJ34100,EndoCAM,PECA1,CD31

Cynomolgus HEK293 Cells
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 65.30 kDa and the accession number is A0A7N9CHZ3.
TMPK-00293 Nectin-2 Protein, Human, Recombinant (His & Avi)

PRR2,CD112,Nectin2,MPH,PVRR2,PVRL2,HVEB

Human HEK293 Cells
Nectin-2 is an adhesion molecule that has been reported to play a role in tumor growth, metastasis and tumor angiogenesis. Nectin-2 expression in ovarian cancer may support tumor cell adhesion, leading to growth and lymph node metastasis. Effect of VEGF on Nectin-2 expression as well as permeability was investigated in HUVEC.
TMPK-00661 IL-22 Protein, Cynomolgus, Recombinant (His)

TIFIL-23,IL-22,IL-D110,IL-TIF,TIFa,Interleukin-22,Cytokine Z...

Cynomolgus HEK293 Cells
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. IL-22 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 17.69 kDa and the accession number is G7PHZ7.
TMPH-03246 AQP2 Protein, Rat, Recombinant (His)

cph,AQP-2,Collecting duct water channel protein,ADH water ch...

Rat E. coli
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. AQP2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.4 kDa and the accession number is P34080.
TMPK-00833 CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc)

FLJ34100,EndoCAM,PECA1,PECAM-1,FLJ58394,GPIIA',CD31

Human HEK293 Cells
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 91.2 kDa and the accession number is P16284-1.
TMPH-01751 Nephrin/NPHS1 Protein, Human, Recombinant (His)

Nephrin,Renal glomerulus-specific cell adhesion receptor,NPH...

Human E. coli
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. Nephrin/NPHS1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.1 kDa and the accession number is O60500.
TMPK-00834 CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His)

PECAM-1,FLJ58394,GPIIA',PECA1,EndoCAM,FLJ34100,CD31

Human HEK293 Cells
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is an adhesion and signaling receptor that is expressed on endothelial and hematopoietic cells and plays important roles in angiogenesis, vascular permeability, and regulation of cellular responsiveness. CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 65.6 kDa and the accession number is P16284-1.
TMPK-01201 BPIFA1/LUNX Protein, Human, Recombinant

Lung-specific protein X,BPI fold-containing family A member ...

Human E. coli
Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submucosal tissue in the human soft palate, lung, uvula, and nasal cavity. BPIFA1 is a critical component of the innate immune response that prevents upper airway diseases.
TMPH-02523 AQP2 Protein, Mouse, Recombinant (His)

ADH water channel,cph,Water channel protein for renal collec...

Mouse E. coli
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. AQP2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.5 kDa and the accession number is P56402.
TMPK-00826 VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated

VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,VEGFA,VPF,MVCD1,VEGF,...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPK-00825 VEGF121 Protein, Human, Recombinant (His & Avi)

VPF,VEGF,VEGFA,VEGFMGC70609,血管内皮生长因子,MGC70609,RP1-261G23.1,M...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPK-01194 IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated

IL-22,Cytokine Zcyto18,白细胞介素,IL-TIF,白介素,Interleukin-22,TIFIL...

Mouse E. coli
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 19.7 kDa and the accession number i...
TMPK-01153 PLVAP Protein, Human, Recombinant (His)

PV1,FELS

Human HEK293 Cells
Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such as high glucose and vascular endothelial growth factor (VEGF) induce its expression, leading to the exacerbation of cellular permeability. Because the new blood vessels are fragile and leaky, PLVAP could possibly be considered a therapeutic target against retinovascular diseases...
TMPK-00822 VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled

RP1-261G23.1,VEGFA,MGC70609,VEGF,VEGFMGC70609,VPF,VAS,MVCD1,...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4.
TMPK-00489 TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

TNFSF15,TNF superfamily member 15,TL1,VEGI192A,TL1A,VEGI-251...

Cynomolgus,Rhesus HEK293 Cells
TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weigh...
TMPH-00674 OmpA Protein, E. coli O157:H7, Recombinant (His & SUMO)

ompA,Outer membrane protein A,Outer membrane porin A

E. coli E. coli
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.; Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells. OmpA Protein, E. coli O157:H7, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is ...
TMPK-00143 TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Flag)

TL1A,TL1,TNFSF15,VEGI,VEGI192A,VEGI-251

Human HEK293 Cells
TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Trimer Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight...
TMPH-03472 OmpA Protein, Salmonella typhi, Recombinant (His)

Outer membrane porin A,Outer membrane protein A,ompA

Salmonella typhi E. coli
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.; Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells. OmpA Protein, Salmonella typhi, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38.9 kDa an...
TMPH-01394 GRIN1 Protein, Human, Recombinant (His)

N-methyl-D-aspartate receptor subunit NR1,Glutamate [NMDA] r...

Human E. coli
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. GRIN1 Protein, Human, Recombinant (His)...
TMPH-03107 Complement C5a Protein, Pig, Recombinant (His)

Complement C5a anaphylatoxin,C5

Sus scrofa (Pig) P. pastoris (Yeast)
Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation....
TMPH-02118 SCN1A Protein, Human, Recombinant (His)

Sodium channel protein brain I subunit alpha,Sodium channel ...

