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Search Results for " leukotriene "

Targets Recommended: Leukotriene Receptor Endogenous Metabolite

197

抑制剂 & 化合物

19

天然产物

11

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T40870	Leukotriene E4 LTE4	Endogenous Metabolite	Metabolism
	Leukotriene E4 (LTE4)（LTE4）通过二肽酶对LTD4 上的作用生成，是过敏性休克慢反应物质（SRS-A）的成分之一。LTE4 存在于血浆和尿液中，可用于检测哮喘。
T37262	14,15-Leukotriene E4 14,15-Leukotriene E4	Others	Others
	Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils...
T37616	Leukotriene A4 methyl ester Leukotriene A4 methyl ester	Others	Others
	白三烯A4甲酯可在大鼠肝脏中主要碱性胞质谷胱甘肽转移酶的催化下转化为白三烯C4单甲酯，可用于代谢相关研究。
T37493	11-trans Leukotriene D4 11-trans Leukotriene D4	Others	Others
	11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.
T38087	20-hydroxy Leukotriene B4 20-hydroxy Leukotriene B4	Others	Others
	20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2...
T37618	Leukotriene B4 dimethyl amide Leukotriene B4 dimethyl amide	Others	Others
	LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on guinea pig lung membranes.
T37261	14,15-Leukotriene D4 14,15-Leukotriene D4	Others	Others
	14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both ...
T37492	11-trans Leukotriene C4 11-trans Leukotriene C4	Others	Others
	11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum ...
T37970	12-epi Leukotriene B4 12-epi Leukotriene B4	Others	Others
	Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic pr...
T37260	14,15-dehydro Leukotriene B4 14,15-dehydro Leukotriene B4	Others	Others
	Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value ...
T38062	N-acetyl Leukotriene E4 N-acetyl Leukotriene E4	Others	Others
	N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans. N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent. In healthy human subjects urinary excretion of N-acetyl LTE4 is about 1.5 nmol/mol creatinine, which is considerably less than that of LTE4 (12 nmol/mol creatinine).
T37256	12-oxo Leukotriene B4 12-oxo Leukotriene B4	Others	Others
	Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give ...
T37494	11-trans Leukotriene E4 11-trans Leukotriene E4	Others	Others
	Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.
T37980	N-methyl Leukotriene C4 N-methyl Leukotriene C4	Others	Others
	Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukot...
T36423	Leukotriene B5	Others	Others
	Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. It is a metabolite of eicosapentaenoic acid formed through the 5-lipoxygenase (5-LO) pathway. LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner. In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells. LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platele...
T37617	Leukotriene B3	Others	Others
	LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemotaxis of human neutrophils.
T37619	Leukotriene B4 Ethanolamide	Others	Others
	The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4...
T38129	Leukotriene F4 LTF4	Others	Others
	LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle. [1] The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4. [1] [2]
T38128	Leukotriene D4 LTD4	Endogenous Metabolite; Drug Metabolite	Metabolism
	Leukotriene D4 (LTD4) 是一种由花生四烯酸形成的强效促炎介质，是一种支气管收缩剂，可诱导成骨细胞衰老。Leukotriene D4 诱导潜在致癌基因的转录活性，可用于研究哮喘。
T37620	Leukotriene C4 methyl ester	Others	Others
	Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute all...
T37615	Leukotriene A3 methyl ester	Others	Others
	Biosynthesis of LTA3 occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway and it is the putative intermediate in the biosynthesis of 3-series leukotrienes. LTA3 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
T14045	Leukotriene B4 LTB4,5(S),12(R)-DiHETE	Others	Others
	Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
T32680	Leukotriene E-4 sulfone	Others	Others
	Leukotriene E-4 sulfone is a synthetic leukotriene.
T32681	Leukotriene F-4 sulfone Ltf4 sulfone	Others	Others
	Leukotriene F-4 sulfone induces vascular permeability changes.
T84522	14,15-Leukotriene C4 Eoxin C4	Others	Others
	Leukotriene C4 (14,15-LTC4) is an inflammatory mediator synthesized from arachidonic acid through the actions of 15- and 12-lipoxygenases (LOs), involving intermediates such as 15-HpETE and 14,15-LTA4. Unlike the majority of leukotrienes formed via the 5-LO pathway, 14,15-LTC4 is an eoxin predominantly produced by eosinophils, although mast cells and nasal polyps can also synthesize it. While its physiological roles are not well understood, 14,15-LTC4 exhibits limited contractile activity on gui...
T73793	20-Carboxy-Leukotriene B4	Others	Others
	20-Carboxy-Leukotriene B4 (20-COOH LTB4) 是 Leukotriene B4 (LTB4) 的代谢物。20-Carboxy-Leukotriene B4 以高亲和力与 BLT1 受体结合。20-Carboxy-Leukotriene B4 抑制 LTB4 介导的中性粒细胞反应，迁移、脱粒、白三烯生物合成。
T84571	20-trifluoro Leukotriene B4 20-trifluoro LTB4	Others	Others

