Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.

Acebilustat是一种白三烯A4水解酶抑制剂，其在第一阶段试验中被证明是安全且耐受性良好[1]。Acebilustat作为一种抗炎化合物，正在开发中，用于治疗囊性纤维化(CF)及其他疾病。它是一个强效的白三烯A4水解酶(LTA4H)抑制剂，该酶催化生成白三烯B4(LTB4)的速率限制步骤，LTB4是一种强效的趋化因子和炎症免疫细胞（包括中性粒细胞）的激活剂[2]。

Rolapitant is made at a stock concentration of 1 mM in 100% DMSO. For most receptor binding studies, the stock solution is diluted with the final concentrations ranged from 0.1 to 3 μM. Radioligand concentrations for competition binding studies ranged from 0.5 to 1 nM. For species comparison studies, 150 pM [125I]-BHSP is incubated with varying concentrations of protein (10-50 μg) prepared from gerbil, rabbit and monkey striata, and from cells expressing cloned rat, mouse and guinea pig NK receptors[1].