Iralukast (CGP 45715A)

Name: Iralukast (CGP 45715A)
Brand: TargetMol
SKU: T37016
Rating: 4.5 (1 reviews)

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产品编号 T37016Cas号 151581-24-7

Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.

Iralukast (CGP 45715A)

还可以

产品编号 T37016Cas号 151581-24-7

Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.

规格	价格	库存
25 mg	¥ 29,300	10-14周
50 mg	¥ 39,300	10-14周
100 mg	¥ 51,500	10-14周

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Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.

体外活性

Both Iralukast and CGP 57698 are able to compete for the two sites labelled by [3H]-LTD4. As in all the G-protein coupled receptors, Iralukast and CGP 57698 do not discriminate between the high and the low affinitystates of the CysLT receptor labelled by LTD4 (Ki1=Ki2=16.6 nM±36% CV and Ki1=Ki2=5.7 nM±19% CV, respectively). Iralukast, displays a slow bindingkinetic, because preincubation (15 min) increases its antagonist potency. Iralukast and CGP 57698 antagonize LTD4-induced contraction of humanbronchi, with pA2 values of 7.77±4.3% CV and 8.51±1.6% CV, respectively, and slopes not significantly different from unity[2].