PB1

Name: PB1
Brand: TargetMol
SKU: T35888
Price: 333 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T35888Cas号 188714-28-5

PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable stability. It serves as a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 demonstrates the potential to enhance the survival of retinal ganglion cells following axotomy in vitro at concentrations in the nanomolar and picomolar range. Consequently, PB1 has proven instrumental in the study of neuroprotective properties[1][2][3].

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PB1

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产品编号 T35888Cas号 188714-28-5

规格	价格	库存
2 mg	¥ 2,120	5日内发货
5 mg	¥ 3,160	5日内发货
25 mg	¥ 11,400	6-8周
50 mg	¥ 14,900	6-8周
100 mg	¥ 23,700	6-8周
1 mL x 10 mM (in DMSO)	¥ 3,470	5日内发货

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TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable stability. It serves as a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 demonstrates the potential to enhance the survival of retinal ganglion cells following axotomy in vitro at concentrations in the nanomolar and picomolar range. Consequently, PB1 has proven instrumental in the study of neuroprotective properties[1][2][3].
体外活性	PB1 produces a robust activation of the BDNF effector ERK1/2. PB1 promotes RGC survival[1].
体内活性	PB1 (150 μM; intraocular injection; 1 week) attenuates the loss of both RGC (retinal ganglion cells) soma and axons in experimental glaucoma[1].PB1 protects RGC soma in experimental glaucoma. PB1 single dose limits the biological activity in vivo. PB1 attenuates the loss of both RGC soma and axons in experimental glaucoma. PB1 (0.001~100 μM; 72 hours) is effective at rescuing acutely axotomized retinal ganglion cells[1][2].

化学信息

分子量	296.11
分子式	C₁₄H₂₂BO₄P
CAS No.	188714-28-5

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 100 mg/mL (337.71 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3771 mL	16.8856 mL	33.7712 mL	168.8562 mL
5 mM	0.6754 mL	3.3771 mL	6.7542 mL	33.7712 mL
10 mM	0.3377 mL	1.6886 mL	3.3771 mL	16.8856 mL
20 mM	0.1689 mL	0.8443 mL	1.6886 mL	8.4428 mL
50 mM	0.0675 mL	0.3377 mL	0.6754 mL	3.3771 mL
100 mM	0.0338 mL	0.1689 mL	0.3377 mL	1.6886 mL