Human E. coli
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neur...
TMPJ-01066 CYCS Protein, Human, Recombinant (His)

CYC,Cytochrome C,CYCS

Human E. coli
Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic...
TMPY-02838 FGFBP3 Protein, Human, Recombinant (His)

C10orf13,FGF-BP3,fibroblast growth factor binding protein 3

Human Baculovirus Insect Cells
FGFBP3 is a member of the fibroblast growth factor-binding protein family. Members of this family binds and activates FGF-1 and FGF-2, thereby contributing to tumor angiogenesis. Fibroblast growth factors (FGFs) are important regulators of cell migration, proliferation and differentiation, e.g., during embryogenesis and wound healing, and under several pathological conditions including tumor growth and tumor angiogenesis. Expression of FGF-BP increases after injury to murine and human skin, in p...
TMPH-03753 MYLK Protein, Human, Recombinant (His)

MYLK,Myosin light chain kinase, smooth muscle,Telokin,Kinase...

Human E. coli
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl...
TMPJ-00734 KNG1 Protein, Human, Recombinant (His)

KNG1,High Molecular Weight Kininogen,BDK,HMWK,KNG,Williams-F...

Human HEK293 Cells
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation...
TMPY-01027 Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)

carnitine palmitoyltransferase 1B (muscle),AV080368,Mcp-1

Mouse HEK293 Cells
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared w...

重组蛋白

VEGF121 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00865
Species: Human
Expression System: HEK293 Cells
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00412
Species: Human
Expression System: HEK293 Cells
BPI Protein, Human, Recombinant (His)
Cat.No: TMPY-02908
Species: Human
Expression System: HEK293 Cells
VEGFA Protein, Pig, Recombinant (His)
Cat.No: TMPH-03131
Species: Sus scrofa (Pig)
Expression System: E. coli
VEGF165 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00823
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant
Cat.No: TMPJ-00864
Species: Human
Expression System: HEK293 Cells
BCL2 Protein, Human, Recombinant (His)
Cat.No: TMPY-02700
Species: Human
Expression System: E. coli
Zot Protein, Vibrio cholerae serotype O1, Recombinant (His)
Cat.No: TMPH-03703
Species: Vibrio cholerae
Expression System: E. coli
APOLD1 Protein, Human, Recombinant (His)
Cat.No: TMPH-00949
Species: Human
Expression System: E. coli
Vespakinin-M Protein, Vespa mandarinia, Recombinant (His & KSI)
Cat.No: TMPH-03701
Species: Vespa mandarinia
Expression System: E. coli
Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc)
Cat.No: TMPH-00031
Species: Aeromonas sobria
Expression System: E. coli
OMP P5 Protein, Haemophilus influenzae, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-00782
Species: Haemophilus influenzae
Expression System: E. coli
OmpA Protein, Klebsiella pneumoniae, Recombinant (His & Myc)
Cat.No: TMPH-02377
Species: Klebsiella pneumoniae
Expression System: E. coli
CD31/PECAM-1 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00562
Species: Cynomolgus
Expression System: HEK293 Cells
Nectin-2 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00293
Species: Human
Expression System: HEK293 Cells
IL-22 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00661
Species: Cynomolgus
Expression System: HEK293 Cells
AQP2 Protein, Rat, Recombinant (His)
Cat.No: TMPH-03246
Species: Rat
Expression System: E. coli
CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, hFc)
Cat.No: TMPK-00833
Species: Human
Expression System: HEK293 Cells
Nephrin/NPHS1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01751
Species: Human
Expression System: E. coli
CD31/PECAM-1 Protein, Human, Recombinant (aa 28-601, His)
Cat.No: TMPK-00834
Species: Human
Expression System: HEK293 Cells
BPIFA1/LUNX Protein, Human, Recombinant
Cat.No: TMPK-01201
Species: Human
Expression System: E. coli
AQP2 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02523
Species: Mouse
Expression System: E. coli
VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00826
Species: Human
Expression System: HEK293 Cells
VEGF121 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00825
Species: Human
Expression System: HEK293 Cells
IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-01194
Species: Mouse
Expression System: E. coli
PLVAP Protein, Human, Recombinant (His)
Cat.No: TMPK-01153
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled
Cat.No: TMPK-00822
Species: Human
Expression System: HEK293 Cells
TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
Cat.No: TMPK-00489
Species: Cynomolgus,Rhesus
Expression System: HEK293 Cells
OmpA Protein, E. coli O157:H7, Recombinant (His & SUMO)
Cat.No: TMPH-00674
Species: E. coli
Expression System: E. coli
TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Flag)
Cat.No: TMPK-00143
Species: Human
Expression System: HEK293 Cells
OmpA Protein, Salmonella typhi, Recombinant (His)
Cat.No: TMPH-03472
Species: Salmonella typhi
Expression System: E. coli
GRIN1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01394
Species: Human
Expression System: E. coli
Complement C5a Protein, Pig, Recombinant (His)
Cat.No: TMPH-03107
Species: Sus scrofa (Pig)
Expression System: P. pastoris (Yeast)
SCN1A Protein, Human, Recombinant (His)
Cat.No: TMPH-02118
Species: Human
Expression System: E. coli
CYCS Protein, Human, Recombinant (His)
Cat.No: TMPJ-01066
Species: Human
Expression System: E. coli
FGFBP3 Protein, Human, Recombinant (His)
Cat.No: TMPY-02838
Species: Human
Expression System: Baculovirus Insect Cells
MYLK Protein, Human, Recombinant (His)
Cat.No: TMPH-03753
Species: Human
Expression System: E. coli
KNG1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00734
Species: Human
Expression System: HEK293 Cells
Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01027
Species: Mouse
Expression System: HEK293 Cells
Cat. No. Product Name Target Signaling Pathways
TMIJ-0202 Desloratadine-d5

Desloratadine-d5 是 Desloratadine 的氘代化合物。Desloratadine 的 CAS 号为 100643-71-8。Desloratadine 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。

同位素标记化合物

Desloratadine-d5
Cat.No: TMIJ-0202
Synonym:
Target:
TargetMol Loading
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