T84504	Leukotriene B4-3-aminopropylamide LTB4-3-aminopropylamide	Others	Others
	Leukotriene B4 (LTB4)-3-aminopropylamide is an analog of LTB4 that exhibits potent and selective binding to the BLT1 receptor with Ki values of 5.1 nM at BLT1 and 1,227 nM at BLT2, indicating its high affinity for BLT1 over BLT2. This compound's effects are mediated through interactions with two receptors, BLT1 and BLT2.
T84978	5-oxo Leukotriene B4 5-keto LTB4	Others	Others
	5-Oxo Leukotriene B4 (5-oxo LTB4) serves as an intermediate metabolite in the production of 12-oxo LTB4.
T1677L	Montelukast sodium MK0476,孟鲁司特钠	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	Montelukast sodium (MK0476) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。
T84506	18-carboxy dinor Leukotriene B4 18-carboxy dinor LTB4	Others	Others
	18-Carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) represents a β-oxidation metabolite of Leukotriene B4 (LTB4). Initially, LTB4 is metabolized in the liver to 20-carboxy LTB4, which subsequently undergoes β-oxidation to form 18-carboxy dinor LTB4.
T1677	Montelukast 孟鲁司特,Singular	Leukotriene Receptor; Lipoxygenase; LTR	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Montelukast (Singular) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。
T72144	6-trans-12-epi-Leukotriene B4	Others	Others
	6-trans-12-epi-Leukotriene B4 是一种花生四烯酸代谢物，是一种有效的抗炎剂。
T6893	MK-886 MK886,L 663536	Apoptosis; Leukotriene Receptor; COX; PPAR; FLAP	Apoptosis; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	MK-886 (L 663536)是一种细胞可渗透的，具有口服活性的 FLAP (IC50为 30 nM) 和白三烯生物合成 (完整白细胞和人全血中的IC50分别为 3 nM 和 1.1μM) 的抑制剂。它也是一种非竞争性PPARα拮抗剂，可以诱导细胞凋亡。
T22946	LY255283 LY 255283	Leukotriene Receptor	GPCR/G Protein
	LY255283 是白三烯 B4 (LTB4) 受体的特异性拮抗剂，抑制人外周血多形核白细胞和由钙离子载体 A23187 激活的单核细胞中 LTB(4) 的产生。
T26519	Ablukast Ro 23-3544,阿鲁司特	Leukotriene Receptor	GPCR/G Protein
	Ablukast (Ro 23-3544) 是白三烯受体的选择性拮抗剂，也是LTD4受体拮抗剂。可改善 LTC4 和抗原诱导的支气管狭窄。
T0694	Pranlukast 普鲁司特,ONO-1078,普仑司特	Leukotriene Receptor; IL Receptor; Others; TNF; NF-κB; LTR	Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB; Others
