Palmitoleoyl-CoA lithium is the lithium salt form of Palmitoleoyl-CoA. It can be activated and transported to mitochondria for metabolism, specifically undergoing β-oxidation. Furthermore, it induces a permeability transition in cardiac mitochondrial membranes, leading to mitochondrial dysfunction. Palmitoleoyl-CoA lithium regulates metabolism through conformational control of the AMPK β1-isoform.