	Pranlukast (ONO-1078) 是一种半胱氨酰白三烯受体 1 拮抗剂，可拮抗或减少支气管痉挛，用于哮喘研究。
T16280	Nedocromil FPL 59002,尼多克罗	Leukotriene Receptor; Prostaglandin Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Nedocromil (FPL 59002) 对多种介质的作用或形成有抑制作用，包括组胺，前列腺素 D2和白三烯 C4。
T6736	Zafirlukast Vanticon,ICI 204219,Accolate,扎鲁司特	Leukotriene Receptor	GPCR/G Protein
	Zafirlukast (ICI 204219) 是一种可口服的白三烯 D4受体拮抗剂，具有平喘、抗炎和抗菌作用。
T20615	Olsalazine 奥沙拉嗪,Dipentium,Salicylic acid	Others	Others
	Olsalazine (Dipentium) 是一种抗炎药，用于治疗炎症性肠病。它也是一种新型的 DNA 去甲基化剂。
T22358	Etalocib LY293111,VML295	Apoptosis; Leukotriene Receptor; LTR	Apoptosis; GPCR/G Protein; Immunology/Inflammation
	Etalocib (LY293111) 是一种具有口服活性的白三烯(LTB4)受体的拮抗剂，抑制 [3H]LTB4结合的 Ki 值为 25 nM。它还可诱导凋亡。它抑制 LTB4诱导的钙动员，lC50值为 20 nM。
T21696	SC-57461A N -甲基- N -[3 - [4 - (苯甲基)苯氧基]丙基Β-丙氨酸盐酸盐	Aminopeptidase	Metabolism
	SC-57461A 是一种口服有活力的非肽类白三烯 A4 (LTA4) 水解酶选择性抑制剂，它能够抑制重组人 (IC50: 2.5 nM) 、小鼠 (IC50: 3 nM) 和小鼠LTA4水解酶 (IC50: 23 nM) 。
T3148	MK-571 sodium L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	MK-571 sodium (L-660711 sodium salt) 是一种可口服的选择性白三烯 D4受体拮抗剂，在豚鼠和人肺膜的 Ki 分别为0.22 和 2.1 nM。
T24327	L 674573 L 674,573,L674,573,L-674,573,L674573,L-674573	Leukotriene Receptor	GPCR/G Protein
	L 674573是白三烯生物合成的抑制剂。
T26524	ABT-080 VML530,VML-530,VML 530,ABT080	Leukotriene Receptor	GPCR/G Protein
	ABT-080 (VML 530)是白三烯合成的抑制剂，有用于治疗哮喘的潜力。
T15002	CP-105696 Pfizer 105696	LTR	Immunology/Inflammation
	CP-105696 是一种具有强效性和选择性白三烯 B4 (LTB4) 受体拮抗剂，可用于研究异体移植物排斥反应。
T2583	Cilastatin 西司他丁,MK0791	Proteasome; Antibacterial; Antibiotic	Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	Cilastatin (MK0791) 是一种可逆的竞争性的肾脏脱氢肽酶 I 抑制剂，IC50为 0.1 μM。它抑制细菌金属叶内酰胺酶CphA 的IC50为 178 μM，可用作抗菌辅助剂。
T22787	FPL 55712	LTR	Immunology/Inflammation
	FPL 55712 是白三烯受体和 SRS-A 拮抗剂，抑制支气管收缩，可用于研究哮喘和冠状动脉血栓。
T10917	LTB4-IN-1 Anti-inflammatory agent 2	LTR	Immunology/Inflammation
	LTB4-IN-1 (Anti-inflammatory agent 2) 是白三烯 (LTB4) 合成抑制剂，IC50 为 70 nM。
T27979	Masilukast ICI-D-3523,ZD-3523,ICI D-3523,MCC-847,SA-09012,D-3523	Leukotriene Receptor	GPCR/G Protein
	Masilukast(MCC-847) 是一种口服的白三烯D4 (LTD4) 受体拮抗剂，可用于研究与炎症相关的疾病。

化合物

Leukotriene E4

Cat.No: T40870

Synonym: LTE4

Target: Endogenous Metabolite

14,15-Leukotriene E4

Cat.No: T37262

Synonym: 14,15-Leukotriene E4

Target: Others

Leukotriene A4 methyl ester

Cat.No: T37616

Synonym: Leukotriene A4 methyl ester

Target: Others

11-trans Leukotriene D4

Cat.No: T37493

Synonym: 11-trans Leukotriene D4

Target: Others

20-hydroxy Leukotriene B4

Cat.No: T38087

Synonym: 20-hydroxy Leukotriene B4

Target: Others

Leukotriene B4 dimethyl amide

Cat.No: T37618

Synonym: Leukotriene B4 dimethyl amide

Target: Others

14,15-Leukotriene D4

Cat.No: T37261

Synonym: 14,15-Leukotriene D4

Target: Others

11-trans Leukotriene C4

Cat.No: T37492

Synonym: 11-trans Leukotriene C4

Target: Others

12-epi Leukotriene B4

Cat.No: T37970

Synonym: 12-epi Leukotriene B4

Target: Others

14,15-dehydro Leukotriene B4

Cat.No: T37260

Synonym: 14,15-dehydro Leukotriene B4

Target: Others

N-acetyl Leukotriene E4

Cat.No: T38062

Synonym: N-acetyl Leukotriene E4

Target: Others

12-oxo Leukotriene B4

Cat.No: T37256

Synonym: 12-oxo Leukotriene B4

Target: Others

11-trans Leukotriene E4

Cat.No: T37494

Synonym: 11-trans Leukotriene E4

Target: Others

N-methyl Leukotriene C4

Cat.No: T37980

Synonym: N-methyl Leukotriene C4

Target: Others

Leukotriene B5

Cat.No: T36423

Target: Others

Leukotriene B3

Cat.No: T37617

Target: Others

Leukotriene B4 Ethanolamide

Cat.No: T37619

Target: Others

Leukotriene F4

Cat.No: T38129

Synonym: LTF4

Target: Others

Leukotriene D4

Cat.No: T38128

Synonym: LTD4

Target: Endogenous Metabolite, Drug Metabolite

Leukotriene C4 methyl ester

Cat.No: T37620

Target: Others

Leukotriene A3 methyl ester

Cat.No: T37615

Target: Others

Leukotriene B4

Cat.No: T14045

Synonym: LTB4,5(S),12(R)-DiHETE

Target: Others

Leukotriene E-4 sulfone

Cat.No: T32680

Target: Others

Leukotriene F-4 sulfone

Cat.No: T32681

Synonym: Ltf4 sulfone

Target: Others

14,15-Leukotriene C4

Cat.No: T84522

Synonym: Eoxin C4

Target: Others

20-Carboxy-Leukotriene B4

Cat.No: T73793

Target: Others

20-trifluoro Leukotriene B4

Cat.No: T84571

Synonym: 20-trifluoro LTB4

Target: Others

Leukotriene B4-3-aminopropylamide

Cat.No: T84504

Synonym: LTB4-3-aminopropylamide

Target: Others

5-oxo Leukotriene B4

Cat.No: T84978

Synonym: 5-keto LTB4

Target: Others

Montelukast sodium

Cat.No: T1677L

Synonym: MK0476,孟鲁司特钠

Target: Leukotriene Receptor, LTR

18-carboxy dinor Leukotriene B4

Cat.No: T84506

Synonym: 18-carboxy dinor LTB4

Target: Others

Cat.No: T1677

Synonym: 孟鲁司特,Singular

Target: Leukotriene Receptor, Lipoxygenase, LTR

6-trans-12-epi-Leukotriene B4

Cat.No: T72144

Target: Others

Cat.No: T6893

Synonym: MK886,L 663536

Target: Apoptosis, Leukotriene Receptor, COX, PPAR, FLAP

Cat.No: T22946

Synonym: LY 255283

Target: Leukotriene Receptor

Cat.No: T26519

Synonym: Ro 23-3544,阿鲁司特

Target: Leukotriene Receptor

Cat.No: T0694

Synonym: 普鲁司特,ONO-1078,普仑司特

Target: Leukotriene Receptor, IL Receptor, Others, TNF, NF-κB, LTR

Cat.No: T16280

Synonym: FPL 59002,尼多克罗

Target: Leukotriene Receptor, Prostaglandin Receptor, Histamine Receptor

Cat.No: T6736

Synonym: Vanticon,ICI 204219,Accolate,扎鲁司特

Target: Leukotriene Receptor

Cat.No: T20615

Synonym: 奥沙拉嗪,Dipentium,Salicylic acid

Target: Others

Cat.No: T22358

Synonym: LY293111,VML295

Target: Apoptosis, Leukotriene Receptor, LTR

Cat.No: T21696

Synonym: N -甲基- N -[3 - [4 - (苯甲基)苯氧基]丙基Β-丙氨酸盐酸盐

Target: Aminopeptidase

Cat.No: T3148

Synonym: L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid

Target: Leukotriene Receptor, LTR

Cat.No: T24327

Synonym: L 674,573,L674,573,L-674,573,L674573,L-674573

Target: Leukotriene Receptor

Cat.No: T26524

Synonym: VML530,VML-530,VML 530,ABT080

Target: Leukotriene Receptor

Cat.No: T15002

Synonym: Pfizer 105696

Target: LTR

Cat.No: T2583

Synonym: 西司他丁,MK0791

Target: Proteasome, Antibacterial, Antibiotic

Cat.No: T22787

Target: LTR

Cat.No: T10917

Synonym: Anti-inflammatory agent 2

Target: LTR

Cat.No: T27979

Synonym: ICI-D-3523,ZD-3523,ICI D-3523,MCC-847,SA-09012,D-3523

Target: Leukotriene Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T25687	Leukotriene C4 LTC4,Leukotriene C	Endogenous Metabolite	Metabolism
	Leukotriene C4 (LTC4) 是一种类花生酸脂质介质，可调节炎症部位白细胞的募集和功能。Leukotriene C4 是支气管收缩、粘液分泌过多和嗜酸性粒细胞增多的介质，在荨麻疹中具有介导作用。
T7786	Tryptanthrin	DNA gyrase	DNA Damage/DNA Repair
	Tryptanthrin 是一种口服具有活性的细胞内Leukotriene (LT) biosynthesis 抑制剂。它能够降低大鼠胸膜炎模型中的 LTB4 水平，并抑制人全血中Leukotriene 的形成 (IC50= 10 µM)。
T5714	5-O-Demethylnobiletin 5-DEMETHYLNOBILETIN,去甲基川陈皮素	Leukotriene Receptor; Lipoxygenase	GPCR/G Protein; Metabolism
	5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) 是从黄芪中分离出的多甲氧基黄酮，具有抗炎活性，可通过直接抑制 5-LOX 发挥作用，IC50为 0.1 μM。
TN1182	11-Keto-beta-boswellic acid 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸	Leukotriene Receptor; NF-κB; Lipoxygenase	GPCR/G Protein; Metabolism; NF-κB
	11-Keto-beta-boswellic acid 是来自乳香的一种五环三萜酸，具有抗炎活性和剂量依赖性心脏保护作用，主要是由于抑制5-脂氧合酶、白三烯、NF-κB 的激活和肿瘤坏死因子 α 的产生。
T21504	γ-Linolenic Acid methyl ester Methyl gamma-linolenate,γ-亚麻酸甲酯	LTR	Immunology/Inflammation
	γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) 是一种弱白三烯 B4 (LTB4) 受体拮抗剂。
T3529	Bestatin hydrochloride 盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素	Integrin; Aminopeptidase; Antibacterial; Antibiotic	Cytoskeletal Signaling; Metabolism; Microbiology/Virology
	Bestatin hydrochloride (Ubenimex hydrochloride) 是CD13(Aminopeptidase N)/APN 和leukotriene A4 hydrolase 抑制剂，可研究癌症。
T4973	Paraxanthine 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE	Endogenous Metabolite	Metabolism
	Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物，能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。
T1257	Bestatin Ubenimex,乌苯美司	Others; Aminopeptidase; Antibacterial; Antibiotic; LTR	Immunology/Inflammation; Metabolism; Microbiology/Virology; Others
	Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。
T19791	Chamazulene BA2784,BA 2784,BA-2784,Dimethulene
	Chamazulene is an anti-inflammatory agent as well as an antioxidant-type inhibitor of leukotriene B4 formation.
TN5180	Triptinin B	Others	Others
	Triptinin A and triptinin B are leukotriene D4 antagonist constituents.
T62258	Bestatin trifluoroacetate	Others	Others
	Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是一种 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，经常用于研究癌症。
TN6057	1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone (Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one
	(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one shows strong inhibitory activity on leukotriene biosynthesis in human polymorphonuclear granulocytes, and it is very effective against mycobacteria.
TN7347	9,11-Dehydro-beta-boswellic acid	Others	Others
	9,11-Dehydro-β-boswellic acid is a compound with urease inhibitory activity and acts as an inhibitor of 5-lipoxygenase (5-LO), a critical enzyme in leukotriene biosynthesis.
TN2552	1-Methyl-2-nonylquinolin-4(1H)-one	Others	Others
	1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM.
TN7307	Hinokiol 8,11,13-Abietatriene-3,12-diol	Others	Others
	Hinokiol exhibits anti-inflammatory activity by significantly inhibiting 5-hydroxy-eicosa-tetra-enoic acid (5-HETE) and leukotriene B(4) (LTB4) formations. Additionally, it demonstrates potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).
TN5070	Stilbostemin B	Others	Others
	Stilbostemin A, stilbostemin B , stilbostemin D , stilbostemin F , and stilbostemin G show structure-dependent inhibition of leukotriene biosynthesis with IC(50) values ranging from 3.7 to >50 microM.
T37972	12-OxoETE	Others	Others
	12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE. 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via a leukotriene B4 receptor or a common activation sequence.
TN2511	Britannilactone diacetate 1,6-O,O-Diacetylbritannilactone	IL Receptor; PARP; ROS; MAPK; Caspase; JAK; JNK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; JAK/STAT signaling; MAPK; Proteases/Proteasome; Stem Cells
	1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro
TN4584	Morolic acid	IL Receptor; COX; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro

天然产物

Leukotriene C4

Cat.No: T25687

Synonym: LTC4,Leukotriene C

Target: Endogenous Metabolite

Cat.No: T7786

Target: DNA gyrase

5-O-Demethylnobiletin

Cat.No: T5714

Synonym: 5-DEMETHYLNOBILETIN,去甲基川陈皮素

Target: Leukotriene Receptor, Lipoxygenase

11-Keto-beta-boswellic acid

Cat.No: TN1182

Synonym: 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸

Target: Leukotriene Receptor, NF-κB, Lipoxygenase

γ-Linolenic Acid methyl ester

Cat.No: T21504

Synonym: Methyl gamma-linolenate,γ-亚麻酸甲酯

Target: LTR

Bestatin hydrochloride

Cat.No: T3529

Synonym: 盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素

Target: Integrin, Aminopeptidase, Antibacterial, Antibiotic

Cat.No: T4973

Synonym: 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

Cat.No: T1257

Synonym: Ubenimex,乌苯美司

Target: Others, Aminopeptidase, Antibacterial, Antibiotic, LTR

Cat.No: T19791

Synonym: BA2784,BA 2784,BA-2784,Dimethulene

Cat.No: TN5180

Target: Others

Bestatin trifluoroacetate

Cat.No: T62258

Target: Others

1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone

Cat.No: TN6057

Synonym: (Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one

9,11-Dehydro-beta-boswellic acid

Cat.No: TN7347

Target: Others

1-Methyl-2-nonylquinolin-4(1H)-one

Cat.No: TN2552

Target: Others

Cat.No: TN7307

Synonym: 8,11,13-Abietatriene-3,12-diol

Target: Others

Cat.No: TN5070

Target: Others

Cat.No: T37972

Target: Others

Britannilactone diacetate

Cat.No: TN2511

Synonym: 1,6-O,O-Diacetylbritannilactone

Target: IL Receptor, PARP, ROS, MAPK, Caspase, JAK, JNK, STAT

Cat.No: TN4584

Target: IL Receptor, COX, HIV Protease

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01658	Leukotriene A4 Hydrolase Protein, Mouse, Recombinant (His) Lta4h,leukotriene A4 hydrolase	Mouse	Baculovirus Insect Cells
	Leukotriene A4 Hydrolase Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.4 kDa and the accession number is P24527.
TMPY-00877	Leukotriene A4 Hydrolase Protein, Human, Recombinant (His) LAT4,leukotriene A4 hydrolase	Human	Baculovirus Insect Cells
	Leukotriene A4 Hydrolase Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is A0A140VK27.
TMPY-01480	LTC4S Protein, Human, Recombinant (His) LTC4S,MGC33147,leukotriene C4 synthase	Human	Baculovirus Insect Cells
	Leukotriene C4 synthase, also known as LTC4 synthase, Leukotriene-C(4) synthase, and LTC4S, is a multi-pass membrane protein that belongs to the MAPEG family. LTC4S is detected in the lung, platelets, and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells, and platelets. LTC4S is essential for the production of cysteinyl leukotrienes (Cys...
TMPH-03749	CYSLTR1 Protein, Human, Recombinant (His) Cysteinyl leukotriene receptor 1,G-protein coupled ...	Human	E. coli
	Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
TMPH-01711	ABCC1 Protein, Human, Recombinant (His) MRP,ATP-binding cassette sub-family C member 1,Leukotrie...	Human	E. coli
	ABCC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.9 kDa and the accession number is P33527.
TMPH-03260	Carboxypeptidase A1 Protein, Rat, Recombinant (His & Myc) Cpa1,Carboxypeptidase A1,Cpa	Rat	E. coli
	Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond. Carboxypeptidase A1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.6 kDa and the accession number is P00731.
TMPH-02125	SLCO2B1 Protein, Human, Recombinant (His & Myc) Solute carrier family 21 member 9,Solute carrier organic ani...	Human	E. coli
	Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
TMPJ-00582	PRG3 Protein, Human, Recombinant (His) Prepro-MBPH,Prepro-Major Basic Protein Homolog,Eosinophil Ma...	Human	HEK293 Cells
	Proteoglycan 3, also known as Eosinophil major basic protein homolog, Prepro-major basic protein homolog, PRG3 and MBPH, contains one C-type lectin domain. Proteoglycans are a major component of the animal extracellular matrix. PRG3 localizes to the eosinophil secondary granule and is expressed in bone marrow, not detected in placenta. PRG3 has similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, PRG3 can stimulate neutrophil superoxide production and IL8 release, histamine an...
TMPY-01481	FLAP Protein, Human, Recombinant (His) FLAP,arachidonate 5-lipoxygenase-activating protein	Human	Baculovirus Insect Cells
	Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk for myocardial infarction, stroke and restenosis, reigniting pharmaceutical interest in this target. It had been found that ALOX5AP/FLAP is a key enzyme in leukotriene formation, in both human pulmonary microvascular endothelial cells and a transformed human brain endothelial cell ...
TMPJ-00020	IL-5 Protein, Human, Recombinant (His & Avi), Biotinylated 白介素,Eosinophil differentiation factor,B-cell differentiation...	Human	HEK293 Cells
	IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cells and eosinophils. Relative to B cells, IL-5 appears to induce the differentiation of activated conventional B-2 cells into Ig-secreting cells. In addition, it induces the growth of B-1 progenitors as well as IgM production by B-1 cells.IL-5 appears to perform a number of functi...
TMPH-02690	PLA2G10 Protein, Mouse, Recombinant (His & Myc) Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi...	Mouse	E. coli
	Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li...

重组蛋白

Leukotriene A4 Hydrolase Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01658

Species: Mouse

Expression System: Baculovirus Insect Cells

Leukotriene A4 Hydrolase Protein, Human, Recombinant (His)

Cat.No: TMPY-00877

Species: Human

Expression System: Baculovirus Insect Cells

LTC4S Protein, Human, Recombinant (His)

Cat.No: TMPY-01480

Species: Human

Expression System: Baculovirus Insect Cells

CYSLTR1 Protein, Human, Recombinant (His)

Cat.No: TMPH-03749

Species: Human

Expression System: E. coli

ABCC1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01711

Species: Human

Expression System: E. coli

Carboxypeptidase A1 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03260

Species: Rat

Expression System: E. coli

SLCO2B1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02125

Species: Human

Expression System: E. coli

PRG3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00582

Species: Human

Expression System: HEK293 Cells

FLAP Protein, Human, Recombinant (His)

Cat.No: TMPY-01481

Species: Human

Expression System: Baculovirus Insect Cells

IL-5 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00020

Species: Human

Expression System: HEK293 Cells

PLA2G10 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02690

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0609	Zafirlukast-d7
	Zafirlukast-d7 是 Zafirlukast 的氘代化合物。Zafirlukast 的 CAS 号为 107753-78-6。Zafirlukast 是一种可口服的白三烯 D4受体拮抗剂，具有平喘、抗炎和抗菌作用。
T11240	Ethacrynic acid D5	Others	Others
	Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by...
TMIJ-0329	Montelukast-d6
	Montelukast-d6 是 Montelukast 的氘代化合物。Montelukast 的 CAS 号为 158966-92-8。Montelukast 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。

同位素标记化合物

Cat.No: TMIH-0609

Ethacrynic acid D5

Cat.No: T11240

Target: Others

Cat.No: TMIJ-0329

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